Perelman School of Medicine at the University of Pennsylvania

Penn Institute for Immunology

Douglas B. Cines

faculty photo
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Education:
A.B. (History, PreMed)
New York University, 1968.
M.D. (Medicine)
New York University School of Medicine, 1972.
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Description of Research Expertise

Thormbosis, fibrinolysis, vascular biology, immunohematology

Description of Clinical Expertise

Coagulation. Immune hematological disorders

Selected Publications

Armstead William M, Hekierski Hugh, Pastor Philip, Yarovoi Serge, Higazi Abd Al-Roof, Cines Douglas B: Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK. Translational stroke research Feb 2018.

Villa Carlos H, Pan Daniel C, Johnston Ian H, Greineder Colin F, Walsh Landis R, Hood Elizabeth D, Cines Douglas B, Poncz Mortimer, Siegel Don L, Muzykantov Vladimir R: Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood advances 2(3): 165-176, Feb 2018.

Florova, G., Azghani, A., Karandashova, S., Schaefer, C., Yarovoi S.V., Declerck, P.J., Cines, D.B., Idell, S. and Komissarov, A.A. : Targeting Plasminogen Activator Inhibitor 1 in Tetracycline-Induced Pleural Injury in Rabbits. Am J Physiol Lung Cell Molec Physiol 314(1): L54-L68, 2018.

Greineder, C.F., Johnston, I.H., Villa, C.H., Golluop, K., Esmon, C.T., Cines, D.B., Poncz, M. and Muzykantov, V.R. : ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model. Blood Advances 1(18): 1452-65, July 2017.

Dai, J., Hayes, V., Johnston, I., Gollomp, K., Areaplly, G.M., Cines, D.B., Poncz, M. and Raouva, L.: Dynamic redistribution of platelet factor 4 on vascular and intravascular cell surfaces: Implications for heparin-induced thrombocytopenia (HIT). ISTH. Berlin, Germany June 2017.

Cines D.B., Levine L.D.: Thrombocytopenia in pregnancy. Blood June 2017 Notes: prepublished online June 21, 2017; DOI 10.1182/blood-2017-05-781971.

Andrianova, I., Hayes, V., Litvinov, R., Cines, D.B., Poncz, M., Weisel, J.W. and Rauova, L.: Pathogenic antibodies in heparin-induced thrombocytopenia (HIT) activate monocytes and induce profound membrane remodeling. ISTH. Berlin, Germany June 2017.

Johnston, I., Lopez, J, Cines, D.B., Raouva, L. and Poncz, M.: Platelet factor 4: Von Willebrand Factor Complexes: An Important Antigenic Target in Heparin-Induced Thrombocytopenia? ISTH. Berlin, Germany June 2017.

Bdeir, Kh., Mei, J., Gollomp, K., Stasiak, M., Zhou, G., Cines, D.B., Worthein, G.S., Poncz, M. and Kowalska, M.A.: Platelet-specific chemokines contribute to the pathogenesis of acute lung injury. American Journal of Respiratory Cell and Molecular Biology 56(2): 261-270, Feb 2017 Notes: PMID: 27755915.

Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M.: Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. The Journal of Clinical Investigation 127(3): 1090-1098, Feb 2017 Notes: PMID: 28218620.

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Last updated: 03/23/2018
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