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Donald L. Siegel, MD, PhD

Donald L. Siegel, MD, PhD

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
510 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 898-9655
Education:
Sc.B. (Biophysics)
Brown University, 1977.
Ph.D. (Biophysics)
Harvard University, 1983.
M.D.
University of Pennsylvania, 1987.
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Description of Research Expertise

Research Interests

Production and characterization of pathogenic human monoclonal auto- and alloantibodies

Research Summary

My laboratory is interested in characterizing the human immune response to auto- and alloantigens on a molecular level in order to understand more about human immune repertoire development. Our goal is to use this information to develop specific therapeutic agents that down-regulate immune responses in the settings of autoimmune disease such as immune hemolytic anemias and thrombocytopenias, transfusion reactions, hemolytic disease of the newborn, and acute rejection of solid organ allografts.
To approach these problems experimentally, we have combined Fab/phage-display technology with a novel cell-surface panning method to isolate large arrays of clinically significant human monoclonal antibodies from individual patients. This approach has enabled us to study the genetic and immunological properties of pathogenic auto- and alloantibodies.

Description of Clinical Expertise

transfusion medicine, blood banking, apheresis, hematopoietic stem cell collection/processing

Selected Publications

Villa C., Pan D., Zaitsev S., Siegel D.L., Muzykantov, V.: Coupling drugs to carrier erythrocytes: A resurrection of an (almost) forgotten approach for vascular drug delivery. Therapeutic Delivery 2015.

Gao, C., Liu, Y., Zhang, H., Zhang, Y., Fukuda, M.N., Palma, A.S., Kozak, R.P., Childs, R.A., Nonaka, M., Li, Z., Siegel, D.L., Hanfland, P., Peehl, D.M., Chai, W., Greene, M.I., Feizi, T.: Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array. J. Biol. Chem. 289: 16462-16477, 2014.

O'Doherty, U., Siegel, D.L.: Transfusion Reactions. The Intensive Care Manual, 2nd edition. Lanken, P.N., Manaker S., Kohl B.A., Hanson C.W. (eds.). Elsevier Saunders, Philadelphia, Page: 450-456, 2014.

Azzato E., Gentile C., Carpenter H., Siegel D., Watt C.: Successful red blood cell gemotyping from leukoreduced packed red blood cell segments. abstracts of the 2014 Annual Meeting of the Association for Molecular Pathology 2014.

Hammers, C., Chen, J., Lin, C., Kacir, S., Siegel, D.L., Payne, A.S., Stanley, J.R.: Persistence of anti-desmoglein 3 IgG+ B-cell clones in pemphigus patients over years. J Invest Dermatol advance online publication 21 August 2014 2014.

Casina V., Wenbing H., Hanby H., Siegel D.L., Mayne L., Englander S.W., Zheng X.L: Deuterium-hydrogen exchange coupled with mass spectrometry revealed a novel autoantibody binding epitope and substrate recognition site in ADAMTS13 protease. Blood 122: 455, 2013.

Garfall A.L., Dougherty A.L., Vogl D.T., Weiss B.W., Cohen A.D., Mangan P.A., O’Doherty U., Siegel D.L., Porter D.L., Stadtmauer E.A.: Stem cell mobilization with Plerixafor + G-CSF in comparison to cyclophosphamide + G-CSF is associated with inferior time-to-progression after autologous stem cell transplantation for multiple myeloma. Blood 2013.

Garfall A.L., Dougherty A.L., Vogl D.T., Weiss B.W., Cohen A.D., Mangan P.A., O’Doherty U., Siegel D.L., Porter D.L., Stadtmauer E.A: Stem cell mobilization with Plerixafor + G-CSF in comparison to cyclophosphamide + G-CSF and time-to-progression after autologous stem cell transplantation for multiple myeloma. Blood 122: 3354, 2013.

Azzato E., Carpenter H., Miszczanczuk M., Dinh L-H., DeMuth F., Magee D., Aqui N., Siegel D., Sachais B.S.: Prospective monitoring of cryoprecipitate resulting in decreased product waste. Transfusion(53), 232a, 2013.

Mangalmurti N.S., Qing D., Siegel D., Lee J.S., Worthen G.S., Albelda S.M.: Transfusions modulate the host inflammatory response and prime the endothelium for subsequent injury through the receptor for advanced glycation end products. Transfusion 120: 52a, 2013.

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Last updated: 08/27/2014
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