Research Description

The goal of our research is to understand the cellular machinery responsible for powering cell movements and shaping the architecture of cells, tissues, and organs.   Our discovery-based research focuses on the role of the cytoskeleton, molecular motors, and signaling pathways in powering cell migration, muscle contraction, and the transport of internal cell compartments.  The pathways investigated in our laboratory are crucial for several normal and pathological processes, including: cell and tissue development, endocytosis, wound healing, immune response, cardiomyopathies, and metastases of tumors.  We use a range of biochemical, cell biological, and biophysical techniques in our research.  These techniques include stopped-flow kinetics, single-molecule fluorescence, optical trapping, and live-cell microscopy.

Diversity & Inclusion Initiatives

• Mentor, Penn Summer Undergraduate Internship Program