We Support Racial Equality!
We in the Mullins laboratory stand in solidarity with the Black community during this defining time of confronting racial and social injustice. The murder of George Floyd by police is only one of many injustices experienced by Black Americans. For hundreds of years, institutional policies and individual actions have oppressed Black people. Today, we continue to see the widespread immoral and abhorrent treatment of racial and ethnic minority groups. These acts of oppression are unequivocally a result of the systemic racism in our society and cannot be ignored. We must proactively oppose these systems of oppression and take action against racism in our scientific community and beyond.
As a laboratory, we are committed to changing the environment that has led to the oppression of people of color in all sectors of our society. We will continue to educate ourselves about the challenges disproportionately affecting people of color so that we can help eliminate those barriers. We will challenge our worldview by continuing to learn about both the systemic oppression and implicit biases affecting people of color. Finally, we pledge to maintain and further cultivate a safe and supportive environment for people of color who join our laboratory.
We are studying the molecular mechanisms by which a BMP (Bone Morphogenetic Protein) signal transduction pathway establishes different aspects of the vertebrate body plan. Various zebrafish mutants of BMP pathway components, as well as antisense knockdown approaches are used to dissect the molecular mechanisms by which this pathway establishes different cell types. We are studying the formation, function, and temporal regulation of a BMP activity gradient, which is implicated in specification of diverse cell types along the dorsal-ventral axis. We have shown that this gradient is essential in neural crest specification and is linked to dorsal-ventral patterning of neural tissue. Moreover, a subset of our defined components also function in post-embryonic heart development. Misregulation of BMP signaling leads to a debilitating disease in humans called FOP. We are currently trying to establish a model for FOP in the zebrafish.
Elaboration of the vertebrate body plan relies not only on zygotic processes, but also on maternally-controlled processes. That is, processes that depend on products derived from the mother that are deposited into the oocyte and are critical for proper development of the embryo. To this end we performed a large-scale maternal-effect mutant screen, not previously performed in a vertebrate, to identify mutants of key genes specifically required in the mother for oocyte development, egg activation, fertilization, the midblastula transition, and establishment of the axes of the vertebrate embryo. We identified numerous mutants in these processes and are studying the molecular and cellular basis for the defects, including positional cloning of the mutated genes.
- A Fond Farewell to Francesca
After completing her studies, Dr. Francesca Tuazon is ready to swim off into the wider world. We send her our best fishes, and we hope her future is tolloidally fintastic!
- A New Paper from the Mullins Lab
Mullins lab alumni join forces with current lab members in the textbook chapter: The maternal coordinate system: Molecular-genetics of embryonic axis formation and patterning in the zebrafish. Ricardo Fuentes, Benjamin Tajer, Manami Kobayashi, Jose L Pelliccia, Yvette Langdon, Elliott W Abrams, Mary C Mullins.
- Jira White Joins the Mullins Lab
The Mullins lab gives a warm and enthusiastic welcome to Jira White, who is joining the lab through Upenn's Post Bac program. Jira already did fantastic work with the lab last summer as an undergrad, and we are thrilled to have her back!
- Pandemic Doesn't Stop Mullins Lab Students from Graduating
Even though the school was closed, recent Mullins lab graduates Francesca Tuazon and Robyn Allen were celebrated with a virtual commencement ceremony.