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Jason D. Christie, MD, MSCE

Jason D. Christie, MD, MSCE

faculty photo
Robert M. Kotloff/Nancy Blumenthal Professor for Advanced Lung Disease
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Education:
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Borders CF, Suzuki Y, Lasky J, Schaufler C, Mallem D, Lee J, Carney K, Bellamy SL, Bermudez CA, Localio AR, Christie JD, Diamond JM, Cantu E: Massive Donor Transfusion Potentially Increases Recipient Mortality After Lung Transplantation. Journal of Thoracic Cardiovascular Surgery 153(5): 1197-1203, May 2017.

Patterson KC, Shah RJ, Porteous MK, Christie JD, D'Errico C, Chadwick M, Triano M, Deshpande C, Rossman MD, Litzky LA, Kreider ME, Miller WT Jr: Interstitial Lung Disease in the Elderly. Chest 151(4): 838-844, April 2017.

Tong Y, Udupa JK, Torigian DA, Odhner D, Wu C, Pednekar G, Palmer S, Rozenshtein A, Shirk MA, Newell JD, Porteous M, Diamond JM, Christie JD, Lederer DJ: Chest Fat Quantification via CT Based on Standardized Anatomy Space in Adult Lung Transplant Candidates. PLoS One 12(1): e0168932, January 2017.

Diamond JM, Arcasoy S, McDonnough JA, Sonett JR, Bacchetta M, D'Ovidio F, Cantu E, Bermudez CA, McBurnie A, Rushefski M, Kalman LH, Oyster M, D'Errico C, Suzuki Y, Giles JT, Ferrante A, Lippel M, Singh G, Lederer DJ, Christie JD: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17(1): 239-245, Jan 2017.

Diamond JM, Cantu E, Porteous M, Suzuki Y, Meyer KC, Lederer D, Milewski RK, Arcasoy S, D'Ovidio F, Bacchetta M, Sonett JR, Singh G, Costa J, Tobias JW, Rodriguez H, Van Deerlin VM, Olthoff KM, Shaked A, Chang BL, Christie JD: Peripheral Blood Gene Expression Changes Associated with Primary Graft Dysfunction after Lung Transplantation. American Journal of Transplant Epub ahead of Print, January 2017.

Anderson BJ, Reilly JP, Shashaty MG, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ: Admission Plasma Levels of the Neuronal Injury Marker Neuron-specific Enolase are Associated with Mortality and Delirium in Sepsis. Journal of Critical Care 36: 18-23, December 2016.

Podolanczuk AJ, Oelsner EC, Barr RG, Hoffman EA, Armstrong HF, Austin JH, Basner RC, Bartels MN, Christie JD, Enright PL, Gochuico BR, Hinckley Stukovsky K, Kaufman JD, Hrudaya Nath P, Newell JD Jr, Palmer SM, Rabinowitz D, Raghu G, Sell JL, Sieren J, Sonavane SK, Tracy RP, Watts JR, Williams K, Kawut SM, Lederer DJ: High Attenuation Areas on Chest Computed Tomography in Community-dwelling Adults: The MESA Study. European Respiratory Journal 48(5): 1442-1452, November 2016.

Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM: Acute Kidney Injury Subphenotypes Based on Creatinine Trajectory Identifies Patients at Increased Risk of Death. Critical Care 20(1): 372, November 2016.

Abbas A A, Diamond J M, Chehoud C, Chang B, Kotzin J J, Young J C, Imai I, Haas A R, Cantu E, Lederer D J, Meyer K, Milewski R K, Olthoff K M, Shaked A, Christie J D, Bushman F D, Collman R G: The Perioperative Lung Transplant Virome: Torque Teno Viruses are Elevated in Donor Lungs and Show Divergent Dynamics In Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Page: [Epub ahead of print] Oct 2016.

Patel NB, Christie JD: Alveolar Type 2 Cell Transplantation in IPF: Recreating the Silver Lining. Chest 150(3): 481-2, September 2016.

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Last updated: 05/04/2017
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