We Support Racial Equality!
We in the Mullins laboratory stand in solidarity with the Black community during this defining time of confronting racial and social injustice. The murder of George Floyd by police is only one of many injustices experienced by Black Americans. For hundreds of years, institutional policies and individual actions have oppressed Black people. Today, we continue to see the widespread immoral and abhorrent treatment of racial and ethnic minority groups. These acts of oppression are unequivocally a result of the systemic racism in our society and cannot be ignored. We must proactively oppose these systems of oppression and take action against racism in our scientific community and beyond.
As a laboratory, we are committed to changing the environment that has led to the oppression of people of color in all sectors of our society. We will continue to educate ourselves about the challenges disproportionately affecting people of color so that we can help eliminate those barriers. We will challenge our worldview by continuing to learn about both the systemic oppression and implicit biases affecting people of color. Finally, we pledge to maintain and further cultivate a safe and supportive environment for people of color who join our laboratory.
We are studying the molecular mechanisms by which a BMP (Bone Morphogenetic Protein) signal transduction pathway establishes different aspects of the vertebrate body plan. Various zebrafish mutants of BMP pathway components, as well as antisense knockdown approaches are used to dissect the molecular mechanisms by which this pathway establishes different cell types. We are studying the formation, function, and temporal regulation of a BMP activity gradient, which is implicated in specification of diverse cell types along the dorsal-ventral axis. We have shown that this gradient is essential in neural crest specification and is linked to dorsal-ventral patterning of neural tissue. Moreover, a subset of our defined components also function in post-embryonic heart development. Misregulation of BMP signaling leads to a debilitating disease in humans called FOP. We are currently trying to establish a model for FOP in the zebrafish.
Elaboration of the vertebrate body plan relies not only on zygotic processes, but also on maternally-controlled processes. That is, processes that depend on products derived from the mother that are deposited into the oocyte and are critical for proper development of the embryo. To this end we performed a large-scale maternal-effect mutant screen, not previously performed in a vertebrate, to identify mutants of key genes specifically required in the mother for oocyte development, egg activation, fertilization, the midblastula transition, and establishment of the axes of the vertebrate embryo. We identified numerous mutants in these processes and are studying the molecular and cellular basis for the defects, including positional cloning of the mutated genes.
- Robyn Leaves to Start Post Doc!
Robyn Allen has gone to the University of Kentucky to start her Post Doc in the Seifert lab. It's hard to over-express our feelings of loss, but we hope her career remains constitutively active.
- Hannah Leaves to start Post Doc!
Hannah Greenfeld Heads off to start her Post Doc in the Zernicka-Goetz lab at Cal Tech. We're very Smad to see her go, but we look forward to seeing how her career develops!
- A New Paper from the Mullins Lab
Hannah's Thesis work on The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning as been published!
- Congrats to Dr. Hannah Greenfeld!
November must be a special month for the Mullins lab! Mullins Lab Graduate Student Hannah Greenfeld successfully defends her thesis!