Perelman School of Medicine at the University of Pennsylvania

Wolf Lab


John A. Wolf, Ph.D. — Google Scholar

Peer–Reviewed Original Articles

  • Koch PF, Cottone C, Adam CD, Ulyanova AV, Russo RJ, Weber MT, Arena JD, Johnson VE, Wolf JA. (2020) Traumatic Brain Injury Preserves Firing Rates But Disrupts Laminar Oscillatory Coupling and Neuronal Entrainment in Hippocampal CA1. eNeuro, 0495-19.2020.
  • Ulyanova AV, Cottone C, Adam CD, Gagnon KG, Cullen DK, Holtzman T, Jamieson BG, Koch PF, Chen HI, Johnson VE, Wolf JA. (2019) Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals. Front Neurosci, 2019 Apr 26;13:397. 
  • Ulyanova AV, Koch PF, Cottone C, Grovola MR, Adam CD, Browne KD, Weber MT, Russo RJ, Gagnon KG, Smith DH, Chen HI, Johnson VE, Cullen DK, Wolf JA. (2018) Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus. eNeuro, 0102-18.2018.
  • Morris J,  Na YJ, Zhu H, Lee JH, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O'Rourke DM, Wolf JA, Grady MS, Sul JY, Kim J, Eberwine J. (2017) Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing. Cell Rep, Dec 5;21(10):2706-2713.
  • Wolf JA, Johnson BN, Johnson VE, Putt ME, Browne KD, Mietus CJ, Brown DP, Wofford KL, Smith DH, Grady MS, Cohen AS, Cullen DK. (2017) Concussion Induces Hippocampal Circuitry Disruption in Swine. Journal of Neurotrauma, 34:1-12.
  • Wofford KL, Harris JP, Browne KD, Brown DP, Grovola MG, Mietus CJ, Wolf JA, Duda JE, Putt ME. (2017) Rapid neuroinflammatory response localized to injured neurons after diffuse traumatic brain injury in swine. Experimental Neurology, 290:85-94.
  • Chen HI, Wolf JA, Smith DH. (2017) Multichannel activity propagation across an engineered axon network. Journal of Neural Engineering, 14:2.
  • Spaethling JM, Na YJ, Lee J, Ulyanova AV, Baltuch GH, Bell TJ, Brem S, Chen HI, Dueck H, Fisher SA, Garcia MP, Khaladkar M, Kung DK, Lucas TH, O'Rourke DM, Stefanik D, Wang J, Wolf JA, Bartfai T, Grady MS, Sul JY, Kim J, Eberwine JH. (2017) Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics. Cell Reports, 18(3):791-803.
  • Wolf JA, Koch PF. (2016) Disruption of Network Synchrony and Cognitive Dysfunction After Traumatic Brain Injury. Frontiers in Systems Neuroscience, 10:43.
  • Chen HCI, Jgamadze D, Serruya MD, Cullen DK, Wolf JA, Smith DH. (2016) Neural substrate expansion for the restoration of brain function. Frontiers in Systems Neuroscience, 10:1.
  • Lovatt D, Ruble BK, Lee J, Dueck H, Kim TK, Fisher S, Francis C, Spaethling JM, Wolf JA, Grady MS, Ulyanova AV, Yeldell SB, Griepenburg JC, Buckley PT, Kim J, Sul JY, Dmochowski IJ, Eberwine J. (2014) Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue. Nature Methods, 11:190–196.
  • Struzyna LA, Wolf JA, Mietus CJ, Adewole DO, Chen HI, Smith DH, Cullen DK. (2015) Rebuilding brain circuitry with living micto-tissue engineered neural networks. Tissue Engineering Part A, 21(21-22):2744-2756.
  • Moyer JT, Halterman BL, Finkel LH, Wolf JA. (2014) Lateral and feedforward inhibition suppress asynchronous activity in a large, biophysically-detailed computational model of the striatal network. Frontiers in Computational Neuroscience, 8:152.
