Chao Zhang

Chao Zhang

Postdoctoral Research Fellow

Research Interest

I am interested in integrating cut-edge multi-Omics big data to address fundamental questions about human evolution (such as local adaptation to environmental changes and evolutionary history of human populations), and eventually understanding the implications or biological mechanisms of genetic variation (especially disease variants) leading to phenotypes/diseases in the light of human evolution. Currently I am leveraging deep whole-genome sequencing data, transcriptomic data and (intermediate-) phenotypic data from diverse African populations to achieve the above-mentioned goals.

Education

July 2018

July 2012

Ph.D. Max-Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS)

B.S.Bioengineering
Yangzhou University, China

Honors

2018

2018

2018

2016

2015 and 2017

Lindau program Awardee, Sino-German Science Center

Presidential Scholarship, UCAS, Chinese Academy of Sciences

Outstanding Graduates of Shanghai, China

PhD National Scholarship, UCAS, Chinese Academy of Sciences

Merit Student, UCAS, Chinese Academy of Sciences

Selected Publications

Chao Zhang*; Yang Gao*; Zhilin Ning*; Yan Lu*; Xiaoxi Zhang; Jiaojiao Liu; Bo Xie; Zhe Xue; Xiaoji Wang; Kai Yuan; Xueling Ge; Yuwen Pan; Chang Liu; Lei Tian; Yuchen Wang; Dongsheng Lu; Boon-Peng Hoh; Shuhua Xu. PGG.SNV: Understanding the evolutionary and medical implications of human single nucleotide variation in diverse populations. Genome Biology, 2019, 20, 215.

Lian Deng*, Chao Zhang*(Contributed equally), Kai Yuan*, Yang Gao*, Yuwen Pan, Xueling Ge, Yaoxi He, Yuan Yuan, Yan Lu, Xiaoxi Zhang, Hao Chen, Haiyi Lou, Xiaoji Wang, Dongsheng Lu, Jiaojiao Liu, Lei Tian, Qidi Feng, Asifullah Khan, Yajun Yang, Zi-Bing Jin, Jian Yang, Fan Lu, Jia Qu, Longli Kang, Bing Su, Shuhua Xu. Prioritizing adaptive variants by analyzing deep-sequenced genomes and quantitative traits of Tibetan highlanders. National Science Review, 2019.

Xin Luo*, Yaoxi He*, Chao Zhang*(Contributed equally), Xiechao He* et al., Trio sequencing does not reveal unexpected mutations in Cas9-edited monkeys. Nature Communication, 2019.

Yang Gao*, Chao Zhang*(Contributed equally), Liyun Yuan* et al., PGG.Han: the Han Chinese genome database and analysis platform. Nucleic Acids Research, 2019.

Chao Zhang*, Yan Lu*, Qidi Feng*, Xiaoji Wang*, Haiyi Lou, Jiaojiao Liu, Zhilin Ning, Kai Yuan, Yuchen Wang, Ying Zhou, Lian Deng, Lijun Liu, Yajun Yang, Shilin Li, Lifeng Ma, Zhiying Zhang, Li Jin, Bing Su, Longli Kang and Shuhua Xu. Differentiated demographic histories and local adaptations between Sherpas and Tibetans. Genome Biology, 2017, 18, 115.

Chao Zhang*, Yang Gao*, Jiaojiao Liu, Zhe Xue, Yan Lu, Lian Deng, Lei Tian, Qidi Feng, Shuhua Xu. PGG.Population: A database for understanding the genomic diversity and genetic ancestry of human populations. Nucleic Acids Research, 2018, 46(D1):D984- D993.

Dongsheng Lu, Haiyi Lou, Kai Yuan, Xiaoji Wang, Yuchen Wang, Chao Zhang*(Contributed equally), Yan Lu, Xiong Yang, Lian Deng, Ying Zhou, Qidi Feng, Ya Hu, Qiliang Ding, Yajun Yang, Shilin Li, Li Jin, Yaqun Guan, Bing Su, Longli Kang, Shuhua Xu. Ancestral Origins and Genetic History of Tibetan Highlanders. The American Journal of Human Genetics, 2016, 3, 580-594.

Chao Zhang*, Jiaojiao Liu*, Furhan Iqbal, Yan Lu, Saima Mustafa, Firdous Bukhari, Haiyi Lou, Ruiqing Fu, Zhendong Wu, Xiong Yang, Ihtisham Bukhari, Muhammad Aslam, Shuhua Xu. A missense point mutation in COL10A1 identified with whole-genome deep sequencing in a 7-generation Pakistan dwarf family. Heredity, 2018, 120(1):83-89.

Chao Zhang*, Jing Li*, Tei Tian, Dongsheng Lu, Kai Yuan, Yuan Yuan, Shuhua Xu. Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations. Scientific Reports, 2015, 5, 9658.

Qidi Feng, Yan Lu, Xumin Ni, Kai Yuan, Yajun Yang, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang, Sijia Wang, Shuhua Xu. Genetic History of Xinjiang's Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia. Molecular Biology and Evolution, 2017, 34, 2572- 2582.

Ling-Xiang Wang*, Yan Lu*, Chao Zhang*(Contributed equally), Lan-Hai Wei*, Yan S, Huang YZ, Wang CC, Mallick S, Wen SQ, Jin L, Xu SH, Li H, Reconstruction of Y-chromosome phylogeny reveals two neolithic expansions of Tibeto-Burman populations, Molecular Genetics and Genomics, 2018.

Lei Tian, Asifullah Khan, Zhilin Ning, Kai Yuan, Chao Zhang, Haiyi Lou, Yuan Yuan, Shuhua Xu. Genome-wide comparison of allele-specific gene expression between African and European populations. Human Molecular Genetics, 2018, 27, 1067-1077.

Jianqi Lu, Haiyi Lou, Ruiqing Fu, Dongsheng Lu, Feng Zhang, Zhendong Wu, Xi Zhang, Changhua Li, Baijun Fang, Fangfang Pu, Jingning Wei, Qian Wei, Chao Zhang, Xiaoji Wang, Yan lu, Shi Yan, Yajun Yang, Li Jin, Shuhua Xu. Assessing genome-wide copy number variation in the Han Chinese population. Journal of Medical Genetics, 2017, 54, 685-692.