Jose L. Pascual Lopez, MD, PhD

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Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Penn e-lert eICU, Philadelphia, PA
Attending Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Attending Surgical Intensivist, Pennsylvania Hospital, Philadelphia, PA
Clinical Associate , University of Pennsylvania School of Nursing
Patient Safety Officer, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending NeuroIntensivist, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Cpl. Michael J. Cresencz Veteran's Affairs Medical Center, Philadelphia, PA
Attending NeuroIntensivist, Penn Presbyterian Hospital, Philadelphia, PA
Co-Medical Director , Surgical ICU, Hospital of the University of Pennsylvania, Philadelphia, PA
Reviewer , Penn Acute Research Collaborative (PARC)
Department: Surgery

Contact information
Division of Trauma & Surgical Critical Care
Penn Presbyterian Medical Center
51 North 39th St., MOB 1st Fl., Ste. 120, Rm. 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
University of Ottawa, Ottawa, Ontario, 1996.
McGill University, Montreal, Quebec, 2005.
McGill University, Montreal, Quebec, 2005.
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Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Description of Clinical Expertise

Jose Pascual is an intensivist/surgeon at the University Of Pennsylvania, board certified in the US/Canada. He finished his fellowship in 2007 and his basic science PhD in resuscitation immunobiology, at McGill, in 2005. His thesis investigated the salutary effects of immunemodulating fluids in shock.

As faculty of Medical and Nursing Schools, Jose teaches students, residents, fellows and advance practice providers in several didactic and skills courses. However, most notable is his role as research mentor for medical, nursing and undergraduate students raising questions at the bedside and attempting to answer them through clinical or basic science research projects. In the last 5 years, Jose has mentored 23 research trainees, several of whom have won awards at national/international scientific meetings.

Jose Pascual’s research interests include Traumatic Brain Injury, shock and ICU education through simulation and patient safety initiatives. His TBI laboratory studies immune responses to injury through intravital microscopy of the cerebral microcirculation investigating the role of the neutrophil in injury and shock.

Jose has launched several ICU educational initiatives using simulation integrated within the ICU to teach day-to-day emergent event management by the multidisciplinary team (NPs, MDs, nurses, pharmacists) through learning from errors or near misses. Initiatives relating to videorecorded simulator-generated or real emergent events have been integrated in ICU Quality Improvement efforts and also published.

Selected Publications

Pascual JL, Gaulton T: Textbook. Opioids in Critical Care. New York: Springer Nature, 2021 (in press).

ElSaadani M, Ahmed SM, Jacovides C, Lopez A, Johnson VE, Kaplan LJ, Smith DH, Pascual JL: Post-TBI antithrombin III recovers Morris water maze cognitive performance, improving cued and spatial learning. Journal of Trauma & Acute Care Surgery Feb. 17 2021 (Epub) Notes: doi: 10.1097/TA.0000000000003112.

Appelbaum R, Martin S, Tinkoff G, Pascual JL, Gandhi RR: Eastern Association for the Surgery of Trauma - Quality, Patient Safety, and Outcomes Committee - Transitions of care: Healthcare handoffs in trauma. American Journal of Surgery Feb. 21 2021 (Epub).

Harnett NG, van Rooij SJH, Ely TD, Lebois LAM, Murty VP, Jovanovic T, Hill SB, Dumornay NM, Merker JB, Bruce SE, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Lewandowski C, Hendry PL, Sheikh S, Storrow AB, Musey PI Jr, Haran JP, Jones CW, Punches BE, Swor RA, McGrath ME, Pascual JL, Seamon MJ, Mohiuddin K, Chang AM, Pearson C, Peak DA, Domeier RM, Rathlev NK, Sanchez LD, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Kessler RC, Koenen KC, Mclean S, Ressler KJ, Stevens JS: Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study. Neuropsychopharmacology Jan. 21 2021 (Epub).

Anesi GL, Jablonski J, Harhay MO, Atkins JH, Bajaj J, Baston C, Brennan PJ, Candeloro CL, Catalano LM, Cereda MF, Chandler JM, Christie JD, Collins T, Courtright KR, Fuchs BD, Gordon E, Greenwood JC, Gudowski S, Hanish A, Hanson Iii CW, Heuer M, Kinniry P, Kornfield ZN, Kruse GB, Lane-Fall M, Martin ND, Mikkelsen ME, Negoianu D, Pascual JL, Patel MB, Pugliese SC, Qasim ZA, Reilly JP, Salmon J, Schweickert WD, Scott MJ, Shashaty MGS, Sicoutris CP, Wang JK, Wang W, Wani AA, Anderson BJ, