Publications
This Page Was Last Updated 03-May-2022
For All Publications: 
Links
Search PubMed for articles
Pharmacological Sciences Graduate Group Faculty
Primary Work Website
| All | Since 2017 | |
|---|---|---|
| Citations | 18478 | 8126 |
| h-index | 74 | 43 |
| i10-index | 253 | 184 |
| TITLE | CITED BY | YEAR |
|---|---|---|
| Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities
Z Cheng, A Al Zaki, JZ Hui, VR Muzykantov, A Tsourkas Science 338 (6109), 903-910 |
1225 | 2012 |
| Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers
S Muro, C Garnacho, JA Champion, J Leferovich, C Gajewski, ... Molecular therapy 16 (8), 1450-1458 |
570 | 2008 |
| Drug delivery by red blood cells: vascular carriers designed by mother nature
VR Muzykantov Expert opinion on drug delivery 7 (4), 403-427 |
382 | 2010 |
| Targeting vascular (endothelial) dysfunction
A Daiber, S Steven, A Weber, VV Shuvaev, VR Muzykantov, I Laher, H Li, ... British journal of pharmacology 174 (12), 1591-1619 |
370 | 2017 |
| A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1
S Muro, R Wiewrodt, A Thomas, L Koniaris, SM Albelda, VR Muzykantov, ... Journal of cell science 116 (8), 1599-1609 |
350 | 2003 |
| Endothelial NADPH Oxidase as the Source of Oxidants in Lungs Exposed to Ischemia or High K+
AB Al-Mehdi, G Zhao, C Dodia, K Tozawa, K Costa, V Muzykantov, ... Circulation research 83 (7), 730-737 |
320 | 1998 |
| Delivering nanoparticles to lungs while avoiding liver and spleen through adsorption on red blood cells
AC Anselmo, V Gupta, BJ Zern, D Pan, M Zakrewsky, V Muzykantov, ... ACS nano 7 (12), 11129-11137 |
251 | 2013 |
| Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species
C Vadseth, JM Souza, L Thomson, A Seagraves, C Nagaswami, ... Journal of Biological Chemistry 279 (10), 8820-8826 |
251 | 2004 |
| 1-Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation-mediated membrane damage
Y Manevich, T Sweitzer, JH Pak, SI Feinstein, V Muzykantov, AB Fisher Proceedings of the National Academy of Sciences 99 (18), 11599-11604 |
248 | 2002 |
| Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems
CH Villa, AC Anselmo, S Mitragotri, V Muzykantov Advanced drug delivery reviews 106, 88-103 |
243 | 2016 |
| Targeting of superoxide dismutase and catalase to vascular endothelium
VR Muzykantov Journal of Controlled Release 71 (1), 1-21 |
239 | 2001 |
| European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach, T Kietzmann, ... Redox biology 13, 94-162 |
227 | 2017 |
| Advanced drug delivery systems that target the vascular endothelium
BS Ding, T Dziubla, VV Shuvaev, S Muro, VR Muzykantov Molecular interventions 6 (2), 98 |
217 | 2006 |
| Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to intercellular adhesion molecule 1
S Muro, T Dziubla, W Qiu, J Leferovich, X Cui, E Berk, VR Muzykantov Journal of Pharmacology and Experimental Therapeutics 317 (3), 1161-1169 |
216 | 2006 |
| The shape of things to come: importance of design in nanotechnology for drug delivery
Y Liu, J Tan, A Thomas, D Ou-Yang, VR Muzykantov Therapeutic delivery 3 (2), 181-194 |
212 | 2012 |
| Prophylactic fibrinolysis through selective dissolution of nascent clots by tPA-carrying erythrocytes
JC Murciano, S Medinilla, D Eslin, E Atochina, DB Cines, VR Muzykantov Nature biotechnology 21 (8), 891-896 |
210 | 2003 |
| Polymeric carriers: role of geometry in drug delivery
EA Simone, TD Dziubla, VR Muzykantov Expert opinion on drug delivery 5 (12), 1283-1300 |
207 | 2008 |
| Distribution of type I, III, IV and V collagen in normal and atherosclerotic human arterial wall: immunomorphological characteristics
BV Shekhonin, SP Domogatsky, VR Muzykantov, GL Idelson, ... Collagen and related research 5 (4), 355-368 |
201 | 1985 |
| Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress
S Muro, X Cui, C Gajewski, JC Murciano, VR Muzykantov, M Koval American Journal of Physiology-Cell Physiology 285 (5), C1339-C1347 |
174 | 2003 |
| Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling
Z Wei, K Costa, AB Al-Mehdi, C Dodia, V Muzykantov, AB Fisher Circulation Research 85 (8), 682-689 |
164 | 1999 |
| ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs
S Muro, C Gajewski, M Koval, VR Muzykantov Blood 105 (2), 650-658 |
160 | 2005 |
| Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury
BD Kozower, M Christofidou-Solomidou, TD Sweitzer, S Muro, DG Buerk, ... Nature biotechnology 21 (4), 392-398 |
158 | 2003 |
| Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
JS Brenner, DC Pan, JW Myerson, OA Marcos-Contreras, CH Villa, ... Nature communications 9 (1), 1-14 |
157 | 2018 |
| Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular …
VR Muzykantov, M Christofidou-Solomidou, I Balyasnikova, DW Harshaw, ... Proceedings of the National Academy of Sciences 96 (5), 2379-2384 |
151 | 1999 |
| In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium
R Rossin, S Muro, MJ Welch, VR Muzykantov, DP Schuster Journal of Nuclear Medicine 49 (1), 103-111 |
149 | 2008 |
| Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting
SM Danilov, VD Gavrilyuk, FE Franke, K Pauls, DW Harshaw, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 280 (6 … |
149 | 2001 |
| Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm
M Howard, BJ Zern, AC Anselmo, VV Shuvaev, S Mitragotri, ... ACS nano 8 (5), 4100-4132 |
146 | 2014 |
| Endothelial endocytic pathways: gates for vascular drug delivery
S Muro, M Koval, V Muzykantov Current vascular pharmacology 2 (3), 281-299 |
144 | 2004 |
| Nanogel carrier design for targeted drug delivery
DM Eckmann, RJ Composto, A Tsourkas, VR Muzykantov Journal of Materials Chemistry B 2 (46), 8085-8097 |
141 | 2014 |
| ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface: Presented in part as posters at the American Thoracic Society (ATS) Meeting …
JC Murciano, S Muro, L Koniaris, M Christofidou-Solomidou, ... Blood, The Journal of the American Society of Hematology 101 (10), 3977-3984 |
141 | 2003 |
| Antioxidant strategies in respiratory medicine
M Christofidou-Solomidou, VR Muzykantov Treatments in respiratory medicine 5 (1), 47-78 |
138 | 2006 |
| Effects of chronic arterial hypertension on constitutive and induced intercellular adhesion molecule-1 expression in vivo
S Komatsu, J Panés, JM Russell, DC Anderson, VR Muzykantov, ... Hypertension 29 (2), 683-689 |
138 | 1997 |
| Polymer nanocarriers protecting active enzyme cargo against proteolysis
TD Dziubla, A Karim, VR Muzykantov Journal of controlled release 102 (2), 427-439 |
136 | 2005 |
| Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells
R Wiewrodt, AP Thomas, L Cipelletti, M Christofidou-Solomidou, DA Weitz, ... Blood, The Journal of the American Society of Hematology 99 (3), 912-922 |
136 | 2002 |
| Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation-and clathrin-dependent endocytosis
S Muro, EH Schuchman, VR Muzykantov Molecular Therapy 13 (1), 135-141 |
130 | 2006 |
| Targeted delivery of therapeutics to endothelium
E Simone, BS Ding, V Muzykantov Cell and tissue research 335 (1), 283-300 |
129 | 2009 |
| Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules
S Muro, VR Muzykantov Current pharmaceutical design 11 (18), 2383-2401 |
128 | 2005 |
| Endothelial delivery of antioxidant enzymes loaded into non-polymeric magnetic nanoparticles
M Chorny, E Hood, RJ Levy, VR Muzykantov Journal of Controlled Release 146 (1), 144-151 |
120 | 2010 |
| Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments
J Liu, GER Weller, B Zern, PS Ayyaswamy, DM Eckmann, VR Muzykantov, ... Proceedings of the National Academy of Sciences 107 (38), 16530-16535 |
117 | 2010 |
| Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies
TD Dziubla, VV Shuvaev, NK Hong, BJ Hawkins, M Madesh, H Takano, ... Biomaterials 29 (2), 215-227 |
117 | 2008 |
| Delivery of acid sphingomyelinase in normal and niemann-pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers
C Garnacho, R Dhami, E Simone, T Dziubla, J Leferovich, EH Schuchman, ... Journal of Pharmacology and Experimental Therapeutics 325 (2), 400-408 |
114 | 2008 |
| Endothelial targeting of antibody-decorated polymeric filomicelles
VV Shuvaev, MA Ilies, E Simone, S Zaitsev, Y Kim, S Cai, A Mahmud, ... ACS nano 5 (9), 6991-6999 |
113 | 2011 |
| Immunotargeting of antioxidant enzyme to the pulmonary endothelium
VR Muzykantov, EN Atochina, H Ischiropoulos, SM Danilov, AB Fisher Proceedings of the National Academy of Sciences 93 (11), 5213-5218 |
105 | 1996 |
| Nanocarriers for vascular delivery of antioxidants
E Hood, E Simone, P Wattamwar, T Dziubla, V Muzykantov Nanomedicine 6 (7), 1257-1272 |
100 | 2011 |
| PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress
M Christofidou-Solomidou, A Scherpereel, R Wiewrodt, K Ng, T Sweitzer, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 285 (2 … |
98 | 2003 |
| Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1
T Bhowmick, E Berk, X Cui, VR Muzykantov, S Muro Journal of Controlled Release 157 (3), 485-492 |
97 | 2012 |
| Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation
S Zaitsev, D Spitzer, JC Murciano, BS Ding, S Tliba, MA Kowalska, ... Blood, The Journal of the American Society of Hematology 115 (25), 5241-5248 |
97 | 2010 |
| The effect of polymeric nanoparticles on biocompatibility of carrier red blood cells
D Pan, O Vargas-Morales, B Zern, AC Anselmo, V Gupta, M Zakrewsky, ... PloS one 11 (3), e0152074 |
96 | 2016 |
| Mouse model of microembolic stroke and reperfusion
DN Atochin, JC Murciano, Y Gursoy-Ozdemir, T Krasik, F Noda, C Ayata, ... Stroke 35 (9), 2177-2182 |
95 | 2004 |
| Biomedical aspects of targeted delivery of drugs to pulmonary endothelium
VR Muzykantov Expert opinion on drug delivery 2 (5), 909-926 |
94 | 2005 |
| Oxidative burst and NO generation as initial response to ischemia in flow-adapted endothelial cells
Y Manevich, A Al-Mehdi, V Muzykantov, AB Fisher American Journal of Physiology-Heart and Circulatory Physiology 280 (5 … |
94 | 2001 |
| Reduction of nanoparticle avidity enhances the selectivity of vascular targeting and PET detection of pulmonary inflammation
BJ Zern, AM Chacko, J Liu, CF Greineder, ER Blankemeyer, ... ACS nano 7 (3), 2461-2469 |
93 | 2013 |
| PECAM‐targeted delivery of SOD inhibits endothelial inflammatory response
VV Shuvaev, J Han, KJ Yu, S Huang, BJ Hawkins, M Madesh, M Nakada, ... The FASEB Journal 25 (1), 348-357 |
93 | 2011 |
| Cerebrovascular thromboprophylaxis in mice by erythrocyte-coupled tissue-type plasminogen activator
K Danielyan, K Ganguly, BS Ding, D Atochin, S Zaitsev, JC Murciano, ... Circulation 118 (14), 1442-1449 |
91 | 2008 |
| Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress
EN Atochina, IV Balyasnikova, SM Danilov, DN Granger, AB Fisher, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 275 (4 … |
91 | 1998 |
| Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood–brain barrier divide
AM Chacko, C Li, DA Pryma, S Brem, G Coukos, V Muzykantov Expert opinion on drug delivery 10 (7), 907-926 |
89 | 2013 |
| Acute and chronic shear stress differently regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1
J Han, BJ Zern, VV Shuvaev, PF Davies, S Muro, V Muzykantov ACS nano 6 (10), 8824-8836 |
89 | 2012 |
| Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes
C Garnacho, SM Albelda, VR Muzykantov, S Muro Journal of Controlled Release 130 (3), 226-233 |
89 | 2008 |
| Advanced drug delivery systems for antithrombotic agents
CF Greineder, MD Howard, R Carnemolla, DB Cines, VR Muzykantov Blood, The Journal of the American Society of Hematology 122 (9), 1565-1575 |
88 | 2013 |
| Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124
EA Simone, BJ Zern, AM Chacko, JL Mikitsh, ER Blankemeyer, S Muro, ... Biomaterials 33 (21), 5406-5413 |
86 | 2012 |
| Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins
S Muro, M Mateescu, C Gajewski, M Robinson, VR Muzykantov, M Koval American Journal of Physiology-Lung Cellular and Molecular Physiology 290 (5 … |
85 | 2006 |
| Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier
CH Villa, DC Pan, S Zaitsev, DB Cines, DL Siegel, VR Muzykantov Therapeutic delivery 6 (7), 795-826 |
82 | 2015 |
| Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme
SM Danilov, VR Muzykantov, AV Martynov, EN Atochina, I Sakharov, ... Lab Invest 64 (1), 118-124 |
82 | 1991 |
| Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation
MD Howard, CF Greineder, ED Hood, VR Muzykantov Journal of controlled release 177, 34-41 |
81 | 2014 |
| Targeted nanocarriers for imaging and therapy of vascular inflammation
AM Chacko, ED Hood, BJ Zern, VR Muzykantov Current opinion in colloid & interface science 16 (3), 215-227 |
81 | 2011 |
| Nanoparticle properties modulate their attachment and effect on carrier red blood cells
DC Pan, JW Myerson, JS Brenner, PN Patel, AC Anselmo, S Mitragotri, ... Scientific reports 8 (1), 1-12 |
