Syllabus
CAMB 542-401 | Topics in Molecular Medicine
| Date | Class Time | Faculty Preceptor | Topic | Assigned Reading | |
|---|---|---|---|---|---|
1 |
Friday, September 5 | 3:30-5:00PM | Mitchell Lazar, MD, PhD | Neuroendocrine control of food intake and obesity |
Research Paper: Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake Clinical Review: Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery |
2 |
Friday, September 12 | 3:30-5:00PM | Maria Basil, MD, PhD |
Research Paper: Clinical Review: Supplemental Reference: |
|
3 |
Monday, September 22 | 3:30-5:00PM | Jonathan Miner, MD, PhD | ||
4 |
Friday, September 26 | 3:30-5:00PM |
Rajan Jain, MD |
Mentor and Mentee Relationships | None |
5 |
Monday, September 29 | 3:30-5:00PM | Audrey Odom John, MD, PhD |
Research Paper: Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens Clinical Review: Measles Clinical Review: Measles 2025 |
|
6 |
Monday, October 6 | 3:30-5:00PM | Elizabeth Traxler, MD, PhD | Molecular Glues to Rewire Gene Expression |
Research Paper: A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction Clinical Review: The Fetal-to-Adult Hemoglobin Switch — Mechanism and Therapy |
7 |
Monday, October 20 | 3:30-5:00PM | Jacob Brenner, MD, PhD | DNA-loaded lipid nanoparticles (DNA-LNPs) for common chronic diseases | Research Paper: Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles |
8 |
Monday, October 27 | 3:30-5:00PM | Mark Sellmyer, MD, PhD | The Bis(monoacylglycero)-phosphate Hypothesis: From Lysosomal Function to Therapeutic Avenues | Research Paper: 64Cu-DOTA-Rituximab PET/CT of B-Cell Non-Hodgkin Lymphoma for Imaging the CD20 Expression
Clinical Review: Scission-Enhanced Molecular Imaging (SEMI) |
9 |
Monday, November 3 | 3:30-5:00PM | Jim Dowling, MD, PhD | Research Paper: Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
Clinical Review: Gene regulation technologies for gene and cell therapy |
|
10 |
Friday, November 7 | 3:30-5:00PM | Alexander Huang, MD | Immune checkpoint blockade |
Research Paper: Restoring function in exhausted CD8 T cells during chronic viral infection Clinical Review: Pembrolizumab versus Ipilimumab in Advanced Melanoma |
11 |
Monday, November 17 | 12:00-1:30PM | Rebecca Ahrens-Nicklas, MD, PhD |
Research Paper: PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease Clinical Review: The Bis(monoacylglycero)-phosphate Hypothesis: From Lysosomal Function to Therapeutic Avenues |
|
12 |
Tuesday, December 2 | 3:30-5:00PM | Edward Kreider, MD, PhD | Co-opting host trafficking to enhance mRNA-LNP vaccine immunogenicity | Research Paper: ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines |