Research Interest
Education
1999 - 2005
1995 - 1999 |
Ph.D. Theoretical Population Genetics, Harvard University, Cambridge, MA B.S. University of Pennsylvania, Philadelphia, PA |
Research Experience
2019 – Present 2014 – 2019 2011 – 2014 2008 - 2011 2009 - 2010 2007 2005 - 2008 2000 |
Senior Research Investigator Assistant Professor (Research) Assistant Researcher Postdoctoral Research Asssociate Visiting Scholar Visiting Scholar Postdoctoral Research Associate Center of Excellence in Genome Science, University of Southern California Graduate Research Assistant |
Publications & Manuscripts
Wang, D., He, J., Perera, D., Cao, Ch., Kossinna, P. Lie, Q., ..., Platt, A., & Zhang, Q. (2023). cLD: Rare-varient linkage disequilibrium between genomic regions identifies novel genomic interactions. PLoS genetics, in press.
Harris, D. N., Platt, A., Hansen, M. E., Fan, S., McQuillan, M. A., Nyambo, T., ... & Tishkoff, S. A. (2023). Diverse African genomes reveal selection on ancient modern human introgressions in Neanderthals. Current Biology.
Puckett, E. E., Davis, I. S., Harper, D. C., Wakamatsu, K., Battu, G., Belant, J. L., ... & Barsh, G. S. (2023). Genetic architecture and evolution of color variation in American black bears. Current Biology, 33(1), 86-97.
Platt, A., Pivirotto, A., Knoblauch, J., & Hey, J. (2019). An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations. PLoS genetics, 15(8), e1008340.
Xiong, Z., Zhang, Q., Platt, A., Liao, W., Shi, X., de Los Campos, G., & Long, Q. (2019). OCMA: Fast, Memory-Efficient Factorization of Prohibitively Large Relationship Matrices. G3: Genes, Genomes, Genetics, 9(1), 13-19.
Platt, A., Weber, C. C., & Liberles, D. A. (2018). Protein evolution depends on multiple distinct population size parameters. BMC evolutionary biology, 18(1), 1-9.
Patel, R., Scheinfeldt, L. B., Sanderford, M. D., Lanham, T. R., Tamura, K., Platt, A., ... & Kumar, S. (2018). Adaptive landscape of protein variation in human exomes. Molecular biology and evolution, 35(8), 2015-2025.
McQuillan, Michael; Zhang, Chao; Tishkoff, Sarah; Platt, Alexander. In press 2020. The importance of including ethnically diverse populations in studies of quantitative trait evolution. Current Opinions in Genetics and Development.
Platt, Alexander; Pivirotto, Alyssa; Knoblauch, Jared; Hey, Jody. 2019. An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations. PLoS Genetics 15 (8), e1008340
Platt, Alexander Time-conditional properties of branches in coalescent gene trees. BioRxiv: 189209 [preprint] available here
Xiong, Zhi; Zhang, Qingrun; Platt, Alexander; Liao, Wenyuan; Xinghua, Shi; de los Campos, Gustavo; Long, Quan (2019) OCMA: Fast, Memory-Efficient Factorization of Prohibitively Large Relationship Matrices. G3: Genes, Genomes, Genetics 9(1),13-19.
Patel, Ravi; Scheinfeld, Laura; Lanham, Tamera; Tamura, Koichiro; Platt, Alexander; Glicksberg, Benjamin; Xu, Ke; Dudley, Joel; Kumar, Sudhir. 2018. Adaptive landscape of protein variation in human exomes. Molecular biology and evolution 35(8),2015-2025
Platt, Alexander;Weber, Claudia; Liberles, David. 2018. Protein evolution depends on multiple distinct population size parameters. BMC evolutionary biology 18.1 (2018): 17
Platt, Alexander; Gugger, Paul; Pellegrini, Matteo; Sork, Victoria. 2015. Genome-wide signature of local adaptation linked to variable CpG methylation in oak populations. Molecular Ecology24:3823-3830.
Brachi, Benjamin; Meyers, Christopher; Villoutreix, Romain; Platt, Alexander; Morton, Timothy; Roux, Fabrice; Bergelson, Joy. 2015. Co-selected genes determine adaptive variation in herbivore resistance throughout the native range of Arabidopsis thaliana. Proceedings of the National Academy of Sciences 112:4032-4037
Yang, Wen-Yun; Platt, Alexander; Wen-Kai Chiang, Charleston; Eskin, Eleazar; Novembre, John; Pasaniuc, Bogdan. 2014. Spatial localization of recent ancestors for admixed individuals. G3: Genes, Genomes, Genetics 4:2505-2518
Lovell, John; Juenger, Thomas; Michaels, Scott; Lasky, Jesse; Platt, Alexander; Richards, James; Yu, Xuhong; Easlon, Hsien; Sen, Saunak; McKay, John. 2013. Protagonistic pleiotropy of FRIGIDA promotes adaptation and positive assortative mating. Proceedings of the Royal Society B: Biological Sciences 280:20131043.
Book Review
David Reich. Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past. 2019 Evolutionary Studies in Imaginative Culture (3.2)
Teaching Experience
2020 Co-Instructor, University of Pennsylvania BIOL 522- Human Evolutionary Genomics.
2015-2019 Guest instructor, Temple University Biology 3211: Human Evolution.
2015-2019 Mentor, Temple University undergraduate independent study program.
2014-2015 Mentor, Temple University NIH Maximizing Access to Research Careers program.
2014 Guest lecturer, Temple University Biology 8003: Introduction to Graduate Research.
2012 Guest lecturer, UCLA EEB 135/235: Population Genetics.
2008 Guest lecturer, Keck School of Medicine at USC: Bayesian Computational Methods in Population Genetics.
2004 Teaching Fellow, Harvard University Organismic and Evolutionary Biology 275: Natural Selection at the Molecular Level.
2002 Teaching Fellow, Harvard University Core Curriculum 50: Evolution. A science class for non-scientist undergraduates.
2000 Teaching Fellow, Harvard University Biological Sciences 252: Coalescence Theory.
1999 Teaching Fellow, Harvard University Biological Sciences 2: Introduction to Organismic Biology.
Other Professional Activites
- • 2019-present Associate Editor -- Journal of Molecular Evolution
- • 2016-present Judge -- INFORMS Analytics Syngenta Crop Challenge Prize Committee