Seale Lab

Publications

1. Control of murine brown adipocyte development by GATA6.
   Jun S, Angueira AR, Fein EC, Tan JME, Weller AH, Cheng L, Batmanov K, Ishibashi J, Sakers AP, Stine RR, Seale P. (2023) Dev Cell. 23:S1534-5807(23)00399-4.
   Pubmed: 37647897; DOI: 10.1016/j.devcel.2023.08.003
2. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming. (preprint)
   Holman CD, Sakers AP, Calhoun RP, Cheng L, Fein EC, Jacobs C, Tsai L, Rosen ED, Seale P. (2023) bioRxiv. 2023.03.20.533514.
   Pubmed: 36993336; DOI: 10.1101/2023.03.20.533514
3. Adipose-tissue plasticity in health and disease. (Review)
   Sakers A, De Siqueira MK, Seale P, Villanueva CJ. (2022) Cell. 185(3):419-446.
   Pubmed: 35120662; DOI: 10.1016/j.cell.2021.12.016
4. Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis.
   Stefkovich M, Traynor S, Cheng L, Merrick D, Seale P. (2021) Mol Metab. 54:101357.
   Pubmed: 34662714; DOI: 10.1016/j.molmet.2021.101357
5. Defining the lineage of thermogenic perivascular adipose tissue.
   Angueira AR, Sakers AP, Holman CD, Cheng L, Arbocco MN, Shamsi D, Lynes MD, Shrestha R, Okada C, Batmanov K, Susztak K, Tseng YH, Liaw L, Seale P. (2021) Nat Metab. 3(4):469-484.
   Pubmed: 33846639; DOI: 10.1038/s42255-021-00380-0
6. Skinny Fat Cells Stimulate Wound Healing.
   Merrick D, Seale P. (2020) Cell Stem Cell. Jun 4;26(6):801-803.
   Pubmed: 32502400; DOI: 10.1016/j.stem.2020.04.021
7. Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes.
   Angueira AR, Shapira SN, Ishibashi J, Sampat S, Sostre-Colón J, Emmett MJ, Titchenell PM, Lazar MA, Lim HW, Seale P. (2020) Cell Rep. Mar 3;30(9):2869-2878.e4.
   Pubmed: 32130892; DOI: 10.1016/j.celrep.2020.02.023
8. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.
   Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P. (2019) Cell Stem Cell. Dec 5;25(6):830-845e8.
   Pubmed: 31564549; DOI: 10.1016/j.stem.2019.08.017
9. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.
   Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, Snyder NW, Gupta RK, Seale P. (2019) Cell Met. Jul 2;30(1):174-189.
   Pubmed: 31155495; DOI: 10.1016/j.cmet.2019.05.005
10. Identification of a mesenchymal progenitor cell hierarchy in adipose tissue.
    Merrick D, Sakers A, Irgebay Z, Okada C, Calvert C, Morley MP, Percec I, Seale P. (2019) Science. Apr 26;364(6438).
    Pubmed: 31023895; DOI: 10.1126/science.aav2501.
11. Transcriptional Control of Brown and Beige Fat Development and Function.
    Shapira SN, Seale P. (2019) Obesity (Silver Spring). Jan;27(1):13-21.
    Pubmed: 30569639; PMC: PMC6309799; DOI: 10.1002/oby.22334
12. EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.
    Shapira SN, Lim HW, Rajakumari S, Sakers AP, Ishibashi J, Harms MJ, Won KJ, Seale P. (2017). Genes Dev. 31(7):660-673.
    PubMed: 28428261; PMC: PMC5411707; DOI: 10.1101/gad.294405.116
13. PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing.
    Kissig M, Ishibashi J, Harms MJ, Lim HW, Stine RR, Won KJ, Seale P. (2017). EMBO J. 36(11):1528-1542.
    PubMed: 28408438; PMC: PMC5452012; DOI: 10.15252/embj.201695588
14. Control of brown and beige fat development.
    Wang W, Seale P. (2016). Nat Rev Mol Cell Biol. 17(11):691-702.
    PubMed: 27552974; PMC: PMC5627770; DOI: 10.1038/nrm.2016.96
15. SnapShot: Brown and Beige Adipose Thermogenesis.
    Kissig M, Shapira SN, Seale P. (2016). Cell. 166(1):258-258.e1.
    PubMed: 27368105; PMC: PMC5478388; DOI: 10.1016/j.cell.2016.06.038
16. EBF2 promotes the recruitment of beige adipocytes in white adipose tissue.
    Stine RR, Shapira SN, Lim HW, Ishibashi J, Harms M, Won KJ, Seale P. (2015). Mol Metab. 5(1):57-65.
    PubMed: 26844207; PMC: PMC4703852; DOI: 10.1016/j.molmet.2015.11.001
17. Brown and Beige Fat: Physiological Roles beyond Heat Generation.
    Kajimura S, Spiegelman BM, Seale P. (2015). Cell Metab. 22(4):546-59.