79 | 2018 |
| Nanocarriers for vascular delivery of anti-inflammatory agents
MD Howard, ED Hood, B Zern, VV Shuvaev, T Grosser, VR Muzykantov Annual review of pharmacology and toxicology 54, 205-226 |
79 | 2014 |
| Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the …
BS Ding, C Gottstein, A Grunow, A Kuo, K Ganguly, SM Albelda, DB Cines, ... Blood 106 (13), 4191-4198 |
79 | 2005 |
| Microphysiological engineering of self-assembled and perfusable microvascular beds for the production of vascularized three-dimensional human microtissues
J Paek, SE Park, Q Lu, KT Park, M Cho, JM Oh, KW Kwon, Y Yi, JW Song, ... Acs Nano 13 (7), 7627-7643 |
78 | 2019 |
| Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation
ED Hood, M Chorny, CF Greineder, IS Alferiev, RJ Levy, VR Muzykantov Biomaterials 35 (11), 3708-3715 |
77 | 2014 |
| Blood clearance and activity of erythrocyte-coupled fibrinolytics
K Ganguly, T Krasik, S Medinilla, K Bdeir, DB Cines, VR Muzykantov, ... Journal of Pharmacology and Experimental Therapeutics 312 (3), 1106-1113 |
77 | 2005 |
| Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers
AJ Calderon, T Bhowmick, J Leferovich, B Burman, B Pichette, ... Journal of Controlled Release 150 (1), 37-44 |
76 | 2011 |
| Urokinase mediates fibrinolysis in the pulmonary microvasculature
K Bdeir, JC Murciano, J Tomaszewski, L Koniaris, J Martinez, DB Cines, ... Blood, The Journal of the American Society of Hematology 96 (5), 1820-1826 |
75 | 2000 |
| Delivery of antioxidant enzyme proteins to the lung
VR Muzykantov Antioxidants and Redox Signaling 3 (1), 39-62 |
74 | 2001 |
| Targeted detoxification of selected reactive oxygen species in the vascular endothelium
VV Shuvaev, M Christofidou-Solomidou, F Bhora, K Laude, H Cai, ... Journal of Pharmacology and Experimental Therapeutics 331 (2), 404-411 |
73 | 2009 |
| Exploiting shape, cellular-hitchhiking and antibodies to target nanoparticles to lung endothelium: Synergy between physical, chemical and biological approaches
AC Anselmo, S Kumar, V Gupta, AM Pearce, A Ragusa, V Muzykantov, ... Biomaterials 68, 1-8 |
72 | 2015 |
| Changes in plasma gelsolin concentration during acute oxidant lung injury in mice
M Christofidou-Solomidou, A Scherpereel, CC Solomides, ... Lung 180 (2), 91-104 |
70 | 2002 |
| Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo
ED Hood, CF Greineder, C Dodia, J Han, C Mesaros, VV Shuvaev, ... Journal of controlled release 163 (2), 161-169 |
68 | 2012 |
| Microthrombosis after experimental subarachnoid hemorrhage: time course and effect of red blood cell-bound thrombin-activated pro-urokinase and clazosentan
JM Pisapia, X Xu, J Kelly, J Yeung, G Carrion, H Tong, S Meghan, ... Experimental neurology 233 (1), 357-363 |
68 | 2012 |
| Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells
AJ Calderon, V Muzykantov, S Muro, DM Eckmann Biorheology 46 (4), 323-341 |
67 | 2009 |
| Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers
EA Simone, TD Dziubla, F Colon-Gonzalez, DE Discher, VR Muzykantov Biomacromolecules 8 (12), 3914-3921 |
67 | 2007 |
| Regulation of the complement-mediated elimination of red blood cells modified with biotin and streptavidin
VR Muzykantov, JC Murciano, RP Taylor, EN Atochina, A Herraez Analytical biochemistry 241 (1), 109-119 |
67 | 1996 |
| Ferritin-based drug delivery systems: Hybrid nanocarriers for vascular immunotargeting
M Khoshnejad, H Parhiz, VV Shuvaev, IJ Dmochowski, VR Muzykantov Journal of Controlled Release 282, 13-24 |
65 | 2018 |
| Icam-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation
MC Coll Ferrer, VV Shuvaev, BJ Zern, RJ Composto, VR Muzykantov, ... PloS one 9 (7), e102329 |
65 | 2014 |
| Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation
BS Ding, N Hong, M Christofidou-Solomidou, C Gottstein, SM Albelda, ... American journal of respiratory and critical care medicine 180 (3), 247-256 |
65 | 2009 |
| Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature
A Scherpereel, JJ Rome, R Wiewrodt, SC Watkins, DW Harshaw, S Alder, ... Journal of Pharmacology and Experimental Therapeutics 300 (3), 777-786 |
64 | 2002 |
| Cell‐selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting
A SCHERPEREEL, R WIEWRODT, M CHRISTOFIDOU‐SOLOMIDOU, ... The FASEB Journal 15 (2), 416-426 |
64 | 2001 |
| Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis
S Zaitsev, K Danielyan, JC Murciano, K Ganguly, T Krasik, RP Taylor, ... Blood 108 (6), 1895-1902 |
62 | 2006 |
| Red blood cell targeting to collagen-coated surfaces
GP Samokhin, MD Smirnov, VR Muzykantov, SP Domogatsky, ... Febs Letters 154 (2), 257-261 |
62 | 1983 |
| Non-affinity factors modulating vascular targeting of nano-and microcarriers
JW Myerson, AC Anselmo, Y Liu, S Mitragotri, DM Eckmann, ... Advanced drug delivery reviews 99, 97-112 |
59 | 2016 |
| Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: targeting to thrombomodulin, but not to PECAM-1 …
M Christofidou-Solomidou, S Kennel, A Scherpereel, R Wiewrodt, ... The American journal of pathology 160 (3), 1155-1169 |
59 | 2002 |
| Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis
S Zaitsev, D Spitzer, JC Murciano, BS Ding, S Tliba, MA Kowalska, ... Journal of Pharmacology and Experimental Therapeutics 332 (3), 1022-1031 |
58 | 2010 |
| The glycocalyx protects erythrocyte-bound tissue-type plasminogen activator from enzymatic inhibition
K Ganguly, JC Murciano, R Westrick, J Leferovich, DB Cines, ... Journal of Pharmacology and Experimental Therapeutics 321 (1), 158-164 |
58 | 2007 |
| Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase
EA Simone, TD Dziubla, DE Discher, VR Muzykantov Biomacromolecules 10 (6), 1324-1330 |
57 | 2009 |
| Carrier-directed targeting of liposomes and erythrocytes to denuded areas of vessel wall
VN Smirnov, SP Domogatsky, VV Dolgov, VB Hvatov, AL Klibanov, ... Proceedings of the National Academy of Sciences 83 (17), 6603-6607 |
57 | 1986 |
| Targeted drug delivery to endothelial adhesion molecules
VR Muzykantov International Scholarly Research Notices 2013 |
56 | 2013 |
| Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis
S Zaitsev, MA Kowalska, M Neyman, R Carnemolla, S Tliba, BS Ding, ... Blood, The Journal of the American Society of Hematology 119 (20), 4779-4785 |
56 | 2012 |
| Collaborative enhancement of antibody binding to distinct PECAM-1 epitopes modulates endothelial targeting
AM Chacko, M Nayak, CF Greineder, HM DeLisser, VR Muzykantov PloS one 7 (4), e34958 |
56 | 2012 |
| Blood clearance of radiolabeled antibody: enhancement by lactosamination and treatment with biotin-avidin or anti-mouse IgG antibodies
AL Klibanov, AV Martynov, MA Slinkin, IY Sakharov, MD Smirnov, ... Journal of nuclear medicine 29 (12), 1951-1956 |
56 | 1988 |
| Erythrocytes as carriers for drug delivery in blood transfusion and beyond
CH Villa, DB Cines, DL Siegel, V Muzykantov Transfusion medicine reviews 31 (1), 26-35 |
55 | 2017 |
| Platelet-endothelial cell adhesion molecule-1-directed endothelial targeting of superoxide dismutase alleviates oxidative stress caused by either extracellular or intracellular …
VV Shuvaev, S Tliba, M Nakada, SM Albelda, VR Muzykantov Journal of Pharmacology and Experimental Therapeutics 323 (2), 450-457 |
55 | 2007 |
| Immunotargeting of erythrocytes-bound streptokinase provides local lysis of a fibrin clot
VR Muzykantov, DV Sakharov, MD Smirnov, GP Samokhin, VN Smirnov Biochimica et Biophysica Acta (BBA)-General Subjects 884 (2), 355-362 |
55 | 1986 |
| Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
OA Marcos-Contreras, CF Greineder, RY Kiseleva, H Parhiz, LR Walsh, ... Proceedings of the National Academy of Sciences 117 (7), 3405-3414 |
54 | 2020 |
| Flexible nanoparticles reach sterically obscured endothelial targets inaccessible to rigid nanoparticles
JW Myerson, B Braender, O Mcpherson, PM Glassman, RY Kiseleva, ... Advanced Materials 30 (32), 1802373 |
54 | 2018 |
| Catalase and superoxide dismutase conjugated with platelet-endothelial cell adhesion molecule antibody distinctly alleviate abnormal endothelial permeability caused by …
J Han, VV Shuvaev, VR Muzykantov Journal of pharmacology and experimental therapeutics 338 (1), 82-91 |
54 | 2011 |
| Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia
S Perkowski, A Scherpereel, JC Murciano, E Arguiri, CC Solomides, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 291 (5 … |
54 | 2006 |
| Delivery of anti-platelet-endothelial cell adhesion molecule single-chain variable fragment-urokinase fusion protein to the cerebral vasculature lyses arterial clots and …
K Danielyan, BS Ding, C Gottstein, DB Cines, VR Muzykantov Journal of Pharmacology and Experimental Therapeutics 321 (3), 947-952 |
53 | 2007 |
| RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1
C Garnacho, V Shuvaev, A Thomas, L McKenna, J Sun, M Koval, ... Blood, The Journal of the American Society of Hematology 111 (6), 3024-3033 |
52 | 2008 |
| Targeted modulation of reactive oxygen species in the vascular endothelium
VV Shuvaev, VR Muzykantov Journal of controlled release 153 (1), 56-63 |
51 | 2011 |
| Platelets inhibit the lysis of pulmonary microemboli
JC Murciano, D Harshaw, DG Neschis, L Koniaris, K Bdeir, S Medinilla, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 282 (3 … |
51 | 2002 |
| Erythrocyte-bound tissue plasminogen activator is neuroprotective in experimental traumatic brain injury
SC Stein, K Ganguly, CM Belfield, X Xu, EW Swanson, XH Chen, ... Journal of neurotrauma 26 (9), 1585-1592 |
50 | 2009 |
| Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature
BS Ding, N Hong, JC Murciano, K Ganguly, C Gottstein, ... Blood, The Journal of the American Society of Hematology 111 (4), 1999-2006 |
50 | 2008 |
| Immunotargeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs
M Christofidou-Solomidou, GG Pietra, CC Solomides, E Arguiris, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 278 (4 … |
50 | 2000 |
| Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo
VV Shuvaev, J Han, S Tliba, E Arguiri, M Christofidou-Solomidou, ... PLoS One 8 (10), e77002 |
49 | 2013 |
| Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders
WM Armstead, K Ganguly, JW Kiessling, J Riley, XH Chen, DH Smith, ... Journal of neurochemistry 113 (2), 303-312 |
49 | 2010 |
| Targeting of antibody-conjugated plasminogen activators to the pulmonary vasculature.
VR Muzykantov, ES Barnathan, EN Atochina, A Kuo, SM Danilov, ... Journal of Pharmacology and Experimental Therapeutics 279 (2), 1026-1034 |
49 | 1996 |
| Portal hypertension enhances endotoxin-induced intercellular adhesion molecule 1 up-regulation in the rat
J Panes, MA Perry, DC Anderson, VR Muzykantov, DL Carden, ... Gastroenterology 110 (3), 866-874 |
48 | 1996 |
| Modulation of endothelial targeting by size of antibody–antioxidant enzyme conjugates
VV Shuvaev, S Tliba, J Pick, E Arguiri, M Christofidou-Solomidou, ... Journal of controlled release 149 (3), 236-241 |
47 | 2011 |
| Soluble urokinase receptor conjugated to carrier red blood cells binds latent pro-urokinase and alters its functional profile
JC Murciano, AAR Higazi, DB Cines, VR Muzykantov Journal of controlled release 139 (3), 190-196 |
46 | 2009 |
| Modulation of angiotensin-converting enzyme in cultured human vascular endothelial cells
IV Balyasnikova, SM Danilov, VR Muzykantov, AB Fisher In Vitro Cellular & Developmental Biology-Animal 34 (7), 545-554 |
46 | 1998 |
| Avidin attachment to biotinylated erythrocytes induces homologous lysis via the alternative pathway of complement
VR Muzykantov, MD Smirnov, GP Samokhin |
46 | 1991 |
| PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E …
H Parhiz, VV Shuvaev, N Pardi, M Khoshnejad, RY Kiseleva, JS Brenner, ... Journal of controlled release 291, 106-115 |
45 | 2018 |
| Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1
J Han, VV Shuvaev, PF Davies, DM Eckmann, S Muro, VR Muzykantov Journal of Controlled Release 210, 39-47 |
45 | 2015 |
| Immunotargeting of glucose oxidase: intracellular production of H2O2and endothelial oxidative stress
AJ Gow, F Branco, M Christofidou-Solomidou, L Black-Schultz, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 277 (2 … |
45 | 1999 |
| Normoxic lung ischemia/reperfusion accelerates shedding of angiotensin converting enzyme from the pulmonary endothelium
EN Atochina, VR Muzykantov, AB Al-Mehdi, SM Danilov, AB Fisher American journal of respiratory and critical care medicine 156 (4), 1114-1119 |
45 | 1997 |
| Enhanced complement susceptibility of avidin-biotin-treated human erythrocytes is a consequence of neutralization of the complement regulators CD59 and decay accelerating factor
AB Zaltzman, CW Van den Berg, VR Muzykantov, BP Morgan Biochemical Journal 307 (3), 651-656 |
45 | 1995 |
| Radioimmunoimaging of lung vessels: an approach using indium-111-labeled monoclonal antibody to angiotensin-converting enzyme.
