Jason D. Christie, MD, MSCE

faculty photo
Paul F. Harron, Jr. Family Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Corrine R. Kliment,Ian J. Barbash,1 Jacob S. Brenner,2 Divay Chandra,Katherine Courtright,Marc C. Gauthier, Keven M. Robinson, Leslie P. Scheunemann, Faraaz A. Shah, Jason D. Christie, and Alison Morris: COVID-19 and the Early-Career Physician-Scientist. Fostering Resilience beyond the Pandemic. ATS Scholar Page: 19-28, March 2021.

John P. Reilly, Nuala J. Meyer,Michael G.S. Shashaty,Brian J. Anderson, Caroline Ittner,1 Thomas G. Dunn, Brian Lim,1 Caitlin Forker,1 Michael P. Bonk, Ethan Kotloff,1 Rui Feng, Edward Cantu,Nilam S. Mangalmurti,Carolyn S. Calfee, Michael A. Matthay,Carmen Mikacenic, Keith R. Walley,James Russell, David C. Christiani, Mark M. Wurfel, Paul N. Lanken,Muredach P. Reilly,and Jason D. Christie: The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness. JCI The Journal of Clinical Investigation Page: 131, January 2021.

George L. Anesi, MD, MSCE, MBE,* Juliane Jablonski, DNP, RN,* Michael O. Harhay, PhD, MPH, Joshua H. Atkins, MD, PhD, Jasmeet Bajaj, MD, Cameron Baston, MD, MSCE, Patrick J. Brennan, MD, Christina L. Candeloro, PharmD, Lauren M. Catalano, MD, MSc, Maurizio F. Cereda, MD, John M. Chandler, MD, Jason D. Christie, MD, MSCE, Tara Collins, CRNP, Katherine R. Courtright, MD, MSHP, Barry D. Fuchs, MD, MS, Emily Gordon, MD, MS, John C. Greenwood, MD, Steven Gudowski, BS, RRT, Asaf Hanish, MS, C. William Hanson III, MD, Monica Heuer, MBA, MPP, Paul Kinniry, MD, Zev Noah Kornfield, MD, Gregory B. Kruse, MSc, MPH, Meghan Lane-Fall, MD, MSHP, Niels D. Martin, MD, Mark E. Mikkelsen, MD, MSCE, Dan Negoianu, MD, Jose L. Pascual, MD, PhD, Maulik B. Patel, MD, Steven C. Pugliese, MD, Zaffer A. Qasim, MBBS, John P. Reilly, MD, MSCE, John Salmon, BS, William D. Schweickert, MD, Michael J. Scott, MBChB, Michael G.S. Shashaty, MD, MSCE, Corinna P. Sicoutris, CRNP, John K. Wang, MD, Wei Wang, PhD, Arshad A. Wani, MD, Brian J. Anderson, MD, MSCE†, and Jacob T. Gutsche, MD†: Characteristics, Outcomes, and Trends of Patients With COVID-19–Related Critical Illness at a Learning Health System in the United States. Ann Intern Med Page: 20-5327, January 2021.

Gary E Weissman, Andrew Crane-Droesch, Corey Chivers, ThaiBinh Luong, Asaf Hanish, Michael Z Levy, Jason Lubken, Michael Becker, Michael E Draugelis, George L Anesi, Patrick J Brennan, Jason D Christie, C William Hanson 3rd, Mark E Mikkelsen, Scott D Halpern: Locally Informed Simulation to Predict Hospital Capacity Needs During the COVID-19 Pandemic. Annals of internal medicine 173: 21-28, July 2020 Notes: Published online 2020 Apr 7.

Pavan K. Bhatraju, Max Cohen, Ryan J. Nagao, Eric D. Morrell,Susanna Kosamo, Xin-Ya Chai, Robin Nance,5 Victoria Dmyterko, Joseph Delaney, Jason D. Christie, Kathleen D. Liu, Carmen Mikacenic, Sina A. Gharib, W. Conrad Liles, Ying Zheng, David C. Christiani, Jonathan Himmelfarb, and Mark M. Wurfel: Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes. BMC Nephrology 21: 284, July 2020.

Patricia C Pawlow, Caroline L Doherty, Nancy P Blumenthal,Lea Ann Matura, Jason D Christie, Mary Ersek: An Integrative Review of the Role of Palliative Care in Lung Transplantation. Progress in Transplantation 30: 147-154, June 2020 Notes: [Epub April 3 2020]

Michaela R Anderson , Imaani Easthausen, Grace Gallagher, Jayaram Udupa, Yubing Tong, Drew Torigian , Joshua Matthew Diamond , Mary Katherine Porteous, Scott M Palmer , Laurie D Snyder , Luke Benvenuto , Meghan Aversa, Selim Arcasoy, John R Greenland, Steven R Hays , Jasleen Kukreja, Edward Cantu, John Shinn Kim, Dympna Gallagher, Matthew R Baldwin, R Graham Barr, David J Lederer, Jason D Christie, Jonathan Paul Singer: Skeletal Muscle Adiposity and Outcomes in Candidates for Lung Transplantation: A Lung Transplant Body Composition Cohort Study. Thorax Page: 147-154, June 2020 Notes: Epub 2020 Apr 3.

Edward Cantu, Mengying Yan, Yoshikazu Suzuki, Taylor Buckley, Vito Galati, Neha Majeti, Christian A Bermudez, Joshua M Diamond, Jason D Christie, Rui Feng : Pre-Procurement In Situ Donor Lung Tissue Gene Expression Classifies Primary Graft Dysfunction Risk. American Journal of Respiratory and Critical Care Medicine Page: 1046-1048, May 2020.

Miano TA Flesch JD, Feng Forker CM, Brown M, Oyster M, Kalman L, Rushefski M, Cantu E , Porteus M, Yang W, Russel Localio Jd A, Diamond JM, Christie JD Shashaty MGS: Early Tacrolimus Concentrations After Lung Transplant are Predicted by Combined Clinical and Genetic Factors and Associated with Acute Kidney Injury. Clinical Pharmacology and Therapeutics Page: 107(2):462-470, February 2020.

Monticelli, Diamond , Saenz S, Tait Wojno, Porteous, Cantu, Artis, Christie J.: Lung Innate Lymphoid Cell Composition is Altered in Primary Graft Dysfunction. American journal of respiratory and critical care medicine Page: 63-72, January 2020.

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Last updated: 05/03/2021
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