Research
Our lab focuses on molecular hematology-oncology with an emphasis on studying signal transduction in normal blood cell development and hematological malignancies. We use genetically-engineered mouse models, bone marrow transplantation, tissue culture cells, gene transcriptional profiling, protein complex purification and mass spectrometric identification, coupled with extensive usage of molecular, cellular, and biochemical technologies.
Our laboratory is interested in studying molecular mechanisms of cytokine receptor signaling in hematopoiesis, hematopoietic stem cell development, and leukemogenesis. Our research connects these processes to fundamental fields like kinase and ubiquitin signaling, genome integrity, and ribosome biogenesis. Our major goal is to apply this knowledge to develop novel gene therapies for blood disorders.