Devon J Shedlock
Department: Microbiology
Contact information
University of Pennsylvania
Room 8-110C, TRC Building 421
3400 Civic Center Blvd.
Philadelphia, PA 19104-5156
Room 8-110C, TRC Building 421
3400 Civic Center Blvd.
Philadelphia, PA 19104-5156
Office: 215-746-1886
Lab: 215-573-1947
Lab: 215-573-1947
Email:
shedlock@exchange.upenn.edu
shedlock@exchange.upenn.edu
Publications
Links
Search PubMed for articles
Department of Pathology & Laboratory Medicine
Abramson Family Cancer Research Institute
Perelman School of Medicine
Abramson Cancer Center
Search PubMed for articles
Department of Pathology & Laboratory Medicine
Abramson Family Cancer Research Institute
Perelman School of Medicine
Abramson Cancer Center
Education:
BS (Biology)
Ursinus College, 1999.
PhD (Cell & Molecular Biology)
University of Pennsylvania School of Medicine, 2003.
Permanent linkBS (Biology)
Ursinus College, 1999.
PhD (Cell & Molecular Biology)
University of Pennsylvania School of Medicine, 2003.
Description of Research Expertise
Our research focuses on the preclinical development and evaluation of novel T cell-based therapies for cancer.Keywords: Immunology, Adaptive, Cancer, Therapy, Vaccine, T cell, CAR
Group Personnel:
Selected Publications
Shedlock Devon J, Bailey Michael A, Popernack Paul M, Cunningham James M, Burton Dennis R, Sullivan Nancy J: Antibody-mediated neutralization of Ebola virus can occur by two distinct mechanisms. Virology 401(2): 228-35, Jun 2010.Shedlock Devon J, Talbott Kendra T, Morrow Matthew P, Ferraro Bernadette, Hokey David A, Muthumani Karuppiah, Weiner David B: Ki-67 staining for determination of rhesus macaque T cell proliferative responses ex vivo. Cytometry. Part A : the journal of the International Society for Analytical Cytology 77(3): 275-84, Mar 2010.
Shedlock Devon J, Silvestri Guido, Weiner David B: Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials. Nature reviews. Immunology 9(10): 717-28, Oct 2009.
Muthumani Karuppiah, Choo Andrew Y, Shedlock Devon J, Laddy Dominick J, Sundaram Senthil G, Hirao Lauren, Wu Ling, Thieu Khanh P, Chung Christopher W, Lankaraman Karthikbabu M, Tebas Pablo, Silvestri Guido, Weiner David B: Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism. Journal of virology 82(23): 11536-44, Dec 2008.
Shedlock Devon J, Hwang Daniel, Choo Andy Y, Chung Christopher W, Muthumani Karuppiah, Weiner David B: HIV-1 viral genes and mitochondrial apoptosis. Apoptosis : an international journal on programmed cell death 13(9): 1088-99, Sep 2008.
Ekkens Melinda J, Shedlock Devon J, Jung Euihye, Troy Amy, Pearce Erika L, Shen Hao, Pearce Edward J: Th1 and Th2 cells help CD8 T-cell responses. Infection and immunity 75(5): 2291-6, May 2007.
Sullivan Nancy J, Geisbert Thomas W, Geisbert Joan B, Shedlock Devon J, Xu Ling, Lamoreaux Laurie, Custers Jerome H H V, Popernack Paul M, Yang Zhi-Yong, Pau Maria G, Roederer Mario, Koup Richard A, Goudsmit Jaap, Jahrling Peter B, Nabel Gary J: Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs. PLoS medicine 3(6): e177, Jun 2006.
Pearce Erika L, Shedlock Devon J, Shen Hao: Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice. Journal of immunology (Baltimore, Md. : 1950) 173(4): 2494-9, Aug 2004.
Shedlock Devon J, Shen Hao: Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science (New York, N.Y.) 300(5617): 337-9, Apr 2003.
Shedlock Devon J, Whitmire Jason K, Tan Joyce, MacDonald Andrew S, Ahmed Rafi, Shen Hao: Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. Journal of immunology (Baltimore, Md. : 1950) 170(4): 2053-63, Feb 2003.