415 Curie Blvd.
Yuanqing Feng
Research Associate
Research Interest
Population genetics, functional genomics, and noncoding variants.
My research mainly focuses on the role of noncoding variants in human adaptation and human diseases. First, I have applied GWAS, selection scanning, and functional genomics to investigate the molecular mechanisms underlying human skin pigmentation (HMG, 2021; Cell, 2023; Nature Genetics, 2023). Second, I have identified loci under natural selection near genes related to SARS-CoV2 infection in African populations and revealed their associations with human diseases (PNAS, 2022). Finally, I am currently using single-cell RNA-seq to identify genes related to malaria in African populations.
Education
2018 2011 2011 |
Ph.D. Molecular Medicine B.S. Pharmaceutical Engineering B.E., International Economics College of Economics, Jilin University, Changchun, China |
Research Experience
2023 – Present |
Research Associate Postdoctoral Research Fellow Postdoctoral Researcher |
Honors
2023 2023 2016 2015 |
Chan Zuckerberg Initiative Next Generation Researcher Pilot Projects ($20,000) Travel stipends for Advanced Gene Mapping Course at The Rockefeller University ($1,000) National Scholarship for Graduate Students, Peking University President's Scholarship, Peking University |
Publications
Y. Feng, et al. Integrative functional genomic analyses identify genetic variants influencing skin pigmentation in Africans. Nature Genetics (2023).
S. Fan, J. Spence, Y. Feng, et al. Whole-genome sequencing reveals a complex African population history and local adaptation. Cell. 186(5):923-939.e14 (2023).
Chao Zhang*, Anurag Verma*, Yuanqing Feng*, Marcelo C. R. Melo, Michael McQuillan, Matthew Hansen, Anastasia Lucas, Joseph Park, Alessia Ranciaro, Simon Thompson, Meagan A. Rubel, Michael C. Campbell, William Beggs, Jibril Hirbo, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Regeneron Genetic Center, Thomas Nyambo, Dawit Wolde Meskel, Gurja Belay, Charles Fokunang, Alfred K. Njamnshi, Sabah A. Omar, Scott M. Williams, Daniel J. Rader, Marylyn D. Ritchie, Cesar de la Fuente-Nunez, Giorgio Sirugo, Sarah A. Tishkoff. Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection. Proc. Natl. Acad. Sci. U. S. A. 119, e2123000119 (2022). *co-first author
Yuanqing Feng, M. A. McQuillan, S. A. Tishkoff, Evolutionary genetics of skin pigmentation in African populations. Hum. Mol. Genet. 30, R88–R97 (2021).
Yuanqing Feng*, Hongzhan Xu*, Jinghao Liu*, Ning Xie, Lei Gao, Yanyun He, Yuan Yao, Fengxiang Lv, Yan Zhang, Jian Lu, Wei Zhang, Chuan-Yun Li, Xinli Hu, Ziheng Yang, Rui-Ping Xiao. Functional and Adaptive Significance of Promoter Mutations That Affect Divergent Myocardial Expressions of TRIM72 in Primates. Mol. Biol. Evol. 38, 2930–2945 (2021). *co-first author
Feng Y, Liu J, Xu H, Gao L, Hu X and Xiao RP. Promoter mutations of TRIM72 contribute to the heart specific evolution of energy metabolism in primates. (In preparation)
Liu F*, Song R*, Feng Y*, Guo J, Chen Y, Zhang Y, Chen T, Wang Y, Huang Y, Li CY, Cao C, Zhang Y, Hu X and Xiao RP. (2015) Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α. Circulation 131:795-804. (*co-first, IF = 17.2) LINK
Xie N, Chen M, Dai R, Zhang Y, Zhao H, Song Zh, Zhang L, Li Zh, Feng Y, Gao H, Wang L, Zhang T, Xiao RP, Wu J, Cao C. (2017) SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/KLF5 pathway. Nature Communications 28:16016. LINK
Guo J, Xie N, Li G, Zhang Y, Lv F, Guo S, Feng Y, Cao CM and Xiao RP. (2015) p55gamma functional mimetic peptide N24 blocks vascular proliferative disorders. Journal of Molecular Medicine 93:1107-18. LINK
Li G, Xie N, Yao Y, Zhang Y, Guo J, Feng Y, Lv F, Xiao RP and Cao CM. (2015) Identification of PI3K regulatory subunit p55gamma as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation. Cardiovascular Research 105:75-85. LINK
