Foteini Mourkioti
Associate Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Graduate Group Affiliations
Contact information
McKay Orthopaedic Research Laboratory
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8214
Fax: 215-573-2133
Lab: 215-573-3645
Fax: 215-573-2133
Lab: 215-573-3645
Email:
fmour@pennmedicine.upenn.edu
fmour@pennmedicine.upenn.edu
Publications
Links
Search PubMed for articles
The Pennsylvania Muscle Institute
Penn Center for Musculoskeletal Disorders
Penn Cardiovascular Institute
Mourkioti Lab
McKay Orthopaedic Research Laboratory
Penn Institute of Regenerative Medicine
Search PubMed for articles
The Pennsylvania Muscle Institute
Penn Center for Musculoskeletal Disorders
Penn Cardiovascular Institute
Mourkioti Lab
McKay Orthopaedic Research Laboratory
Penn Institute of Regenerative Medicine
Education:
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
Permanent linkBA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
Description of Research Expertise
Keywords: muscle stem cells, stem cell activation, muscle disorders, mechanobiology, aging, telomeres, NF-kB signaling, muscle regeneration, stem cell regulation, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.Selected Publications
Bautista C.A., Srikumar A., Tichy E.D., Qian G., Jiang X., Qin L., Mourkioti F., Dyment N. CD206: CD206+ tendon resident macrophages and potential crosstalk with fibroblasts and the ECM during tendon growth and maturation. Front. Physiol., Sec. Skeletal Physiology 14, February 2023.Ma N., Chen D., Lee, J.H., Kuri P., Hernandez E.B., Kocan B., Mahmood H., Tichy E.D., Rompolas P., Mourkioti F.: Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states. Science Advances. Science, 8(11): 1-14, March 2022.
Stanley A, Tichy ED, Kocan J, Roberts DW, Shore EM and Mourkioti F.: Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva NPJ Regenerative Medicine-Nature 7(1), January 2022 Notes: doi: 10.1038/s41536-021-00201-8.
Tichy ED, Mourkioti F. : Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections. STAR Protoc 2(4), September 2021 Notes: d10.1016/j.xpro.2021.100830.
Tichy ED, Ma N., Sidibe D., Loro E., Kocan J., Chen DZ., Khurana TS., Hasty P., Mourkioti F.: Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening Cell Reports. Cell Press, 35(6), May 2021.
Lutian Yao, Elisia D. Tichy, Leilei Zhong, Sarthak Mohanty, Luqiang Wang, Emily Ai, Shuying Yang, Foteini Mourkioti1*, Ling Qin *: Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation. Journal of Bone and Mineral Research 36(6): 1159-1173, February 2021.
Suradip Das,, Kevin D. Browne, Franco A. Laimo, Joseph C. Maggiore, Melanie C. Hilman, Halimulati Kaisaier, Carlos A. Aguilar, Zarina S. Ali, Foteini Mourkioti, D. Kacy Cullen: Pre-Innervated Tissue Engineeried Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss. Communications Biology-Nature 3(1), June 25 2020 Notes: doi: 10.1038/s42003-020-1056-4.
Sangkyun Cho, Manasvita Vashisth, Amal Abbas, Stephanie Majkut1,, Kenneth Vogel, Yuntao Xia, Irena Ivanovska, Jerome Irianto, Manorama Tewari, Elisia Tichy, Foteini Mourkioti, Hsin-Yao Tang, Roger A. Greenberg, Benjamin Prosser, and Dennis E. Discher : Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest Developmental Cell 49(6): 920-935, May 2019.
Alexandra Stanley, Su-jin Heo, Robert L. Mauck, Foteini Mourkioti and Eileen M. Shore: Elevated BMP and mechanical signaling through YAP1/RhoA poises FOP mesenchymal progenitors for osteogenesis. Journal of Bone and Mineral Research 34(10): 1894-1909, May 2019.
Haupt J., Stanley A., McLeod, CM., Cosgrove BD., Culbert, AL., Wang L., Mourkioti F., Mauck RL., Shore EM.: ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification. Molecular Biology of the Cell 30(1): 17-29, January 2019.