The Lee Visualization Lab is dedicated to the improved visualization and surgical resection of brain tumors – both benign and malignant. Directed by John Y.K. Lee, MD, MSCE, the lab has both clinical and small animal research effort.
We believe that fluorescence-guided surgery will help neurosurgeons to better detect areas of tumor and increase our ability to achieve total resection, ultimately improving patient outcomes. Our lab is interested in near-infrared fluorescent dyes, because of their increased penetration through normal tissue as well as the lack of any normal autofluorescence in brain when compared to fluorophores in the visible-light range. We are interested in novel compounds and novel application of existing compounds in order to help the surgeon localize tumors intraoperatively, distinguish normal brain from cancerous tissue and clear the surgical margins in real-time. In addition, we are always exploring novel imaging techniques in collaboration with bioengineering and physics, as many of the dyes have unique imaging properties beyond what our eyes can see.
In addition to fluorescent tumor visualization, our lab also continues to refine and innovate novel ways to visualize neurosurgical pathology in the operating room relying on endoscopic refinements, especially as it pertains to skull base surgery.
The Power of Combining Photodynamic Therapy and Fluorescence-Guided Surgery
October 9, 2020
Recently, Clare Teng, a third-year medical student at Penn published groundbreaking work on the use of SPION nanoparticles as a theragnostic agent that provides photodynamic therapy and near-infrared visualization in Neuro-Oncology. In recognition of the novelty of this research, Teng's work was chosen to be featured on the cover of the journal. Congratulations, Clare!
The Lee Lab at the 2019 CNS Annual Meeting
Steve Cho, a current fourth-year medical student at the University of Pennsylvania, delivered 2 talks along with a poster presentation at the Congress of Neurological Surgeons (CNS) Annual Meeting in San Fransisco. Congrats Steve!