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Jose L. Pascual L., MD, PhD, FACS, FCCM, FRCSC

Jose L. Pascual L., MD, PhD, FACS, FCCM, FRCSC

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Associate Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Department: Surgery

Contact information
Division of Trauma & Surgical Critical Care
Perelman School of Medicine at the University of Pennsylvania
51 North 39th St,MOB 1st floor, Suite 120, Room 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
University of Ottawa, Ottawa, Ontario, 1996.
McGill University, Montreal, Quebac, 2005.
McGill University, Montreal, Quebec, 2005.
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Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Description of Clinical Expertise

Jose Pascual is an intensivist/surgeon at the University Of Pennsylvania, board certified in the US/Canada. He finished his fellowship in 2007 and his basic science PhD in resuscitation immunobiology, at McGill, in 2005. His thesis investigated the salutary effects of immunemodulating fluids in shock.

As faculty of Medical and Nursing Schools, Jose teaches students, residents, fellows and advance practice providers in several didactic and skills courses. However, most notable is his role as research mentor for medical, nursing and undergraduate students raising questions at the bedside and attempting to answer them through clinical or basic science research projects. In the last 5 years, Jose has mentored 23 research trainees, several of whom have won awards at national/international scientific meetings.

Jose Pascual’s research interests include Traumatic Brain Injury, shock and ICU education through simulation and patient safety initiatives. His TBI laboratory studies immune responses to injury through intravital microscopy of the cerebral microcirculation investigating the role of the neutrophil in injury and shock.

Jose has launched several ICU educational initiatives using simulation integrated within the ICU to teach day-to-day emergent event management by the multidisciplinary team (NPs, MDs, nurses, pharmacists) through learning from errors or near misses. Initiatives relating to videorecorded simulator-generated or real emergent events have been integrated in ICU Quality Improvement efforts and also published.

Selected Publications

Pascual JL, Cannon J. : Hemorrhagic Shock: Recognition, Pathophysiology and Management. Nova Science Publishers, Inc., New York, NY. Jan 2017.

Li S, Eisenstadt R, Kumasaka K, Johnson VE, Marks J, Nagata K, Browne KD, Smith DH, Pascual JL. : Does enoxaparin interfere with HMGB1 signaling after TBI? A potential mechanism for reduced cerebral edema and hastened neurological recovery. J Trauma Acute Care Surg Mar 2016 (accepted for publication)

Chung JC, Earl-Royal E, Delgado MK, Pascual JL, Reilly PM, Wiebe DJ, Holena DN.: Where We Fail: Location and Timing of Failure to Rescue in Trauma. Am Surgeon, April 2016.

Hersperger S, Becker A, Heiderich G, Smith B, Holena D, Schutz A, Mancini DJ, Kumar HRN, Mook M, Holland S, Motuk S, Martin N, Reilly PM, Kim P, Pascual JL.: BECOMING A TRAUMA CENTER OVERNIGHT: Using Simulation to Train Seasoned Yet Trauma-Naïve Providers Prior to Becoming Trauma Providers. Quick Shot, 68th Annual Meeting of The Southwestern Surgical Congress, Coronado, CA April 2016.

Hatchimonji JS, Nunn AM, Holena DN, Smith BP, Martin ND, Reilly PM, Schwab CW, Pascual JL.: BOARDING ICU PATIENTS: ARE OUR ROUNDING PRACTICES SUBPAR? Quick Shot, 68th Annual Meeting of The Southwestern Surgical Congress, Coronado, CA April 2016.

Kaufman EJ, Wiebe DJ, Martin ND, Pascual JL, Reilly PM, Holena DN: Variation in ICU Utilization and Mortality After Blunt Splenic Injury. Accepted to J Surg Res, Mar 2016.

Barry ME, Hochman BR, Lane-Fall MB, Zappile D, Holena DN, Smith BP, Kaplan LJ, Huffenberger A, Reilly PM, Pascual JL.: Operating room-to ICU handoffs captured on video: Are nighttime transitions more dangerous? Submitted to The Joint Commission Journal on Quality and Patient Safety Feb 2016.

Lane-Fall M, Pascual JL. : Developing a standardized OR to ICU handoff process. Poster at the 45th Congress of SCCM, Orlando, FL, Feb 2016.

Jablonski J, Pascual JL, Martin N.: Do antipsychotics improve ICU outcomes in patients with delirium? Poster at the 45th Congress of SCCM, Orlando, FL, Feb 2016.

ND Martin, SP Patel, K Chreiman, J Pascual, DN Holena, B Braslow, PM Reilly, L Kaplan.: Surgery for Patients In Extremis: Reasonable Care or Surgical Futility? Quickshot, 11th Annual Academic Surgical Congress, Jacksonville, FL Feb 2016.

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Last updated: 02/03/2017
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