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Peter F. Davies, Ph.D.

Peter F. Davies, Ph.D.

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Robinette Foundation Professor of Cardiovascular Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
Education:
BSc. (Chemistry/Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, UK, 1969.
MSc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
Cambridge University, UK, 1975.
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Description of Research Expertise

CVI Program Unit Administrator:
Biotechnology / Nanomedicine / Imaging

Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics andcomputational fluid dynamics. Stent design.

Rotation Projects
Please discuss with Dr. Davies.

Lab Personnel:
Juan Jimenez PhD, Postdoctoral Fellow
Armen Karamanian MD, Graduate Student
Mete Civelek PhD, Postdoctoral Fellow
Yun Fang PhD, Postdoctoral Fellow
Jennifer Clark PhD, Postdoctoral Fellow
Technical Staff: Congzhu Shi PhD, Technical Staff

Description of Other Expertise

Biophysics; Lipid metabolism

Selected Publications

172. Jimenez, J.M., Prasad, V., Yu, M., Kampmeyer, C., Kaakour, A-H., Wang, P., Maloney, S.F., Wright, N., Johnston, I., Jiang, Y-Z., Davies P.F. : Macro and microscale variables regulate coronary stent hemodynamics, fibrin deposition and thrombomodulin expression. J. Royal Society Interface. The Royal Society, London, In Press, February 19th 2014.

Karamanian, A., Jimenez, J.M., Davies, P.F. : Loss of flow-sensitive endothelial Claudin-5 expression at atherosusceptibility sites in vivo. Circulation Research In preparation 2013.

Fang, Y. and Davies P.F.: MicroRNA-92a regulates Kruppel-like Factors 4 and 2 (KLF4; KLF2) in athero-susceptible endothelium. ATVB 32: 979-987, Jan 2012.

Han, J., Zern, B., Shuvaev, V., Davies, P.F., Muzykantov, V. : Acute and chronic shear stress differentially regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1 (PECAM-1). ACS Nano 6: 8824-8836, 2012.

Civelek, M., Manduchi, E., Riley R, Stoeckert CJ, Davies PF. : Coronary artery endothelial transcriptome in vivo: Identification of ER-stress and enhanced ROS by gene connectivity network analysis. Circulation Cardiovascular Genetics 4: 243-252, May 2011.

Guerraty, M.A., Grant, G., Pritchard, W.P., Karanian, J.W., Chiesa, O.A., Davies, P.F. : Site-specific expression of activated leukocyte adhesion molecule (ALCAM/CD166) in patho-susceptible regions of swine aortic valve endothelium. J. Heart Valve Disease 20: 165-167, March 2011.

Fang, Y., Shi, C., Manduchi, E., Grant, G., Davies, P.F.: MicroRNA-10a regulation of pro-inflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc. Natl. Acad Sci. USA 107: 13450-5, July 2010.

Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG: Endothelial Heterogeneity associated with Regional Athero-susceptibility and Adaptation to Disturbed Blood Flow in vivo. Seminars in Thrombosis and Hemostasis 36: 265-275, May 2010 Notes: Special Issue: Under-recognized Significance of Endothelial Heterogeneity.

Guerraty, M.A, Grant, G.R., Karanian, J.W., Chiesa, O.A., Pritchard, W.P., Davies, P.F.: Hypercholesterolemia induces side-specific phenotype changes and PPARγ pathway activation in swine aortic valve endothelium. Arterio. Thromb. Vasc. Biol. 30: 225-231, Feb 2010.

Civelek, M., Grant, GR, Irolla, CR, Shi C, Riley R, Chiesa O, Stoeckert CJ, Karanian JW, Pritchard WF, Davies PF. : Pre-lesional arterial endothelial responses in hypercholesterolemia: Universal ATP-Binding Cassette A1 (ABCA1) upregulation contrasts with region-specific gene expression in vivo. Am. J. Physiology (Heart and Circulatory) 298: 163-170, Feb 2010.

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Last updated: 02/25/2014
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