Michael C. Milone

faculty photo
Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
3400 Spruce Street 7103 Founders Pavilion
Philadelphia, PA 19104
Office: 215-662-6575
Fax: 215-662-7529
B.S (Chemical Biology)
Stevens Institute of Technology, 1993.
Ph.D (Experimental Pathology/ Immunology)
UMDNJ - Graduate School of Biomedical Sciences, 1999.
M.D. (Medical Doctor)
UMDNJ- New Jersey Medical School, 1999.
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Description of Research Expertise

Research in my laboratory aims toward improving cancer and transplantation therapy through the development of new immunotherapeutic modalities. Active research projects in my laboratory include:

1) Developing improved chimeric antigen receptors (CARs) for adoptive immunotherapy of cancer.

These projects are focused upon understanding the mechanisms of signal transduction of artificial chimeric antigen receptors through traditional biochemical studies along with high resolution dynamic imaging of artificial and natural T cell receptors. New CAR designs are also under development to permit more controlled activation of T cells.

2) Developing novel T cell stimulatory substrates based upon nano- and micro-fabricated surfaces for control of T cell proliferation and differentiation.

This project is part of a collaborative effort supported by the NIH Common Fund. Details of this project can be found at the center's website (www.mechanicalbiology.org) or the NIH common fund site (http://commonfund.nih.gov/nanomedicine/devcenters/mechanicalbiology.asp)

Description of Clinical Expertise

Clinical Laboratory Toxicology, Therapeutic Drug Monitoring, Clinical Chemistry, Blood Banking/Transfusion Medicine, Therapeutic Apheresis

Selected Publications

Porter David L, Hwang Wei-Ting, Frey Noelle V, Lacey Simon F, Shaw Pamela A, Loren Alison W, Bagg Adam, Marcucci Katherine T, Shen Angela, Gonzalez Vanessa, Ambrose David, Grupp Stephan A, Chew Anne, Zheng Zhaohui, Milone Michael C, Levine Bruce L, Melenhorst Jan J, June Carl H: Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Science translational medicine 7(303): 303ra139, Sep 2015.

Wang E, Wang LS, Tsai C, Bhoj V, Gershenson Z, et al.: Generation of Potent T cell Immunotherapy for Cancer using DAP12-based, Multichain, Chimeric Immunoreceptors. Cancer immunology research In Press, May 2015.

Xiang Yan, Stine Zachary E, Xia Jinsong, Lu Yunqi, O'Connor Roddy S, Altman Brian J, Hsieh Annie L, Gouw Arvin M, Thomas Ajit G, Gao Ping, Sun Linchong, Song Libing, Yan Benedict, Slusher Barbara S, Zhuo Jingli, Ooi London L, Lee Caroline G L, Mancuso Anthony, McCallion Andrew S, Le Anne, Milone Michael C, Rayport Stephen, Felsher Dean W, Dang Chi V: Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. The Journal of clinical investigation In press, Apr 2015.

Frigault Matthew J, Lee Jihyun, Basil Maria Ciocca, Carpenito Carmine, Motohashi Shinichiro, Scholler John, Kawalekar Omkar U, Guedan Sonia, McGettigan Shannon E, Posey Avery D, Ang Sonny, Cooper Laurence J N, Platt Jesse M, Johnson F Brad, Paulos Chrystal M, Zhao Yangbing, Kalos Michael, Milone Michael C, June Carl H: Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells. Cancer immunology research Jan 2015.

Moon Edmund K, Wang Liang-Chuan, Dolfi Douglas V, Wilson Caleph B, Ranganathan Raghuveer, Sun Jing, Kapoor Veena, Scholler John, Puré Ellen, Milone Michael C, June Carl H, Riley James L, Wherry E John, Albelda Steven M: Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20(16): 4262-73, Aug 2014.

Bashour Keenan T, Tsai Jones, Shen Keyue, Lee Joung-Hyun, Sun Eileen, Milone Michael C, Dustin Michael L, Kam Lance C: Crosstalk between CD3 and CD28 is spatially modulated by protein lateral mobility. Molecular and Cellular Biology Page: 955-64, Mar 2014.

Cardamone David, Milone Michael C, Glaser Laurel, Frey Noelle V, Kricka Larry J: Eltrombopag and serum of a different hue. Archives of pathology & laboratory medicine 137(9): 1175, Sep 2013.

Grupp Stephan A, Kalos Michael, Barrett David, Aplenc Richard, Porter David L, Rheingold Susan R, Teachey David T, Chew Anne, Hauck Bernd, Wright J Fraser, Milone Michael C, Levine Bruce L, June Carl H: Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. The New England journal of medicine 368(16): 1509-18, Apr 2013.

LeGall J, Milone MC, Waxman I, Shaw LM, Harrison L, Duffy D, van de Ven C, Militano O, Geyer MB, Morris E, Bhatia M, Satwani P, George D, Garvin JH, Bradley MB, Schwartz J, Baxter-Lowe LA, Cairo MS.: The Pharmacokinetics and Safety of Twice Daily Intravenous Busulfan During Conditioning in Pediatric Allogeneic Stem Cell Transplantation Recipients. Bone Marrow Transplant. 48(1): 19-25, Jan 2013.

Kunii Naoki, Zhao Yangbing, Jiang Shuguang, Liu Xiaojun, Scholler John, Balagopalan Lakshmi, Samelson Lawrence E, Milone Michael C, June Carl H: Enhanced function of redirected human T cells expressing linker for activation of T-cells that is resistant to ubiquitylation. Human gene therapy 24(1): 27-37, Jan 2013.

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Last updated: 09/17/2015
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