About

The Aspirin to Prevent Pregnancy Loss and Preeclampsia (APPLE) Study is recruiting pregnant people to participate! If you are less than 7 weeks pregnant, you may be eligible to participate in this study.

Interested in participating? Take our prescreening survey!

To be eligible for the study, you must meet the inclusion criteria below.

Inclusion Criteria

  1. Sign and date informed consent form
  2. Willingness to comply with all study procedures and availability for study duration
  3. Ability to take oral medication and ability to adhere to the prescribed aspirin regimen
  4. Gestation age less than or equal to 6 weeks 6 days (as determined by patient LMP or ART date)
  5. 18-45 years of age
  6. One or more risk factors for pregnancy loss/preeclampsia

There are also some potential risk factors that may exclude you from participating in the study. If you have any of the following, you are not eligible to participate.

Exclusion Criteria

  1. Known allergies to aspirin or non-steroidal anti-inflammatory agents (NSAIDs)
  2. Clinical indication for anticoagulant therapy including prior or current:
    • Thrombosis
    • Antiphospholipid syndrome
    • Known major thrombophilia
  3. Clinical indication for chronic use of NSAIDs during pregnancy
  4. Medical contradindication to aspirin therapy including:
    • Uncontrolled, uncontrolled asthma
    • Untreated, symptomatic nasal polyps
    • Bleeding disorders
    • History of gastrointestional ulcer
  5. Patients with pelvic pain or bleeding who require urgent care.