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Peter Leslie Dutton
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Emeritus Professor of Biochemistry and Biophysics
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Department: Biochemistry and Biophysics
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Contact information
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1005 Stellar-Chance Laboratories
32 422 Curie Blvd.
Philadelphia, PA 19104
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32 422 Curie Blvd.
Philadelphia, PA 19104
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Office: (215) 898-0991
34 Fax: (215) 573-2235
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Email:
DUTTON@MAIL.MED.UPENN.EDU
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DUTTON@MAIL.MED.UPENN.EDU
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Publications
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Education:
21 a B.Sc. 1f (Chemistry (Honors)) c
2c University of Wales, 1963.
21 a Ph.D. 19 (Biochemistry) c
2c University of Wales, 1967.
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Permanent link21 a B.Sc. 1f (Chemistry (Honors)) c
2c University of Wales, 1963.
21 a Ph.D. 19 (Biochemistry) c
2c University of Wales, 1967.
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Description of Research Expertise
1d9 The Dutton lab is interested in determining factors governing electron tunneling through natural proteins engaged in electron transfer, energy conversion, signaling, regulation and enzyme redox catalysis. We are also involved in de novo design and synthesis of proteins engineered to perform natural functions such as electron transfer, proton translocation, charge driven conformational changes and redox catalysis in structured highly simplified settings26 29
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136 Noy, D. Moser, C. C., and Dutton, P.L. : Modeling (B)Chl proteins: syntheses 2 (Chapter 27) In: Chlorophylls. In press. B. Grimm, R. Porra, W. Rüdige, & H. Scheer (eds.). Kluwer Academic Publishers, Dordrecht, The Netherlands, 2003.
d8 Huang, S.S., Gibney, B.R, Stayrook, S.E., Dutton, P.L., and Lewis, M. : Crystal Structure of a Maquette Scaffold In Press: J Mol. Biol. 2003.
12d Chen, X., Discher, B., Pilloud, D. L., Gibney, B. R., Moser, C. C., and Dutton, P. L. : De novo Design of a Cytochrome b Maquette for Electron Transfer and Coupled Reactions on Electrodes J. Phys. Chem. B. 106: 617-624, 2002.
164 Munro, A. W., Leys, D. G., McLean, K. J., Marshall, K. R. Ost, T. W. B., Daff, S., Noble, M. A., Green, A. J., Miles, C. S., Chapman, S. K., Lysek, D., Moser, C. C., Page, C.C., and Dutton, P.L. : P450 BM3 – The Very Model of a Modern Flavocytochrome T.I.B.S. 27: 250-257, 2002.
103 Dai, Q-H., Tommos, C., Fuentes, E.J., Blomberg, M., Dutton, P. L., and Wand, J.W. : Structure of a De Novo Designed protein Model of Radical Enzymes J.A.C.S. 124: 10952-10953, 2002.
152 Tronin, A., Strzalka, J., chen, X., Dutton, P.L. Ocko, B.M. and Blasie, J.K. : Orientational Distributions of the Di-a-helical Synthetic Peptide ZnPPIX-BBC16 in Langmuir Monolayers by X-Ray Reflectivity and Polarized Epifluorescence Langmuir 17: 3061-3066, 2001.
155 Grosset, A.M., Gibney, B. R., Rabanal, F., Moser, C. C., and Dutton, P. L. : Proof of Principle in a De novo Designed Protein Maquette: An Allosterically Regulated, Charge Activated Conformational Switch in a Tetra a-Helix Bundle Biochemistry 40: 5474-5487, 2001.
102 Darrouzet, E., Moser, C. C., Dutton, P. L., and Daldal, F. : Large Scale Domain Movement in the Cytochrome bc1: A new Device for Electron Transfer in Proteins TIBS 26: 445-451, 2001.
fc Kennedy, M.L., Gibney, B.R., and Dutton, P.L. : Model Hemoprotein Reduction Potentials: The Effects of Histidine to Iron Coordination Equilibrium J.A.C.S. 123: 4635-4636, 2001.
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Selected Publications
161 Moser, C.C, Page., C.C., Cogdell, R.G., Barber, J., Rutherford, A.W., Wraight, C.A., and Dutton, P.L. : Length, Time, and Energy Scales in Photosystems Advances in Protein: Membrane Structure, Advances in Protein Science. In Press. D.C. Rees (eds.). Academic Press, 63, 2003.136 Noy, D. Moser, C. C., and Dutton, P.L. : Modeling (B)Chl proteins: syntheses 2 (Chapter 27) In: Chlorophylls. In press. B. Grimm, R. Porra, W. Rüdige, & H. Scheer (eds.). Kluwer Academic Publishers, Dordrecht, The Netherlands, 2003.
d8 Huang, S.S., Gibney, B.R, Stayrook, S.E., Dutton, P.L., and Lewis, M. : Crystal Structure of a Maquette Scaffold In Press: J Mol. Biol. 2003.
12d Chen, X., Discher, B., Pilloud, D. L., Gibney, B. R., Moser, C. C., and Dutton, P. L. : De novo Design of a Cytochrome b Maquette for Electron Transfer and Coupled Reactions on Electrodes J. Phys. Chem. B. 106: 617-624, 2002.
164 Munro, A. W., Leys, D. G., McLean, K. J., Marshall, K. R. Ost, T. W. B., Daff, S., Noble, M. A., Green, A. J., Miles, C. S., Chapman, S. K., Lysek, D., Moser, C. C., Page, C.C., and Dutton, P.L. : P450 BM3 – The Very Model of a Modern Flavocytochrome T.I.B.S. 27: 250-257, 2002.
103 Dai, Q-H., Tommos, C., Fuentes, E.J., Blomberg, M., Dutton, P. L., and Wand, J.W. : Structure of a De Novo Designed protein Model of Radical Enzymes J.A.C.S. 124: 10952-10953, 2002.
152 Tronin, A., Strzalka, J., chen, X., Dutton, P.L. Ocko, B.M. and Blasie, J.K. : Orientational Distributions of the Di-a-helical Synthetic Peptide ZnPPIX-BBC16 in Langmuir Monolayers by X-Ray Reflectivity and Polarized Epifluorescence Langmuir 17: 3061-3066, 2001.
155 Grosset, A.M., Gibney, B. R., Rabanal, F., Moser, C. C., and Dutton, P. L. : Proof of Principle in a De novo Designed Protein Maquette: An Allosterically Regulated, Charge Activated Conformational Switch in a Tetra a-Helix Bundle Biochemistry 40: 5474-5487, 2001.
102 Darrouzet, E., Moser, C. C., Dutton, P. L., and Daldal, F. : Large Scale Domain Movement in the Cytochrome bc1: A new Device for Electron Transfer in Proteins TIBS 26: 445-451, 2001.
fc Kennedy, M.L., Gibney, B.R., and Dutton, P.L. : Model Hemoprotein Reduction Potentials: The Effects of Histidine to Iron Coordination Equilibrium J.A.C.S. 123: 4635-4636, 2001.
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