Agenda

Monday, March 17, 2025
10am - 6pm

Symposium organizers: Bryson Katona, MD, PhD, Jessica Long, MS, CGC,  and E. John Wherry, PhD

Please note that not all sessions will be available to virtual attendees.

10:00am – 10:05am

Welcome and Opening Remarks 

 

10:05am – 10:20am 

Overview of Penn’s Lynch syndrome program

Bryson Katona, MD, PhD

10:20am – 10:30am 

 Opportunities for giving

Tricia Bruning
Clinical Care Symposium - Moderator: Jessica Long, MS, CGC

10:30am – 10:45am 

 Lynch syndrome genetics and cancer risk  Jessica Long, MS, CGC

10:45am – 11:00am 

 What’s new this year in Lynch syndrome  Avi Anantharajah, MS, CGC
11:00am - 11:20am Prostate cancer risk and screening in Lynch syndrome  Kara Maxwell, MD, PhD

11:20am-11:40am

 Breast cancer risk and screening in Lynch syndrome  Payal Shah, MD
11:40am - 12:00pm Pancreatic cancer screening in Lynch syndrome: Who, When, and How Bryson Katona, MD, PhD

12:00pm-12:40pm

Lunch with the experts (in-person attendees only)
  • Oncology (Breast and ovarian cancer) | Payal Shah, MD
  • Oncology (Prostate cancer) | Kara Maxwell, MD, PhD 
  • Oncology (Pancreatic and colorectal cancer) | Kim Reiss-Binder, MD 
  • Adult Genetics | Avi Anantharajah, MS, CGC & Joanna Mercado, MS, CGC 
  • Surgery | Najjia Mahmoud, MD
  • Gastroenterology | Michael Kochman, MD
  • Nutrition | Jessica Griffin, RD 
  • Dermatology | Neha Jariwala, MD
  • Research | Michaela Dungan, Daniel Clay, Julia Youngman, Sara Karley
  • Gynecology | Elizabeth Greenstein Clement, MD 
  • Gynecology Oncology | Stefan M Gysler, MD, MHS
12:40pm - 1:40pm Expert panel discussion - Moderator: Bryson Katona, MD, PhD
  • Gastroenterology | Michael Kochman, MD, PhD
  • Dermatology | Emily Chu, MD
  • Genetics | Jesica Long, MS, CGC
  • Urology | Daniel Lee, MD
  • Colorectal surgery | Najjia Mahmoud, MD
  • Oncology | Kim Reiss-Binder, MD, Payal Shah, MD, Kara Maxwell, MD, PhD
  • Nutrition | Jessica Griffin, RD
  • Gynecology | Elizabeth Greenstein Clement, MD 
  • Gynecology Oncology | Stefan M Gysler, MD, MHS

1:40pm - 2:40pm 

Borrelli Family Keynote talk

Lynch Syndrome: an insider's perspective

 C. Richard Boland, MD

2:40pm - 3:00pm

Break
Research Symposium - Moderator: E. John Wherry, PHD

3:00pm - 3:20pm

 Investigating the Microbiome-Immune System Dynamics in Lynch Syndrome: Unravelling Chronic Immune Activity-Driven Susceptibility to Cancer Joel Babdor, PhD
3:20pm - 3:40pm Repeat Gastric Body and Antrum Biopsies in Lynch Syndrome Have a Low Yield of Gastric Intestinal Metaplasia and Helicobacter Pylori Jessica Vadaketh, MD

3:40pm - 4:00pm

 Molecular mechanisms of neoantigen immunosurveillance in Lynch syndrome Shira Rosenberg

4:00pm - 4:20pm

 Controversial areas in pancreatic cancer surveillance in Lynch syndrome: A Survey Across the International Pancreatic Cancer Early Detection (PRECEDE) Consortium  Anjeli Manam, MD

4:20pm - 4:40pm

 ExCITE-seq Profiling of Colorectal Tissues in Lynch Syndrome: Uncovering Cellular and Molecular Mechanisms of Cancer Susceptibility

Hairu Yang, PhD

4:40pm - 5:00pm

 PMS2CL interference leading to erroneous identification of a pathogenic PMS2 variant in Black patients Jacqueline Cappadocia

5:00pm - 6:00pm

Cocktail Hour (in-person attendees only)