Our Mission

One Penn Medicine. One Research, drives integrated, innovative research across the Penn Medicine Health System, providing technology advancements and care for our patients and community.

If you are a health care provider in search of Penn Medicine clinical trials that are enrolling patients please view our clinical research opportunities.

For physicians seeking support for Expanded Access Protocols please contact OCR Regulatory.

The central hub for clinical research is the Office of Clinical Research, whose goal is to foster collaborative and innovative research that pursues new ways to care for our patients, accelerates patients’ access to experimental therapy and provides Penn Medicine physicians opportunities to engage in our research mission.

Meet the Office of Clinical Research

Featured Highlights

Seeing Beyond the Biopsy: Giant Cell Arteritis Diagnosis & Monitoring Through Advanced Imaging

Giant cell arteritis (GCA) is the most common form of systemic vasculitis in adults over 50, carrying severe risks like irreversible vision loss and stroke if left untreated. While invasive biopsies and blood markers have long guided diagnosis, high-resolution MR imaging is transforming how clinicians detect and manage the disease. In this Curetalks session, Dr. Rennie Rhee of Penn Medicine shares insights on how advanced imaging identifies early subclinical disease, distinguishes GCA from similar conditions, and detects localized flares even when standard laboratory markers appear normal.

Outsmarting the "Sleeper Cells" - Preventing Breast Cancer Recurrence

For millions of breast cancer survivors, completing initial treatment brings immense relief, but it often comes with a lingering fear of recurrence. Breast cancer can return years or even decades after an individual is declared cancer-free, driven by dormant "sleeper cells" that hide undetected in the body until they suddenly awaken to form aggressive metastatic tumors. Join us for a compelling CureTalks with Dr. Angela DeMichele and Dr. Lewis A. Chodosh of University of Pennsylvania, where they will share their groundbreaking work shifting the paradigm from treating recurrence to preventing it altogether.

CAR T Cell Therapy Leads to 10-year Remissions in B-cell Lymphoma Patients

Long-term follow-up from one of the earliest CAR T cell therapy clinical trials shows potential cures in more than one-third of patients treated at Penn Medicine.

Emma Meagher Speaks at FDA: Agency Turns to AI to Speed Up Clinical Trials

The FDA recently announced a revolutionary pilot program to review clinical trial data in real-time. By utilizing cloud-based platforms and AI, regulators can now see safety signals and clinical endpoints as they happen—rather than waiting months for data transfers. At Penn Medicine, we are proud to be at the forefront of this shift. Emma A. Meagher, M.D., senior vice dean for clinical and translational research, joined the FDA's press conference to share why this is such a pivotal moment for the field.

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Penn Medicine- Clinical Research