Selected publications from the Song Lab

All hands on deck: Adipocytes lept-in to drive nerve regeneration

Rashid A, Wang Q, Song, Y. Cell Metabolism 2023 Dec 05;25(12):2095.

Spliceosome malfunction causes neurodevelopmental disorders with overlapping features

Li D*^#, Wang Q*, Bayat A, Battig MR, Zhou Y, Bosch DGM, van Haaften G, Granger L, Petersen AK, Pérez-Jurado LA, Aznar-Laín G, Aneja A, Hancarova M, Bendova S, Schwarz M, Pourova RK, Sedlacek Z, Keena BA, March ME, Hou C, O’Connor N, Bhoj EJ, Harr MH, Lemire G, Boycott KM, Towne M, Li M, Tarnopolsky M, Brady L, Parker MJ, Faghfoury H, Parsley LK, Agolini E, Dentici ML, Novelli A, Wright M, Palmquist R, Lai K, Scala M, Striano P, Iacomino M, Zara F, Cooper A, Maarup TJ, Byler M, Lebel RR, Balci TB, Louie R, Lyons M, Douglas J, Nowak C, Afenjar A, Hoyer J, Keren B, Maas SM, Motazacker MM, Martinez-Agosto JA, Rabani AM, McCormick EM, Falk MJ, Ruggiero SM, Helbig I, Møller RS, Tessarollo L, Ardori FT, Palko ME, Hsieh TC, Krawitz PM, Ganapathi M, Gelb BD, Jobanputra V, Wilson A, Greally J, Jacquemont S, Jizi K, Bruel AL, Quelin C, Misra VK, Chick E, Romano C, Greco D, Arena A, Morleo M, Nigro V, Seyama R, Uchiyama Y, Matsumoto N, Taira R, Tashiro K, Sakai Y, Yigit G, Wollnik B, Wagner M, Kutsche B, Hurst ACE, Thompson ML, Schmidt R, Randolph L, Spillmann RC, Shashi V, Higginbotham EJ, Cordeiro D, Carnevale A, Costain G, Khan T, Funalot B, Mau-Them FT, Moya LFG, García-Miñaúr S, Osmond M, Chad L, Quercia N, Carrasco D, Li C, Sanchez-Valle A, Kelley M, Nizon M, Jensson BO, Sulem P, Stefansson K, Gorokhova S, Busa T, Rio M, Habdallah HH, Lesieur-Sebellin M, Amiel J, Pingault V, Mercier S, Vincent M, Philippe C, Fatus-Fauconnier C, Friend K, Halligan RK, Biswas S, Rosser J, Shoubridge C, Corbett M, Barnett C, Gecz J, Leppig K, Slavotinek A, Marcelis C, Pfundt R, de Vries BBA, van Slegtenhorst MA, Brooks AS, Cogne , Rambaud T, Tümer Z, Zackai EH, Akizu N, Song Y^#, Hakonarson H. Journal of Clinical Investigation In press. (#Co-corresponding author).

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Study reveals three genes linked to neurodevelopmental disorders TECH EXPLORIST
New Discoveries Unveil the Complexities of Neurodevelopmental Disorders Express Healthcare Management
新的神经发育障碍的相关的基因及其机制 BioArtMed

Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila

Trombley S*, Powell J*, Guttipatti P*, Matamoros A, Lin X, O’Harrow T, Steinschaden T, Miles L, Wang Q, Wang S, Qiu J, Li Q, Li F^#, Song Y^#. Nature Communications 2023 Oct 14;14(1):6490.

The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation
Li F*, Lo TY*, Miles L*, Wang Q*, Noristani HN, Li D, Niu J, Trombley S, Goldshteyn J, Wang C, Wang S, Qiu J, Pogoda K, Mandal K, Brewster M, Rompolas P, He Y, Janmey PA, Thomas GM, Li S, Song Y. Nature Communications 2021 Jun 22;12(1):3845.
Editorial highlights: From brain to behaviour Featured articles

Pathogenic variants in SMARCA5, a chromatin remodeler, cause a range of syndromic neurodevelopmental features
Li D*^#, Wang Q*, Gong NN, Kurolap A, Feldman HB, Boy N, Brugger M, Grand K, McWalter K, Sacoto MJG, Wakeling E, Hurst J, March ME, Bhoj EJ, Nowaczyk MJM, Gonzaga-Jauregui C, Mathew M, Dava-Wala S, Siemon A, Bartholomew D, Huang Y, Lee H, Martinez JA, Schwaibold EMC, Brunet T, Choukair D, Pais LS, White SM, Christodoulou J, Brown D, Lindstrom K, Grebe T, Tiosano D, Kayser MS, Tan TY, Deardorff MA, Song Y^#, Hakonarson A. Science Advances 2021 May 12;7(20):eabf2066. (#Co-corresponding author).
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Researchers discover new genetic variants responsible for neurodevelopmental disorders medicalxpress.com Mirage News
神经发育疾病的新致病基因 BioArt

