Jason D. Christie, MD, MSCE

faculty photo
Paul F. Harron, Jr. Family Professor
Member, Biomedical Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Department of Biostatistics and Epidemiology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
Adjunct Investigator, Institute for Environmental Medicine, Perelman School of Medicine at the University of Pennsylvania
Chief, Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania
Executive Committee, Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania
Department: Medicine

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Diamond JM, Cantu E, Calfee CS, Anderson MR, Clausen ES, Shashaty MGS, Courtwright AM, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Todd JL, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, Orens JB, Dhillon GS, Weinacker AB, Lama VN, Patel MG, Singer JP, Hsu J, Localio AR, Christie JD.: The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation. Am J Respir Crit Care Med 209: 91-100, Jan 2024.

Diamond JM, Benvenuto L, Claridge T, Witek S, Christie JD, Singer JP, Anderson MR.: Provider beliefs and practices regarding the management of obesity in lung transplant recipients. JHLT Open 2024.

Diamond JM, Anderson MR, Cantu E, Clausen ES, Shashaty MGS, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, Orens JB, Dhillon GS, Lama VN, Patel MG, Singer JP, Hachem RR, Michelson AP, Hsu J, Russell Localio A, Christie JD.: Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates. J Heart Lung Transplant Dec 2023.

Gleeson PK, Morales KH, Buckey TM, Fadugba OO, Apter AJ, Christie JD, Himes BE.: Factors associated with aeroallergen testing among adults with asthma in a large health system. J Allergy Clin Immunol Glob 2: 100167, Sep 2023.

Keim G, Hsu JY, Pinto NP, McSherry ML, Gula AL, Christie JD, Yehya N.: Readmission Rates After Acute Respiratory Distress Syndrome in Children. JAMA Netw Open 6: e2330774, Sep 2023.

Miano TA, Feng R, Griffiths S, Kalman L, Oyster M, Cantu E, Yang W, Diamond JM, Christie JD, Scheetz MH, Shashaty MGS.: Development and validation of a population pharmacokinetic model to guide perioperative tacrolimus dosing after lung transplantation. medRxiv Jun 2023.

Cantu E, Jin D, McCurry M, Friskey J, Lisowski J, Saleh A, Diamond JM, Anderson M, Clausen E, Hsu J, Gallop R, Christie JD, Schaubel D.: Transplanting candidates with stacked risks negatively affects outcomes. J Heart Lung Transplant Jun 2023.

Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE.: Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation. bioRxiv May 2023.

Keim G, Percy AG, Himebauch AS, Hsu JY, Christie JD, Yehya N.: Acute respiratory failure-related excess mortality in pediatric sepsis. Thorax May 2023.

Anderson MR, Diamond J, Shashaty M, Singer JP, Tong Y, Udupa J, Torigian DA, Palmer S, Lederer DJ, Christie JD, Al-Naamani N.: Accuracy and Reproducibility of Automated Measurement of Body Composition: A Lung Transplant Body Composition Cohort Study. Ann Am Thorac Soc Apr 2023.

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Last updated: 07/08/2024
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