Welcome to the Rader Lab

The Rader Lab has a history of leveraging human gene discovery to elucidate the biology and molecular physiology of genes and pathways that influence lipoprotein metabolism, cardiometabolic traits, and cardiovascular diseases. More recently, Dr. Rader’s extensive expertise in lipid metabolism has increasingly led to a focus on neurodegeneration, using human genetics as a starting point. State-of-the-art technologies including CRISPR gene targeting in human iPSC cells, single-cell RNA sequencing, and multi-omics are employed in the investigation of complex diseases. The Rader lab research team integrates computational genomics, fundamental mechanistic investigation in cell and animal model systems, and targeted deep phenotyping in human subjects to establish clinical relevance and accelerate translation of research insights to potential treatment of human cardiometabolic disorders.

 

Learn more about our research

Announcements

 

News

  • Rader Lab presence at recent and upcoming scientific meetings:

    The Rader Lab was represented by Dr. Eleonora Scorletti at the 2025 Keystone Symposium: Obesity and Adipose Tissue / MASH Pathogenesis and Therapeutic Approaches, held February 23rd-26th in Banff, Alberta, CA. Her poster presentation, titled Recall-by-Genotype and Deep Phenotyping of homozygous carriers of PNPLA3-I148M without clinical liver disease, was well received and generated a great deal of attention.

     

    Dr. Scorletti will also present as an Invited Speaker at the 2025 European Association for the Study of the Liver (EASL) Congress, taking place May  7th-10th in Amsterdam, NL. She will address the question: Targeting lipid metabolism for SLD precision therapy?

    David Zhang (MD/PhD student) was invited to give an oral presentation at the European Atherosclerosis Society (EAS) 2025 Congress to be held May 4th-7th in Glasgow, UK. His talk is titled  A Loss-of-Function Missense Variant in ANGPTL3 Exerts Protective Effects Against Kidney Disease Risk.

Spotlight

  • Congratulations to Dr. Eleonora Scorletti, recipient of a K99/R00 Pathway to Independence Award for her project proposal titled The role of lipid droplet proteins in eicosanoid production and non-alcoholic fatty liver disease. Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)