Dana T Graves

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Contact information
240 South 40th Street
F1B Evans Building
Philadelphia, PA 19104
Office: 215-898-9068
Fax: 215-573-8071
Lab: 215-573-2286
Education:
B.A. (Chemistry)
SUNY at Binghamton, 1976.
D.D.S.
Columbia University, 1980.
D.M.Sc. (Oral Biology)
Harvard University, 1984.
Cert. (Periodontology )
Harvard University, 1984.
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Description of Research Expertise

Inflammation.
Inflammation has a profound effect on the connective tissue, causing its resorption and limiting repair of damaged structures. I am interested in how cytokines regulate inflammation and cell death including the activation of transcription factors that globally affect pro-apoptotic gene expression. These studies involve the use of specific inhibitors of apoptosis and cytokines as well as mice with targeted genetic deletions to study their functional role in repair of injured connective tissue and bone.
Diabetes.
Diabetes-associated cytokine dysregulation may represent a common link in a number of diabetic complications including retinopathy and impaired wound healing. A limited ability to repair lost tissue may also represent a mechanism for greater net loss of bone and connective tissue in diabetes-enhanced periodontal disease and impaired fracture healing in diabetics. My laboratory is investigating mechanisms through which these processes are affected by diabetes via altered transcription factor activity and cytokine dysregulation.

Selected Publications

Graves Dana T, Wu Yingying, Badadani Mallikarjun: Pyk2 contributes to re-epithelialization by promoting MMP expression. American journal of physiology. Cell physiology Apr 2014.

Coimbra Leila S, Steffens Joao Paulo, Rossa Carlos, Graves Dana T, Spolidorio Luis C: Clopidogrel enhances periodontal repair in rats through decreased inflammation. Journal of clinical periodontology 41(3): 295-302, Mar 2014.

Bhattacharya Rupa, Xu Fanxing, Dong Guangyu, Li Shuai, Tian Chen, Ponugoti Bhaskar, Graves Dana T: Effect of bacteria on the wound healing behavior of oral epithelial cells. PloS one 9(2): e89475, 2014.

Pacios Sandra, Andriankaja Oelisoa, Kang Jun, Alnammary Maher, Bae Jason, de Brito Bezerra Beatriz, Schreiner Helen, Fine Daniel H, Graves Dana T: Bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis. The American journal of pathology 183(6): 1928-35, Dec 2013.

Ponugoti Bhaskar, Xu Fanxing, Zhang Chenying, Tian Chen, Pacios Sandra, Graves Dana T: FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress. The Journal of cell biology 203(2): 327-43, Oct 2013.

Wada Keisuke, Yu Weiling, Elazizi Mohamad, Barakat Sandrine, Ouimet Michelle A, Rosario-Meléndez Roselin, Fiorellini Joseph P, Graves Dana T, Uhrich Kathryn E: Locally delivered salicylic acid from a poly(anhydride-ester): impact on diabetic bone regeneration. Journal of controlled release : official journal of the Controlled Release Society 171(1): 33-7, Oct 2013.

Alblowi Jazia, Tian Chen, Siqueira Michelle F, Kayal Rayyan A, McKenzie Erin, Behl Yugal, Gerstenfeld Louis, Einhorn Thomas A, Graves Dana T: Chemokine expression is upregulated in chondrocytes in diabetic fracture healing. Bone 53(1): 294-300, Mar 2013.

Li Shuai, Dong Guangyu, Moschidis Anastasios, Ortiz Javier, Benakanakere Manjunatha R, Kinane Denis F, Graves Dana T: P. gingivalis modulates keratinocytes through FOXO transcription factors. PloS one 8(11): e78541, 2013.

Xu, F., Zhang, C., Graves, D.T. : Abnormal cell responses and role of TNF- α in impaired diabetic wound healing BioMed Research International 2013.

Paglia David N, Wey Aaron, Breitbart Eric A, Faiwiszewski Jonathan, Mehta Siddhant K, Al-Zube Loay, Vaidya Swaroopa, Cottrell Jessica A, Graves Dana, Benevenia Joseph, O'Connor J Patrick, Lin Sheldon S: Effects of local insulin delivery on subperiosteal angiogenesis and mineralized tissue formation during fracture healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society Dec 2012.

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Last updated: 11/04/2013
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