Publications

  1. Vantsev, N.A., Zhao, L., Morioka, S., Kajiho, H., Sasaki, J., Sasaki, T., Abrams, C.S., and Tong, W. (2026). PITPβ Drives JAK2 V617F-Mediated Myeloproliferative Neoplasms by Promoting PtdIns(3,4)P ₂ -Dependent AKT Hyperactivation. bioRxiv, 2026.03.26.714558. https://doi.org/10.64898/2026.03.26.714558.
  2. Singh, B., Hossain, M.A., Liang, X.H., Fages, J., Salinas, C.S., Greenberg, R.A., and Tong, W. (2026). Lnk deficiency enhances translesion synthesis to alleviate replication stress and promote hematopoietic stem cell fitness. J Clin Invest 136. https://doi.org/10.1172/JCI191713.
  3. Ren, J.-G., Xing, B., Lv, K., O’Keefe, R.A., Wu, M., Wang, R., Bauer, K.M., Ghazaryan, A., Burslem, G.M., Zhang, J., et al. (2023). RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia. J Clin Invest 133, e165510. https://doi.org/10.1172/jci165510.
  4. Lv, K., Ren, J.-G., Han, X., Gui, J., Gong, C., and Tong, W. (2021). Depalmitoylation rewires FLT3-ITD signaling and exacerbates leukemia progression. Blood 138, 2244–2255. https://doi.org/10.1182/blood.2021011582.
  5. Holdreith, N., Lee, G., Chandra, V., Salinas, C.S., Nicholas, P., Olson, T.S., and Tong, W. (2022). LNK (SH2B3) inhibition expands healthy and Fanconi anemia human hematopoietic stem and progenitor cells. Blood Advances 6, 731–745. https://doi.org/10.1182/bloodadvances.2021004205.
  6. Lv, K., Gong, C., Antony, C., Han, X., Ren, J.-G., Donaghy, R., Cheng, Y., Pellegrino, S., Warren, A.J., Paralkar, V.R., et al. (2021). HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis. Cell Stem Cell 28, 1275-1290.e9. https://doi.org/10.1016/j.stem.2021.02.008.
  7. Donaghy, R., Han, X., Rozenova, K., Lv, K., Jiang, Q., Doepner, M., Greenberg, R.A., and Tong, W. (2019). The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination. Blood 133, 1560–1571. https://doi.org/10.1182/blood-2018-10-877563.
  8. Balcerek, J., Jiang, J., Li, Y., Jiang, Q., Holdreith, N., Singh, B., Chandra, V., Lv, K., Ren, J., Rozenova, K., et al. (2018). Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia. Nat Commun 9, 3915. https://doi.org/10.1038/s41467-018-06380-1.
  9. Lv, K., Jiang, J., Donaghy, R., Riling, C.R., Cheng, Y., Chandra, V., Rozenova, K., An, W., Mohapatra, B.C., Goetz, B.T., et al. (2017). CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies. Genes Dev 31, 1007–1023. https://doi.org/10.1101/gad.297135.117.
  10. Giani, F.C., Fiorini, C., Wakabayashi, A., Ludwig, L.S., Salem, R.M., Jobaliya, C.D., Regan, S.N., Ulirsch, J.C., Liang, G., Steinberg-Shemer, O., et al. (2016). Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell Stem Cell 18, 73–78. https://doi.org/10.1016/j.stem.2015.09.015.
  11. Rozenova, K., Jiang, J., Donaghy, R., Aressy, B., Greenberg, R.A., and Tong, W. (2015). MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Blood 125, 1730–1738. https://doi.org/10.1182/blood-2014-07-588145.
  12. Cheng, Y., Chikwava, K., Wu, C., Zhang, H., Bhagat, A., Pei, D., Choi, J.K., and Tong, W. (2015). LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest 126, 1267–1281. https://doi.org/10.1172/JCI81468.
  13. Jiang, J., Balcerek, J., Rozenova, K., Cheng, Y., Bersenev, A., Wu, C., Song, Y., and Tong, W. (2012). 14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. J Clin Invest 122, 2079–2091. https://doi.org/10.1172/JCI59719.
  14. Bersenev, A., Wu, C., Balcerek, J., Jing, J., Kundu, M., Blobel, G.A., Chikwava, K.R., and Tong, W. (2010). Lnk constrains myeloproliferative diseases in mice. J. Clin. Invest. 120, 2058–2069. https://doi.org/10.1172/JCI42032.
  15. Bersenev, A., Wu, C., Balcerek, J., and Tong, W. (2008). Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. J Clin Invest 118, 2832–2844. https://doi.org/10.1172/JCI35808.
  16. Scott, L.M., Tong, W., Levine, R.L., Scott, M.A., Beer, P.A., Stratton, M.R., Futreal, P.A., Erber, W.N., McMullin, M.F., Harrison, C.N., et al. (2007). JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis. N Engl J Med 356, 459–468. https://doi.org/10.1056/NEJMoa065202.
  17. Tong, W., Zhang, J., and Lodish, H.F. (2005). Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 105, 4604–4612. https://doi.org/10.1182/blood-2004-10-4093.