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Ahmed Diab, PhD
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Assistant Professor of Otorhinolaryngology: Head and Neck Surgery
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Core Member, Center for Genome Integrity
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Member, Institute of Translational Medicine and Therapeutics
6d
Member, Institute for Immunology & Immune Health (I3H)
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Member, Abramson Cancer Center Cancer Therapeutics Program
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Assistant Investigator, Abramson Family Cancer Research Institute
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Department: Otorhinolaryngology: Head and Neck Surgery
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1
23
1f
Graduate Group Affiliations
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b
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6b
- Cell and Molecular Biology 6a
- Pharmacology 5c
- Immunology e
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Contact information
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Department of Otorhinolaryngology, Head and Neck Surgery
45 Perelman School of Medicine at the University of Pennsylvania
2c Biomedical Research Building BRB1209
31 421 Curie Blvd
Philadelphia, PA 19104
26
45 Perelman School of Medicine at the University of Pennsylvania
2c Biomedical Research Building BRB1209
31 421 Curie Blvd
Philadelphia, PA 19104
35
a3
12
18
Publications
23 a
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2
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Education:
21 9 B.S. 39 (Biology, Minor in Chemistry, Magna Cum Laude) c
46 The American University in Cairo (AUC), Egypt, 2010.
21 9 M.S. 18 (Biosciences) c
6c King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, 2011.
21 a Ph.D. 1b (Cancer Biology) c
3e Purdue University, West Lafayette, IN, 2016.
c
3
3
3
3
8d
Permanent link21 9 B.S. 39 (Biology, Minor in Chemistry, Magna Cum Laude) c
46 The American University in Cairo (AUC), Egypt, 2010.
21 9 M.S. 18 (Biosciences) c
6c King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, 2011.
21 a Ph.D. 1b (Cancer Biology) c
3e Purdue University, West Lafayette, IN, 2016.
c
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1f Tumor Microenvironment
10 Virology
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Description of Research Expertise
34 Cancer Immunology and Immunotherapy1f Tumor Microenvironment
10 Virology
e 29
23
205 Apurva T. Prabhakar, Claire D. James, Allison Q. Nguyen, Phoebe V. Bridy, Xu Wang, Ryan J. Zoldork, Jenny D. Roe, Austin J. Witt, Srimanya S. Panidepu, Molly L. Bristol, Krista Dalton, Andreas Wieland, Ahmed Diab, Anthony C. Faber, Elliot J. Androphy, Devraj Basu, Paul F. Lambert, Megan E. Spurgeon, Iain M. Morgan: E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cycles. BioRxiv October 2025.
1cf Sannigrahi MK, Raghav L, Rich DJ, Schrank TP, Califano JA, Lukens JN, Sun L, Morgan IM, Cohen RB, Lin A, Liu X, Brown EJ, You J, Mirabello L, Mishra SK, Shimunov D, Brody RM, Pearson AT, Gimotty PA, Diab A, Jalaly JB, Basu D. : Tumor-intrinsic and immune-related features associated with treatment failure in human papillomavirus-related oropharyngeal cancer. J Natl Cancer Inst March 2025.
171 Miller ZA, Muthuswami S, Mueller A, Ma RZ, Sywanycz SM, Naik A, Huang L, Brody RM, Diab A, Carey RM, Lee RJ. : GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells. Cell Death Discov 10(1):339, July 2024
1c3 Sannigrahi MK, Raghav L, Rich DJ, Schrank TP, Califano JA, Lukens JN, Sun L, Morgan IM, Cohen RB, Lin A, Liu X, Brown EJ, You J, Mirabello L, Mishra SK, Shimunov D, Brody RM, Pearson AT, Gimotty PA, Diab A, Jalaly JB, Basu D.: Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability. bioRxiv November 2024.
13a Malay K. Sannigrahi, Lovely Raghav, Ahmed Diab, Devraj Basu: The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas. Tumour Virus Research November 2024.
139 Thirimanne HN, Wu F, Janssens DH, Swanger J, Diab A, Feldman H, Amezquita RA, Gottardo R, Paddison PJ, Henikoff S, Clurman BE: Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations. Elife 11: e74338, Feb 2022.
150 Diab A, Gem H, Swanger J, Kim HY, Smith K, Zou G, Raju S, Kao m, Fitzgibbon M, Loeb KR, Rodriquez CP, Mendez E, Galloway DA, Sidorova JM, Clurman BE: FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition. Proc Natl Acad Sci U S A 117(45): 28287-28296, Nov 2020.
10f Diab A, Kao M, Kehrli K, Kim HY, Sidorova J, Mendez E: Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition. Mol Cancer Res 17(5): 1115-1128, May 2019.
1a4 Mendez E, Rodriquez CP, Kao MC, Raju S, Diab A, Harbison RA, Konnick EQ, Mugundu GM, Santana-Davila R, Martins R, Futran ND, Chow LQM: A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res 24(12): 2740-2748, Jun 2018.
2c
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1d
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Selected Publications
304 Simone L. Park, Mark M. Painter, Sasikanth Manne, Victor Alcalde, Maura McLaughlin, Matthew A. Sullivan, Divij Mathew, Leonel Torres, Yinghui J. Huang, David B. Reeg, Naomi R. Douek, Trenton Campos, Max Klapholz, Maria A. Cardenas, Victoria Fang, Shin Foong Ngiow, KC Wumesh, Rishi R. Goel, Amy E. Baxter, Jennifer E. Wu, Melody Tan, Corbett T. Berry, Christoph T. Ellebrecht, Alexander C. Huang, Emily Papazian, Ying Liu, Karthik Rajasekaran, Robert M. Brody, Erica R. Thaler, Devraj Basu, Ahmed Diab, Josephine R. Giles, E. John Wherry: Divergent ontogeny of tissue resident memory and tissue resident exhausted CD8+ T cells underlies distinct functional potential. Nature Immunology October 2025.205 Apurva T. Prabhakar, Claire D. James, Allison Q. Nguyen, Phoebe V. Bridy, Xu Wang, Ryan J. Zoldork, Jenny D. Roe, Austin J. Witt, Srimanya S. Panidepu, Molly L. Bristol, Krista Dalton, Andreas Wieland, Ahmed Diab, Anthony C. Faber, Elliot J. Androphy, Devraj Basu, Paul F. Lambert, Megan E. Spurgeon, Iain M. Morgan: E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cycles. BioRxiv October 2025.
1cf Sannigrahi MK, Raghav L, Rich DJ, Schrank TP, Califano JA, Lukens JN, Sun L, Morgan IM, Cohen RB, Lin A, Liu X, Brown EJ, You J, Mirabello L, Mishra SK, Shimunov D, Brody RM, Pearson AT, Gimotty PA, Diab A, Jalaly JB, Basu D. : Tumor-intrinsic and immune-related features associated with treatment failure in human papillomavirus-related oropharyngeal cancer. J Natl Cancer Inst March 2025.
171 Miller ZA, Muthuswami S, Mueller A, Ma RZ, Sywanycz SM, Naik A, Huang L, Brody RM, Diab A, Carey RM, Lee RJ. : GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells. Cell Death Discov 10(1):339, July 2024
1c3 Sannigrahi MK, Raghav L, Rich DJ, Schrank TP, Califano JA, Lukens JN, Sun L, Morgan IM, Cohen RB, Lin A, Liu X, Brown EJ, You J, Mirabello L, Mishra SK, Shimunov D, Brody RM, Pearson AT, Gimotty PA, Diab A, Jalaly JB, Basu D.: Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability. bioRxiv November 2024.
13a Malay K. Sannigrahi, Lovely Raghav, Ahmed Diab, Devraj Basu: The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas. Tumour Virus Research November 2024.
139 Thirimanne HN, Wu F, Janssens DH, Swanger J, Diab A, Feldman H, Amezquita RA, Gottardo R, Paddison PJ, Henikoff S, Clurman BE: Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations. Elife 11: e74338, Feb 2022.
150 Diab A, Gem H, Swanger J, Kim HY, Smith K, Zou G, Raju S, Kao m, Fitzgibbon M, Loeb KR, Rodriquez CP, Mendez E, Galloway DA, Sidorova JM, Clurman BE: FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition. Proc Natl Acad Sci U S A 117(45): 28287-28296, Nov 2020.
10f Diab A, Kao M, Kehrli K, Kim HY, Sidorova J, Mendez E: Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition. Mol Cancer Res 17(5): 1115-1128, May 2019.
1a4 Mendez E, Rodriquez CP, Kao MC, Raju S, Diab A, Harbison RA, Konnick EQ, Mugundu GM, Santana-Davila R, Martins R, Futran ND, Chow LQM: A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res 24(12): 2740-2748, Jun 2018.
2c