Hamid Bassiri

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3501 Civic Center Blvd.
Colket Translational Research Bldg, Room 3014
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Office: 267-425-2133
Fax: 215-590-3770
Lab: 267-426-7626
BA (Biology)
University of Pennsylvania, 1991.
PhD (Immunology)
University of Pennsylvania School of Medicine, 2002.
University of Pennsylvania School of Medicine, 2004.
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Description of Research Expertise

Our lab is interested in mechanisms of tumor immune surveillance and ways to harness the activity of innate lymphocytes for cellular cancer immunotherapy. The current projects in the lab include:
1) Directing natural killer T cell anti-tumor responses
2) Alterations in tumor microenvironment with polyamine antagonism
3) Mechanisms of chimeric antigen receptor T cell-mediated cytokine storm syndrome
4) Effect of augmenting TCR-mediated signals in chronic viral infections

Natural killer T cells
Tumor microenvironment
Cellular immunotherapy

Jennie Altman (Lab manager and Research technician)
Adriana Benavides (Post-doctoral fellow)
Gabrielle Ferry (Research technician)

Description of Clinical Expertise

Pediatric infectious diseases (care of immunocompetent and immunocompromised patients)
General pediatrics

Selected Publications

Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE.: iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer Immunology Research 2(1): 59-69, Jan 2014.

Bassiri H, Das R, Nichols KE.: Invariant NKT cells: Killers and conspirators against cancer. OncoImmunology 2(12): e27440, Dec 2013.

Das R, Bassiri H, Guan P, Wiener S, Banerjee PP, Zhong M-C, Veillette A, Orange JS, Nichols KE.: The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17): 3386-3395, Feb 2013.

May RM, Okumura M, Hsu C-J, Bassiri H, Yang E, Rak G, Mace EM, Philip NH, Zhang W, Baumgart T, Orange JS, Nichols KE, Kambayashi T.: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood 121(16): 3135-3146, Feb 2013.

Cen O, Ueda A, Guzman L, Jain J, Bassiri H, Nichols KE, Stein PL.: The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. Journal of Immunology 182(3): 1370-8, Feb 2009.

Nunez-Cruz S, Yeo WCJ, Rothman J, Ojha P, Bassiri H, Juntilla M, Davidson D, Veillette A, Koretzky GA, Nichols KE.: Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of Immunology 181(4): 2311-20, Aug 2008.

Bassiri H, Janice YWC, Rothman J, Koretzky GA, Nichols KE.: X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunologic Research 42(1-3): 145-59, 2008.

Bassiri H, Carding SR.: A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. Journal of Immunology 166(10): 5945-54, May 2001.

Reya T, Bassiri H, Biancaniello R, Carding SR.: Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. Developmental Immunology 5(4): 287-302, 1998 Notes: Shared first authorship.

Contractor NV, Bassiri H, Reya T, Park AY, Baumgart DC, Wasik MA, Emerson SG, Carding SR.: Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. Journal of Immunology 160(1): 385-94, Jan 1998 Notes: Shared first authorship.

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Last updated: 08/05/2015
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