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Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape. Nat Nanotechnol

Omo-Lamai S, Wang Y, Patel MN, Milosavljevic A, Zuschlag D, Poddar S, Wu J, Wang L, Dong F, Espy C, Majumder A, Essien EO, Shen M, Channer B, Papp TE, Tobin M, Maheshwari R, Jeong S, Patel S, Shah A, Murali S, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Discher D, Gaskill PJ, Tsourkas A, Muzykantov VR, Brodsky I, Shin S, Whitehead KA, Parhiz H, Katzen J, Miner JJ, Trauner D, Brenner JS. – Nat Nanotechnol. 2025 Aug 11. doi: 10.1038/s41565-025-01974-5. Epub ahead of print. PMID: 40789922.

Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

Bishal Basak, Erika L F Holzbaur PMID: 40783388 PMCID: PMC12335601 DOI: 10.1038/s41467-025-62379-5

Mechanical regulation of extracellular vesicle activity during tumour progression

Kshitiz Parihar, Di-Ao Liu, Ghmkin Hassan, David A Issadore, Paul A Janmey, Valerie M Weaver, Wei Guo, Ravi Radhakrishnan – PMID: 40770502 PMCID: PMC12337232 (available on 2026-08-06) DOI: 10.1038/s41551-025-01446-0

Breaking a Lewis Acidity Trend for Rare Earths by Excited State Quenching

Wilharm RK, Gau MR, Trauner D, Schelter EJ J Am Chem Soc. 2025 Aug 6;147(31):27143-27147. doi: 10.1021/jacs.5c05257. Epub 2025 Jul 24. PMID: 40705825.

What do we know of human fuel use during aerobic exercise and how do we know it?

Jessie Axsom, Zolt Arany – PMID: 40763088 DOI:10.1152/physiol.00002.2025

Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy: A Meta-Analysis

Ali A Khan, Fayez H Fayad, Chan W Kim, Feven Ataklte, Phinnara Has, Ali Nebipasagil, Zolt Arany, Athena Poppas, Wen-Chih Wu, Gaurav Choudhary, Tasnim F Imran – PMID: 40768944 DOI: 10.1016/j.jacadv.2025.102047

Reprogramming of endolysosomes for melanogenesis in BLOC-1-deficient melanocytes

Philip S Goff, Shyamal Patel, Dawn C Harper, Tom Carter, Michael S Marks, Elena V Sviderskaya – PMID: 40683250 PMCID: PMC12320751 (available on 2026-07-18) DOI: 10.1016/j.cub.2025.06.031

A myosin hypertrophic cardiomyopathy mutation disrupts the super-relaxed state and boosts contractility by enhanced actin attachment

Robert C Cail, Bipasha Barua, Faviolla A Báez-Cruz, Donald A Winkelmann, Yale E Goldman, E Michael Ostap – PMID: 40501550 PMCID: PMC12157379 DOI: 10.1101/2025.06.02.657466

Matrix Stiffening Induces Mechanical Memory and Nuclear Fragility in Cardiomyocytes via Microtubule-Lamin Coupling

Nesrine Bouhrira, Sebastian Pizarro, Victor Senf, Kenneth B Margulies – PMID: 40777352 PMCID: PMC12330650 DOI: 10.1101/2025.07.17.665449

Acidic Nanoparticles Prevent HIV Pre-Exposure Prophylaxis (PrEP)-Induced Oligodendrocyte Impairments by Restoring Lysosomal pH in Adolescent Models

Caela C Long, Lindsay K Festa, Melanie Cruz-Berrios, Teshawn D Johnson, Claire H Mitchell, Kelly L Jordan-Sciutto, Judith B Grinspan – PMID: 40676765 PMCID: PMC12334864 DOI: 10.1002/glia.70050

AAV-microutrophin gene therapy confers durable cardioprotection against pharmacologic and exercise-induced injury in the mdx mouse

Coral M Kasden, Maria P Corzo, Christopher D Greer, Tanvi Singh, Rufranshell Reyes, Alaine Castillo, Zoltan Arany, Benjamin W Kozyak, Hansell H Stedman – PMID: 40671677 DOI: 10.1016/j.ymthe.2025.07.013

Autophagic stress activates distinct compensatory secretory pathways in neurons

Sierra D Palumbos, Jacob Popolow, Juliet Goldsmith, Erika L F Holzbaur PMID: 40623183 PMCID: PMC12280970 DOI: 10.1073/pnas.2421886122

Structural-functional characterization of the MIRO1-TRAK1 complex

Erika E Ravitch, Elana E Baltrusaitis, Tania A Perez, Kyle R Barrie, Adam R Fenton, Erika L F Holzbaur, Roberto Dominguez – PMID: 40615373 PMCID: PMC12227652 DOI: 10.1038/s41467-025-61174-6

Amino acid-level differences in alpha-tubulin sequences are uniquely required for meiosis

Li Chen, Xi Chen, Anna Kashina – PMID: 40434897 PMCID: PMC12260170 (available on 2026-07-01) DOI: 10.1091/mbc.E24-11-0529

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

César Cárdenas, Marioly Müller, Andrew McNeal, Alenka Lovy, Fabian Jaňa, Galdo Bustos, Felix Urra, Natalia Smith, Jordi Molgó, J Alan Diehl, Todd W Ridky, J Kevin Foskett – PMID: 40478732 PMCID: PMC12239728 DOI: 10.1016/j.celrep.2025.115869

Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered Ligand

Hetzler BE, Donthamsetti P, Wolesensky RM, Stanley C, Isacoff EY, Trauner D. – bioRxiv [Preprint]. 2025 Jun 15:2025.06.10.658926. doi: 10.1101/2025.06.10.658926. PMID: 40661587; PMCID: PMC12259131.

Predicting Pancreatitis in Children With Blunt Abdominal Trauma

Matthew S Marks, Anna Liveris, Stephen M Blumberg, Srinivas H Reddy, James A Meltzer – PMID: 40476662 DOI: 10.1097/PEC.0000000000003421

TBC1D30 regulates proinsulin and insulin secretion and is the target of a genomic association signal for proinsulin

Parsons VA, Vadlamudi S, Voos KM, Rohy AE, Moxley AH, Cannon ME, Rosen JD, Mills CA, Herring LE, Broadaway KA, Lorenzo DN, Mohlke KL. Diabetologia. 2025 Mar 10. doi: 10.1007/s00125-025-06391-w. Online ahead of print. PMID: 40064677

Familial SYNGAP1 variants define the boundaries of a complex neurodevelopmental disorder with epilepsy

Harrison AG, Magielski JH, McSalley I, Ganesan S, Prentice AJ, Cunningham KG, Pierce SR, Boland MJ, Prosser BL, Helbig I, McKee JL. Epilepsia. 2025 May 23. doi: 10.1111/epi.18469. Epub ahead of print. PMID: 40407699.

Disease-associated Kv1.3 Variants are Energy Compromised with Impaired Nascent Chain Folding

Aaron Sykes, Lannawill Caruth, Sophia Gross, Shefali Setia Verma, Toshinori Hoshi, Carol Deutsch – PMID: 40409708 DOI: 10.1016/j.jmb.2025.169226