Glial metabolic reprograming promotes axon regeneration and functional recovery in the central nervous system
Li F, Sami A, Noristani HN, Slattery K, Qiu J, Groves T, Wang S, Veerasammy K, Chen YX, Morales J, Hanes P, Sehgal A, He Y, Li S^#, and Song Y^#. Cell Metabolism 2020 Sep 9;S1550-4131(20)30475-7.
Editorial highlights:
Preview: Surprising New Players in Glia-Neuron Crosstalk: Role in CNS Regeneration
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Researchers discover new path to neuron regeneration after spinal cord injury medicalxpress.com
Glial Cell Metabolism Linked with Functional Regeneration of CNS Neurons genengnews.com newsbreak.com
New Path to Neuron Regeneration After Spinal Cord Injury Discovered neurosciencenews.com
胶质细胞代谢决定中枢轴突再生 BioArt

Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
Wang Q, Fan H, Li F, Sharum SR, Krishnamurthy V, Song Y^#, Zhang K^#. eLife 2020 Oct 6;9:e57395. (^#Co-corresponding author).

Bi-allelic loss-of-function variants in NUP188 cause a recognizable syndrome characterized by neurologic, ocular and cardiac abnormalities
Muir AM, Cohen JL, Sheppard SE, Guttipatti P, Lo TY, Weed N, Doherty D, Fagerberg C, Kjærsgaard L, Larsen MJ, Wemmenhove-Lohner K, Hirsh Y, Zeevi DA, Zackai EH, Bhoj E, Song Y^#, Mefford HC^# (2020). Am J Hum Genet May 7;106(5):623-631. (^#Co-corresponding author).

The microtubule regulator ringer functions downstream of the RNA repair/splicing pathway to promote axon regeneration
Monahan Vargas, EJ*, Matamoros AJ*, Qiu J*, Jan CH, Qin Wang, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S and Song Y (2020). Genes Dev Feb 1;34(3-4):194-208.

The mechanosensitive ion channel Piezo inhibits axon regeneration
Song Y^#, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Yang X, Rompolas P, Jan LY, Jan YN^# (2019). Neuron April 17;102(2):373-389. (^#Co-corresponding author).
Highlighted in Nature Reviews Neuroscience (2019) The mechanics of neural regeneration
F1000Prime Recommended
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神经再生，愿力与你同在 BioArt

All Publications

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila
Powell J, Steinschaden T, Horowitz R, Song Y. Neural Regeneration Research in press.

All hands on deck: Adipocytes lept-in to drive nerve regeneration

Rashid A, Wang Q, Song, Y. Cell Metabolism 2023 Dec 05;25(12):2095.

Spliceosome malfunction causes neurodevelopmental disorders with overlapping features

Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila

Trombley S*, Powell J*, Guttipatti P*, Matamoros A, Lin X, O’Harrow T, Steinschaden T, Miles L, Wang Q, Wang S, Qiu J, Li Q, Li F^#, Song Y^#. Nature Communications 2023 Oct 14;14(1):6490.

A designer peptide to treat glioblastoma by targeting cancer-neuron interaction

Dong W, Fekete A, Chen X, Liu H, Beilhartz G, Chen X, Bahrampour S, Xiong Y, Yang Q, Zhao H, Kong T, Chen X, Morioka M, Jung G, Kim JE, Schramek D, Dirks PB, Song Y, Kim TH, He Y, Wanggou S, Li X, Melnyk R, Wang LY, Huang X. Nature Cancer 2023 Sep 11.

Drosophila laser axotomy injury model to investigate RNA repair and splicing in axon regeneration

Wang Q, Trombley S, Rashidzada M, Song Y. Methods Mol Biol. 2023;2636:401-419.

Spatiotemporal modulation of neural repair
Fan H, Wang Q, Zhang K, Song Y. Opsin-free Optogenetics. CRC Press 2022 November.

Mechanosensitive ion channels, axonal growth, and regeneration
Miles L, Powell J, Casey K, Song Y. The Neuroscientist 2022 Apr 13;10738584221088575.

Non-canonical role of the ATR pathway in axon regeneration as a mechanosensitive brake
Li F^#, Song Y^#. Neural Regeneration Research 2022 Nov 17(11): 2423-2424.

The chromatin remodeler ISWI acts during Drosophila development to regulate adult sleep
Gong NN, Dilley LC, Williams CE, Moscato EH, Szuperak M, Wang Q, Jensen M, Girirajan S, Tan TY, Deardorff MA, Li D, Song Y, Kayser MS. Science Advances 2021 Feb 17;7(8):eabe2597.

Genome-wide surveillance of transcription errors in response to genotoxic stress
Fritsch C, Gout JF, Haroon S, Towheed A, Chung C, LaGosh J, McGann E, Zhang X, Song Y, Simpson S, Danthi PS, Benayoun BA, Wallace D, Thomas K, Lynch M, Vermulst M. PNAS 2021 Jan 5;118(1):e2004077118..

Patterned neuronal activities dictate cell type-specific axon regeneration
Ruppell KT*, Wang F*, Li F*, Shang Y, Gong J, Guttipatti P, Song Y, Xiang Y. Submitted.

