Kelly Lab

Selected Publications

1. Gan Z, Burkart-Hartman EM, Han D-H, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP: Nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev. 2011; 25:2619-2630. PMCID: PMC3248683
    
2. Kim C, Wen J, Wong J, Wang S, Wang C, Spiering S, Kan NG, Forcales S, Puri PL, Leone TC, Marine JE, Calkins H, Kelly DP, Judge DP, Chen H-SV: Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature. 2013; Feb 7;494:105-110. PMCID: PMC3573229
    
3. Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP: Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest. 2013; Jun 3;123(6):2564-2575. PMCID: PMC3668841
    
4. Lai L, Leone TC, Keller MP, Martin OJ, Broman AT, Nigro J, Kapoor K, Koves TR, Stevens R, Ilkayeva OR, Vega RB, Attie AD, Muoio DM, Kelly DP: Energy metabolic re-programming in the hypertrophied and early stage failing heart: A multi-systems approach. Circ Heart Fail. 2014; 7:1022-1031. PMCID: PMC4241130
    
5. Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP: The failing heart relies on ketone bodies as a fuel. Circulation. 2016 Feb 23;133(8):698-705. PMCID: PMC4766035
    
6. Ahn B, Soundarapandian MM, Sessions H, Peddibholta S, Roth G, Li J-L, Sugarman E, Koo A, Malany S, Wang M, Yea K, Brooks J, Leone TC, Han X, Vega RB, Kelly DP: MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-3579. PMCID: PMC5004938
    
7. Vega RB, Konhilas J, Kelly DP, Leinwand L: Molecular mechanisms underlying cardiac adaptation to exercise. Cell Metab. 2017; May 2;25(5):1012-1026.
    
8. Sakamoto T, Matsuura TR, Wan S, Ryba DM, Kim J, Won KJ, Lai L, Petucci C, Petrenko N, Musunuru K, Vega RB, Kelly DP: A critical role for estrogen-related receptor signaling in cardiac maturation. Circ Res. 2020 Jun 5;126(12):1685-1702. PMCID: PMC7274895
    
9. Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoi DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP: RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure. JCI. 2023 Mar 16;e162309. PMCID: PMC: 36927960
    
10. Matsuura TR, Puchalska P, Crawford PA, Kelly DP: Ketones and the heart: Metabolic principles and therapeutic implications. Circ Res. 2023 Mar 31;132(7):882-898.  PMID: 36996176
     
11. Sakamoto T and Kelly DP: Cardiac Maturation.  JMCC, 2023, Dec 30:187:38-50.  PMID: 38160640

Complete List