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Current Studies
PI: Niels Martin, MD
Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
Phase 3 Trial of TAK-330 for Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation
A phase 3, prospective, randomized, open-label, adaptive group sequential, multicenter trial with blinded endpoint assessment to evaluate the efficacy and safety of TAK-3301 for the reversal of direct oral factor Xa inhibitor-induced anticoagulation in patients requiring urgent surgery/invasive procedure.
PI: Jeremy Cannon, MD
Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA)
A prospective multi-center observational trial of the utilization of aortic occlusion in the acute resuscitation of trauma and acute care surgery patients.
PI: Niels Martin, MD
Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery
External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients
This pilot study aims to demonstrate that external drainage of thoracic duct lymph during sepsis results in a reduction in circulating pro-inflammatory cytokines by assessing early thoracic duct cannulation and external lymph drainage in adult surgical intensive care patients.
PI: Benjamin Abella, MD, MPhil
Department of Emergency
Evaluation of Alere NT-proBNP
This study will collect blood specimens to evaluate a new diagnostic blood test that will help physicians diagnose individuals that may have new symptoms of heart failure or to determine the severity in those with heart failure.
PI: Benjamin S. Abella, MD MPhil
Department of Emergency Medicine
Exosomal Markers of Brain Injury After Cardiac Arrest
A prospective cohort study to quantify neurologic injury and characterize neuronal injury patterns among out-of-hospital cardiac arrest patients at 4 acute time points following return of spontaneous circulation (ROSC)
PI: Benjamin Abella, MD, MPhil
Department of Emergency Medicine
Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP)
ICECAP is a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.
PI: Atul Kalanuria, MD
Department of Neurology
COVID-19 and Miscellaneous
Move to Completed studies
Phase 2, Randomized Study of the Tolerability and Safety of the OsciPulse Device for the Prevention of Venus Thromboembolism (VTE)
PI: Atul Kalanuria, MD
Department of Neurology
MOBI-1
MOBI-1 will evaluate the use of the Infrascanner for the monitoring of traumatic intracranial hematomas. The Infrascanner is a hand-held, non-invasive device, which is FDA-cleared to detect traumatic intracranial hematomas. MOBI-1 aims to expand the utility of the device by evaluating its ability to serially monitor patients with intracranial hematomas, following the initial detection with CT, to detect expansion prior to the observance of clinical signs.
PI: Danielle Sandsmark, MD, PhD
Department of Neurology
Brain Oxygen Optimization in Severe Traumatic Brain Injury – Phase 3 (BOOST-3)
BOOST-3 is a comparative effectiveness study to test the efficacy of a prescribed treatment protocol based on monitoring the partial pressure of brain tissue oxygen (PbtO2).
PI: Ramon Diaz-Arrastia, MD, PhD
Department of Neurology
Head Injury Serum Markers and Multi-Modalities for Assessing Response To Trauma (HeadSMART II)
The goal of this study is to develop an In-Vitro Diagnostic, the BRAINBox TBI Test, to aid in the diagnosis and prognosis of patients with mild Traumatic Brain Injury (TBI) by incorporating blood biomarkers, clinical assessments, and tools to measure associated neurocognitive impairments.
PI: Ramon Diaz-Arrastia, MD, PhD
Department of Neurology
Clinical Evaluation of the i-STAT Traumatic Brain Injury Test
This study evaluates the ability of the i-STAT blood test to detect acute biomarkers of traumatic brain injury (TBI).
PI: Ramon Diaz-Arrastia, MD, PhD
Department of Neurology
Penn Acute Research Collaborative – Traumatic Brain Injury
This study collects biochemical and clinical data from patients with TBI in an effort to improve classification of TBI, permit appropriate selection and stratification of patients for clinical trials, and contribute to the development of a new taxonomy for TBI.
PI: Adam Cuker, MD
Department of Medicine
Phase 2, Randomized Study of the Tolerability and Safety of the OsciPulse Device for the Prevention of Venous Thromboembolism (VTE)
This study aims to assess the tolerability and hemodynamic impact of the OsciPulse device on venous blood flow in an inpatient setting.
PI: A.T. Johnson, PhD
Department of Physics and Astronomy
Volatile Organic Molecule (VOC) Detection of COVID-19 Infection
The purpose of this pilot study is to determine the feasibility of a new COVID-19 screening platform. This technology detects infection through DNA-functionalized carbon nanotube (DNA-NT) sensors in an electronic nose system.
PI: Benjamin Abella, MD, MPhil
Department of Emergency Medicine
Volatile Organic Molecule (VOC) Detection of Ovarian Cancer
This early-stage study aims to measure volatile organic compound (VOC) signals in urine samples from patients with varying stages of prostate cancer and compare them against urine samples from patients with benign urology conditions as controls.
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