  • Pisapia JM, Halpern CH, Muller UJ, Vinai P, Wolf JA, Whiting DM, Wadden TA, Baltuch GH, Caplan AL. (2013) Ethical considerations in deep brain stimulation for the treatment of addiction and overeating associated with obesity. AJOB Neuroscience, 4:35–46.
  • Halpern CH, Tekriwal A, Santollo J, Keating JG, Wolf JA, Daniels D, Bale TL. (2013) Amelioration of Binge Eating by Nucleus Accumbens Shell Deep Brain Stimulation in Mice Involves D2 Receptor Modulation. The Journal of Neuroscience, 33:7122–7129.
  • Cullen DK, Tang-Schomer MD, Struzyna LA, Patel AR, Johnson VE, Wolf JA, Smith DH. (2012) Micro–Tissue Engineered Constructs with Living Axons for Targeted Tract Reconstruction. Tissue Engineering Part A, Nov;18(21-22):2280–9.
  • Stephen JH, Halpern CH, Barrios CJ, Balmuri U, Pisapia JM, Wolf JA, Kampman KM, Baltuch GH, Caplan AL, Stein SC. (2012) Deep brain stimulation compared with methadone maintenance for the treatment of heroin dependence: a threshold and cost–effectiveness analysis. Addiction, 107, 624–634.
  • Halpern, CH, Torres, N, Hurtig, HI, Wolf JA, Stephen, J, Oh, MY, Williams, NN, Dichter, MA, Jaggi, JL, Caplan, AL, Kampman, KM, Wadden, TA, Whiting, DM, Baltuch, GH. (2011). Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management. Acta Neurochir (Wien), 153, 2293–2306.
  • Cullen DK, Wolf JA, Vernekar VN, Vukasinovic J, LaPlaca MC. (2011) Neural Tissue Engineering and Biohybridized Microsystems for Neurobiological Investigation In Vitro (Part 1), Critical Reviews in Biomedical Engineering 39(3), 201–240.
  • Cullen DK, Wolf JA, Smith DH, Pfister BJ. (2011) Neural Tissue Engineering for Neuroregeneration and Biohybridized Interface Microsystems In Vivo (Part 2), Critical Reviews in Biomedical Engineering. 39(3), 241–259.
  • Cullen DK, Browne KD, Xu Y, Adeeb S, Wolf JA, McCarron RM, Yang S, Chavko M, Smith DH. (2011) Blast–Induced Color Change in Photonic Crystals Corresponds with Brain Pathology. J. Neurotrauma, 28:2307–2318.
  • Wolf JA, Finkel LH, Contreras D. (2009) Sublinear summation of afferent inputs to the nucleus accumbens in the awake rat. J Physiology, 587:1695–1704.
  • Ishikawa M, Moyer JT, Wolf JA, Quock RM, Davies NM, Schluter OM, Dong, Y. (2009) Homeostatic Synapse–driven Membrane Plasticity in Nucleus Accumbens Neurons. J Neuroscience, 29:5820–5831.
  • Halpern CH, Wolf JA, Bale TL, Stunkard AJ, Danish SF, Grossman M, Jaggi JL, Grady MS, Baltuch, G. (2008) Deep Brain Stimulation May Play a Role in the Treatment of Obesity. J Neurosurgery 109(4):625–34.
  • Moyer JT, Wolf JA, Finkel LH. (2007) Effects of dopaminergic modulation interact cooperatively to regulate activity–dependent synaptic plasticity in the ventral striatal medium spiny neuron. J Neurophysiology, 98(6):3731–48.
  • Pfister BJ, Iwata A, Taylor AG, Wolf JA, Meaney DF, Smith DH. (2006) Development of transplantable nervous tissue constructs comprised of stretch–grown axons. J Neurosci Methods, 153:95–103.
  • Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit–Marand M, O'Donnell P, Finkel LH. (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neuroscience, 25:9080–9095. (Cover article)
  • Wolf JA, Moyer, JT, Finkel, LH. (2005) The role of NMDA currents in state transitions of the nucleus accumbens medium spiny neuron. Neurocomputing, 65–66:565–70.
