Jason D. Christie, MD, MSCE

faculty photo
Robert M. Kotloff/Nancy P. Blumenthal Professor for Advanced Lung Disease
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Education:
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Jones TK1, Feng R2, Kerchberger VE3, Reilly JP4, Anderson BJ5, Shashaty MGS6, Wang F7, Dunn TG4, Riley TR8, Abbott J9, Ittner CAG10, Christiani DC11,12, Mikacenic C13, Wurfel MM14, Ware LB15, Calfee CS16, Matthay MA17, Christie JD18, Meyer NJ19.: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. American Journal of respiratory and critical care medicine September 2019 Notes: [Epub ahead of print]

Miano TA1,2,3, Flesch JD4, Feng R2,3, Forker CM4, Brown M4, Oyster M4, Kalman L4, Rushefski M4, Cantu E 3rd5, Porteus M4, Yang W1,2,3, Russel Localio Jd A2,3, Diamond JM4, Christie JD2,3,4, Shashaty MGS2,4.: Early Tacrolimus Concentrations After Lung Transplant are Predicted by Combined Clinical and Genetic Factors and Associated with Acute Kidney Injury. Clinical Pharmacology and Therapeutics September 2019 Notes: [Epub ahead of print]

Anderson MR1, Udupa JK2, Edwin E3, Diamond JM4, Singer JP5, Kukreja J6, Hays SR5, Greenland JR5, Ferrante A3, Lippel M1, Blue T1, McBurnie A1, Oyster M4, Kalman L4, Rushefski M4, Wu C2, Pednekar G2, Liu W1, Arcasoy S1, Sonett J7, D'Ovidio F7, Bacchetta M8, Newell JD9, Torigian D2, Cantu E10, Farber DL11, Giles JT1, Tong Y2, Palmer S12, Ware LB13, Hancock WW14, Christie JD4, Lederer DJ: Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study. The journal of heart and lung transplantation Page: [Epub ahead of print] August 2019.

Sivakumar P1, Thompson JR2, Ammar R2, Porteous M3, McCoubrey C3, Cantu E 3rd4, Ravi K5, Zhang Y5, Luo Y6, Streltsov D1, Beers MF3,7, Jarai G1, Christie JD3,: RNA sequencing of transplant-stage idiopathic pulmonary fibrosis lung reveals unique pathway regulation. ERJ open research August 2019.

Anderson MR1, Edwin EA1, Diamond JM2, Ferrante A Jr1, Sonett J1, D'Ovidio F1, Arcasoy S1, Cantu E 3rd2, Christie JD2, Lederer DJ1.: Aryl-Hydrocarbon Receptor Repressor Gene in Primary Graft Dysfunction after Lung Transplantation. American journal of respiratory cell and molecular biology Page: 268-271, August 2019.

Monticelli LA1, Diamond JM2, Saenz SA3, Tait Wojno ED4, Porteous MK5, Cantu E6, Artis D7, Christie JD8.: Lung Innate Lymphoid Cell Composition is Altered in Primary Graft Dysfunction. American journal of respiratory and critical care medicine Page: [Epub ahead of print] August 2019.

Simon-Soro A1, Sohn MB2, McGinniss JE1, Imai I3, Brown MC1, Knecht VR1, Bailey A4, Clarke EL5, Cantu E6, Li H2, Bittinger K7, Diamond JM8, Christie JD1, Bushman FD9, Collman RG10.: Upper Respiratory Dysbiosis with a Facultative-Dominated Ecotype in Advanced Lung Disease and Dynamic Change after Lung Transplant. Annals of the American Thoracic Society August 2019 Notes: Epub ahead of print.

Shashaty MGS1,2, Forker CM1, Miano TA2, Wu Q2, Yang W2, Oyster ML1, Porteous MK1, Cantu EE 3rd3, Diamond JM1, Christie JD: The association of post-lung transplant acute kidney injury with mortality is independent of primary graft dysfunction: A cohort study. Clinical Transplantation July 2019 Notes: Epub ahead of print.

Anderson MR1, Kolaitis NA2, Gao Y2, Kukreja J2, Greenland J2, Hays S2, Wolters P2, Golden J2, Diamond J3, Palmer S4, Arcasoy S1, Udupa J5, Christie JD3, Lederer DJ1,6, Singer JP2.: A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates. American Journal of Transplantation July 2019 Notes: Epub ahead of print.

Zaffiri L1, Shah RJ2, Stearman RS3, Rothhaar K3, Emtiazjoo AM4, Yoshimoto M3, Fisher AJ3, Mickler EA3, Gartenhaus MD3, Cohort LTOG5, Diamond JM6, Geraci MW3, Christie JD6, Wilkes DS7.: Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation. Transplant Immunology Page: 101224, July 2019.

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Last updated: 11/06/2019
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