Jason D. Christie, MD, MSCE

faculty photo
Paul F. Harron, Jr. Family Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Education:
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Gary E Weissman, Andrew Crane-Droesch, Corey Chivers, ThaiBinh Luong, Asaf Hanish, Michael Z Levy, Jason Lubken, Michael Becker, Michael E Draugelis, George L Anesi, Patrick J Brennan, Jason D Christie, C William Hanson 3rd, Mark E Mikkelsen, Scott D Halpern: Locally Informed Simulation to Predict Hospital Capacity Needs During the COVID-19 Pandemic. Annals of internal medicine 173: 21-28, July 2020 Notes: [Epub April 7 2020]

Patricia C Pawlow, Caroline L Doherty, Nancy P Blumenthal,Lea Ann Matura, Jason D Christie, Mary Ersek: An Integrative Review of the Role of Palliative Care in Lung Transplantation. Progress in Transplantation 30: 147-154, June 2020 Notes: [Epub April 3 2020]

Michaela R Anderson , Imaani Easthausen, Grace Gallagher, Jayaram Udupa, Yubing Tong, Drew Torigian , Joshua Matthew Diamond , Mary Katherine Porteous, Scott M Palmer , Laurie D Snyder , Luke Benvenuto , Meghan Aversa, Selim Arcasoy, John R Greenland, Steven R Hays , Jasleen Kukreja, Edward Cantu, John Shinn Kim, Dympna Gallagher, Matthew R Baldwin, R Graham Barr, David J Lederer, Jason D Christie, Jonathan Paul Singer: Skeletal Muscle Adiposity and Outcomes in Candidates for Lung Transplantation: A Lung Transplant Body Composition Cohort Study. Thorax Page: 147-154, June 2020 Notes: Epub 2020 Apr 3.

Edward Cantu, Mengying Yan, Yoshikazu Suzuki, Taylor Buckley, Vito Galati, Neha Majeti, Christian A Bermudez, Joshua M Diamond, Jason D Christie, Rui Feng : Pre-Procurement In Situ Donor Lung Tissue Gene Expression Classifies Primary Graft Dysfunction Risk. American Journal of Respiratory and Critical Care Medicine Page: 1046-1048, May 2020.

Miano TA1,2,3, Flesch JD4, Feng R2,3, Forker CM4, Brown M4, Oyster M4, Kalman L4, Rushefski M4, Cantu E 3rd5, Porteus M4, Yang W1,2,3, Russel Localio Jd A2,3, Diamond JM4, Christie JD2,3,4, Shashaty MGS2,4.: Early Tacrolimus Concentrations After Lung Transplant are Predicted by Combined Clinical and Genetic Factors and Associated with Acute Kidney Injury. Clinical Pharmacology and Therapeutics Page: 107(2):462-470, February 2020.

Monticelli, Diamond , Saenz S, Tait Wojno, Porteous, Cantu, Artis, Christie J.: Lung Innate Lymphoid Cell Composition is Altered in Primary Graft Dysfunction. American journal of respiratory and critical care medicine Page: 63-72, January 2020.

Hilary E Faust, John P Reilly, Brian J Anderson, Caroline A G Ittner, Caitlyn M Forker, Peggy Zhang, Benjamin A Weaver, Daniel N Holena, Paul N Lanken, Jason D Christie, Nuala J Meyer, Nilam S Mangalmurti, Michael G S Shashaty : Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients Chest [Epub October 14 2019] 157: 67-76, January 2020.

Anderson MR, Udupa JK, Edwin E, Diamond JM, Singer JP, Kukreja J, Hays SR, Greenland JR, Ferrante A, Lippel M, Blue T, McBurnie A, Oyster M, Kalman L, Rushefski M, Wu C2, Pednekar G, Liu W, Arcasoy S, Sonett J, D'Ovidio F, Bacchetta M, Newell JD, Torigian D, Cantu E, Farber DL, Giles JT, Tong Y, Palmer S, Ware LB, Hancock WW, Christie JD, Lederer DJ: Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study. The journal of heart and lung transplantation Page: 1246-1256] December 2019.

Brian J Anderson , Carolyn S Calfee , Kathleen D Liu , John P Reilly , Kirsten N Kangelaris , Michael G S Shashaty , Aili L Lazaar , Andrew I Bayliffe , Robert J Gallop, Todd A Miano, Thomas G Dunn, Erik Johansson, Jason Abbott, Alejandra Jauregui, Thomas Deiss, Kathryn Vessel, Annika Belzer, Hanjing Zhuo, Michael A Matthay, Nuala J Meyer, Jason D Christie : Plasma sTNFR1 and IL8 for Prognostic Enrichment in Sepsis Trials: A Prospective Cohort Study Critical Care (London, England) Page: 9-23, December 2019.

Simon-Soro A, Sohn MB, McGinniss JE, Imai I, Brown MC, Knecht VR, Bailey A, Clarke EL, Cantu E, Li H, Bittinger K, Diamond JM, Christie JD, Bushman FD, Collman RG10.: Upper Respiratory Dysbiosis with a Facultative-Dominated Ecotype in Advanced Lung Disease and Dynamic Change after Lung Transplant. Annals of the American Thoracic Society Page: 1383-1391, November 2019.

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Last updated: 11/12/2020
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