Jose L. Pascual Lopez, MD, PhD

Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Penn e-lert eICU, Philadelphia, PA
Attending Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Attending Surgical Intensivist, Pennsylvania Hospital, Philadelphia, PA
Clinical Associate , University of Pennsylvania School of Nursing
Patient Safety Officer, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending NeuroIntensivist, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Cpl. Michael J. Cresencz Veteran's Affairs Medical Center, Philadelphia, PA
Attending NeuroIntensivist, Penn Presbyterian Hospital, Philadelphia, PA
Co-Medical Director , Surgical ICU, Hospital of the University of Pennsylvania, Philadelphia, PA
Reviewer , Penn Acute Research Collaborative (PARC)
Department: Surgery
Contact information
Division of Trauma & Surgical Critical Care
Penn Presbyterian Medical Center
51 North 39th St., MOB 1st Fl., Ste. 120, Rm. 108
Philadelphia, PA 19104
Penn Presbyterian Medical Center
51 North 39th St., MOB 1st Fl., Ste. 120, Rm. 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
Fax: 215-243-4679
Education:
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
M.D.
University of Ottawa, Ottawa, Ontario, 1996.
Ph.D.
McGill University, Montreal, Quebec, 2005.
FRCS (C)
McGill University, Montreal, Quebec, 2005.
Permanent linkN/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
M.D.
University of Ottawa, Ottawa, Ontario, 1996.
Ph.D.
McGill University, Montreal, Quebec, 2005.
FRCS (C)
McGill University, Montreal, Quebec, 2005.
Description of Research Expertise
Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.Description of Clinical Expertise
Jose Pascual is an intensivist/surgeon at the University Of Pennsylvania, board certified in the US/Canada. He finished his fellowship in 2007 and his basic science PhD in resuscitation immunobiology, at McGill, in 2005. His thesis investigated the salutary effects of immunemodulating fluids in shock.As faculty of Medical and Nursing Schools, Jose teaches students, residents, fellows and advance practice providers in several didactic and skills courses. However, most notable is his role as research mentor for medical, nursing and undergraduate students raising questions at the bedside and attempting to answer them through clinical or basic science research projects. In the last 5 years, Jose has mentored 23 research trainees, several of whom have won awards at national/international scientific meetings.
Jose Pascual’s research interests include Traumatic Brain Injury, shock and ICU education through simulation and patient safety initiatives. His TBI laboratory studies immune responses to injury through intravital microscopy of the cerebral microcirculation investigating the role of the neutrophil in injury and shock.
Jose has launched several ICU educational initiatives using simulation integrated within the ICU to teach day-to-day emergent event management by the multidisciplinary team (NPs, MDs, nurses, pharmacists) through learning from errors or near misses. Initiatives relating to videorecorded simulator-generated or real emergent events have been integrated in ICU Quality Improvement efforts and also published.
Selected Publications
Bele P, Thaploo A, Coons M, Culkin MC, Santos P, Martinez-Quinones P, Georges AP, Anderson E, Browne KD, Jacovides C, Kaplan LJ, Meaney DF, Smith DH, Pascual JL.: Daily quetiapine after severe TBI improves learning and memory. J Trauma Acute Care Surg May 2024.Haering, S., Seligowski, A. V., Linnstaedt, S. D., Michopoulos, V., House, S. L., Beaudoin, F. L., An, X., Neylan, T. C., Clifford, G. D., Germine, L. T., Rauch, S. L., Haran, J. P., Storrow, A. B., Lewandowski, C., Musey, P. I., Jr., Hendry, P. L., Sheikh, S., Jones, C. W., Punches, B. E., Swor, R. A., Gentile, N. T., Hudak, L. A., Pascual, J. L., Seamon, M. J., Pearson, C., Peak, D. A., Merchant, R. C., Domeier, R. M., Rathlev, N. K., O'Neil, B. J., Sanchez, L. D., Bruce, S. E., Harte, S. E., McLean, S. A., Kessler, R. C., Koenen, K. C., Stevens, J. S., Powers, A.: Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study. Psychol Med Page: 1-11, May 2024.
Horwitz A, McCarthy K, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Domeier RM, Rathlev NK, Sergot P, Sanchez LD, Bruce SE, Joormann J, Harte SE, Koenen KC, McLean SA, Sen S.: Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning. J Anxiety Disord 104: 102876, May 2024.
Vemu R, Yane TK, Glova GS, Paglia PL, Okyan K, Meaney DF, Chreiman K, Kaplan LJ, Pascual JL.: A simple engineering alteration to IO access device electronics can lead to improved placement accuracy confirmation. J Trauma Acute Care Surg 96: e28-e32, Apr 2024.
Culkin MC, Bele P, Georges AP, Santos P, Niziolek G, Kaplan LJ, Smith DH, Pascual JL.: Dose-Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood-Brain Barrier Permeability Following Traumatic Brain Injury: An In Vivo Murine Study. Neurocrit Care Mar 2024.
Garrison-Desany HM, Meyers JL, Linnstaedt SD, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Jovanovic T, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Gentile NT, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Joormann J, Harte SE, McLean SA, Koenen KC, Denckla CA.: Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk. Front Psychiatry 15: 1249382, Mar 2024.
Feather CB, Rehrig S, Allen R, Barth N, Kugler EM, Cullinane DC, Falank CR, Bhattacharya B, Maung AA, Seng S, Ratnasekera A, Bass GA, Butler D, Pascual JL, Srikureja D, Winicki N, Lynde J, Nowak B, Azar F, Thompson LA, Nahmias J, Manasa M, Tesoriero R, Kumar SB, Collom M, Kincaid M, Sperwer K, Santos AP, Klune JR, Turcotte J.: To close or not to close? Wound management in emergent colorectal surgery, an EAST Multicenter prospective cohort study. J Trauma Acute Care Surg Mar 2024.
Borst B, Jovanovic T, House SL, Bruce SE, Harnett NG, Roeckner AR, Ely TD, Lebois LAM, Young D, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Hudak LA, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Harte SE, Koenen KC, Kessler RC, McLean SA, Ressler KJ, Stevens JS, van Rooij SJH.: Sex differences in response inhibition-related neural predictors of PTSD in recent trauma-exposed civilians. Biol Psychiatry Cogn Neurosci Neuroimaging Mar 2024.
Gummadi, Sriharsha, Pascual L, Jose L.: Postoperative Neurologic Complications in the Older Adult. Current Geriatrics Reports 13(2): 61-69, February 2024.
Hinojosa CA, Liew A, An X, Stevens JS, Basu A, van Rooij SJH, House SL, Beaudoin FL, Zeng D, Neylan TC, Clifford GD, Jovanovic T, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Datner EM, Chang AM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, Sergot P, Sanchez LD, Bruce SE, Miller MW, Pietrzak RH, Joormann J, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Ressler KJ, Fani N.: Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals. Psychol Med Jan 2024.