Daniel Hui

PhD Student
Genomics and Computational Biology

Research Interest

I am interested in the genetic basis for human traits and diseases, with a focus on cardiometabolic diseases and related anthropometric traits. I am especially interested in using individuals from diverse ancestry and environment in order to facilitate discovering and quantifying the effects of different genetic loci. I hope the research I conduct will improve human health for populations all around the world, especially for conditions that have a large healthcare burden and are significantly genetic in their etiology.

Education

Anticipated	Ph.D. University of Pennsylvania, Genomics and Computational Biology Advisors: Sarah Tishkoff, PhD and Marylyn Ritchie, PhD
	B.S. University of Pittsburgh Computer Science

Research Experience

2019 – Present	Graduate Research Assistant, University of Pennsylvania Tishkoff Lab
2017 – 2019	Research Assistant (Bioinformatics), Brigham and Women’s Hospital, Harvard Medical School The Broad Institute
2014 – 2017	Undergraduate Research Assistant, Children’s Hospital of University of Pittsburgh Medical Center

Publications and Presentations

Keat K, Hui D, Xiao B, Bradford Y, Cindi Z, Daar ES, Gulick R, Riddler SA, Sinxadi P, Haas DW, Ritchie MD. Leveraging Multi-Ancestry Polygenic Risk Scores for Body Mass Index to Predict Antiretroviral Therapy-Induced Weight Gain. Pac Symp Biocomput. 2023;28:233-244.

Truong, V. Q., Woerner, J. A., Cherlin, T. A., Bradford, Y., Hui, D. H., Lucas, A. M., Shivakumar, M. K., Kumar, R., Pividori, M., Okeh, C. C., Jones, S. C., Bossa, A. C., Turner, S. D., Ritchie, M. D., & Verma, S. S. (2022). Quality control procedures for genome-wide association studies. Current Protocols, 2, e603. doi: 10.1002/cpz1.603

Vilija G. Jokubaitis, Omar Ibrahim, Jim Stankovich, Pavlina Kleinova, Daniel Hui, …, Nikolaos Patsopoulos, Dana Horakova, Helmut Butzkueven. Not all roads lead to the immune system: The Genetic Basis of Multiple Sclerosis Severity Implicates Central Nervous System and Mitochondrial Involvement. Brain (accepted). 2022.

Daniel Hui*, Brenda Xiao*, …, Shefali Verma, Dokyoon Kim, Marylyn D. Ritchie. Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index. Pacific Symposium on Biocomputing. December 2022, 437-448.

Dan Ju*, Daniel Hui*, Dorothy A. Hammond, Ambroise Wonkam, Sarah A. Tishkoff. Importance of Including Non-European Populations in Large Human Genetic Studies to Enhance Precision Medicine. Annual Review of Biomedical Data Science. 2022; 5:1

Daniel Hui, Shadi Mehrabi, Alexandra Quimby, Tingfang Chen, Sixing Chen, Joseph Park, Binglan Li, Regeneron Genetics Center, Penn Medicine Biobank, Daniel Rader, Marylyn Ritchie, Jason Brant, Douglas Epstein*, Iain Mathieson*. Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort. PLOS Genetics (accepted). 2022.

Ahmadmehrabi S, Li B, Hui D, Park J, Ritchie M, Rader DJ, Ruckenstein MJ, Epstein DJ, Brant J. A Genome-First Approach to Rare Variants in Dominant Postlingual Hearing Loss Genes in a Large Adult Population. Otolaryngol Head Neck Surg. 2021 Jul 20:1945998211029544. doi: 10.1177/01945998211029544.

Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E, Verma A, Miller JE, Kullo I, Hakonarson H, Sleiman P, Schaid D, Stein CM, Edwards DRV, Feng Q, Wei WQ, Medina MW, Krauss RM, Hoffmann TJ, Risch N, Voight BF, Rader DJ, Ritchie MD. A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts. Nat Genet. 2021 Jul;53(7):972-981. doi: 10.1038/s41588-021-00879-y.

Theocharidis G, Baltzis D, Roustit M, Tellechea A, Dangwal S, Khetani RS, Shu B, Zhao W, Fu J, Bhasin S, Kafanas A, Hui D, Sui SH, Patsopoulos NA, Bhasin M, Veves A. Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers. Diabetes. 2020 Oct;69(10):2157-2169. doi: 10.2337/db20-0188.

Sung Chun, Maxim Imakaev, Daniel Hui, Nikolaos Patsopoulos, Benjamin Neale, Sekar Kathiresan, Nathan Stitziel, Shamil Sunyaev. Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics. American Journal of Human Genetics, 2020.

Nadia Boutaoui, Sandeep Puranik, Rong Zhang, Ting Wang, Daniel Hui, John Brehm, Erick Forno, Wei Chen, Juan Celedon. Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells. Epigenetics, 2019.

Daniel Hui, Zhou Fang, Jerome Lin, Qing Duan, Yun Li, Ming Hu, Wei Chen. LAIT: a local ancestry inference toolkit. BMC Genetics, 2017.