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Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered Ligand

Hetzler BE, Donthamsetti P, Wolesensky RM, Stanley C, Isacoff EY, Trauner D. – bioRxiv [Preprint]. 2025 Jun 15:2025.06.10.658926. doi: 10.1101/2025.06.10.658926. PMID: 40661587; PMCID: PMC12259131.

Predicting Pancreatitis in Children With Blunt Abdominal Trauma

Matthew S Marks, Anna Liveris, Stephen M Blumberg, Srinivas H Reddy, James A Meltzer – PMID: 40476662 DOI: 10.1097/PEC.0000000000003421

TBC1D30 regulates proinsulin and insulin secretion and is the target of a genomic association signal for proinsulin

Parsons VA, Vadlamudi S, Voos KM, Rohy AE, Moxley AH, Cannon ME, Rosen JD, Mills CA, Herring LE, Broadaway KA, Lorenzo DN, Mohlke KL. Diabetologia. 2025 Mar 10. doi: 10.1007/s00125-025-06391-w. Online ahead of print. PMID: 40064677

Familial SYNGAP1 variants define the boundaries of a complex neurodevelopmental disorder with epilepsy

Harrison AG, Magielski JH, McSalley I, Ganesan S, Prentice AJ, Cunningham KG, Pierce SR, Boland MJ, Prosser BL, Helbig I, McKee JL. Epilepsia. 2025 May 23. doi: 10.1111/epi.18469. Epub ahead of print. PMID: 40407699.

Disease-associated Kv1.3 Variants are Energy Compromised with Impaired Nascent Chain Folding

Aaron Sykes, Lannawill Caruth, Sophia Gross, Shefali Setia Verma, Toshinori Hoshi, Carol Deutsch – PMID: 40409708 DOI: 10.1016/j.jmb.2025.169226

Venovenous extracorporeal membrane oxygenation with mechanical chest compression for cardiopulmonary resuscitation: a porcine model study

Sertic F, Gregorio P, Chatterjee S, Usman A, Broniec G, Bermudez A, Richards T, Salas J, Gray K, Tschabrunn C, Bermudez CA, Venovenous extracorporeal membrane oxygenation with mechanical chest compression for cardiopulmonary resuscitation: a porcine model study, JTCVS Open (2025), doi: https://doi.org/10.1016/j.xjon.2025.04.016.

Protocol for live imaging of axonal transport in iPSC-derived iNeurons

Dou D, Holzbaur ELF, Boecker CA. STAR Protoc. 2025 Mar 21;6(1):103556. doi: 10.1016/j.xpro.2024.103556. Epub 2025 Jan 12. PMID: 39804773

Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states

Cail RC, Baez-Cruz FA, Winkelmann DA, Goldman YE, Ostap EM. J Biol Chem. 2025 Mar 19:108412. doi: 10.1016/j.jbc.2025.108412. Online ahead of print. PMID: 40118457

Precision Medicine Is in the Eye of the Beholder

Circ Heart Fail. 2025 Mar;18(3):e012759. doi: 10.1161/CIRCHEARTFAILURE.125.012759. Epub 2025 Mar 11. PMID: 40066597

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk

Tan K, Tay D, Tan W, Ng HK, Wong E, Morley MP, Singhera GK, Lee CJM, Jain PR, Tai FL, Hanson PJ, Cappola TP, Margulies KB, Foo R, Loh M. Clin Epigenetics. 2025 Mar 8;17(1):45. doi: 10.1186/s13148-025-01854-8. PMID: 40057770

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

Wei K, Hill BL, Thompson JC, Miller ZA, Mueller A, Lee RJ, Carey RM. Head Neck. 2025 Mar 5;. doi: 10.1002/hed.28120. [Epub ahead of print] PubMed PMID: 40040415; NIHMSID:NIHMS2059808.

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis

Lee WD, Weilandt DR, Liang L, MacArthur MR, Jaiswal N, Ong O, Mann CG, Chu Q, Hunter CJ, Ryseck RP, Lu W, Oschmann AM, Cowan AJ, TeSlaa TA, Bartman CR, Jang C, Baur JA, Titchenell PM, Rabinowitz JD. Cell Metab. 2025 Mar 4;37(3):758-771.e8. doi: 10.1016/j.cmet.2024.12.009. Epub 2025 Jan 30. PubMed PMID: 39889702; PubMed Central PMCID: PMC11926601

High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory

Chavali SS, Carman PJ, Shuman H, Ostap EM, Sindelar CV. Proc Natl Acad Sci U S A. 2025 Mar 4;122(9):e2415457122. doi: 10.1073/pnas.2415457122. Epub 2025 Feb 27. PMID: 40014570

Priming and release of cytokine IL-1β in microglial cells from the retina

Campagno KE, Lu W, Sripinun P, Albalawi F, Cenaj A, Mitchell CH. Exp Eye Res. 2025 Mar;252:110246. doi: 10.1016/j.exer.2025.110246. Epub 2025 Jan 21. PMID: 39848558

Mechanism of actin filament severing and capping by gelsolin

Barrie KR, Rebowski G, Dominguez R. Nat Struct Mol Biol. 2025 Feb;32(2):237-242. doi: 10.1038/s41594-024-01412-5. Epub 2024 Oct 24. PubMed PMID: 39448849; PubMed Central PMCID: PMC11832341.

The association of heart rate with adverse outcomes and recurrent heart failure hospitalization in peripartum cardiomyopathy

Berkowitz J, Sagaityte E, Khalid M, Lopez D, Mohebali D, Bello N, Arany Z, French K, Poppas A, Sabe M, Wu WC, Joseph J, Djousse L, Choudhary G, Imran TF. Clin Res Cardiol. 2025 Feb 24. doi: 10.1007/s00392-025-02615-6. Online ahead of print. PMID: 39992386

Genes of the Fatty Acid Oxidation Pathway are Upregulated in Female as Compared to Male Cardiomyocytes

Berkowitz J, Sagaityte E, Khalid M, Lopez D, Mohebali D, Bello N, Arany Z, French K, Poppas A, Sabe M, Wu WC, Joseph J, Djousse L, Choudhary G, Imran TF. Clin Res Cardiol. 2025 Feb 24. doi: 10.1007/s00392-025-02615-6. Online ahead of print. PMID: 39992386

ROR2 drives right ventricular heart failure via disruption of proteostasis

Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards JJ. bioRxiv [Preprint]. 2025 Feb 2:2025.02.01.635961. doi: 10.1101/2025.02.01.635961. PMID: 39975092

Pro-cognitive reshaping of neuronal dynamics by a human CSF-based factor

Santos MD, Forrest MP, Bomba-Warczak E, Parnell E, Edassery SL, Yang K, Hayes LN, Coughlin JM, Eckman BL, Lammert C, Martin-de-Saavedra MD, Barbolina M, Sawa A, Savas JN, Penzes P. -bioRxiv [Preprint]. 2024 Dec 26:2024.12.26.629959. doi: 10.1101/2024.12.26.629959. PMID: 39763806

Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

Bomba-Warczak EK, Velez KM, Zhou LT, Guillermier C, Edassery S, Steinhauser ML, Savas JN, Duncan FE.- Elife. 2024 Oct 31;13:RP93172. doi: 10.7554/eLife.93172. PMID: 39480006