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Emma Anne Meagher, M.D.

Emma Anne Meagher, M.D.

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Associate Professor of Medicine at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics
University of Pennsylvania
8032 Maloney Building
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-662-2174
Fax: 215-573-8996
Education:
M.D. (Medicine)
Royal College of Surgeons in Ireland, 1987.
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Description of Research Expertise

Development of novel therapeutics for Dyslipidemia

Description of Clinical Expertise

Focused on the cardiovascular risk reduction with a focus on women’s cardiovascular health, hypertension and dyslipidemia.

Selected Publications

Blom D, Averna M, Meagher EA, du Toit Theron, H, Sirtori C, Hegele R, Shah P, Gaudet D, Stefanutti C, Vigna G, Foulds P, Bloedon L, Rader D, Cuchel M.: Long-Term Efficacy and Safety of Lomitapide for the Treatment of Homozygous Familial Hypercholesterolemia: Results of the Phase 3 Extension Trial. AHA Scientific Sessions in press. Nov 2015 Notes: Poster Presentation.

Adamo JE, Wilhelm EE, Steele SJ.: Advancing a Vision for Regulatory Science Training. Clinical Translational Sciences 8(5): 615-618, Oct 2015.

Pfund C, Spencer KC, Asquith P, House SC, Miller S, Sorkness CA: Building National Capacity for Research Mentor Training: An Evidence-Based Approach to Training the Trainers. CBE Life Sciences Education 14:ar24(2): 1-12, June 2015.

Stefanutti C, Blom DJ, Averna MR, Meagher EA, Theron Hd, Marais AD, Hegele RA, Sirtori CR, Shah PK, Gaudet D, Vigna GB, Sachais BS, Di Giacomo S, du Plessis AM, Bloedon LT, Balser J, Rader DJ, Cuchel M.: The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial. Atherosclerosis 240(2): 408-414, Jun 2015.

Raper A, Kolansky DM, Sachais BS, Meagher EA, Baer AL, Cuchel M.: Long-term clinical results of microsomal triglyceride transfer protein inhibitor use in a patient with homozygous familial hypercholesterolemia. Journal of Clinical Lipidology 9(1): 107-112, Jan-Feb 2015.

Stefanutti C, Blom D, Averna M, Meagher E, du Toit Theron, H, Marais D, Hegele R, Sirtori C, Shah P, Gaudet D, Vigna G, du Plessis A, Bloedon L, Rader D, Cuchel M.: Homozygous Familial Hypercholesterolemia Presents with a Wide Spectrum of LDL-C Levels in a Genetically Confirmed Cohort of Patients. The Second World Congress of Clinical Lipidology, Vienna, Austria Dec 2014 Notes: Poster Presentation.

Meagher, E., Ziolek, T., Singleton, MK, Davison, C., & Heagerty, D. : Training and Retaining MD and Other Scientist Members: A Symbiotic Partnership between IRBs and Academic Programs. Poster presented at the PRIM&R Annual Advancing Ethical Research Conference, Boston, MA. Nov 2013.

Cuchel M, Blom DJ, Averna MR, Meagher EA, du Toit Theron H, Sirtori CR, Hegele RA, Shah PK, Gaudent D, Stefanutti C, Vigna GB, di Ferrara U, Bloedon LT, Rader DJ, HoFH Lomitapide Study Investigators: Sustained LDL-C Lowering and Stable Hepatic Fat Levels in Patients with Homozygous Familial Hypercholesterolemia Treated with the Microsomal Triglyceride Transfer Protein Inhibitor, Lomitapide: Results of an Ongoing Long-Term Extension Study. AHA Scientific Sessions. Circulation 128(22 (Supplement) A16516), Nov 2013 Notes: Poster Presentation.

Cuchel M, Meagher E, du Toit Theron H, Blom, DJ, Marais AD, Hegele RA, Averna M, Sirtori CR, Shah PK, Gaudent D, Stefanutti C, Vigna G, Du Plessis AME, Bloedon LT, Rader DJ.: Aminotransferase elevations observed in a phase 3 study of patients with homozygous familial hypercholesterolemia treated with lomitapide were clinically manageable. 81st European Atherosclerosis Society Congress Jun 2013 Notes: Poster Presentation.

Cuchel M, Meagher EA, du Toit Theron H, Blom DJ, Marais AD, Hegele RA, Averna MR, Sirtori CR, Shah PK, Gaudet D, Stefanutti C, Vigna GB, Du Plessis AM, Propert KJ, Sasiela WJ, Bloedon LT, Rader DJ : Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet 5(381 (9860)): 40-46, Jan 2013.

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Last updated: 07/06/2016
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