Dana T Graves

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Contact information
240 South 40th Street
F1B Evans Building
Philadelphia, PA 19104
Office: 215-898-9068
Fax: 215-573-8071
Lab: 215-573-2286
B.A. (Chemistry)
SUNY at Binghamton, 1976.
Columbia University, 1980.
D.M.Sc. (Oral Biology)
Harvard University, 1984.
Cert. (Periodontology )
Harvard University, 1984.
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Description of Research Expertise

Inflammation has a profound effect on the connective tissue, causing its resorption and limiting repair of damaged structures. I am interested in how cytokines regulate inflammation and cell death including the activation of transcription factors that globally affect pro-apoptotic gene expression. These studies involve the use of specific inhibitors of apoptosis and cytokines as well as mice with targeted genetic deletions to study their functional role in repair of injured connective tissue and bone.
Diabetes-associated cytokine dysregulation may represent a common link in a number of diabetic complications including retinopathy and impaired wound healing. A limited ability to repair lost tissue may also represent a mechanism for greater net loss of bone and connective tissue in diabetes-enhanced periodontal disease and impaired fracture healing in diabetics. My laboratory is investigating mechanisms through which these processes are affected by diabetes via altered transcription factor activity and cytokine dysregulation.

Selected Publications

Alblowi Jazia, Tian Chen, Siqueira Michelle F, Kayal Rayyan A, McKenzie Erin, Behl Yugal, Gerstenfeld Louis, Einhorn Thomas A, Graves Dana T: Chemokine expression is upregulated in chondrocytes in diabetic fracture healing. Bone 53(1): 294-300, Mar 2013.

Xu, F., Zhang, C., Graves, D.T. : Abnormal cell responses and role of TNF- α in impaired diabetic wound healing BioMed Research International 2013.

Paglia David N, Wey Aaron, Breitbart Eric A, Faiwiszewski Jonathan, Mehta Siddhant K, Al-Zube Loay, Vaidya Swaroopa, Cottrell Jessica A, Graves Dana, Benevenia Joseph, O'Connor J Patrick, Lin Sheldon S: Effects of local insulin delivery on subperiosteal angiogenesis and mineralized tissue formation during fracture healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society Dec 2012.

Bastos Alliny S, Graves Dana T, Loureiro Ana Paula de Melo, Rossa Júnior Carlos, Abdalla Dulcinéia Saes Parra, Faulin Tanize do Espírito Santo, Olsen Câmara Niels, Andriankaja Oelisoa M, Orrico Silvana R P: Lipid peroxidation is associated with the severity of periodontal disease and local inflammatory markers in patients with type 2 diabetes. The Journal of clinical endocrinology and metabolism 97(8): E1353-62, Aug 2012.

Kang Jun, de Brito Bezerra Beatriz, Pacios Sandra, Andriankaja Oelisoa, Li Yu, Tsiagbe Vincent, Schreiner Helen, Fine Daniel H, Graves Dana T: Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis. Infection and immunity 80(6): 2247-56, Jun 2012.

Albert David A, Ward Angela, Allweiss Pamela, Graves Dana T, Knowler William C, Kunzel Carol, Leibel Rudolph L, Novak Karen F, Oates Thomas W, Papapanou Panos N, Schmidt Ann Marie, Taylor George W, Lamster Ira B, Lalla Evanthia: Diabetes and oral disease: implications for health professionals. Annals of the New York Academy of Sciences 1255: 1-15, May 2012.

Pacios Sandra, Kang Jun, Galicia Johnah, Gluck Kenneth, Patel Hemal, Ovaydi-Mandel Amy, Petrov Sophia, Alawi Faizan, Graves Dana T: Diabetes aggravates periodontitis by limiting repair through enhanced inflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26(4): 1423-30, Apr 2012.

Bezerra Beatriz de Brito, Andriankaja Oelisoa, Kang Jun, Pacios Sandra, Bae Hyung Jin, Li Yu, Tsiagbe Vincent, Schreiner Helen, Fine Daniel H, Graves Dana T: A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium. Journal of clinical periodontology 39(4): 333-41, Apr 2012.

Ponugoti Bhaskar, Dong Guangyu, Graves Dana T: Role of forkhead transcription factors in diabetes-induced oxidative stress. Experimental diabetes research 2012: 939751, 2012.

Andriankaja, O.M., Galicia, J., Dong, G., Xiao, W., Alawi, F., Graves, D.T. : Gene expression dynamics during diabetic periodontitis Journal of Dental Research 91(12): 1160-1165, 2012.

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Last updated: 11/04/2013
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