SM Danilov, AV Martynov, AL Klibanov, MA Slinkin, S IYu, AG Malov, ... Journal of Nuclear Medicine: Official Publication, Society of Nuclear … |
45 | 1989 |
| Directed targeting of immunoerythrocytes provides local protection of endothelial cells from damage by hydrogen peroxide.
VR Muzykantov, DV Sakharov, SP Domogatsky, NV Goncharov, ... The American journal of pathology 128 (2), 276 |
45 | 1987 |
| Acute administration of catalase targeted to ICAM-1 attenuates neuropathology in experimental traumatic brain injury
EM Lutton, R Razmpour, AM Andrews, LA Cannella, YJ Son, VV Shuvaev, ... Scientific reports 7 (1), 1-15 |
44 | 2017 |
| Loading PEG-catalase into filamentous and spherical polymer nanocarriers
EA Simone, TD Dziubla, E Arguiri, V Vardon, VV Shuvaev, ... Pharmaceutical research 26 (1), 250-260 |
44 | 2009 |
| Streptavidin-biotin crosslinking of therapeutic enzymes with carrier antibodies
VV Shuvaev, T Dziubla, R Wiewrodt, VR Muzykantov Bioconjugation protocols, 3-19 |
44 | 2004 |
| Endothelial cells internalize monoclonal antibody to angiotensin-converting enzyme
VR Muzykantov, EN Atochina, A Kuo, ES Barnathan, K Notarfrancesco, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 270 (5 … |
44 | 1996 |
| Targeting therapeutics to endothelium: are we there yet?
RY Kiseleva, PM Glassman, CF Greineder, ED Hood, VV Shuvaev, ... Drug delivery and translational research 8 (4), 883-902 |
43 | 2018 |
| PECAM-directed immunotargeting of catalase: specific, rapid and transient protection against hydrogen peroxide
TD Sweitzer, AP Thomas, R Wiewrodt, MT Nakada, F Branco, ... Free Radical Biology and Medicine 34 (8), 1035-1046 |
42 | 2003 |
| Activation of endothelial NADPH oxidase as the source of a reactive oxygen species in lung ischemia
AB Fisher, AB Al-Mehdi, V Muzykantov Chest 116, 25S-26S |
42 | 1999 |
| Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor
CF Greineder, AM Chacko, S Zaytsev, BJ Zern, R Carnemolla, ED Hood, ... PloS one 8 (11), e80110 |
41 | 2013 |
| Compositions and methods for selective dissolution of nascent intravascular blood clots
VR Muzykantov, JC Murciano, D Cines US Patent 7,041,287 |
40 | 2006 |
| Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium
L Goitre, PV DiStefano, A Moglia, N Nobiletti, E Baldini, L Trabalzini, ... Scientific reports 7 (1), 1-12 |
39 | 2017 |
| Drug delivery by erythrocytes:“Primum non nocere”
CH Villa, J Seghatchian, V Muzykantov Transfusion and Apheresis Science 55 (3), 275-280 |
39 | 2016 |
| Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function
A Ukidve, Z Zhao, A Fehnel, V Krishnan, DC Pan, Y Gao, A Mandal, ... Proceedings of the National Academy of Sciences 117 (30), 17727-17736 |
38 | 2020 |
| Unintended effects of drug carriers: Big issues of small particles
H Parhiz, M Khoshnejad, JW Myerson, E Hood, PN Patel, JS Brenner, ... Advanced drug delivery reviews 130, 90-112 |
38 | 2018 |
| Targeted endothelial nanomedicine for common acute pathological conditions
VV Shuvaev, JS Brenner, VR Muzykantov Journal of Controlled Release 219, 576-595 |
37 | 2015 |
| Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications
S Rahmani, CH Villa, AF Dishman, ME Grabowski, DC Pan, H Durmaz, ... Journal of drug targeting 23 (7-8), 750-758 |
37 | 2015 |
| Biomimetic channel modeling local vascular dynamics of pro-inflammatory endothelial changes
A Thomas, H Daniel Ou-Yang, L Lowe-Krentz, VR Muzykantov, Y Liu Biomicrofluidics 10 (1), 014101 |
36 | 2016 |
| Biomedical aspects of drug targeting
VR Muzykantov, VP Torchilin Springer Science & Business Media |
36 | 2013 |
| Attachment of biotinylated antibody to red blood cells: antigen-binding capacity of immunoerythrocytes and their susceptibility to lysis by complement
VR Muzykantov, RP Taylor Analytical biochemistry 223 (1), 142-148 |
36 | 1994 |
| Targeted interception of signaling reactive oxygen species in the vascular endothelium
J Han, VV Shuvaev, VR Muzykantov Therapeutic delivery 3 (2), 263-276 |
35 | 2012 |
| In situ imaging of intracellular calcium with ischemia in lung subpleural microvascular endothelial cells
K Tozawa, AB Al-Mehdi, V Muzykantov, AB Fisher Antioxidants & redox signaling 1 (2), 145-154 |
35 | 1999 |
| Interaction of mAb to angiotensin-converting enzyme (ACE) with antigen in vitro and in vivo: antibody targeting to the lung induces ACE antigenic modulation
S Danilov, E Atochina, H Hiemisch, T Churak-ova, A Moldobayeva, ... International Immunology 6 (8), 1153-1160 |
35 | 1994 |
| Endothelial nanomedicine for the treatment of pulmonary disease
JS Brenner, C Greineder, V Shuvaev, V Muzykantov Expert opinion on drug delivery 12 (2), 239-261 |
34 | 2015 |
| Characterization of Endothelial Internalization and Targeting of Antibody—Enzyme Conjugates in Cell Cultures and in Laboratory Animals
S Muro, VR Muzykantov, JC Murciano Bioconjugation Protocols, 21-36 |
34 | 2004 |
| Targeting superoxide dismutase to endothelial caveolae profoundly alleviates inflammation caused by endotoxin
VV Shuvaev, RY Kiseleva, E Arguiri, CH Villa, S Muro, ... Journal of Controlled Release 272, 1-8 |
33 | 2018 |
| Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme
VR Muzykantov, EA Puchnina, EN Atochina, H Hiemish, MA Slinkin, ... Journal of Nuclear Medicine 32 (3), 453-460 |
33 | 1991 |
| Vascular drug delivery using carrier red blood cells: focus on RBC surface loading and pharmacokinetics
PM Glassman, CH Villa, A Ukidve, Z Zhao, P Smith, S Mitragotri, ... Pharmaceutics 12 (5), 440 |
32 | 2020 |
| ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model
CF Greineder, IH Johnston, CH Villa, K Gollomp, CT Esmon, DB Cines, ... Blood advances 1 (18), 1452-1465 |
32 | 2017 |
| Size and targeting to PECAM vs ICAM control endothelial delivery, internalization and protective effect of multimolecular SOD conjugates
VV Shuvaev, S Muro, E Arguiri, M Khoshnejad, S Tliba, ... Journal of Controlled Release 234, 115-123 |
32 | 2016 |
| Development of 124I immuno-PET targeting tumor vascular TEM1/endosialin
AM Chacko, C Li, M Nayak, JL Mikitsh, J Hu, C Hou, L Grasso, ... Journal of nuclear medicine 55 (3), 500-507 |
32 | 2014 |
| Drug delivery carriers on the fringes: natural red blood cells versus synthetic multilayered capsules
VR Muzykantov Expert opinion on drug delivery 10 (1), 1-4 |
32 | 2013 |
| Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium
VV Shuvaev, M Christofidou-Solomidou, A Scherpereel, E Simone, ... Journal of controlled release 118 (2), 235-244 |
32 | 2007 |
| Targeting drug delivery in the vascular system: Focus on endothelium
PM Glassman, JW Myerson, LT Ferguson, RY Kiseleva, VV Shuvaev, ... Advanced drug delivery reviews 157, 96-117 |
31 | 2020 |
| Pharmacokinetic and pharmacodynamic properties of drug delivery systems
PM Glassman, VR Muzykantov Journal of Pharmacology and Experimental Therapeutics 370 (3), 570-580 |
31 | 2019 |
| Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions
JS Brenner, K Bhamidipati, PM Glassman, N Ramakrishnan, D Jiang, ... Nanomedicine: Nanotechnology, Biology and Medicine 13 (4), 1495-1506 |
31 | 2017 |
| Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK …
WM Armstead, K Ganguly, JW Kiessling, XH Chen, DH Smith, AAR Higazi, ... Journal of Cerebral Blood Flow & Metabolism 29 (8), 1463-1474 |
31 | 2009 |
| The functional effects of biotinylation of anti-angiotensin-converting enzyme monoclonal antibody in terms of targeting in vivo
VR Muzykantov, VD Gavriluk, A Reinecke, EN Atochina, A Kuo, ... Analytical biochemistry 226 (2), 279-287 |
31 | 1995 |
| Specific killing of human endothelial cells by antibody-conjugated glucose oxidase
VR Muzykantov, DV Sakharov, VV Sinitsyn, SP Domogatsky, ... Analytical biochemistry 169 (2), 383-389 |
31 | 1988 |
| Superoxide Dismutase‐Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain
S Kartha, L Yan, CL Weisshaar, ME Ita, VV Shuvaev, VR Muzykantov, ... Advanced healthcare materials 6 (17), 1700500 |
30 | 2017 |
| Dynamic factors controlling targeting nanocarriers to vascular endothelium
V R Muzykantov, R Radhakrishnan, D M Eckmann Current drug metabolism 13 (1), 70-81 |
30 | 2012 |
| Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent
KC Gersh, S Zaitsev, DB Cines, V Muzykantov, JW Weisel Blood, The Journal of the American Society of Hematology 117 (18), 4964-4967 |
30 | 2011 |
| Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo
K Ganguly, MS Goel, T Krasik, K Bdeir, SL Diamond, DB Cines, ... Journal of Pharmacology and Experimental Therapeutics 316 (3), 1130-1136 |
30 | 2006 |
| Vascular immunotargeting to endothelial surface in a specific macrodomain in alveolar capillaries
JC Murciano, D WIN HARSHAW, L Ghitescu, SM Danilov, VR Muzykantov American journal of respiratory and critical care medicine 164 (7), 1295-1302 |
30 | 2001 |
| Avidin attachment to red blood cells via a phoshpolipid derivative of biotin provides complement-resistant immunoerythrocytes
VR Muzykantov, MD Smirnov, AL Klibanov Journal of immunological methods 158 (2), 183-190 |
30 | 1993 |
| Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
VR Muzykantov, AAR Higazi, JC Murciano, D Cines US Patent 6,488,927 |
29 | 2002 |
| Immunotargeting of drugs to the pulmonary vascular endothelium as a therapeutic strategy
VR Muzykantov Pathophysiology 5 (1), 15-33 |
29 | 1998 |
| Biocompatible coupling of therapeutic fusion proteins to human erythrocytes
CH Villa, DC Pan, IH Johnston, CF Greineder, LR Walsh, ED Hood, ... Blood advances 2 (3), 165-176 |
28 | 2018 |
| Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors
N Ramakrishnan, RW Tourdot, DM Eckmann, PS Ayyaswamy, ... Royal Society open science 3 (6), 160260 |
28 | 2016 |
| Targeting recombinant therapeutics to circulating red blood cells
VR Muzykantov, SV Zaitsev, BS Ding, DB Cines US Patent 8,333,973 |
28 | 2012 |
| Targeting antioxidant and antithrombotic biotherapeutics to endothelium
R Carnemolla, VV Shuvaev, VR Muzykantov Seminars in thrombosis and hemostasis 36 (03), 332-342 |
28 | 2010 |
| Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
VR Muzykantov, AAR Higazi, JC Murciano, D Cines, RP Taylor US Patent 7,172,760 |
28 | 2007 |
| Targeting of enzyme immobilized on erythrocyte membrane to collagen-coated surface
VR Muzykantov, DV Sakharov, MD Smirnov, SP Domogatsky, ... FEBS letters 182 (1), 62-66 |
28 | 1985 |
| Spatially controlled assembly of affinity ligand and enzyme cargo enables targeting ferritin nanocarriers to caveolae
VV Shuvaev, M Khoshnejad, KW Pulsipher, RY Kiseleva, E Arguiri, ... Biomaterials 185, 348-359 |
27 | 2018 |
| Vascular targeting of radiolabeled liposomes with bio-orthogonally conjugated ligands: single chain fragments provide higher specificity than antibodies
ED Hood, CF Greineder, T Shuvaeva, L Walsh, CH Villa, VR Muzykantov Bioconjugate chemistry 29 (11), 3626-3637 |
27 | 2018 |
| Targeted endothelial delivery of nanosized catalase immunoconjugates protects lung grafts donated after cardiac death
G Preissler, F Loehe, IV Huff, U Ebersberger, VV Shuvaev, I Bittmann, ... Transplantation 92 (4), 380 |
27 | 2011 |
| Targeting delivery of drugs in the vascular system
V Muzykantov, S Muro International journal of transport phenomena 12 (1-2), 41 |
27 | 2011 |
| Evaluation of quantitative parameters of the interaction of antibody-bearing liposomes with target antigens
AL Klibanov, VR Muzykantov, NN Ivanov, VP Torchilin Analytical Biochemistry 150 (2), 251-257 |
27 | 1985 |
| A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation
RE Fuentes, S Zaitsev, HS Ahn, V Hayes, MA Kowalska, MP Lambert, ... The Journal of clinical investigation 126 (2), 483-494 |
