Perelman School of Medicine at the University of Pennsylvania

Penn Institute for Immunology

Jan Joseph Melenhorst

faculty photo
Adjunct Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
SPE South Tower, Rm. 9-105,
3400 Civic Center Boulevard, Blg. 421
Philadelphia, PA 19104-5156
Office: 215.573.6852
Lab: N/A
Education:
BSc (Biology, Geography, Associate Professor in Continuing Education)
Moller Institute, 1988.
MS (Medical Biology)
Nijmegen Katholic University, 1991.
PhD (Immunology)
Leiden University, 1998.
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Description of Clinical Expertise

As a translational immunologist my interest is in improving the potency and safety of adoptive immunogene therapy via correlative studies and product/process development. My translational interest also lies in streamlining the immunogene manufacturing process while maintaining or improving product potency.

Description of Other Expertise

Immunology of human allogeneic hematopoietic stem cell transplantation.

Description of Research Expertise

My expertise is in human T cell immunology and immunogene therapy, understanding and improving the anti-tumor efficacy of gene-engineered T cells for the treatment of cancers.

Selected Publications

Marcucci KT, Jadlowsky JK, Hwang WT, Suhoski-Davis M, Gonzalez VE, Kulikovskaya I, Gupta M, Lacey SF, Plesa G, Chew A, Melenhorst JJ, Levine BL, June CH.: Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients. Mol Ther. 26(1): 269-279, Jan 2018.

Joseph A. Fraietta1,2,3, Simon F. Lacey1,2,3*, Elena J. Orlando4,*, Iulian Pruteanu-Malinici4, Mercy Gohil2, Stefan Lundh2, Alina C. Boesteanu2, Yan Wang2, Roddy S. O’Connor2, Wei-Ting Hwang5, Edward Pequignot2, David E. Ambrose2, Changfeng Zhang2, Nicholas Wilcox2, Felipe Bedoya2, Corin Dorfmeier2, Fang Chen2, Lifeng Tian2, Harit Parakandi2, Minnal Gupta2, Regina M. Young2, F. Brad Johnson1, Irina Kulikovskaya2, Li Liu2, Jun Xu2, Sadik H. Kassim4, Megan M. Suhoski-Davis2, Bruce L. Levine1,2, Noelle V. Frey2,6, Donald L. Siegel1,2,7, Alexander C. Huang3,8, E. John Wherry3,8, Hans Bitter4, Jennifer L. Brogdon4, David L. Porter1,6, Carl H. June1,2,3 and Jan J. Melenhorst1,2,3,‡: Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T cell Therapy of Chronic Lymphocytic Leukemia Nature Medicine (in production) 2018.

Guedan S, Posey AD Jr., Shaw C, Wing A, Da T, Patel PR, McGettigan SE, Casado-Medrano V, Kawalekar OU, Uribe-Herranz M, Song D, Melenhorst JJ, Lacey SF, Scholler J, Keith B, Young RM, June CH.: Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation. JCI Insight Epub ahead of print, 2018.

Schuster SJ, Svoboda J, Chong EA, Nasta SD, Mato AR, Anak Ö, Brogdon JL, Pruteanu-Malinici I, Bhoj V, Landsburg D, Wasik M, Levine BL, Lacey SF, Melenhorst JJ, Porter DL, June CH.: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas. N Engl J Med 377(26): 2545-2554, Dec 2017.

Obstfeld AE, Frey NV, Mansfield K, Lacey SF, June CH, Porter DL, Melenhorst JJ, Wasik MA.: Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy; clinicopathological insights. Blood 130(23): 2569-2572, Dec 2017.

Tchou J, Zhao Y, Levine BL, Zhang PJ, Davis MM, Melenhorst JJ, Kulikovskaya I, Brennan AL, Liu X, Lacey SF, Posey AD Jr, Williams AD, So A, Conejo-Garcia JR, Plesa G, Young RM, McGettigan S, Campbell J, Pierce RH, Matro JM, DeMichele AM, Clark AS, Cooper LJ, Schuchter LM, Vonderheide RH, June CH.: Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer. Cancer Immunol Res. 5(12): 1152-1161, Dec 2017.

Mueller KT, Maude SL, Porter DL, Frey N, Wood P, Han X, Waldron E, Chakraborty A, Awasthi R, Levine BL, Melenhorst JJ, Grupp SA, June CH, Lacey SF.: Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia. Blood 130(21): 2317-2325, Nov 2017 Notes: 2017 Sep 21. pii: blood-2017-06-786129. doi: 10.1182/blood-2017-06-786129.

O'Rourke DM, Melenhorst JJ, Nasrallah MP, Desai A, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV.: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med. AAAS, 9(399): eaaa0984, July 2017.

Elise A. Chong, J. Joseph Melenhorst, Simon F. Lacey, David E. Ambrose, Vanessa Gonzalez, Bruce Levine, Carl H. June, and Stephen J. Schuster: PD-1 Blockade Modulates Chimeric Antigen Receptor (CAR) Modified T Cells and Induces Tumor Regression: Refueling the CAR. Blood. Blood, 129(8): 1039-1041, Feb 2017.

Fitzgerald JC, Weiss SL, Maude SL, Barrett DM, Lacey SF, Melenhorst JJ, Shaw P, Berg RA, June CH, Porter DL, Frey NV, Grupp SA, Teachey DT: Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia. Crit Care Med 45(2), Feb 2017.

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Last updated: 01/13/2018
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