Donald L. Siegel, MD, PhD

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
9-112 South Tower, Big 421
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 662-3942
Lab: (215) 898-9655
Education:
Sc.B. (Biophysics)
Brown University, 1977.
Ph.D. (Biophysics)
Harvard University, 1983.
M.D.
University of Pennsylvania, 1987.
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Description of Research Expertise

Research Interests

Discovery and characterization of diagnostic and therapeutic monoclonal antibodies

Research Summary

My laboratory studies human immune repertoires in health and disease using phage display technologies for the production of human and non-human monoclonal antibodies relevant to transfusion medicine, benign hematology, infectious diseases, and oncology. Current studies focus on developing targeted drug delivery methods using red cell antibodies coupled to novel anti-thrombotic/anti-inflammatory molecules; cloning monoclonal primate neutralizing Dengue, Ebola, MERS and Zika virus antibodies for human in vivo antibody gene expression therapy; and isolating recombinant human and humanized antibody fragments for the design of T-cell chimeric antigen receptors for cancer therapy.

Description of Clinical Expertise

transfusion medicine, blood banking, apheresis, hematopoietic stem cell collection/processing, cGMP manufacture of cellular therapies for phase I first-in-human clinical trials

Selected Publications

Don Siegel: Transfusion Medicine Meets Cell & Gene Therapy: ISCT Featured Member. ISCT Telegraft June 2020.

Don Siegel: Your Guide to Donating Blood During Coronavirus – And After. Shape Magazine May 2020.

Don Siegel: Controversial Uses of Blood Components. AABB May 2020.

Don Siegel: How One NBF Grant Recipient Proliferated His Success in Many Different Aspects of His Career. AABB News March 2020.

Nobles, C., Sherrill-Mix, S., Everett, J.K., Reddy, S., Fraietta, J., Porter, D., Frey, N., Gill, S.I., Grupp, S., Maude, S., Siegel, D.L., Levine, B.L. June, C.H., Lacey, S., Melenhorst, J., Bushman, F.: Linking CART19 immunotherapy outcome with genomic modification by vector integration. J Clin Invest 130: 673-685, 2020.

Parvathaneni, K., Siegel, D.L., Bhoj, V.G.: Engineered antigen-expressing CAAR-T cells targeting autoreactive B cells to ADAMTS13 in the context of thrombotic thrombocytopenic purpura. Molecular Therapy 28: 410, 2020.

Lamontagne, A., Colligon, T.A., Taylor, C., Lewitt, L., Holland. D., Buchholz, K., Migliaccio, T., Brennan, A., Levine, B.L., Plesa, G., Siegel, DL: Maintaining excellence in a high volume academic cell therapy production facility through optimization of space utilization, operations, scheduling and staffing. Cytotherapy 22: S149-S150, 2020.

Xu, J., Gohil, M., Stadtmauer, E., Fraietta, J.A., Gonzalez, V.E., Salas-McKee, J., Jadlowsky, J., Gladney. W., Lamontagne, A., Fesnak, A., Siegel, D. Levine. B.L., Lacey, S., June, C., Davis, M.M.: Characterization of autologous T cells engineered to express NY-ESO-1 TCR with multiplexed CRISPR/Cas9 editing (NYCE T cells. Cytotherapy 22: S35-S36, 2020.

Diorio, C., Shaw, P., Pequignot, E., Orlenko, A., Chen, F., Aplenc, R., Barrett, D.M., Bassiri, H., Edward Behrens, E., Gonzalez, V., Koterba, N., Levine, B.L., Maude, S.L., Meyer, N.J., Moore, J.H., Paessler, M., Porter, D.L., Rush, J., Siegel, D.L., Suhoski, M., Zhang, D., June, C.H., Grupp, S.A., Melenhorst, J.J., Lacey, S.F., Weiss, S.L., Teachey, D.T.: Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children. Blood Adv in press, 2020.

Choi, H., Kudchodkar, S.B., Reuschel, E.L., Asija, K., Borole, P., Agarwal, S., Van Gorder, L., Reed, C.C., Gulendram, G., Ramos, S., Broderick, K.E., Kim, J.J., Ugen, K.E., Kobinger, G., Siegel, D.L., Weiner, D.B., Muthumani, K.: Synthetic nucleic acid antibody prophylaxis confers rapid and durable protective immunity against Zika virus challenge. Human Vaccines & Immunotherapeutics 16: 907-918, 2020.

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Last updated: 08/30/2020
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