Prof. Dr. med. Matthias Kloor
Prof. Dr. med. Matthias Kloor Website
As a physician scientist I have been working in the field of molecular pathology, tumor immunology, and pathogenesis of hereditary cancer for more than a decade. My research interests are dedicated to molecular models of tumor formation and their transfer into the clinical application, with a main focus on tumor immunology and immunological approaches for cancer prevention and treatment. My research during the last 10 years as leader of the research group ‘Immune biology of microsatellite-unstable cancer’ has been focused on the identification of relevant neoantigens specifically generated in microsatellite-unstable (MSI-H) cancers. These research activities have led to the first-in-human clinical trial examining a frameshift peptide neoantigen vaccine in MSI-H cancer patients. I complement the studies on cancer vaccines by examining mechanisms of immune evasion that allow MSI-H tumors to develop in spite of pronounced anti-tumoral immune responses
