Weber Lab

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Sleep, plasticity, psychiatric disorders

We are interested in how neural circuits control brain states and how different brain states in turn shape spontaneous neural activity and thereby influence behavior and emotions. 

We are particularly interested in REM sleep — the sleep stage associated with vivid dreaming —  as this brain state constitutes a unique neurophysiological and neurochemical environment, which largely impacts the status of neural circuits and single neurons.

We study these questions in the mouse model employing an inter-disciplinary approach including optogenetics, in vivo electrophysiology, calcium imaging, viral tracing, behavioral assays and computational modeling. 

Our lab is part of the Chronobiology Program at Penn. With its strong focus on sleep research arising from Center for Sleep and Circadian Neurobiology and the Chronobiology Program, Penn offers an excellent environment for the inter-disciplinary study of sleep across multiple model organisms in health and disease.



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