26 | 2016 |
| NOX2 in lung inflammation: quantum dot based in situ imaging of NOX2-mediated expression of vascular cell adhesion molecule-1
RL Orndorff, N Hong, K Yu, SI Feinstein, BJ Zern, AB Fisher, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 306 (3 … |
26 | 2014 |
| Nanocarrier hydrodynamics and binding in targeted drug delivery: challenges in numerical modeling and experimental validation
PS Ayyaswamy, V Muzykantov, DM Eckmann, R Radhakrishnan Journal of nanotechnology in engineering and medicine 4 (1) |
26 | 2013 |
| Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
VR Muzykantov, AAR Higazi, JC Murciano, D Cines, RP Taylor US Patent 7,837,997 |
26 | 2010 |
| Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases
Z Zhao, A Ukidve, V Krishnan, A Fehnel, DC Pan, Y Gao, J Kim, MA Evans, ... Nature Biomedical Engineering 5 (5), 441-454 |
24 | 2021 |
| Ferritin nanocages with biologically orthogonal conjugation for vascular targeting and imaging
M Khoshnejad, CF Greineder, KW Pulsipher, CH Villa, B Altun, DC Pan, ... Bioconjugate chemistry 29 (4), 1209-1218 |
24 | 2018 |
| Vascular accessibility of endothelial targeted ferritin nanoparticles
M Khoshnejad, VV Shuvaev, KW Pulsipher, C Dai, ED Hood, E Arguiri, ... Bioconjugate chemistry 27 (3), 628-637 |
24 | 2016 |
| Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect
CF Greineder, JB Brenza, R Carnemolla, S Zaitsev, ED Hood, DC Pan, ... The FASEB Journal 29 (8), 3483-3492 |
24 | 2015 |
| Fusion proteins for inhibition and dissolution of coagulation
VR Muzykantov, C Gottstein, BS Ding, DB Cines US Patent App. 12/089,250 |
24 | 2009 |
| Target-sensitive immunoerythrocytes: interaction of biotinylated red blood cells with immobilized avidin induces their lysis by complement
VR Muzykantov, AB Zaltsman, MD Smirnon, GP Samokhin, BP Morgan Biochimica et Biophysica Acta (BBA)-Biomembranes 1279 (2), 137-143 |
24 | 1996 |
| In vivo administration of glucose oxidase conjugated with monoclonal antibodies to angiotensin-converting enzyme
VR Muzykantov, AV Martynov, EA Puchina, SM Danilov Am Rev Respir Dis 139, 1464-1473 |
24 | 1989 |
| Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain
OA Marcos-Contreras, JS Brenner, RY Kiseleva, V Zuluaga-Ramirez, ... Journal of Controlled Release 301, 54-61 |
23 | 2019 |
| Targeted carriers for intracellular drug delivery
S Muro-Galindo, VR Muzykantov US Patent 9,707,299 |
23 | 2017 |
| Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles
MD Howard, ED Hood, CF Greineder, IS Alferiev, M Chorny, ... Molecular pharmaceutics 11 (7), 2262-2270 |
23 | 2014 |
| The spatial dynamics of fibrin clot dissolution catalyzed by erythrocyte‐bound vs. free fibrinolytics
KC Gersh, S Zaitsev, V Muzykantov, DB Cines, JW Weisel Journal of Thrombosis and Haemostasis 8 (5), 1066-1074 |
23 | 2010 |
| Attachment of antibody to biotinylated red blood cells: immuno‐red blood cells display high affinity to immobilized antigen and normal biodistribution in rats
M VR, M JC Biotechnology and applied biochemistry 24 (1), 41-45 |
23 | 1996 |
| Avidin acylation prevents the complement-dependent lysis of avidin-carrying erythrocytes
VR Muzykantov, MD Smirnov, GP Samokhin Biochemical journal 273 (2), 393-397 |
23 | 1991 |
| Protection of cultured endothelial cells from hydrogen peroxide-induced injury by antibody-conjugated catalase
DV Sakharov, VR Muzykantov, SP Domogatsky, SM Danilov Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 930 (2), 140-144 |
23 | 1987 |
| Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9
M Khoshnejad, JS Brenner, W Motley, H Parhiz, CF Greineder, CH Villa, ... Scientific reports 8 (1), 1-9 |
22 | 2018 |
| Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans
CF Greineder, ED Hood, A Yao, M Khoshnejad, JS Brenner, IH Johnston, ... Journal of Controlled Release 226, 229-237 |
22 | 2016 |
| Antibody-based tumor vascular theranostics targeting endosialin/TEM1 in a new mouse tumor vascular model
C Li, AM Chacko, J Hu, K Hasegawa, J Swails, L Grasso, WS El-Deiry, ... Cancer biology & therapy 15 (4), 443-451 |
22 | 2014 |
| Systemic administration of platelet-activating factor in rat reduces specific pulmonary uptake of circulating monoclonal antibody to angiotensin-converting enzyme
EN Atochina, HH Hiemisch, VR Muzykantov, SM Danilov Lung 170 (6), 349-358 |
22 | 1992 |
| Site-specific modification of single-chain antibody fragments for bioconjugation and vascular immunotargeting
CF Greineder, CH Villa, LR Walsh, RY Kiseleva, ED Hood, M Khoshnejad, ... Bioconjugate chemistry 29 (1), 56-66 |
21 | 2018 |
| Quantitative analysis of thrombomodulin-mediated conversion of protein C to APC: translation from in vitro to in vivo
R Carnemolla, KR Patel, S Zaitsev, DB Cines, CT Esmon, VR Muzykantov Journal of immunological methods 384 (1-2), 21-24 |
21 | 2012 |
| Avidin-induced lysis of biotinylated erythrocytes by homologous complement via the alternative pathway depends on avidin's ability of multipoint binding with biotinylated membrane
VR Muzykantov, MD Smirnov, GP Samokhin Biochimica et Biophysica Acta (BBA)-Biomembranes 1107 (1), 119-125 |
21 | 1992 |
| Type I and III collagens as a possible target for drug delivery to the injured sites of vascular bed
MD Smirnov, GP Samokhin, VR Muzykantov, GL Idelson, SP Domogatsky, ... Biochemical and Biophysical Research Communications 116 (1), 99-105 |
21 | 1983 |
| Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia‐reperfusion injury
R Carnemolla, CH Villa, CF Greineder, S Zaitsev, KR Patel, MA Kowalska, ... The FASEB Journal 31 (2), 761-770 |
20 | 2017 |
| Avidin attachment to biotinylated amino groups of the erythrocyte membrane eliminates homologous restriction of both classical and alternative pathways of the complement
VR Muzykantov, MD Smirnov, AL Klibanov FEBS letters 318 (2), 108-112 |
20 | 1993 |
| Streptavidin‐induced lysis of homologous biotinylated erythrocytes Evidence against the key role of the avidin charge in complement activation via the alternative pathway
VR Muzykantov, MD Smirnov, GP Samokhin FEBS letters 280 (1), 112-114 |
20 | 1991 |
| Collaborative enhancement of endothelial targeting of nanocarriers by modulating platelet-endothelial cell adhesion molecule-1/CD31 epitope engagement
AM Chacko, J Han, CF Greineder, BJ Zern, JL Mikitsh, M Nayak, D Menon, ... ACS nano 9 (7), 6785-6793 |
19 | 2015 |
| Targeting of radiolabeled monoclonal antibody against ACE to the pulmonary endothelium
VR Muzykantov, SM Danilov Targeted delivery of imaging agents, 465-485 |
19 | 1995 |
| Endothelial targeted strategies to combat oxidative stress: Improving outcomes in traumatic brain injury
EM Lutton, SK Farney, AM Andrews, VV Shuvaev, GY Chuang, ... Frontiers in neurology, 582 |
18 | 2019 |
| Targeted therapeutics and nanodevices for vascular drug delivery: Quo vadis?
VR Muzykantov IUBMB life 63 (8), 583-585 |
18 | 2011 |
| Synthetic carriers for vascular delivery of protein therapeutics
TD Dziubla, VR Muzykantov Biotechnology and genetic engineering reviews 22 (1), 267-298 |
18 | 2006 |
| Conjugation of catalase to a carrier antibody via a streptavidinŐbiotin cross‐linker
VR Muzykantov Biotechnology and applied biochemistry 26 (2), 103-109 |
18 | 1997 |
| Hemolytic complement activity assay in microtitration plates
VR Muzykantov, GP Samokhin, MD Smirnov, S Domogatsky J. Appl. Biochem 7 (3), 223-227 |
18 | 1985 |
| Vascular endothelial effects of collaborative binding to platelet/endothelial cell adhesion molecule-1 (PECAM-1)
RY Kiseleva, CF Greineder, CH Villa, OA Marcos-Contreras, ED Hood, ... Scientific reports 8 (1), 1-10 |
17 | 2018 |
| Uniform field magnetization and targeting of therapeutic formulations
RJ Levy, M Chorny, V Muzykantov, E Hood US Patent 9,028,829 |
17 | 2015 |
| Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer
C Li, J Wang, J Hu, Y Feng, K Hasegawa, X Peng, X Duan, A Zhao, ... Oncotarget 5 (16), 6994 |
17 | 2014 |
| Immunotargeting of streptavidin to the pulmonary endothelium
VR Muzykantov, EN Atochina, V Gavriljuk, SM Danilov, AB Fisher Journal of Nuclear Medicine 35 (8), 1358-1365 |
17 | 1994 |
| Fast lysis by complement and uptake by liver of avidin-carrying biotinylated erythrocytes
VR Muzykantov, N Seregina, MD Smirnov The International journal of artificial organs 15 (10), 622-627 |
17 | 1992 |
| Cytotoxicity of glucose oxidase conjugated with antibodies to target cells: killing efficiency depends on the conjugate internalization
VR Muzykantov, OV Trubetskaya, EA Puchnina, DV Sakharov, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1053 (1), 27-31 |
17 | 1990 |
| The role of carrier geometry in overcoming biological barriers to drug delivery
C Jordan, V V Shuvaev, M Bailey, V R Muzykantov, T D Dziubla Current pharmaceutical design 22 (9), 1259-1273 |
16 | 2016 |
| Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo
R Carnemolla, CF Greineder, AM Chacko, KR Patel, BS Ding, S Zaitsev, ... Journal of Pharmacology and Experimental Therapeutics 347 (2), 339-345 |
16 | 2013 |
| Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 …
WM Armstead, K Ganguly, J Riley, JW Kiessling, DB Cines, AAR Higazi, ... Pediatric Critical Care Medicine 12 (6), e369-e375 |
16 | 2011 |
| Targeting pulmonary endothelium
VR Muzykantov Biomedical aspects of drug targeting, 129-148 |
16 | 2002 |
| Tannin-mediated attachment of avidin provides complement-resistant immunoerythrocytes that can be lysed in the presence of activator of complement
VR Muzykantov, MD Smirnov, AB Zaltzman, GP Samokhin Analytical biochemistry 208 (2), 338-342 |
16 | 1993 |
| Molecularly engineered nanobodies for tunable pharmacokinetics and drug delivery
PM Glassman, LR Walsh, CH Villa, OA Marcos-Contreras, ED Hood, ... Bioconjugate chemistry 31 (4), 1144-1155 |
15 | 2020 |
| Clot penetration and retention by plasminogen activators promote fibrinolysis
OA Marcos-Contreras, K Ganguly, A Yamamoto, R Shlansky-Goldberg, ... Biochemical pharmacology 85 (2), 216-222 |
15 | 2013 |
| Red blood cell targeting to smooth muscle cells
MA Glukhova, SP Domogatsky, AE Kabakov, VR Muzykantov, OI Ornatsky, ... FEBS letters 198 (1), 155-158 |
15 | 1986 |
| Erythrocytes as carriers of immunoglobulin-based therapeutics
W Ji, PN Smith, RR Koepsel, JD Andersen, SL Baker, L Zhang, S Carmali, ... Acta Biomaterialia 101, 422-435 |
14 | 2020 |
| Targeted protein replacement for the treatment of lysosomal storage disorders
SM Galindo, VR Muzykantov, EH Schuchman US Patent 9,655,953 |
13 | 2017 |
| RBC-coupled tPA prevents whereas tPA aggravates JNK MAPK-mediated impairment of ATP-and Ca-sensitive K channel-mediated cerebrovasodilation after cerebral photothrombosis
WM Armstead, K Ganguly, J Riley, S Zaitsev, DB Cines, AAR Higazi, ... Translational stroke research 3 (1), 114-121 |
13 | 2012 |
| Effect of glycocalyx on drug delivery carriers targeted to endothelial cells
AJ Calderon, M Baig, B Pichette, V Muzykantov, S Muro, DM Eckmann International journal of transport phenomena 12 (1-2), 63 |
13 | 2011 |
| Catalase and SOD conjugated with PECAM antibody distinctly alleviate abnormal endothelial permeability caused by exogenous ROS and vascular endothelial growth factor
J Han, VV Shuvaev, VR Muzykantov Journal of Pharmacology and Experimental Therapeutics |
13 | 2011 |
| Synthesis and characterization of polymer nanocarriers for the targeted delivery of therapeutic enzymes
E Simone, T Dziubla, V Shuvaev, VR Muzykantov Free Radicals and Antioxidant Protocols, 145-164 |
13 | 2010 |
| Effect of flow rate and blood cellular elements on the efficiency of red blood cell targeting to collagen-coated surfaces.