Chloride intracellular channel 1 cooperates with potassium channel to promote medulloblastoma growth
Francisco MA, Wanggou S, Fan JJ, Dong W, Chen X, Momin A, Abeysundara N, Min HK, Chan J, McAdam R, Sia M, Pusong RJ, Liu S, Patel N, Ramaswamy V, Kijima N, Wang LY, Song Y, Kafri R, Taylor MD, Li X, Huang X (2020). J. Exp. Med. 217.5: e20190971.

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression
Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan FJ, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida M, Dirks P, Song Y, Hui CC, Sun Y, Wang LY, Li X, Huang X (2018). Neuron Nov 21;100(4):799-815.e7.

Targeted Delivery and Tolerability of MRI-Guided CED Infusion into the Cerebellum of NonHuman Primates
Salegio E, Campagna MV, Allen PC, Stockinger DE, Song Y, Hwa GGC (2018). Human Gene Therapy Methods Aug;29(4):169-176.

A Drosophila in vivo injury model for studying neuroregeneration in the peripheral and central nervous system
Li D*, Li F*, Guttipatti P, Song Y (2018). J. Vis. Exp. (135), e57557.

Before the birth of the Song Lab

Regulation of axon regeneration by the RNA repair/splicing pathway
Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Meltzer S, Han C, Nguyen T, Bresnahan JC, Beattie MS, Jan LY, and Jan YN (2015). Nature Neuroscience 18(6): 817-25.
Highlighted in Nature (2015) A way to regrow nerve fibres
Highlighted in Nature Reviews Neuroscience (2015) Splicing up repair mechanisms

A naturally-monomeric infrared fluorescent protein for protein labeling in vivo
Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Lin S, Murthy Z, Zhang S, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X (2015). Nature Methods 12: 763–765.

Dendritic fragmentation and clearance by phagocytic epidermal cells in Drosophila dendrite pruning and dendrite injury
Han C*, Song Y*, Xiao H, Wang D, Franc N, Jan LY, Jan YN (2014). Neuron 5;81(3): 544-60 (*Co-first author).
Highlighted in Nature Reviews Neuroscience (2014) Epidermal cells eat up dendrites

Female exposure modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila
Yuan Q*, Song Y*, Yang C, Jan LY, Jan YN (2014). Nature Neuroscience 17(1): 81-8 (*Co-first author).
Highlighted in Nature Reviews Neuroscience (2014) The feminine touch dampens aggression
Highlighted in Nature Neuroscience (2014) How sex prevents violence: the magic of caress (and GABA)

Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam
Song Y, Ori-McKenney KM, Zheng Y, Han C, Jan LY, Jan YN (2012). Genes Dev 26: 1612-1625.
Highlighted in Genes Dev (2012) No simpler than mammals: axon and dendrite regeneration in Drosophila
Highlighted in F1000 (2012)

mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues
Robinson BW*, Germano G*, Song Y*, Abrams J, Scott M, Guariento I, Tiso N, Argenton F, Basso G, Rhodes J, Kanki JP, Look AT, Balice-Gordon RJ, Felix CA (2011). Br J Haematol 152(3): 307-21 (*Co-first author).

Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation
Song Y, Willer JR, Scherer PC, Panzer JA, Kugath A, Skordalakes E, Gregg RG, Willer GB, Balice-Gordon RJ (2010). PLoS One 5(10):e13743.
Highlighted in F1000 (2011)

Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)
Song Y, Selak MA, Watson CT, Coutts C, Scherer PC, Panzer JA, Gibbs S, Scott M, Willer G, Gregg RG, Ali DW, Bennett MJ and Balice-Gordon RJ (2009). PLoS One 4(12): e8329.

New dogs in the dogma: Lrp4 and Tid1 in neuromuscular synapse formation
Song Y, Balice-Gordon RJ (2008). Neuron 60: 526-8.

Agrin is required for posterior development and axon pathway formation in embryonic zebrafish
Kim M, Liu I, Song Y, Halfter W, Balice-Gordon RJ, Linney E and Cole GJ (2007). Glycobiology 17: 231-47.

Formation and plasticity of neuromuscular synaptic connections
Song Y, Panzer JA, Wyatt RM, Balice-Gordon RJ (2006). International Anesthesiology Clinics 44: 145-78.

In vivo imaging of preferential motor axon outgrowth to and synaptogenesis at prepatterned acetylcholine receptor clusters in embryonic zebrafish skeletal muscle
Panzer JA*, Song Y*, Balice-Gordon RJ (2006). Journal of Neuroscience 18: 934-47 (*Co-first author).
Highlighted in F1000 (2006)

Ca²⁺-dependent regulation of rho GTPases triggers turning of nerve growth cones
Jin M, Guan CB, Jiang YA, Chen G, Zhao CT, Cui K, Song YQ, Wu CP, Poo MM, Yuan XB (2005). Journal of Neuroscience 25: 2338-2347.

Signaling and crosstalk of Rho GTPases in mediating axon guidance
Yuan XB, Jin M, Xu X, Song YQ, Wu CP, Poo MM, Duan S (2003). Nature Cell Biology 5: 38-45.