David E. Kaplan

faculty photo
Assistant Professor of Medicine at the Veteran's Administration Medical Center
Department: Medicine

Contact information
Division of Gastroenterology
421 Curie Boulevard
9th Floor
Philadelphia, PA 19104
Office: 215-823-5800 x 6729
Fax: 215-823-4289
Education:
B.A. (Political Science)
University of California, San Diego, 1992.
M.D.
University of Texas Southwestern Medical School, 1997.
M.Sc. (Patient-Oriented Research)
University of Pennsylvania, 2007.
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Description of Research Expertise

Hepatitis C and hepatocellular carcinoma immunopathogenesis

Description of Clinical Expertise

Hepatology, viral and non-viral chronic liver disease and cirrhosis, hepatocellular carcinoma, end-stage liver disease

Selected Publications

Doi H, Iyer TK, Carpenter EL, Li H, Chang KM, Vonderheide RH, Kaplan DE.: Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population. Hepatology 55(3): 709-719, March 2012.

Li Y, Siegel DL, Scholler N, Kaplan DE.: Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library. BMC Biotechnology 12(1): 23, May 2012.

Cai X, Zhai J, Kaplan DE, Zhang Y, Zhou L, Chen X, Qian G, Zhao Q, Li Y, Gao L, Cong W, Zhu M, Yan Z, Shi L, Wu D, Wei L, Shen F, Wu M : Background Progenitor Activation is Associated with Recurrence after Hepatectomy of Combined Hepatocellular Cholangiocarcinoma. Hepatology Jun 2012 Notes: DOI: 10.1002/hep.25874.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R.: Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study. Annals of Internal Medicine 155(6): 353-360, September 2011.

Xu Y, Li H, Gao RL, Adeyemo O, Itkin M, Kaplan DE.: Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients. Clinical Immunology 139(3): 302-313, June 2011 Notes: doi:10.1016/j.clim.2011.02.014.

Rech A, Mick R, Kaplan D, Chang K-M, Domchek SM, Vonderheide RH.: Homeostasis of peripheral FoxP3+ CD4+ regulatory T cells in patients with early and late stage breast cancer. Cancer Immunol Immunother 59(4): 599-607, April 2010.

Forde KA, Law C, O'Flynn R, Kaplan DE.: Do statins reduce hepatitis C RNA titers during routine clinical use? World J Gastroenterology 15(40): 5020-7, October 2009.

Stiffler JD, Nguyen M, Sohn JA, Liu C, Kaplan DE, Seeger C.: Focal distribution of hepatitis C virus RNA in infected livers. PloS one 4(8): e6661, August 2009.

Kaplan DE, Sugimoto K, Valiga M, Newton K, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM. : Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132(2): 654-666, February 2007.

Kaplan DE, Sugimoto K, Ikeda F, Stadanlick J, Valiga M, Shetty K, Reddy KR, Chang KM.: T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 41(6): 1365-75, June 2005.

Sugimoto K, Kaplan DE, Ikeda F, Ding J, Schwartz J, Nunes FA, Alter HJ, Chang KM.: Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection. Journal of Virology 79(11): 6976-83, June 2005.

Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, Reddy KR, Chang KM.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48(6): 903-913, June 2008.

Harris RA, Sugimoto K, Kaplan DE, Ikeda F, Kamoun M, Chang KM.: Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans. Hepatology 48(1): 70-9, July 2008.

Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134(7): 1927-37, 1937.e1-2, June 2008.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R : Adherence to Hepatitis C Virus Therapy in HIV/Hepatitis C-Coinfected Patients. AIDS Behav 17(1): 94-103, Jan 2013 Notes: doi: 10.1007/s10461-012-0288-9.

Carpenter EL, Mick R, Rech AJ, Beatty GL, Colligon TA, Rosenfeld MR, Kaplan DE, Chang KM, Domchek SM, Kanetsky PA, Fecher LA, Flaherty KT, Schuchter LM, Vonderheide RH.: Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancers. Clinical cancer research : an official journal of the American Association for Cancer Research 15(13): 4277-87, July 2009.

Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM; SyNCH Study Group: Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C. Clin Trials 9(1): 102-112, Feb 2012.

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Last updated: 03/31/2014
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