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Perelman School of Medicine at the University of Pennsylvania Advanced Search

Peter Leslie Dutton,

Peter Leslie Dutton

faculty photo
Eldridge Reeves Johnson Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations

Contact information
1005 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 898-0991
Fax: (215) 573-2235
Education:
B.Sc. (Chemistry (Honors))
University of Wales, 1963.
Ph.D. (Biochemistry)
University of Wales, 1967.
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Description of Research Expertise

The Dutton lab is interested in determining factors governing electron tunneling through natural proteins engaged in electron transfer, energy conversion, signaling, regulation and enzyme redox catalysis. We are also involved in de novo design and synthesis of proteins engineered to perform natural functions such as electron transfer, proton translocation, charge driven conformational changes and redox catalysis in structured highly simplified settings

Selected Publications

Moser, C.C, Page., C.C., Cogdell, R.G., Barber, J., Rutherford, A.W., Wraight, C.A., and Dutton, P.L. : Length, Time, and Energy Scales in Photosystems Advances in Protein: Membrane Structure, Advances in Protein Science. In Press. D.C. Rees (eds.). Academic Press, 63, 2003.

Noy, D. Moser, C. C., and Dutton, P.L. : Modeling (B)Chl proteins: syntheses 2 (Chapter 27) In: Chlorophylls. In press. B. Grimm, R. Porra, W. Rüdige, & H. Scheer (eds.). Kluwer Academic Publishers, Dordrecht, The Netherlands, 2003.

Huang, S.S., Gibney, B.R, Stayrook, S.E., Dutton, P.L., and Lewis, M. : Crystal Structure of a Maquette Scaffold In Press: J Mol. Biol. 2003.

Chen, X., Discher, B., Pilloud, D. L., Gibney, B. R., Moser, C. C., and Dutton, P. L. : De novo Design of a Cytochrome b Maquette for Electron Transfer and Coupled Reactions on Electrodes J. Phys. Chem. B. 106: 617-624, 2002.

Munro, A. W., Leys, D. G., McLean, K. J., Marshall, K. R. Ost, T. W. B., Daff, S., Noble, M. A., Green, A. J., Miles, C. S., Chapman, S. K., Lysek, D., Moser, C. C., Page, C.C., and Dutton, P.L. : P450 BM3 – The Very Model of a Modern Flavocytochrome T.I.B.S. 27: 250-257, 2002.

Dai, Q-H., Tommos, C., Fuentes, E.J., Blomberg, M., Dutton, P. L., and Wand, J.W. : Structure of a De Novo Designed protein Model of Radical Enzymes J.A.C.S. 124: 10952-10953, 2002.

Tronin, A., Strzalka, J., chen, X., Dutton, P.L. Ocko, B.M. and Blasie, J.K. : Orientational Distributions of the Di-a-helical Synthetic Peptide ZnPPIX-BBC16 in Langmuir Monolayers by X-Ray Reflectivity and Polarized Epifluorescence Langmuir 17: 3061-3066, 2001.

Grosset, A.M., Gibney, B. R., Rabanal, F., Moser, C. C., and Dutton, P. L. : Proof of Principle in a De novo Designed Protein Maquette: An Allosterically Regulated, Charge Activated Conformational Switch in a Tetra a-Helix Bundle Biochemistry 40: 5474-5487, 2001.

Darrouzet, E., Moser, C. C., Dutton, P. L., and Daldal, F. : Large Scale Domain Movement in the Cytochrome bc1: A new Device for Electron Transfer in Proteins TIBS 26: 445-451, 2001.

Kennedy, M.L., Gibney, B.R., and Dutton, P.L. : Model Hemoprotein Reduction Potentials: The Effects of Histidine to Iron Coordination Equilibrium J.A.C.S. 123: 4635-4636, 2001.

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Last updated: 08/25/2004
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