Mullins Lab

We Support Racial Equality!

We in the Mullins laboratory stand in solidarity with the Black community during this defining  time of confronting racial and social injustice. The murder of George Floyd by police is only one of many injustices experienced by Black Americans. For hundreds of years, institutional policies and individual actions have oppressed Black people. Today, we continue to see the widespread immoral and abhorrent treatment of racial and ethnic minority groups. These acts of oppression are unequivocally a result of the systemic racism in our society and cannot be ignored. We must proactively oppose these systems of oppression and take action against racism in our scientific community and beyond.

As a laboratory, we are committed to changing the environment that has led to the oppression of people of color in all sectors of our society. We will continue to educate ourselves about the challenges disproportionately affecting people of color so that we can help eliminate those barriers. We will challenge our worldview by continuing to learn about both the systemic oppression and implicit biases affecting people of color. Finally, we pledge to maintain and further cultivate a safe and supportive environment for people of color who join our laboratory.

Research Overview

We are studying the molecular mechanisms by which a BMP (Bone Morphogenetic Protein) signal transduction pathway establishes different aspects of the vertebrate body plan. Various zebrafish mutants of BMP pathway components, as well as antisense knockdown approaches are used to dissect the molecular mechanisms by which this pathway establishes different cell types. We are studying the formation, function, and temporal regulation of a BMP activity gradient, which is implicated in specification of diverse cell types along the dorsal-ventral axis. We have shown that this gradient is essential in neural crest specification and is linked to dorsal-ventral patterning of neural tissue. Moreover, a subset of our defined components also function in post-embryonic heart development. Misregulation of BMP signaling leads to a debilitating disease in humans called fibrodysplasia ossificans progressiva (FOP). We are currently trying to establish a model for FOP in the zebrafish.

Elaboration of the vertebrate body plan relies not only on zygotic processes, but also on maternally-controlled processes: that is, processes that depend on products derived from the mother that are deposited into the oocyte and are critical for proper development of the embryo. To this end, we performed a large-scale maternal-effect mutant screen, not previously performed in a vertebrate, to identify mutants of key genes specifically required in the mother for oocyte development, egg activation, fertilization, the mid-blastula transition, and establishment of the axes of the vertebrate embryo. We identified numerous mutants in these processes and are studying the molecular and cellular basis for the defects, including positional cloning of the mutated genes.

Latest News

  • The Mullins Lab Attends the 2024 CDB Retreat Thursday, May 9, 2024

    The Mullinses had the fin-tastic opportunity to present their work at the annual Dept. of Cell & Development Biology Retreat in Galloway, NJ! Postdoc Manami Kobayashi gave a talk, while graduate students William Jones, Allison Marvin, Bakary Samasa, and Meg Guerin gave poster presentations. William Jones and Jeet Patel served on the planning committee and helped put together an excellent retreat!

  • Mullins Lab Members Present at The Allied Genetics Conference 2024 Sunday, March 10, 2024

    Mullins Lab members presented their exciting zebrafish science at The Allied Genetics Conference from March 6-10, 2024, in National Harbor, MD! Post-docs Manami Kobayashi and Jeet Patel and graduate student William Jones presented talks. Graduate students Meg Guerin, Allison Marvin, and Bakary Samasa and visiting graduate student Ingrid Pinto Borguero presented posters. We also got to explore the National Harbor including the Capital Ferris Wheel! It was a fun conference!

  • Mary Mullins Wins Christiane Nüsslein-Volhard Award 2023 Tuesday, July 11, 2023

    Mary Mullins has won the prestigious Christiane Nüsslein-Volhard Award 2023 at the European Zebrafish Society meeting in Krakow, Poland! This award honors Mary's outstanding contributions to the field of zebrafish genetics. Congratulations, Mary! Read the full award announcement here: https://www.ezsociety.org/cnv-awardee-2023.

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