Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory


Foteini Mourkioti

faculty photo
Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Graduate Group Affiliations

Contact information
McKay Orthopaedic Research Laboratory
112A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8214
Fax: 215-573-2133
Lab: 215-573-3645
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
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Description of Research Expertise

muscle disorders, telomeres, NF-kB signaling, muscle regeneration, stem cells, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.

Selected Publications

Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM.: Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine 20(3): 255-64. Feb 2014.

Mourkioti Foteini, Kustan Jackie, Kraft Peggy, Day John W, Zhao Ming-Ming, Kost-Alimova Maria, Protopopov Alexei, DePinho Ronald A, Bernstein Daniel, Meeker Alan K, Blau Helen M: Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nature cell biology 15(8): 895-904, Aug 2013.

Sacco Alessandra*, Mourkioti Foteini*, Tran Rose, Choi Jinkuk, Llewellyn Michael, Kraft Peggy, Shkreli Marina, Delp Scott, Pomerantz Jason H, Artandi Steven E, Blau Helen M: Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell 143(7): 1059-71, Dec 2010 Notes: * notes equal contribution.

Kratsios Paschalis, Catela Catarina, Salimova Ekaterina, Huth Marion, Berno Valeria, Rosenthal Nadia, Mourkioti Foteini: Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. Circulation research 106(3): 559-72, Feb 2010.

Kratsios P, Huth M, Temmerman L, Salimova E, Al Banchaabouchi M, Sgoifo A, Manghi M, Suzuki K, Rosenthal N, Mourkioti F*: Antioxidant amelioration of dilated cardiomyopathy caused by conditional deletion of NEMO/IKKgamma in cardiomyocytes. Circulation research 106(1): 133-44, Jan 2010 Notes: * corresponding author.

Ruffell Daniela*, Mourkioti Foteini*, Gambardella Adriana*, Kirstetter Peggy, Lopez Rodolphe G, Rosenthal Nadia, Nerlov Claus: A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proceedings of the National Academy of Sciences of the United States of America 106(41): 17475-80, Oct 2009 Notes: * notes equal contribution.

Mourkioti Foteini, Slonimsky Esfir, Huth Marion, Berno Valeria, Rosenthal Nadia: Analysis of CRE-mediated recombination driven by myosin light chain 1/3 regulatory elements in embryonic and adult skeletal muscle: a tool to study fiber specification. Genesis (New York, N.Y. : 2000) 46(8): 424-30, Aug 2008.

Mourkioti Foteini*, Rosenthal Nadia: NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases. Journal of molecular medicine (Berlin, Germany) 86(7): 747-59, Jul 2008 Notes: * notes corresponding author.

Lara-Pezzi Enrique, Winn Nadine, Paul Angelika, McCullagh Karl, Slominsky Esfir, Santini Maria Paola, Mourkioti Foteini, Sarathchandra Padmini, Fukushima Satsuki, Suzuki Ken, Rosenthal Nadia: A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. The Journal of cell biology 179(6): 1205-18, Dec 2007.

Mourkioti Foteini, Kratsios Paschalis, Luedde Tom, Song Yao-Hua, Delafontaine Patrick, Adami Raffaella, Parente Valeria, Bottinelli Roberto, Pasparakis Manolis, Rosenthal Nadia: Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. The Journal of clinical investigation 116(11): 2945-54, Nov 2006.

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Last updated: 07/18/2017
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