GP Samokhin, MD Smirnov, VR Muzykantov, SP Domogatsky, ... Journal of applied biochemistry 6 (1-2), 70-75 |
13 | 1984 |
| Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
I Tombácz, D Laczkó, H Shahnawaz, H Muramatsu, A Natesan, ... Molecular Therapy 29 (11), 3293-3304 |
12 | 2021 |
| The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)
JS Brenner, RY Kiseleva, PM Glassman, H Parhiz, CF Greineder, ... Pulmonary circulation 8 (1), 2045893217752329 |
12 | 2018 |
| Antioxidant polymer nanocarriers for use in preventing oxidative injury
VR Muzykantov, T Dziubla US Patent 7,597,907 |
12 | 2009 |
| Oxidative inactivation of angiotensin-converting enzyme
S IIu, EA Dukhanina, EA Puchnina, SM Danilov, VR Muzykantov Biokhimiia (Moscow, Russia) 56 (1), 55-62 |
12 | 1991 |
| Monoclonal antibodies to angiotensin-converting enzyme: a powerful tool for lung and vessel studies
S Danilov, I Sakharov, A Martynov, A Faerman, V Muzykantov, A Klibanov, ... Journal of molecular and cellular cardiology 21, 165-170 |
12 | 1989 |
| Red blood cell hitchhiking: a novel approach for vascular delivery of Nanocarriers
JS Brenner, S Mitragotri, VR Muzykantov Annual review of biomedical engineering 23, 225-248 |
11 | 2021 |
| Cross-linker-modulated nanogel flexibility correlates with tunable targeting to a sterically impeded endothelial marker
JW Myerson, O McPherson, KG DeFrates, JH Towslee, ... ACS nano 13 (10), 11409-11421 |
11 | 2019 |
| Coupling of anti-thrombotic agents to red blood cells offers safer and more effective management of thrombosis.
JC Murciano, VR Muzykantov Discovery Medicine 3 (18), 28-29 |
11 | 2003 |
| Stiffness can mediate balance between hydrodynamic forces and avidity to impact the targeting of flexible polymeric nanoparticles in flow
S Farokhirad, A Ranganathan, J Myerson, VR Muzykantov, ... Nanoscale 11 (14), 6916-6928 |
10 | 2019 |
| Mechanism of collaborative enhancement of binding of paired antibodies to distinct epitopes of platelet endothelial cell adhesion molecule-1
R Kiseleva, CF Greineder, CH Villa, ED Hood, VV Shuvaev, J Sun, ... PloS one 12 (1), e0169537 |
10 | 2017 |
| The emerging role for red blood cells in haemostasis: opportunity for intervention
CH Villa, VR Muzykantov, DB Cines ISBT Science Series 11 (S1), 158-164 |
10 | 2016 |
| Nanoscale antioxidant therapeutics
T Dziubla, S Muro, VR Muzykantov, M Koval Oxidative Stress, Disease and Cancer, 1023-1043 |
10 | 2006 |
| Pathologically stiff erythrocytes impede contraction of blood clots
V Tutwiler, RI Litvinov, A Protopopova, C Nagaswami, C Villa, E Woods, ... Journal of Thrombosis and Haemostasis 19 (8), 1990-2001 |
9 | 2021 |
| Biomimetic microfluidic platform for the quantification of transient endothelial monolayer permeability and therapeutic transport under mimicked cancerous conditions
CG Uhl, VR Muzykantov, Y Liu Biomicrofluidics 12 (1), 014101 |
9 | 2018 |
| Vascular targeting of antithrombotic agents
R Carnemolla, VR Muzykantov IUBMB life 63 (8), 632-639 |
9 | 2011 |
| Method and compositions for polymer nanocarriers containing therapeutic molecules
E Simone, VR Muzykantov, TD Dziubla US Patent 7,927,629 |
9 | 2011 |
| Catalase targeting to the surface endothelial antigens protects pulmonary vasculature against oxidative insult
EN Atochina, IV Balyasnikova, SM Danilov, DN Granger, AB Fisher, ... Am. J. Physiol 275, L806-L817 |
9 | 1998 |
| A new approach to the investigation of oxidative injury to the pulmonary endothelium: use of angiotensin-converting enzyme as a marker.
VR Muzykantov, SM Danilov Biomedical Science 2 (1), 11-21 |
9 | 1991 |
| The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
C Peghaire, NP Dufton, M Lang, II Salles-Crawley, J Ahnström, V Kalna, ... Nature communications 10 (1), 1-17 |
8 | 2019 |
| Targeted protein replacement for the treatment of lysosomal storage disorders
SM Galindo, VR Muzykantov, EH Schuchman US Patent 8,889,127 |
8 | 2014 |
| Delivery of acid sphingomyelinase in normal and Niemann-Pick disease mice using ICAM-1-targeted polymer nanocarriers
C Garnacho, R Dhami, E Simone, T Dziubla, J Leferovich, EH Schuchman, ... Journal of Pharmacology and Experimental Therapeutics |
8 | 2008 |
| Purification of radiolabeled monoclonal antibodies to angiotensin-converting enzyme significantly improves specificity and efficacy of its targeting into the lung
H Hiemisch, V Gavrilyuk, E Atochina, M Slinkin, V Torchilin, V Muzykantov, ... Nuclear medicine and biology 20 (4), 435-441 |
8 | 1993 |
| In vivo administration of antibodies against type I collagen in rat: the specific accumulation in spleen
GL Idelson, VR Muzykantov, EE Chekneva, AA Shnyra, BV Shekhonin, ... Collagen and related research 7 (6), 383-397 |
8 | 1987 |
| Avidin attachment to biotinylated human neutrophils induces generation of superoxide anion
VR Muzykantov, TA Kushnareva, MD Smirnov, EK Ruuge Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1177 (3), 229-235 |
7 | 1993 |
| Fluorescence microscopy imaging calibration for quantifying nanocarrier binding to cells during shear flow exposure
A Ranganathan, J Campo, J Myerson, V Shuvaev, B Zern, V Muzykantov, ... Journal of biomedical nanotechnology 13 (6), 737-745 |
6 | 2017 |
| Systems approaches to design of targeted therapeutic delivery
JW Myerson, JS Brenner, CF Greineder, VR Muzykantov Wiley Interdisciplinary Reviews: Systems Biology and Medicine 7 (5), 253-265 |
6 | 2015 |
| Assessment of protein binding with magnetic microrobots in fluid
EB Steager, B Zern, MS Sakar, V Muzykantov, V Kumar 2013 IEEE International Conference on Robotics and Automation, 5502-5507 |
6 | 2013 |
| RBC-coupled tPA prevents impairment of cerebral vasodilatory responses through inhibition of JNK and potentiation of p38 MAPK after cerebral photothrombosis in the newborn pig
WM Armstead, K Ganguly, J Riley, JW Kiessling, DB Cines, AAR Higazi, ... Pediatric critical care medicine: a journal of the Society of Critical Care … |
6 | 2011 |
| Enhancement of intracellular delivery and tissue targeting of drugs and genes
VR Muzykantov, SM Albelda US Patent 7,157,087 |
6 | 2007 |
| Biomedical Aspects of Drug Targeting
V Torchilin, V Muzykantov Kluwer Academic |
6 | 2002 |
| Local tissue injury induced by glucose oxidase conjugated with anti-collagen antibody
VR Muzykantov, MM Peclo, OY Printseva Journal of immunological methods 119 (1), 65-73 |
6 | 1989 |
| Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers
PM Glassman, ED Hood, LT Ferguson, Z Zhao, DL Siegel, S Mitragotri, ... Advanced Drug Delivery Reviews 178, 113992 |
5 | 2021 |
| Supramolecular organization predicts protein nanoparticle delivery to neutrophils for acute lung inflammation diagnosis and treatment
JW Myerson, PN Patel, N Habibi, LR Walsh, YW Lee, DC Luther, ... bioRxiv |
5 | 2020 |
| Epitope-dependent selective targeting of thrombomodulin monoclonal antibodies to either surface or intracellular compartment of endothelial cells
VR Muzykantov, IV Balyasnikova, A Joshi, AB Fisher, MD Smirnov, ... Drug delivery 5 (3), 197-206 |
5 | 1998 |
| Immunotargeting of plasminogen activators to the pulmonary endothelium
VR Muzykantov, ES Barnathan US Patent 5,653,979 |
5 | 1997 |
| Interaction of avidin-carrying red blood cells with nucleated cells
VR Muzykantov, AB Zaltzman, IV Fuki, MD Smirnov, GP Samokhin, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1179 (2), 148-156 |
5 | 1993 |
| Glucose Oxidase Conjugated with Anti-endothelial Monoclonal Antibodies: in Vitro and in Vivo Studies
VR Muzykantov, SM Danilov International journal of radiation biology 60 (1-2), 11-15 |
5 | 1991 |
| Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation
JW Myerson, PN Patel, KM Rubey, ME Zamora, MH Zaleski, N Habibi, ... Nature nanotechnology 17 (1), 86-97 |
4 | 2022 |
| Bivalent engagement of endothelial surface antigens is critical to prolonged surface targeting and protein delivery in vivo
RY Kiseleva, PG Glassman, KM LeForte, LR Walsh, CH Villa, VV Shuvaev, ... The FASEB Journal 34 (9), 11577-11593 |
4 | 2020 |
| Design parameters modulating intracellular drug delivery: anchoring to specific cellular epitopes, carrier geometry, and use of auxiliary pharmacological agents
S Muro, VR Muzykantov Organelle-Specific Pharmaceutical Nanotechnology, 449-474 |
4 | 2010 |
| Streptavidin-mediated coupling of therapeutic proteins to carrier erythrocytes
VR Muzykantov, JC Murciano Erythrocyte engineering for drug delivery and targeting (M. Maniani, Ed … |
4 | 2002 |
| Immunoconjugates of catalase attenuate radiation-induced pulmonary fibrosis in C57bl mice
M Christofidou-Solomidou, J McDonough, A Scherpereel, R Wiewrodt, ... International Journal of Radiation Oncology, Biology, Physics 51 (3), 235 |
4 | 2001 |
| Bimodal effect of exogenous hydrogen peroxide on human neutrophils: cytotoxic effect and modulation of respiratory burst in response to an agonist
EA Puchina, AN Ledenev, VR Muzykantov, EK Ruuge, VA Tkachuk Biokhimiia (Moscow, Russia) 57 (5), 694-700 |
4 | 1992 |
| Evaluation of the lung microvascular status using radiolabelled monoclonal antibody angiotensin-converting enzyme
V Muzykantov, E Puchnina, E Atochina, I Sakharov, S Danilov Advances in vascular pathology 1989. v. 1 |
4 | 1989 |
| Specific accumulation of monoclonal antibodies against the angiotensin-converting enzyme in rat lungs
SM Danilov, VR Muzykantov, AV Martynov, YI Sakharov, EN Atochina, ... Electronic Journal of Information Technology in Construction 301 (1-6), 251-255 |
4 | 1988 |
| Nanotherapeutic-directed approaches to analgesia
LL Mazaleuskaya, VR Muzykantov, GA FitzGerald Trends in Pharmacological Sciences 42 (7), 527-550 |
3 | 2021 |
| Vascular immunotargeting: take the highway to the first exit
VR Muzykantov, JS Brenner Hepatology (Baltimore, Md.) 68 (5), 1672 |
3 | 2018 |
| Compositions containing thrombomodulin domains and uses thereof
VR Muzykantov, BS Ding, DB Cines, C Gottstein, SM Albelda US Patent App. 13/124,295 |
3 | 2011 |
| NO gets a test ride on high-tech transporting nanodevices: A commentary on" Sustained-release nitric oxide from long-lived circulating nanoparticles"
VR Muzykantov Free radical biology & medicine 49 (4), 528-529 |
3 | 2010 |
| Targeting and prolonging association of drugs to the luminal surface of the pulmonary vascular endothelial cells using antibodies that bind to ICAM-1
VR Muzykantov, JC Murciano, DN Granger US Patent 7,674,466 |
3 | 2010 |
| Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium
VR Muzykantov The Pulmonary Endothelium: Function in Health and Disease, 355 |
3 | 2009 |
| Chair's Summary
VR Muzykantov Proceedings of the American Thoracic Society 6 (5), 398-402 |
3 | 2009 |
| Compositions and methods for selective dissolution of nascent intravascular blood clots
V Muzykantov, J Murciano, D Cines US Patent App. 11/352,720 |
3 | 2006 |
| Biological barriers for drug targeting
VR Muzykantov Biomedical aspects of drug targeting, 27-44 |
3 | 2002 |
| Avidin/Biotin-Mediated Conjugation of Antibodies to Erythrocytes: An Approach for in vivo Immunoerythrocyte Exploration
VR Muzykantov A laboratory guide to biotin-labeling in biomolecule analysis, 167-182 |
3 | 1996 |
| Sublethal doses of exogenous hydrogen peroxide prime human neutrophils to formyl peptide
EA Puchnina-Artushenko, AV Ledenev, EK Ruuge, VR Muzykantov Agents and Actions 39 (1), C192-C194 |
3 | 1993 |
| Methods and compositions for drug delivery
V Muzykantov, J Brenner, J Myerson, D Pan, SS Mitragotri US Patent 11,123,441 |
2 | 2021 |
| A numerical study on drug delivery via multiscale synergy of cellular hitchhiking onto red blood cells
M Nikfar, M Razizadeh, R Paul, V Muzykantov, Y Liu Nanoscale 13 (41), 17359-17372 |
2 | 2021 |
| A Microfluidic Model of Microvascular Inflammation: Characterization and Testing of Endothelial-Targeted Therapeutics
CF Greineder, I Johnston, CH Villa, DB Cines, M Poncz, VR Muzykantov Blood 126 (23), 3454 |
2 | 2015 |
| Method and compositions for polymer nanocarriers containing therapeutic molecules
E Simone, VR Muzykantov, TD Dziubla US Patent 8,568,786 |
2 | 2013 |
| Platelet-Targeted Pro-Urokinase as a Novel Thromboprophylaxis Fibrinolytic Strategy
R Fuentes, MA Kowalska, S Tliba, DW Bougie, RH Aster, DB Cines, ... Blood, The Journal of the American Society of Hematology 116 (21), 3339-3339 |
2 | 2010 |
| Enhancement of intracellular delivery and tissue targeting of drugs and genes
V Muzykantov, S Albelda US Patent App. 11/599,831 |
2 | 2007 |
| Nanocarriers for the Vascular Delivery of Drugs to the Lungs
T Dziubla, V Muzykantov Nanoparticulates as drug carriers, 499-526 |
2 | 2006 |
| Antibody conjugates targeted to endothelial cell adhesion molecules are internalized via a protein kinase C-dependent pathway that resembles macropinocytosis
S Muro, R Wiewrodt, L Koniaris, S Albelda, V Muzykantov, M Koval J Cell Sci 116, 1599-1609 |
2 | 2003 |
| Laser speckle-flowmetry: A novel two-dimensional technique for the study of cerebral blood flow in normal and ischemic mouse brain, in vivo
C Ayata, Y Ozdemir, A Dunn, DN Atochin, PL Huang, VR Muzykantov, ... Stroke 34 (1), 251-251 |
2 | 2003 |
| 14 Immunotargeting of Catalase to the Pulmonary Vascular Endothelium
VR Muzykantov Drug Targeting, 241-254 |
2 | 2000 |
| Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)
H Parhiz, JS Brenner, PN Patel, TE Papp, H Shahnawaz, Q Li, R Shi, ... Journal of Controlled Release 344, 50-61 |
1 | 2022 |
| Targeting vascular inflammation through emerging methods and drug carriers
J Nong, PM Glassman, VR Muzykantov Advanced Drug Delivery Reviews, 114180 |
1 | 2022 |
| Target-mediated exposure enhancement: a previously unexplored limit of TMDD
PM Glassman, VR Muzykantov Journal of pharmacokinetics and pharmacodynamics 47 (5), 411-420 |
1 | 2020 |
| CRISPR/Cas9-mediated genetic engineering of hybridomas for creation of antibodies that allow for site-specific conjugation
M Khoshnejad, JS Brenner, H Parhiz, VR Muzykantov Bioconjugation, 81-93 |
1 | 2019 |
| Blood clot contraction is reduced in sickle cell disease due to increased rigidity of erythrocytes
V Tutwiler, RI Litvinov, AD Protopopova, C Nagaswami, JE Russell, ... Biophysical Journal 114 (3), 540a-541a |
1 | 2018 |
| Targeted antioxidant interventions for vascular pathologies
ED Hood, VV Shuvaev, VR Muzykantov Oxidative Stress and Biomaterials, 323-349 |
1 | 2016 |
| Nanocarriers for Therapeutic Enzymes
MD Howard, ED Hood, VR Muzykantov Enzyme Nanocarriers, 159-192 |
1 | 2015 |
| Synthesis and evaluation of radioiodinated gold nanoprobes for dual modality PET/CT imaging of pulmonary inflammatory marker ICAM-1
AM Chacko, JL Mikitsh, Y Xingchen, B Zern, A Wright, CB Murray, ... JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 56, S239-S239 |
1 | 2013 |
| PECAM targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and vivo
R Carnemolla, CF Greineder, AM Chacko, KR Patel, BS Ding, S Zaytsev, ... Journal of Pharmacology and Experimental Therapeutics |
1 | 2013 |
| Imaging of molecular signatures of specific structures, functions, and pathological alterations in the lung tissue. Chair's Summary.
