Ahmed Diab, PhD
Assistant Professor of Otorhinolaryngology: Head and Neck Surgery
Core Member, Center for Genome Integrity
Member, Institute for Immunology & Immune Health (I3H)
Member, Institute of Translational Medicine and Therapeutics
Member, Abramson Cancer Center Cancer Therapeutics Program
Department: Otorhinolaryngology: Head and Neck Surgery
Graduate Group Affiliations
Contact information
Department of Otorhinolaryngology, Head and Neck Surgery
Perelman School of Medicine at the University of Pennsylvania
Biomedical Research Building BRB1209
421 Curie Blvd
Philadelphia, PA 19104
Perelman School of Medicine at the University of Pennsylvania
Biomedical Research Building BRB1209
421 Curie Blvd
Philadelphia, PA 19104
Publications
Education:
B.S. (Biology, Minor in Chemistry, Magna Cum Laude)
The American University in Cairo (AUC), Egypt, 2010.
M.S. (Biosciences)
King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, 2011.
Ph.D. (Cancer Biology)
Purdue University, West Lafayette, IN, 2016.
Permanent linkB.S. (Biology, Minor in Chemistry, Magna Cum Laude)
The American University in Cairo (AUC), Egypt, 2010.
M.S. (Biosciences)
King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, 2011.
Ph.D. (Cancer Biology)
Purdue University, West Lafayette, IN, 2016.
Selected Publications
Thirimanne HN, Wu F, Janssens DH, Swanger J, Diab A, Feldman H, Amezquita RA, Gottardo R, Paddison PJ, Henikoff S, Clurman BE: Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations. Elife 11: e74338, Feb 2022.Diab A, Gem H, Swanger J, Kim HY, Smith K, Zou G, Raju S, Kao m, Fitzgibbon M, Loeb KR, Rodriquez CP, Mendez E, Galloway DA, Sidorova JM, Clurman BE: FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition. Proc Natl Acad Sci U S A 117(45): 28287-28296, Nov 2020.
Diab A, Kao M, Kehrli K, Kim HY, Sidorova J, Mendez E: Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition. Mol Cancer Res 17(5): 1115-1128, May 2019.
Mendez E, Rodriquez CP, Kao MC, Raju S, Diab A, Harbison RA, Konnick EQ, Mugundu GM, Santana-Davila R, Martins R, Futran ND, Chow LQM: A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res 24(12): 2740-2748, Jun 2018.
Diab A, Foca A, Zoulim F, Durantel D, Andrisani O: The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals. Antiviral Res 149: 211-220, Jan 2018.
Diab A, Foca A, Fusil F, Lahlali T, Jalaguier P, Amirache F, N'Guyen L, Isorce N, Cosset FL, Zoulim F, Andrisani O, Durantel D: Polo-like-kinase 1 is a proviral host factor for hepatitis B virus replication. Hepatology 66(6): 1750-1765, Dec 2017.
Fan H, Cui Z, Zhang H, Mani SK, Diab A, Lefrancois L, Fares N, Merle P, Andrisani O: DNA demethylation induces SALL4 gene re-expression in subgroups of hepatocellular carcinoma associated with Hepatitis B or C virus infection. Oncogene 36(17): 2435-2445, Apr 2017.
Mani SK, Zhang H, Diab A, Pascuzzi PE, Lefancois L, Fares N, Bancel B, Merle P, Andrisani O: EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. J Hepatol 65(5): 888-898, Nov 2016.
Diab A, Foca A, Jalaguier P, Isorce N, Zoulim F, Andrisani O, Durantel D : The hepatitis B virus (HBV) highjacks polo-like-kinase1 activity to its own benefit: therapeutic implications Hepatitis B Meeting, Bad Nauheim, Germany Oct 2015 Notes: oral presentation.
Zhang H, Diab A, Fan H, Mani SK, Hullinger R, Merle P, Andrisani O: PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis. Cancer Res 75(11): 2363-74, Jun 2015.