Jose L. Pascual L., MD, PhD, FACS, FCCM, FRCSC

faculty photo
Associate Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Department: Surgery

Contact information
Division of Trauma & Surgical Critical Care
Perelman School of Medicine at the University of Pennsylvania
51 North 39th St,MOB 1st floor, Suite 120, Room 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
Education:
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
M.D.
University of Ottawa, Ottawa, Ontario, 1996.
FRCS (C)
McGill University, Montreal, Quebac, 2005.
Ph.D.
McGill University, Montreal, Quebec, 2005.
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Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Description of Clinical Expertise

Jose Pascual is an intensivist/surgeon at the University Of Pennsylvania, board certified in the US/Canada. He finished his fellowship in 2007 and his basic science PhD in resuscitation immunobiology, at McGill, in 2005. His thesis investigated the salutary effects of immunemodulating fluids in shock.

As faculty of Medical and Nursing Schools, Jose teaches students, residents, fellows and advance practice providers in several didactic and skills courses. However, most notable is his role as research mentor for medical, nursing and undergraduate students raising questions at the bedside and attempting to answer them through clinical or basic science research projects. In the last 5 years, Jose has mentored 23 research trainees, several of whom have won awards at national/international scientific meetings.

Jose Pascual’s research interests include Traumatic Brain Injury, shock and ICU education through simulation and patient safety initiatives. His TBI laboratory studies immune responses to injury through intravital microscopy of the cerebral microcirculation investigating the role of the neutrophil in injury and shock.

Jose has launched several ICU educational initiatives using simulation integrated within the ICU to teach day-to-day emergent event management by the multidisciplinary team (NPs, MDs, nurses, pharmacists) through learning from errors or near misses. Initiatives relating to videorecorded simulator-generated or real emergent events have been integrated in ICU Quality Improvement efforts and also published.

Selected Publications

Nagata K, Suto Y, Cognetti J, Browne KD, Kumasaka K, Johnson VE, Kaplan L, Marks J, Smith DH, Pascual JL.: Early low-anticoagulant desulfated heparin after traumatic brain injury: Reduced brain edema and leukocyte mobilization is associated with improved watermaze learning ability weeks after injury. J Trauma Acute Care Surg May 2018.

Martin N, Pascual JL, Crowe D, Toevs C, Cereda MF, Mikkelsen M, Kaplan LJ: Comfort At The Crossroads: Service, Therapy and Emotional Support Animals In The ICU And At The End-of-Life J Trauma Acute Care Surg Mar 2018.

Moore S, Weiss B, Pascual JL, Kaplan LJ.: Management of Acute Respiratory Failure in the Patient with Sepsis or Septic Shock. Surg Infect (Larchmt). Feb/Mar 2018.

Nagata K, Suto Y, Cognetti J, Browne KD, Kumasaka K, Johnson V, Kaplan L, Marks JA, Smith DH, Pascual JL.: Non-Anticoagulant desulfated heparin acutely reduces leukocyte mobilization and brain edema and improves watermaze learning ability weeks after traumatic brain injury. Podium presentation at the 76th Annual Meeting of the American Association for the Surgery of Trauma, Baltimore, MD. Sept 2017.

Sherma A, Sinha S, Oselkin M, Pascual J, Schuster J,: External carotid pseudoaneurysm due to wound vacuum placement after self-inflicted shotgun blast to face. Podium at 3rd Annual Critical Care Spectacular Case Presentation Competition, Philadelphia Drinker Society,Philadelphia, PA June 2017.

Resnick S, Seamon MJ, Holena DH, Pascual JL, Reilly PM, Martin ND.: Early Declaration of Death by Neurologic Criteria Results in Greater Organ Donor Potential J Surg Res May (Epub) 2017.

J, Gray J, Miano T, Redline G, Teufel H, Collins T, Pascual-Lopez J, Sylvia M, Martin ND: Pain, Agitation, and Delirium Guidelines: Interprofessional Perspectives to Translate the Evidence. Dimens Crit Care Nurs Page: 36(3):164-173. May/Jun 2017.

Nagata K, Browne KD, Suto Y, Kumasaka K, Cognetti J, Johnson VE, Marks J, Smith DH, Pascual JL.: Early Heparin Administration After TBI: Prolonged Cognitive Recovery Associated With Reduced Cerebral Edema and Neutrophil Sequestration. J Trauma Acute Care Surg. 2017 May 22. doi: 10.1097/TA.0000000000001590. J Trauma Acute Care Surg. May 2017.

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Last updated: 05/24/2018
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