Current Studies

PI: Jeremy Cannon, MD
Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
Trauma Resuscitation with Low-Titer Group O Whole Blood or Products (TROOP)
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and cryoprecipitate) in critically injured patients who require large-volume blood transfusions.

PI: Jeremy Cannon, MD
Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
Trauma And Prothrombin Complex Concentrate (TAP) Trial
This is a prospective, multicenter, randomized, double-blind, placebo-controlled, large simple trial evaluating the use of BE1116 (4-Factor Prothrombin Complex Concentrate [Kcentra® / Beriplex®]) to improve survival in patients with traumatic injury and acute major bleeding.

PI: Niels Martin, MD
Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
Phase 3 Trial of TAK-330 for Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation
A phase 3, prospective, randomized, open-label, adaptive group sequential, multicenter trial with blinded endpoint assessment to evaluate the efficacy and safety of TAK-3301 for the reversal of direct oral factor Xa inhibitor-induced anticoagulation in patients requiring urgent surgery/invasive procedure.

PI: Jeremy Cannon, MD
Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA)
A prospective multi-center observational trial of the utilization of aortic occlusion in the acute resuscitation of trauma and acute care surgery patients.

PI: Niels Martin, MD
Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
This pilot study aims to demonstrate that external drainage of thoracic duct lymph during sepsis results in a reduction in circulating pro-inflammatory cytokines by assessing early thoracic duct cannulation and external lymph drainage in adult surgical intensive care patients.

PI: Benjamin Abella, MD, MPhil
Department of Emergency
Evaluation of Alere NT-proBNP
This study will collect blood specimens to evaluate a new diagnostic blood test that will help physicians diagnose individuals that may have new symptoms of heart failure or to determine the severity in those with heart failure.

PI: John Greenwood, MD, MS
Department of Emergency Medicine and Department of Anesthesiology and Critical Care
Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP)
ICECAP is a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.

PI: Andrea L.C. Schneider, MD, PhD
Division of Neurocritical Care, Department of Neurology
Continuous Glucose Monitoring in TBI
This study investigates the feasibility of continuous glucose monitoring to measure glycemic variability in hospitalized acute traumatic brain injury (TBI) patients and prospective associations of glycemic variability with TBI outcomes.

PI: John Chandler, MD
Department of Neurology
MOBI-1
MOBI-1 will evaluate the use of the Infrascanner for the monitoring of traumatic intracranial hematomas. The Infrascanner is a hand-held, non-invasive device, which is FDA-cleared to detect traumatic intracranial hematomas. MOBI-1 aims to expand the utility of the device by evaluating its ability to serially monitor patients with intracranial hematomas, following the initial detection with CT, to detect expansion prior to the observance of clinical signs.

PI: Danielle Sandsmark, MD, PhD
Department of Neurology
Brain Oxygen Optimization in Severe Traumatic Brain Injury – Phase 3 (BOOST-3)
BOOST-3 is a comparative effectiveness study to test the efficacy of a prescribed treatment protocol based on monitoring the partial pressure of brain tissue oxygen (PbtO2).

PI: A.T. Johnson, PhD
Department of Physics and Astronomy
Volatile Organic Molecule (VOC) Detection of COVID-19 Infection
The purpose of this pilot study is to determine the feasibility of a new COVID-19 screening platform. This technology detects infection through DNA-functionalized carbon nanotube (DNA-NT) sensors in an electronic nose system.

PI: Benjamin Abella, MD, MPhil
Department of Emergency Medicine
Volatile Organic Molecule (VOC) Detection of Ovarian Cancer
This early-stage study aims to measure volatile organic compound (VOC) signals in urine samples from patients with varying stages of prostate cancer and compare them against urine samples from patients with benign urology conditions as controls.

Current Studies

Trauma and Surgical Critical Care

Cardiac Arrest and Emergency Medicine

Traumatic Brain Injury (TBI) and Neurology

COVID-19 and Miscellaneous