    PubMed: 26445512; PMC: PMC4613812; DOI: 10.1016/j.cmet.2015.09.007
18. Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation.
    Seale P. (2015). Diabetes. 64(7):2369-75.
    PubMed: 26050669; PMC: PMC4477361; DOI: 10.2337/db15-0203
19. PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.
    Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P. (2015). Genes Dev. 29(3):298-307.
    PubMed: 25644604; PMC: PMC4318146; DOI: 10.1101/gad.252734.114
20. Functions of Prdm16 in thermogenic fat cells.
    Ishibashi J, Seale P. (2015). Temperature. 2(1):65-72.
    PubMed: 27227007; PMC: PMC4843880; DOI: 10.4161/23328940.2014.974444
21. Ebf2 is a selective marker of brown and beige adipogenic precursor cells.
    Wang W, Kissig M, Rajakumari S, Huang L, Lim HW, Won KJ, Seale P. (2014). PNAS. 111(40):14466-71.
    PubMed: 25197048; PMC: PMC4209986; DOI: 10.1073/pnas.1412685111
22. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
    Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P. (2014). Cell Metab. 19(4):593-604.
    PubMed: 24703692; PMC: PMC4012340; DOI: 10.1016/j.cmet.2014.03.007
23. Brown and beige fat: development, function and therapeutic potential.
    Harms M, Seale P. (2013). Nat Med. 19(10):1252-63.
    PubMed: 24100998; DOI: 10.1038/nm.3361
24. Brown adipose tissue biology and therapeutic potential.
    Seale P. (2013). Front Endocrinol (Lausanne). 4:14.
    PubMed: 23513074; PMC: PMC3601303; DOI: 10.3389/fendo.2013.00014
25. EBF2 determines and maintains brown adipocyte identity.
    Rajakumari S, Wu J, Ishibashi J, Hee-Woong L, Won KJ, Reed RR, Seale P. (2013). Cell Metab. 17(4):562-74.
    PubMed: 23499423; PMC: PMC3622114; DOI: 10.1016/j.cmet.2013.01.015
26. An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.
    Ishibashi J, Firtina Z, Rajakumari S, Wood KH, Conroe HM, Steger DJ, Seale P. (2012). Mol Cell Biol. 32(12):2289-99.
    PubMed: 22473998; PMC: PMC3372274; DOI: 10.1128/MCB.06529-11
27. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
    Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. (2011). J Clin Invest. 121(1):96-105.
    PubMed: 21123942; PMC: PMC3007155; DOI: 10.1172/JCI44271
28. Transcriptional control of brown adipocyte development and thermogenesis.
    Seale P. (2010). Int J Obes (Lond). 34 Suppl 1:S17-22.
    PubMed: 20935660; DOI: 10.1038/ijo.2010.178
29. Beige can be slimming.
    Ishibashi J, Seale P. (2010). Science. 328(5982):1113-4.
    PubMed: 20448151; PMC: PMC2907667; DOI: 10.1126/science.1190816
30. Transcriptional control of brown fat development.
    Kajimura S, Seale P, Spiegelman BM. (2010). Cell Metab. 11(4):257-62. Review.
    PubMed: 20374957; PMC: PMC2857670; DOI: 10.1016/j.cmet.2010.03.005
31. Transcriptional control of preadipocyte determination by Zfp423.
    Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. (2010). Nature. 464(7288):619-23.
    PubMed: 20200519; PMC: PMC2845731; DOI: 10.1038/nature08816
32. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
    Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. (2009). Nature. 460(7259):1154-8.
    PubMed: 19641492; PMC: PMC2754867; DOI: 10.1038/nature08262
33. Brown fat in humans: turning up the heat on obesity.
    Seale P, Lazar MA. (2009). Diabetes. 58:1482-4. Preview.
    PubMed: 19564460; PMC: PMC2699856; DOI: 10.2337/db09-0622
34. Transcriptional control of brown adipocyte development and physiological function--of mice and men.
    Seale P, Kajimura S, Spiegelman, BM. (2009). Genes Dev. 23:788-97. Review.
    PubMed: 19339685; PMC: PMC2763499; DOI: 10.1101/gad.1779209
35. PRDM16 Controls a Brown Fat/Skeletal Muscle Switch.
    Seale P, Bjork B, Yang W, Kajimura S, Kuang S, Scime A, Devarakonda S, Chin S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. (2008). Nature, 454, 961-967.
    PubMed: 18719582; PMC: PMC2583329; DOI: 10.1038/nature07182
36. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
    Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. (2008). Genes Dev. 22, 1397-409.
    PubMed: 18483224; PMC: PMC2377193; DOI: 10.1101/gad.1666108
37. Transcriptional control of brown fat determination by PRDM16.
    Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. (2007). Cell Metab. 6, 38-54.
    PubMed: 17618855; PMC: PMC2564846; DOI: 10.1016/j.cmet.2007.06.001