  • Iwata A, Stys, PK, Wolf JA, Chen XH, Taylor AG, Meaney DF, Smith DH. (2004) Traumatic axonal injury induces proteolytic cleavage of the voltage–gated sodium channels modulated by tetrodotoxin and protease inhibitors. J Neuroscience, 24:4605–4613.
  • Lusardi TA, Wolf JA, Putt ME, Smith DH, Meaney, DF. (2004) Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neurons. J Neurotrauma, 21:61–72.
  • Lusardi TA, Smith DH, Wolf JA, Meaney DF. (2003) The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons. Biorheology, 40:401–9.
  • Wolf JA, Stys PK, Lusardi T, Meaney D, Smith DH. (2001) Traumatic axonal injury induces calcium influx modulated by tetrodotoxin–sensitive sodium channels. J Neuroscience, 21:1923–1930.
  • Wolf JA, Schroeder LF, Finkel LH. (2001) Computational modeling of medium spiny projection neurons in nucleus accumbens: Toward the cellular mechanisms of afferent stream integration. Proc. IEEE, 89: 1083–1092.
  • Smith DH, Wolf JA, Meaney DF. (2001) A new strategy to produce sustained growth of central nervous system axons: continuous mechanical tension. Tissue Eng 7:131–139.
  • Wolf JA, Schroeder LF, Contreras D, Finkel LH. (2001) Afferent stream integration in a model of the nucleus accumbens. Engineering in Medicine and Biology Society, 1:796-801.
  • Smith DH, Wolf JA, Lusardi TA, Lee VM, Meaney DF. (1999) High tolerance and delayed elastic response of cultured axons to dynamic stretch injury. J Neuroscience, 19:4263–4269.
  • Chen XH, Meaney DF, Xu BN, Nonaka M, McIntosh TK, Wolf JA, Saatman KE, Smith DH. (1999) Evolution of neurofilament subtype accumulation in axons following diffuse brain injury in the pig. J Neuropathol Exp Neurol, 58:588–96.
  • Smith DH, Chen XH, Nonaka M, Trojanowski JQ, Lee VM, Saatman KE, Leoni MJ, Xu BN, Wolf JA, Meaney DF. (1999) Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. J Neuropathol Exp Neurol, 58:982–92.
  • Nonaka M, Chen X, Pierce J, Leoni MJ, McIntosh TK, Wolf JA, Smith DH. (1999) Prolonged activation of NK-kB following traumatic brain injury in rats. Journal of Neurotrauma, 16(11):1023-1034.
  • Smith DH, Chen XH, Pierce JE, Wolf JA, Trojanowski, JQ, Graham, DI, McIntosh, TK. (1997) Progressive atrophy and neuron death for one year following brain trauma in the rat. J Neurotrauma, 14:715–27.

Invited Book Chapters and Commentaries

  • Cullen DK, Harris JP, Browne KD, Wolf JA, Duda JE, Meaney DF, Margulies SS, Smith DH. (2016) A Porcine Model of Traumatic Brain Injury via Head Rotational Acceleration. Injury Models of the Central Nervous System,  Ed: Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello, Human Press & Springer Protocols.
  • Wolf JA. (2011) Optogenetics 101: A Light Revolution in Neuroscience. ScienceProgress
  • Halpern CH, Church E, Wolf JA, Bale TL, Stunkard AJ, Wadden TA, Jaggi JL, Wadden T, Grady MS, Baltuch GH. (2011) Eds Vinai. Neurosurgery in the treatment of obesity. (in press)
  • Wolf JA, Moyer JT, Finkel LH. (2008) The effects of dopaminergic modulation on afferent input integration in the ventral striatal medium spiny neuron. The Basal Ganglia IX, Ed. Henk Groenewegen, Springer.
  • Wolf JA, Moyer JT (2008) Dopaminergic Modulation of Corticostriatal Interactions and Implications for Parkinson's Disease. Cortico–subcortical Dynamics in Parkinson's Disease, Ed: Kuei Y. Tseng, Humana Press & Springer Editorials.