VR Muzykantov Proceedings of the American Thoracic Society 6 (5), 398-402 |
1 | 2009 |
| tPA contributes to impaired cerebral hemodynamics after piglet photothrombotic injury through JNK and not ERK MAPK
JW Kiessling, V Muzykantov, DB Cines, AA Higazi, WM Armstead Stroke 40 (4), E215-E215 |
1 | 2009 |
| Prophylactic fibrinolysis of cerebral thrombi by erythrocyte-bound tissue type plasminogen activator protects against ischemic stroke
K Danielyan, K Ganguly, D Atochin, D Fisher, S Zaytsev, D Cines, ... Stroke 37 (2), 683-683 |
1 | 2006 |
| Intracellular uptake and trafficking of immunoconjugates targeted to endothelial surface adhesion molecules
S Muro, R Wiewrodt, A Thomas, SM Albelda, L Koniaris, VR Muzykantov, ... Molecular Biology of the Cell 12, 91A-91A |
1 | 2001 |
| PECAM-directed immunotargeting of active reporter enzyme to the heart.
AP Scherpereel, DW Harshaw, R Wiewrodt, M Christofidou-Solomidou, ... Circulation 102 (18), 188-188 |
1 | 2000 |
| PECAM-directed intracellular immunotargeting of genes
R Wiewredt, CD Campbell, SI Feinstein, D Schaffer, SM Albelda, ... AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 159 (3), A347-A347 |
1 | 1999 |
| Immunotargeting of glucose oxidase conjugated to an anti-Thrombomodulin antibody causes ARDS-like oxidative lung injury in mice
M Christofidou-Solomidou, K Ng, S Kennel, G Pietra, V Muzykantov, ... AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 159 (3), A890-A890 |
1 | 1999 |
| Endothelial cells selectively internalize monoclonal antibody reacting with chondroitin sulfate-free thrombomodulin
VR Muzykantov, IV Balyasnikova, AB Fisher, MD Smirnov, NL Esmon, ... Circulation 96 (8), 230-230 |
1 | 1997 |
| Biotinylation of Erythrocytes Prepares to Allow Circulation-Stable Immunoerythrocytes Capable of Recognizing the Antigen
JC Murciano, VR Muzykantov, A Herráez Erythrocytes as Drug Carriers in Medicine, 93-99 |
1 | 1997 |
| Heteropolymer mediated binding of target antigens to primate erythrocytes (E) VIA CR1. in vitro analyses
RP Taylor, CJ Reist, HY Liang, V Muzykantov, M Zachary, WM Scheid, ... Molecular Immunology 30, 54 |
1 | 1993 |
| STREPTAVIDIN AND AVIDIN INDUCE THE ERYTHROCYTE LYSIS VIA THE ALTERNATIVE PATHWAY OF COMPLEMENT ACTIVATION-EVIDENCE AGAINST THE ROLE OF AVIDIN CHARGE IN HEMOLYSIS
VR Muzykantov, MD Smirnov, GP Samokhin BIOLOGICHESKIE MEMBRANY 7 (8), 831-837 |
1 | 1990 |
| Monoclonal antibody to angiotensin-converting enzyme
SM Danilov, VR Muzykantov Pulmonary Blood Vessels in Lung Disease 26, 85-93 |
1 | 1990 |
| The erythrocyte as a potential container for directed transport of drugs to damaged parts of the circulatory bed
GP Samokhin, MD Smirnov, VR Muzykantov, SP Domogatskiĭ Biulleten'Vsesoiuznogo Kardiologicheskogo Nauchnogo Tsentra AMN SSSR 9 (1 … |
1 | 1986 |
| Protection of endothelial cells against the cytotoxic effect of hydrogen peroxide by immune erythrocytes
VR Muzykantov, DV Sakharov, SP Domogatskiĭ, NV Goncharov, ... Doklady Akademii Nauk SSSR 288 (3), 748-751 |
1 | 1986 |
| Streptavidin-biotin crosslinking of therapeutic enzymes with carrier antibodies
VV Shuvaev, T Dziubla, R Wiewrodt, VR Muzykantov Methods in Molecular Biology 283, 3-9 |
1 | |
| Dual Affinity to RBCs and Target Cells (DART) Enhances Both Organ-and Cell Type-Targeting of Intravascular Nanocarriers
LT Ferguson, ED Hood, T Shuvaeva, VV Shuvaev, MC Basil, Z Wang, ... ACS nano 16 (3), 4666-4683 |
2022 | |
| Combating complement's deleterious effects on nanomedicine by conjugating complement regulatory proteins to nanoparticles
Z Wang, ED Hood, J Nong, J Ding, OA Marcos‐Contreras, PM Glassman, ... Advanced Materials 34 (8), 2107070 |
2022 | |
| Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain
PM Glassman, J Nong, JW Myerson, V Zuluaga-Ramirez, ... bioRxiv |
2022 | |
| Pathologically stiff erythrocytes impede contraction of blood clots: Reply to comment
V Tutwiler, RI Litvinov, A Protopopova, C Nagaswami, C Villa, E Woods, ... Journal of thrombosis and haemostasis: JTH 19 (11), 2894-2895 |
2021 | |
| Methods and compositions for drug delivery
V Muzykantov, JS Brenner, CH Villa, L Ferguson, E Hood US Patent App. 17/219,295 |
2021 | |
| Fusion proteins and antibodies targeting human red blood cell antigens
CH Villa, VR Muzykantov, DL Siegel, C Greineder US Patent App. 16/768,822 |
2021 | |
| Nanocarriers Targeting Intercellular Adhesion Molecule Enhance Delivery to the Inflamed Brain
J Nong, O Marcos-Contreras, P Glassman, J Brenner, V Muzykantov The FASEB Journal 35 |
2021 | |
| Therapeutic Targeting of Lipid Nanoparticles
V Muzykantov, D Weissman, H Parhiz, VV Shuvaev, O Marcos-Contreras US Patent App. 16/577,281 |
2020 | |
| Erythrocyte rigidity modulates blood clot contraction and polyhedrocyte formation
V Tutwiler, RI Litvinov, C Nagaswami, JE Russel, DL Siegel, C Villa, ... MOLECULAR BIOLOGY OF THE CELL 29 (26) |
2018 | |
| Quantitative basis for design and vascular targeting of flexible polymeric nanoparticles
S Farokhirad, A Ranganathan, J Myerson, V Muzykantov, P Ayyaswamy, ... Bulletin of the American Physical Society 63 |
2018 | |
| Vascular Targeting of mRNA Provides Orders of Magnitude Elevation of Delivery and Transgene Expression Selectivley in the Lungs
H Parhiz, VV Shuvaev, N Pardi, M Khoshnejad, RY Kiseleva, S Tuyishime, ... MOLECULAR THERAPY 26 (5), 70-70 |
2018 | |
| Targeted carriers for intracellular drug delivery
S Muro-Galindo, VR Muzykantov US Patent App. 15/623,828 |
2017 | |
| Targeted protein replacement for the treatment of lysosomal storage disorders
SM Galindo, VR Muzykantov, EH Schuchman US Patent App. 15/490,053 |
2017 | |
| TARGETING RECOMBINANT THROMBOMODULIN FUSION PROTEIN TO RED BLOOD CELLS PROTECTS AGAINST STROKE
D Atochin, S Zaitsev, R Carnemolla, V Muzykantov, PL Huang JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 36, 440-441 |
2016 | |
| Nanogel Drug Carriers Presenting Platelet GPIbα Mimic and Enhance Platelet Adhesion
JW Myerson, I Johnston, J Wu, R McClintock, Z Ruggeri, M Poncz, ... The FASEB Journal 30, 943.2-943.2 |
2016 | |
| Coupling Therapeutics to Human Erythrocytes Demonstrates Target-Dependent Effects on Red Cell Physiology While Preserving Efficacy
CH Villa, D Pan, I Johnston, CF Greineder, ME Reid, DB Cines, M Poncz, ... Blood 128 (22), 701 |
2016 | |
| Erythrocyte Rigidity Affects Blood Clot Contraction and Formation of Polyhedrocytes
V Tutwiler, RI Litvinov, C Nagaswami, JE Russell, DL Siegel, CH Villa, ... Blood 128 (22), 3814 |
2016 | |
| Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity
CH Villa, CF Greineder, I Johnston, D Pan, R Carnemolla, DB Cines, ... Blood 126 (23), 3493 |
2015 | |
| Immuno-imaging and-therapy in ovarian cancer and sarcoma with de novo single-chain fv-fc fusion protein targeting TEM1/CD248
C Li, J Wang, EI Matthaiou, Y Guo, J Hu, AM Chacko, VR Muzykantov, ... Journal for ImmunoTherapy of Cancer 2 (3), 1-2 |
2014 | |
| Immunotargeting of tumor vasculature: preclinical development of novel antibody-based imaging and therapy against TEM1/CD248
C Li, J Wang, J Hu, AM Chacko, A Zhao, C Divgi, V Muzykantov, ... Journal for ImmunoTherapy of Cancer 1 (1), 1-1 |
2013 | |
| Abstract B68: Targeted theranostics of tumor vasculature by multivalent scFv constructs against TEM1
C Li, J Hu, AM Chacko, J Wang, A Zhao, X Duan, V Muzykantov, ... Clinical Cancer Research 19 (19 Supplement), B68-B68 |
2013 | |
| Co-targeting of Thrombomodulin and the Endothelial Protein C Receptor Protects the Pulmonary Vasculature in a Mouse Model of Acute Endothelial Injury
CF Greineder, S Zaytsev, VR Muzykantov Arteriosclerosis, Thrombosis, and Vascular Biology 33 (suppl_1), A6-A6 |
2013 | |
| A novel series of scFv antibody-based I-124 PET probes targeting the tumor vascular marker TEM1
AM Chacko, L Chunsheng, JL Mikitsh, W Junying, C Hou, V Muzykantov, ... JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 56, S83-S83 |
2013 | |
| Fusion proteins for inhibition and dissolution of coagulation of thrombi
VR Muzykantov, C Gottstein, BS Ding, DB Cines US Patent App. 13/528,125 |
2013 | |
| tibodies to Erythrocytes: An Approach for in vivo Immunoerythrocyte Exploration
VR Muzykantov A Laboratory Guide to Biotin-Labeling in Biomolecule Analysis, 167 |
2012 | |
| Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)
R Fuentes, HS Ahn, VM Hayes, V Tutwiler, Y Wang, DW Bougie, ... Blood, The Journal of the American Society of Hematology 120 (21), 1171-1171 |
2012 | |
| Targeting Thrombomodulin to Endothelial ICAM-1 Rather Than PECAM-1 Allows Partnering with the Endothelial Protein C Receptor and Enhances Protection of Endothelial Barrier Function
CF Greineder, S Zaytsev, B Zern, AM Chacko, VR Muzykantov Blood, The Journal of the American Society of Hematology 120 (21), 3351-3351 |
2012 | |
| Peptide Quantum Dot Conjugates Detect Integrin αvβ3
RL Orndorff, NK Hong, K Yu, K Debolt, VR Muzykantov, S Huang, ... The FASEB Journal 26, 1129.2-1129.2 |
2012 | |
| Collaborative Enhancement of Antibody Binding to Distinct PECAM-1 Epitopes
AM Chacko, M Nayak, CF Greineder, HM DeLisser, VR Muzykantov |
2012 | |
| Iron Oxide Nanoparticles Are Less Toxic to Endothelial Cells When Coated With Dextran and Polyethylene Glycol
M Yu, V Muzykantov, AM Clyne Summer Bioengineering Conference 54587, 1255-1256 |
2011 | |
| Targeting of an antioxidative conjugate-effects on hydrogen peroxide-induced toxicity in human pulmonary microvascular endothelial cells: 5AP3-5
AS Sebastiani, MI Hermanns, VR Muzykantov, VV Shuvaev, R Wiewrodt, ... European Journal of Anaesthesiology| EJA 28, 75-76 |
2011 | |
| tPA Contributes To Impairment of ATP and Ca Sensitive K Channel Mediated Cerebrovasodilation After Piglet Photothrombosis Through Upregulation of JNK MAPK
W Armstead, J Riley, D Cines, V Muzykantov, A Higazi STROKE 42 (3), E211-E211 |
2011 | |
| Monte Carlo Simulations of Absolute Binding Free Energy of Targeted Nanocarriers to Cell Surfaces
J Liu, B Zern, P Ayyaswamy, D Eckmann, V Muzykantov, ... Biophysical Journal 100 (3), 614a-615a |
2011 | |
| Avidin attachment to biotinylated erythrocytes induces homologous
