Hamid Bassiri

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics

Contact information
3501 Civic Center Blvd.
Colket Translational Research Bldg, Room 3014
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Office: 267-425-2133
BA (Biology)
University of Pennsylvania, 1991.
PhD (Immunology)
University of Pennsylvania School of Medicine, 2002.
University of Pennsylvania School of Medicine, 2004.
Permanent link
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Description of Research Expertise

T cell development
Tumor biology
Natural killer T cells

Description of Clinical Expertise

Pediatric infectious diseases (care of immunocompetent and immunocompromised patients)
General pediatrics

Selected Publications

Das Rupali, Bassiri Hamid, Guan Peng, Wiener Susan, Banerjee Pinaki P, Zhong Ming-Chao, Veillette André, Orange Jordan S, Nichols Kim E: The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood Feb 2013 Notes: Epub ahead of print Feb 21 2013.

May Rebecca M, Okumura Mariko, Hsu Chin-Jung, Bassiri Hamid, Yang Enjun, Rak Gregory, Mace Emily M, Philip Naomi H, Zhang Weiguo, Baumgart Tobias, Orange Jordan S, Nichols Kim E, Kambayashi Taku: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood Feb 2013 Notes: Epub ahead of print Feb 13 2013

Cen Osman, Ueda Aki, Guzman Laura, Jain Jimmy, Bassiri Hamid, Nichols Kim E, Stein Paul L: The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. Journal of immunology (Baltimore, Md. : 1950) 182(3): 1370-8, Feb 2009.

Bassiri Hamid, Janice Yeo W C, Rothman Jennifer, Koretzky Gary A, Nichols Kim E: X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunologic research 42(1-3): 145-59, 2008.

Nunez-Cruz Selene, Yeo W C Janice, Rothman Jennifer, Ojha Priti, Bassiri Hamid, Juntilla Marisa, Davidson Dominique, Veillette André, Koretzky Gary A, Nichols Kim E: Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of immunology (Baltimore, Md. : 1950) 181(4): 2311-20, Aug 2008.

Bassiri H, Carding S R: A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. Journal of immunology (Baltimore, Md. : 1950) 166(10): 5945-54, May 2001.

Reya T, Bassiri H, Biancaniello R, Carding S R: Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. Developmental immunology 5(4): 287-302, 1998 Notes: Shared first authorship.

Li B, Bassiri H, Rossman M D, Kramer P, Eyuboglu A F, Torres M, Sada E, Imir T, Carding S R: Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. Journal of immunology (Baltimore, Md. : 1950) 161(3): 1558-67, Aug 1998.

Contractor N V, Bassiri H, Reya T, Park A Y, Baumgart D C, Wasik M A, Emerson S G, Carding S R: Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. Journal of immunology (Baltimore, Md. : 1950) 160(1): 385-94, Jan 1998 Notes: Shared first authorship.

Samoilova E B, Horton J L, Bassiri H, Zhang H, Linsley P S, Carding S R, Chen Y: B7 blockade prevents activation-induced cell death of thymocytes. International immunology 9(11): 1663-8, Nov 1997.

Bassiri H, Nichols K E: X-linked lymphoproliferative disease (XLP). Atlas of Genetics and Cytogenetics in Oncology and Haematology April 2012 Notes: http://AtlasGeneticsOncology.org/Kprones/XlinkedlymphoproliferID10028.html.

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Last updated: 08/08/2013
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