Jason D. Christie, MD, MSCE

faculty photo
Paul F. Harron, Jr. Family Professor
Member, Biomedical Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Department of Biostatistics and Epidemiology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
Adjunct Investigator, Institute for Environmental Medicine, Perelman School of Medicine at the University of Pennsylvania
Chief, Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania
Executive Committee, Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Education:
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Maria C Basil, Fabian L Cardenas-Diaz, Jaymin J Kathiriya, Michael P Morley, Justine Carl, Alexis N Brumwell, Jeremy Katzen, Katherine J Slovik, Apoorva Babu, Su Zhou, Madison M Kremp, Katherine B McCauley, Shanru Li, Joseph D Planer, Shah S Hussain, Xiaoming Liu, Rebecca Windmueller, Yun Ying, Kathleen M Stewart, Michelle Oyster, Jason D Christie, Joshua M Diamond, John F Engelhardt, Edward Cantu, Steven M Rowe, Darrell N Kotton, Harold A Chapman, Edward E Morrisey: Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature 604: 120-126, April 2022 Notes: Epub 2022 Mar 30.

Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM.: Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Crit Care Med 50: e284-e293, Mar 2022.

Farrell CL, Miano TA, Griffiths S, Christie JD, Diamond JM, Shashaty MGS.: Early post-lung transplant calcineurin inhibitor management varies widely: An international survey. Clin Transplant February 2022.

Tatiana Akimova, Tianyi Zhang, Lanette M Christensen, Zhonglin Wang, Rongxiang Han, Dmitry Negorev, Arabinda Samanta, Isaac E Sasson, Trivikram Gaddapara, Jing Jiao, Liqing Wang, Tricia R Bhatti, Matthew H Levine, Joshua M Diamond, Ulf H Beier, Rebecca A Simmons, Edward Cantu, David S Wilkes, David J Lederer, Michaela Anderson, Jason D Christie, Wayne W Hancock : Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. American Journal of Respiratory and Critical Care Medicine 204(9): 1060-1074, November 2021 Notes: Online ahead of print.

Courtwright AM, Kamoun M, Diamond JM, Kearns J, Ahya VN, Christie JD, Clausen E, Hadjiliadis D, Patel N, Salgado JC, Cevasco M, Cantu EE, Crespo MM, Bermudez CA.: Lung transplantation outcomes after crossing low-level donor specific antibodies without planned augmented immunosuppression. Clin Transplant 35(11): e14447. November 2021.

Julia A Maheshwari, Nicholas A Kolaitis, Michaela R Anderson, Luke Benvenuto, Ying Gao, Patricia P Katz, John Greenland, Paul J Wolters, Kenneth Covinsky, Steven R Hays, Jasleen Kukreja, Daniel R Calabrese , Aida Venado, Rupal J Shah , Lorriana E Leard, Binh Trinh, Chiung-Yu Huang, David Glidden, Mary Ellen Kleinhenz, Jeffrey A Golden, Nicole Sutter, Gayelan Tietje-Ulrich, Rachel N Criner, Selim M Arcasoy, Jason D Christie, Joshua Diamond, Jonathan P Singer : Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Annuals of the American Thoracic Society 9: 1464-1474. September 2021.

Mulong Du, Joe G N Garcia, Jason D Christie, Junyi Xin, Guoshuai Cai, Nuala J Meyer, Zhaozhong Zhu, Qianyu Yuan, Zhengdong Zhang, Li Su, Sipeng Shen, Xuesi Dong , Hui Li, John N Hutchinson, Paula Tejera, Xihong Lin, Meilin Wang, Feng Chen, David C Christiani: Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Intensive Care Medicine 7: 761-771, July 2021.

Yehya N, Fazelinia H, Lawrence GG, Spruce LA, Mai MV, Worthen GS, Christie JD.: Plasma Nucleosomes Are Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med 49: 1149-1158, Jul 2021.

Changhai Li , Kunal Patel, Zhenxiao Tu, Xiaofeng Yang, Liudmila Kulik, Ali Alawieh, Patterson Allen 4, Qi Cheng 1 2, Caroline Wallace, Jane Kilkenny, Jennie Kwon, Barry Gibney, Edward Cantu, Ashish Sharma, Mauricio Pipkin, Tiago Machuca, Amir Emtiazjoo, Martin Goddard, V Michael Holers, Satish Nadig, Jason Christie, Stephen Tomlinson, Carl Atkinson : A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. American Journal of Transplantation 6: 2067-2078, June 2021.

Patricia C Pawlow, Nancy P Blumenthal, Jason D Christie, Lea Ann Matura, Subhash Aryal, Mary Ersek : The Supportive Care Needs of Primary Caregivers of Lung Transplant Candidates. Journal of Pain and Symptom Management 21: 3924, May 2021 Notes: Online ahead of print.

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Last updated: 06/07/2022
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