Hamid Bassiri

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3501 Civic Center Blvd.
Colket Translational Research Bldg, Room 3014
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Office: 267-425-2133
Fax: 215-590-3770
Lab: 267-426-7626
BA (Biology)
University of Pennsylvania, 1991.
PhD (Immunology)
University of Pennsylvania School of Medicine, 2002.
University of Pennsylvania School of Medicine, 2004.
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Description of Research Expertise

Our lab is interested in mechanisms of tumor immune surveillance and ways to harness the activity of innate lymphocytes for cellular cancer immunotherapy. The current projects in the lab include:
1) Directing natural killer T cell anti-tumor responses
2) Alterations in tumor microenvironment with polyamine antagonism
3) Mechanisms of chimeric antigen receptor T cell-mediated cytokine storm syndrome
4) Effect of augmenting TCR-mediated signals in chronic viral infections

Natural killer T cells
Tumor microenvironment
Cellular immunotherapy

Jennie Altman (Lab manager and Research technician)
Adriana Benavides (Post-doctoral fellow)
Gabrielle Ferry (Research technician)

Description of Clinical Expertise

Pediatric infectious diseases (care of immunocompetent and immunocompromised patients)
General pediatrics

Selected Publications

Bassiri Hamid, Das Rupali, Guan Peng, Barrett David M, Brennan Patrick J, Banerjee Pinaki P, Wiener Susan J, Orange Jordan S, Brenner Michael B, Grupp Stephan A, Nichols Kim E: iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer Immunology Research 2(1): 59-69, Jan 2014.

Bassiri Hamid, Das Rupali, Nichols Kim E: Invariant NKT cells: Killers and conspirators against cancer. Oncoimmunology 2(12): e27440, Dec 2013.

Das Rupali, Bassiri Hamid, Guan Peng, Wiener Susan, Banerjee Pinaki P, Zhong Ming-Chao, Veillette André, Orange Jordan S, Nichols Kim E: The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood Feb 2013 Notes: Epub ahead of print Feb 21 2013.

May Rebecca M, Okumura Mariko, Hsu Chin-Jung, Bassiri Hamid, Yang Enjun, Rak Gregory, Mace Emily M, Philip Naomi H, Zhang Weiguo, Baumgart Tobias, Orange Jordan S, Nichols Kim E, Kambayashi Taku: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood Feb 2013 Notes: Epub ahead of print Feb 13 2013

Cen Osman, Ueda Aki, Guzman Laura, Jain Jimmy, Bassiri Hamid, Nichols Kim E, Stein Paul L: The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. Journal of immunology (Baltimore, Md. : 1950) 182(3): 1370-8, Feb 2009.

Nunez-Cruz Selene, Yeo W C Janice, Rothman Jennifer, Ojha Priti, Bassiri Hamid, Juntilla Marisa, Davidson Dominique, Veillette André, Koretzky Gary A, Nichols Kim E: Differential requirement for the SAP-Fyn interaction during NK T cell development and function. Journal of immunology (Baltimore, Md. : 1950) 181(4): 2311-20, Aug 2008.

Bassiri Hamid, Janice Yeo W C, Rothman Jennifer, Koretzky Gary A, Nichols Kim E: X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. Immunologic research 42(1-3): 145-59, 2008.

Bassiri H, Carding S R: A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. Journal of immunology (Baltimore, Md. : 1950) 166(10): 5945-54, May 2001.

Reya T, Bassiri H, Biancaniello R, Carding S R: Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. Developmental immunology 5(4): 287-302, 1998 Notes: Shared first authorship.

Contractor N V, Bassiri H, Reya T, Park A Y, Baumgart D C, Wasik M A, Emerson S G, Carding S R: Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. Journal of immunology (Baltimore, Md. : 1950) 160(1): 385-94, Jan 1998 Notes: Shared first authorship.

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Last updated: 06/26/2015
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