Welcome to the Rader Lab

The Rader Lab has a history of leveraging human gene discovery to elucidate the biology and molecular physiology of genes and pathways that influence lipoprotein metabolism, cardiometabolic traits, and cardiovascular diseases. More recently, Dr. Rader’s extensive expertise in lipid metabolism has increasingly led to a focus on neurodegeneration, using human genetics as a starting point. State-of-the-art technologies including CRISPR gene targeting in human iPSC cells, single-cell RNA sequencing, and multi-omics are employed in the investigation of complex diseases. The Rader lab research team integrates computational genomics, fundamental mechanistic investigation in cell and animal model systems, and targeted deep phenotyping in human subjects to establish clinical relevance and accelerate translation of research insights to potential treatment of human cardiometabolic disorders.

 

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