VR Muzykantov, MD Smirnov, GP Samokhin |
2011 | |
| Platelet-Targeted Pro-Uiokinase as a Novel Thromboprophylaxis Fibrinolytic Strategy
R Fuentes, MA Kowalska, S Tliba, DW Bougie, RH Aster, DB Cines, ... BLOOD 116 (21), 1367-1367 |
2010 | |
| Monte Carlo Simulations of Absolute Binding Free Energy of Targeted Nanocarriers to Cell Surfaces
J Liu, B Zern, PS Ayyaswamy, DM Eckmann, VR Muzykantov, ... APS Division of Fluid Dynamics Meeting Abstracts 63, MK. 004 |
2010 | |
| Intraendothelial Delivery of Superoxide Dismutase Inhibits Inflammatory Activation Mediated by Superoxide Flux in Endosomes
VV Shuvaev, J Han, VR Muzykantov ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 30 (11), E268-E268 |
2010 | |
| In Vivo Modeling and Detection of Ovarian Cancer Vascular Marker TEM1
L Chunsheng, K Hasegawa, AM Chacko, V Muzykantov, C Divgi, ... JOURNAL OF IMMUNOTHERAPY 33 (8), 901-901 |
2010 | |
| Thromboprophylaxis by cell-bound thrombolytics
VR Muzykantov JOURNAL OF THROMBOSIS AND HAEMOSTASIS 8, 42-42 |
2010 | |
| Stable and reversible fusion protein conjugated to red blood cells for drug delivery in thromboprophylaxis
OA Marcos-Contreras, M Gonzalez de la Fuente, DB Cines, ... JOURNAL OF THROMBOSIS AND HAEMOSTASIS 8, 16-16 |
2010 | |
| Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis (vol 332, pg 1022, 2010)
S Zaitsev, D Spitzer, JC Murciano, BS Ding, S Tliba, MA Kowalska, ... JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 333 (3), 976-976 |
2010 | |
| 124I-PET imaging of the ovarian cancer vascular marker TEM1
AM Chacko, C Li, V Muzykantov, G Coukos, C Divgi Journal of Nuclear Medicine 51 (supplement 2), 1110-1110 |
2010 | |
| PET imaging of 124I-labeled polymer nanoparticles directed to the pulmonary endothelium
AM Chacko, B Zern, E Simone, V Muzykantov Journal of Nuclear Medicine 51 (supplement 2), 1489-1489 |
2010 | |
| RBC Coupled tPA Prevents Impairment of Hypercapnic and Hypotensive Cerebrovasodilation After Piglet Photothrombosis Through Inhibition of JNK and Potentiation of p38 MAPK
W Armstead, K Ganguly, J Riley, W Kiessling, D Cines, A Higazi, ... STROKE 41 (4), E251-E251 |
2010 | |
| How I became a biochemist—from Moscow to Philadelphia, by way of Charlottesville: A story of one Wood/Whelan fellowship journey
VR Muzykantov IUBMB life 62 (4), 313-314 |
2010 | |
| Latest news
P Links Good Old Days |
2010 | |
| Erythrocyte-Bound Tissue Pasminogen Activator is Neuroprotective in Experimental Traumatic Brain Injury (vol 26, pg 1585, 2009)
VR Muzykantov JOURNAL OF NEUROTRAUMA 27 (1), 299-299 |
2010 | |
| Anti-inflammatory Properties of Superoxide Dismutase Targeted to Endothelial Cells
VV Shuvaev, CF Greineder, VR Muzykantov ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 29 (7), E66-E66 |
2009 | |
| Targeted Delivery of Catalase to the Pulmonary Endothelium Preserves Graft Function of Non-Heart-Beating Donor Lungs in Pigs.
R Wiewrodt, F Loehe, I Huff, H Ebersberger, V Shuvaev, I Bittmann, ... C53. LUNG TRANSPLANTATION: DONOR SELECTION AND RECIPIENT MANAGEMENT, A4612 |
2009 | |
| THE PULMONARY ENDOTHELIUM: FUNCTION IN HEALTH AND DISEASE
US Kayyali, BL Fanburg, KR Stenmark, EV Gerasimovskaya, M Frid, ... |
2009 | |
| Characterization of Lipid Peroxidation Using a Novel Thiadiazabicyclo Endogenous Glutathione Adduct in a Paraquat-Induced Model of Oxidative Stress
SS Basu, VV Shuvaev, VR Muzykantov, IA Blair CHEMICAL RESEARCH IN TOXICOLOGY 21 (12), 2442-2442 |
2008 | |
| RBC-tPA helps prevent hypercapnic and hypotensive cerebrovasodilator impairment by inhibiting ERK MAPK upregulation after cerebral hypoxia/ischemia.
WM Armstead, K Ganguly, JW Kiessling, AA Higazi, S Zaitsev, DB Cines, ... STROKE 39 (2), 665-665 |
2008 | |
| Vaskuläres Immuntargeting von anti-PECAM/Katalase-Konjugaten ins pulmonale Endothel verbessert die Funktion der Spenderlungen bei der Lungentransplantation in Schweinen
G Preissler, F Löhe, I Huff, H Ebersberger, I Hermanns, K Fischer, K Jauch, ... Pneumologie 62 (S 2), P358 |
2008 | |
| RBC-coupled tPA prevents cerebrovasodilatory impairment and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK unregulation
K Ganguly, WM Armstead, JW Kiessling, XH Chen, DH Smith, AA Higazi, ... Nature Neuroscience |
2008 | |
| Anchoring Of Thrombomodulin On Endothelium Protects Against Mouse Lung Ischemia-reperfusion Injury
BS Ding, N Hong, C Gottstein, SM Albelda, DB Cines, AB Fisher, ... Circulation 116 (suppl_16), II_193-II_193 |
2007 | |
| Targeting of Drugs to ICAM for Treatment of Acute Lung Injury. Revision
V Muzykantov PENNSYLVANIA UNIV PHILADELPHIA |
2007 | |
| PECAM-1 directed endothelial targeting of superoxide dismutase alleviates oxidative stress caused by either extracellular or intracellular superoxide
VV Shuvaev, S Tliba, M Nakada, SM Albelda, VR Muzykantov Journal of Pharmacology and Experimental Therapeutics |
2007 | |
| Cell adhesion molecules-targeted polymeric worm micelles as selective in vivo drug delivery systems against endothelial cells
MA Ilies, Y Kim, VV Shuvaev, S Zaitsev, S Cai, DE Discher, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 234 |
2007 | |
| Delivery of anti-PECAM scFv-urokinase fusion protein to the cerebral vasculature lyses arterial clots and attenuates post-ischemic brain edema
K Danielyan, BS Ding, C Gottstein, DB Cines, VR Muzykantov Journal of Pharmacology and Experimental Therapeutics |
2007 | |
| RBC-coupled tPA does not aggravate cerebral ischemia and hemorrhage in animal models
K Danielyan, S Zaitsev, BS Ding, K Ganguly, D Atochin, D Cines, ... STROKE 38 (2), 564-565 |
2007 | |
| Erythrocyte Coupled tPA Improves Outcomes of Percussion Brain Trauma in Rats.
K Ganguly, SC Stein, RF Groff, J Zhang, DH Smith, DB Cines, ... Blood, The Journal of the American Society of Hematology 108 (11), 897-897 |
2006 | |
| Targeted drug delivery to vascular endothelium
VR Muzykantov CHEMICO-BIOLOGICAL INTERACTIONS 161 (3), 208-208 |
2006 | |
| Erythrocyte-coupled tissue plasminogen activator reduces ischemic damage without increasing hemorrhage volume following experimental fluid percussion injury
R Groff, J Zhang, K Ganguly, S Stein, V Muzykantov, D Smith JOURNAL OF NEUROTRAUMA 23 (6), 1036-1036 |
2006 | |
| Specificity and size‐dependence of immunotargeting of the anti‐PECAM/catalase conjugates to endothelium
VV Shuvaev, S Tliba, J Czuprina, J Pick, SM Albelda, VR Muzykantov The FASEB Journal 20 (5), A1180-A1180 |
2006 | |
| DISSOCIATION BETWEEN ALVEOLAR TRANSMIGRATION OF NEUTROPHILS AND LUNG INJURY IN HYPEROXIA
E Arguiri, CC Solomides, SM Albelda, V Muzykantov, ... |
2006 | |
| Plasminogen Activators as Prophylactic Fibrinolytics: Overcoming Free Protein Shortcomings
DA Christian, K Ganguly, Y Kim, S Cai, VR Muzykantov, DE Discher The 2006 Annual Meeting |
2006 | |
| Tissue Plasminogen Activator Carrying Worm Micelles as Prophylactic Fibrinolytic Agents
Y Kim, K Ganguly, K Danielya, M Tewari, DA Christian, S Cai, ... The 2006 Annual Meeting |
2006 | |
| HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY-Human complement receptor type 1-directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic …
S Zaitsev, K Danielyan, JC Murciano, K Ganguly, T Krasik, RP Taylor, ... Blood 108 (6), 1895-1902 |
2006 | |
| Coupling Tissue Type Plasminogen Activator to Carrier Erythrocyte Protects Against Plasma Inhibitors.
K Ganguly, DB Cines, VR Muzykantov Blood 106 (11), 1881 |
2005 | |
| Fibrin affinity of erythrocyte-coupled tPA endures hemodynamic forces and enhances fibrinolysis in vivo
K Ganguly, MS Goel, T Krasik, K Bdeir, S Diamond, D Cines, ... Journal of Pharmacology and Experimental Therapeutics |
2005 | |
| The Modular Antibody Targeting of Catalase Loaded Nanocarriers Provides Protection of Endothelial Cells from H2o2 Mediated Injury
T Dziubla, V Shuvaev, S Muro, V Muzykantov The 2005 Annual Meeting |
2005 | |
| Immunotargeting of tissue type plasminogen activator to circulating red blood cells
S Zaitsev, G Spitalny, T Krasik, K Ganguly, R Taylor, JC Murciano, ... THROMBOSIS AND HAEMOSTASIS 93 (4), A13-A13 |
2005 | |
| Superoxide dismutase nanoconjugates targeted to endothelium augment antioxidant protection
VV Shuvaev, J Pick, S Tliba, T Dziubla, VR Muzykantov FASEB JOURNAL 19 (5), A1207-A1207 |
2005 | |
| Regulation of anti-ICAM-1 nanocarrier endocytosis and sorting by endothelial cell Na+/H+ exchanger proteins
S Muro, M Mateescu, V Muzykantov, M Koval FASEB JOURNAL 19 (4), A733-A733 |
2005 | |
| Compositions and methods for selective dissolution of nascent intravascular blood clots
VR Muzykantov, JC Murciano, D Cines |
2005 | |
| HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY-Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase
BS Ding, C Gottstein, A Grunow, A Kuo, K Ganguly, SM Albeida, DB Cines, ... Blood 106 (13), 4191-4198 |
2005 | |
| HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY-ICAM-1 recycling in endothelial cells: A novel pathway for sustained intracellular delivery and prolonged effects of drugs
S Muro, C Gajewski, M Koval, VR Muzykantov Blood 105 (2), 650-658 |
2005 | |
| Conjugation of Plasminogen Activators to Carrier Erythrocytes Imparts New Biological Properties to Their Soluble Counterparts.
K Ganguly, T Krasik, K Bdeir, DB Cines, VR Muzykantov, JC Murciano Blood, The Journal of the American Society of Hematology 104 (11), 534-534 |
2004 | |
| Immunotargeting of tissue type plasminogen activator to circulating red blood cells
SV Zaitsev, G Spitalny, T Krasik, R Taylor, JC Murciano, DB Cines, ... CIRCULATION 110 (17), 149-149 |
2004 | |
| Endothelial immunotargeting of superoxide dismutase corrects endothelial dysfunction in angiotensin II-induced hypertension
K Laude, H Cai, VV Shuvaev, A Bikineyeva, S Dikalov, V Muzykantov, ... HYPERTENSION 44 (4), 555-555 |
2004 | |
| Targeting of Drugs to ICAM for Treatment of Acute Lung Injury
V Muzykantov PENNSYLVANIA UNIV PHILADELPHIA |
2004 | |
| PROTEIN SYNTHESIS, POST-TRANSLATION MODIFICATION, AND DEGRADATION-Pro-thrombotic State Induced by Post-translational Modification of Fibrinogen by Reactive Nitrogen Species.
