Home | News | Directories | Calendar | Maps | Contact Us | Webmail
Penn Medicine Advanced Search

Peter F. Davies, Ph.D., Sc.D.

Peter F. Davies, Ph.D., Sc.D.

faculty photo
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
Education:
B.Sc. (Chemistry/Ag. Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, 1969.
M.Sc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
University of Cambridge, 1975.
Sc.D. (Higher Doctorate)
University of Cambridge, 2015.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, systems biology, systems biology, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Systems biology of the endothelium. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics and computational fluid dynamics. Endocardial endothelium and 4D-flow MRI.

Rotation Projects
Please discuss with Dr. Davies.

Lab Personnel:
Juan Jimenez PhD, Postdoctoral Fellow
Margaret McCormick PhD, Postdoctoral Fellow
Yizhou Jiang PhD, Postdoctoral Fellow
Technical Staff: Congzhu Shi PhD
Alex Sotolongo, Medical School Fellow

Description of Other Expertise

Biophysics; Lipid metabolism

Selected Publications

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. Journal of Biomechanics In Press , December 2016.

Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang Y-Z: Perspectives. Cell Mechanics and Epigenetics: Flow-induced Epigenetic Mechanisms of Mechanotransduction in the Endothelium. Journal of Biomechanics In Press, November 2016.

Davies PF, Manduchi E, Stoeckert CJ, Jiang YZ: Endothelial epigenetics and its role in mediating biomechanical stress of hypertension. J. Hypertension 34; Suppl 1-ISH 2016: e371, September 2016.

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Integrated regional cardiac hemodynamic imaging and RNA sequencing reveals corresponding heterogeneity of ventricular wall shear stress and the endocardial transcriptome. J Am Heart Assoc 18;5(4). pii: e003170.: doi: 10.1161/JAHA.115.003170, April 2016.

Davies P.F.: In: LabStudio: Design Research Between Architecture & Biology. Sabin J and Jones P. Pub: Routledge / Taylor and Francis (2016). In Press. Routledge / Taylor and Francis In Press(In Press), In Press 2016.

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. J. Clin Invest. 125: 2995-3007, August 2015.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release 210: 39-47, July 2015.

Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics 16: 506, July 2015.

Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR. : Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. 9(7): 6785-6793, July 2015.

Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35: 1317-1326, June 2015.

back to top
Last updated: 12/05/2016
The Trustees of the University of Pennsylvania