C Vadseth, JM Souza, L Thomson, A Seagraves, C Nagaswami, ... Journal of Biological Chemistry 279 (10), 8820-8826 |
2004 | |
| Hyperoxia potentiates oxidative injury in murine lungs induced by glucose oxidase targeted to thrombomodulin
M Christofidou-Solomidou, A Scherpereel, A Bohen, E Arguiri, V Shuvaev, ... FASEB JOURNAL 17 (4), A247-A247 |
2003 | |
| PROTEIN AND VESICLE TRAFFICKING, CYTOSKELETON-Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress (Call …
S Muro, X Cui, C Gajewski, JC Murciano, VR Muzykantov, M Koval American Journal of Physiology-Cell Physiology 54 (5), C1339 |
2003 | |
| HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY-ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface
JC Murciano, S Muro, L Koniaris, M Christofidou-Solomidou, ... Blood 101 (10), 3977-3984 |
2003 | |
| Tissue-plasminogen activator (tPA) coupling to erythrocytes prolongs its half-life and allows selective lysis of nascent, but not pre-existing clots.
JC Murciano, SP Medinilla, D Eslin, M Poncz, DB Cines, VR Muzykantov BLOOD 100 (11), 700A-700A |
2002 | |
| Dynamics of fibrin clot lysis under flow conditions by erythrocyte-linked tPA
MS Goel, JC Murciano, S Medinilla, A Yamamoto, DB Cines, ... Proceedings of the Second Joint 24th Annual Conference and the Annual Fall … |
2002 | |
| Catalase immunotargeting reduces lung transplant ischemia-reperfusion injury
BD Kozower, TD Sweitzer, SA Kanaan, S Albelda, VR Muzykantov, ... Journal of the American College of Surgeons 195 (3), S28 |
2002 | |
| Glucose oxidase vascular immunotargeting to pulmonary endothelium enhances luminal expression of ICAM-1 and P-selectin in the lung
A Scherpereel, JC Murciano, R Wiewrodt, S Kennel, V Muzykantov, ... FASEB JOURNAL 16 (4), A439-A439 |
2002 | |
| PKC-mediated endocytosis of conjugates targeted to ICAM-1
S Muro, AP Thomas, VR Muzykantov, M Koval FASEB JOURNAL 16 (4), A439-A439 |
2002 | |
| ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION-Platelet-Endothelial Cell Adhesion Molecule-1-Directed Immunotargeting to Cardiopulmonary Vasculature
A Scherpereel, JJ Rome, R Wiewrodt, SC Watkins, DW Harshaw, S Alder, ... Journal of Pharmacology and Experimental Therapeutics 300 (3), 777-786 |
2002 | |
| Vascular immunotargeting to lung graft endothelium
BD Kozower, TD Sweitzer, SA Kanaan, T Tagawa, SM Albelda, ... The Journal of Heart and Lung Transplantation 21 (1), 58 |
2002 | |
| Calendar of Events 153
VR Muzykantov, S Mitragotri, A Rothen-Weinhold, SY Ng, W Zauner, ... Journal of Controlled Release 71, 367-369 |
2001 | |
| Brain'01 Session 35 Experimental Stroke Hypoxia (Part I)-(Wednesday 11: 30, Poster)-Cerebral microembolism: Characterization of fibrinolysis and blood flow in a rodent model
DN Atochin, JC Murciano, VR Muzykantov, PL Huang Journal of Cerebral Blood Flow and Metabolism 21 (1), S383 |
2001 | |
| Cerebral microembolism: characterization of fibrinolysis and blood flow in a rodent model
DN Atochin, JC Murciano, VR Muzykantov, PL Huang JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 21, S383-S383 |
2001 | |
| IMMUNOTARGETING OF GLUCOSE OXIDASE TO ENDOTHELIUM IN VIVO CAUSES OXIDATIVE VASCULAR INJURY IN THE LUNGS
VR MUZYKANTOV AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 278 (4) |
2000 | |
| Coupling of the urokinase receptor to carrier erythrocytes: A new strategy to improve the therapeutic profile of urokinase
JC Murciano, AAR Higazi, DB Cines, VR Muzykantov THROMBOSIS AND HAEMOSTASIS, 210-210 |
1999 | |
| A novel 85 kD surface endothelial glycoprotein is a target for drug delivery to specific macrodomain in the lung alveolar capillaries.
VR Muzykantov, JC Murciano, D Harshaw, L Ghitescu AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 159 (3), A349-A349 |
1999 | |
| ACE-directed immunotargeting of DNA to the pulmonary vasculature.
S Danilov, E Atochina, V Gavriluk, S Reisher, S Feinstein, HA Jaffe, ... AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 159 (3), A348-A348 |
1999 | |
| Antibody directed targeting of catalase to the endothelial antigen PECAM augments pulmonary antioxidant defense in vivo.
M Christofidou-Solomidou, K Ng, S Kennel, S Albelda, V Muzykantov AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 159 (3), A287-A287 |
1999 | |
| A new model of pulmonary embolism in rodents reveals the role for urokinase in dissolution of fibrin clots.
JC Murciano, K Bdeir, D Neschis, L Koniaris, AA Higazi, M Golden, ... AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 159 (3), A455-A455 |
1999 | |
| Pulmonary Immunotargeting of plasminogen activator conjugated with a non-internalizable ICAM-1 antibody
JC Murciano, DW Harshaw, DN Granger, VR Muzykantov CIRCULATION 98 (17), 728-729 |
1998 | |
| Immunotargeting of glucose oxidase: A novel model of site-specific oxidative injury to the pulmonary endothelium
M Christofidou-Solomidou, W Harshaw, L Schultz, SM Albelda, ... FASEB JOURNAL 12 (4), A337-A337 |
1998 | |
| BINDING OF BIOTINYLATED ERYTHROCYTES TO AVIDIN-COATED SURFACE INDUCES THEIR LYSIS BY HOMOLOGOUS COMPLEMENT-A NEW APPROACH TO DEVELOPMENT OF TARGET-SENSITIVE CARRIERS FOR DRUG …
VR MUZYKANTOV, AB ZALTZMAN, MD SMIRNOV, GP SAMOKHIN BIOLOGICHESKIE MEMBRANY 12 (3), 233-246 |
1995 | |
| ENDOTHELIAL-CELLS INTERNALIZE MONOCLONAL-ANTIBODY TO ACE
V MUZYKANTOV, A KUO, C DODIA, E ATOCHINA, E BARNATHAN, ... FASEB JOURNAL 9 (6), A1454-A1454 |
1995 | |
| DRUG TARGETING TO THE PULMONARY ENDOTHELIUM-AN APPROACH EXPLORING THE MONOCLONAL-ANTIBODY TO ACE
VR MUZYKANTOV, EN ATOCHINA, SM DANILOV, AB FISHER JOURNAL OF CELLULAR BIOCHEMISTRY, 172-172 |
1995 | |
| INTERACTION OF AVIDIN-CARRYING ERYTHROCYTES WITH HOMOLOGOUS NUCLEATED CELLS
VR MUZYKANTOV, AB ZALTZMAN, IV FUKI, MD SMIRNOV, ... BIOLOGICHESKIE MEMBRANY 10 (4), 383-396 |
1993 | |
| Tannin-Mediated Attachment of Avidin to Erythrocytes does not Cause Their Complement-Mediated Lysis
VR Muzykantov, MD Smirnov, AB ZALTSMAN, GP Samokhin BIOCHEMISTRY-MOSCOW 58 (7), 716-720 |
1993 | |
| Tannin-mediated attachment of avidin to erythrocytes does not cause their lysis by complement
VR Muzykantov, MD Smirnov, AB Zal'tsman, GP Samokhin Biokhimiia (Moscow, Russia) 58 (7), 1027-1032 |
1993 | |
| Hydrogen Peroxide as Inflammatory Mediator
VR Muzykantov Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation … |
1993 | |
| AVIDIN ATTACHMENT TO BIOTINYLATED HUMAN NEUTROPHILS INDUCED GENERATION OF SUPEROXIDE RADICAL
VR MUZYKANTOV, TI KUSHNAREVA, MD SMIRNOV, EK RUGE BIOLOGICHESKIE MEMBRANY 9 (12), 1211-1221 |
1992 | |
| LUNG ACCUMULATION OF MONOCLONAL-ANTIBODY TO ANGIOTENSIN-CONVERTING ENZYME-SPECIES SPECIFICITY
S DANILOV, E ATOCHINA, V GAVRILUK, G DEICHMAN, ... EUROPEAN JOURNAL OF NUCLEAR MEDICINE 19 (8), 741-741 |
1992 | |
| AVIDIN ATTACHMENT OF BIOTINYLATED ERYTHROCYTES ELIMINATES HOMOLOGOUS RESTRICTION OF THE CLASSICAL PATHWAY OF COMPLEMENT
VR MUZYKANTOV, MD SMIRNOV, AL KLIBANOV BIOLOGICHESKIE MEMBRANY 9 (7), 693-699 |
1992 | |
| ACTIVATION OF THE PHOSPHOINOSITIDE TURNOVER IN HUMAN ENDOTHELIAL-CELLS BY SUBLETHAL DOSES OF HYDROGEN-PEROXIDE
VR MUZYKANTOV, EA PUCHNINAARTUSHENKO, EV CHEKNEVA, ... BIOLOGICHESKIE MEMBRANY 9 (2), 131-142 |
1992 | |
| Dual Effects of Exogenous Hydrogen Peroxide on Human Neutrophils: Cytotoxicity and Modulation of Respiratory Burst in Response to Agonist
EA Puchnina, AN Ledenev, VR Muzykantov, EK Ruuge, VA TKACHUK Biochemistry 57 (5), 471-475 |
1992 | |
| AVIDIN ATTACHMENT TO ERYTHROCYTES THROUGH THE BIOTINYL LIPID DOES NOT INDUCE LYSIS OF AVIDIN-CARRYING ERYTHROCYTES BY COMPLEMENT
VR MUZYKANTOV, MD SMIRNOV, AL KLIBANOV BIOLOGICHESKIE MEMBRANY 8 (9), 921-927 |
1991 | |
| AVIDIN-INDUCED LYSIS OF RED-BLOOD-CELLS VIA THE ALTERNATIVE PATHWAY OF COMPLEMENT DEPENDS ON THE AVIDIN CAPABILITY OF MULTIPOINT BINDING TO BIOTINYLATED MEMBRANE-COMPONENTS
VR MUZYKANTOV, MD SMIRNOV, GP SAMOKHIN BIOLOGICHESKIE MEMBRANY 8 (2), 146-155 |
1991 | |
| Radiolabeled monoclonal antibody to angiotensin-converting enzyme recognizes the leukocyte-mediated changes in the pulmonary endothelium
VR Muzykantov, SM Danilov International Journal of Immunopharmacology 13 (6), 792 |
1991 | |
| METHOD OF DETERMINATION OF THE RATE OF SUPEROXIDE RADICAL FORMATION BY HUMAN NEUTROPHILS VIA SPIN TAURON TRAP
AN LEDENEV, EA PUCHNINA, VR MUZYKANTOV, EK RUUGE ZHURNAL FIZICHESKOI KHIMII 64 (11), 3087-3092 |
1990 | |
| Method of measuring the rate of formation of superoxide radicals by human neutrophils using the Tiron spin trap
AN LEDENEV, EA PUCHNINA, VR MUZYKANTOV, EK RUUGE Russian journal of physical chemistry 64 (11), 1663-1666 |
1990 | |
| IMAGING OF LUNG VESSELS USING IN-111-LABELED MONOCLONAL-ANTIBODY TO ANGIOTENSIN-CONVERTING ENZYME
S DANILOV, A MARTYNOV, A KLIBANOV, A SLINKIN, I SAKHAROV, ... EUROPEAN JOURNAL OF NUCLEAR MEDICINE 14 (5-6), 230-230 |
1988 | |
| Red blood cell targeting to human aortic smooth muscle cells
MA Glukhova, SP Domogatskii, AE Kabakov, VR Muzykantov, ... Bulletin of Experimental Biology and Medicine 102 (5), 1550-1552 |
1986 | |
| Targeted delivery of erythrocytes to human aortic smooth muscle cells
MA Glukhova, SP Domogatskiĭ, AE Kabakov, VR Muzykantov, ... Biulleten'Eksperimental'noi Biologii i Meditsiny 102 (11), 571-573 |
1986 | |
| Protection of endothelial cells from the cytotoxic action of hydrogen peroxide by means of immunoerythrocytes
VR Muzykantov, DV Sakharov, SP Domogatskii Electronic Journal of Information Technology in Construction 288 (1-6), 189-192 |
1986 | |
| Localization of different types of collagen (I, III, IV, V) in the connective tissue of the popliteal artery and skeletal muscle of man (immunoelectronmicroscopic analysis)
VF Kondalenko, GL Idel'son, VR Muzykantov, SP Domagatskiĭ, ... Arkhiv Anatomii, Gistologii i Embriologii 89 (8), 78-83 |
1985 | |
| IMMUNOTARGETING OF ENZYME IMMOBILIZED ON ERYTHROCYTE-MEMBRANE TO COLLAGEN-COATED SURFACE
VR MUZYKANTOV, DV SAKHAROV, SP DOMOGATSKY, MD SMIRNOV, ... JOURNAL OF CELL BIOLOGY 99 (4), A368-A368 |
1984 | |
| MODIFIED RED-BLOOD-CELLS AS DRUG TARGETING VEHICLES
GP SAMOKHIN, MD SMIRNOV, VR MUZYKANTOV, VN SMIRNOV JOURNAL OF CELL BIOLOGY 97 (5), A464-A464 |
1983 | |
| Correction to “Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis”
K Bdeir, A Kuo, V Stepanova, JP Atkinson, M Poncz, DB Cines, ... |
||
| Targeted delivery of drugs in the vascular system
V Muzykantov, S Muro |
||
| Review for Themed Issue ‘Redox biology and oxidative stress in health and
A Daiber, S Steven, A Weber, VV Shuvaev, VR Muzykantov, I Laher, H Li, ... |
||
| Endothelial targeting of a recombinant construct fusing a PECAM-1
DB Cines, VR Muzykantov, BS Ding, C Gottstein, A Grunow, A Kuo, ... |
||
| ICAM-directed vascular immunotargeting of anti-thrombotic agents to the
SM Albelda, DN Granger, DB Cines, VR Muzykantov, JC Murciano, ... |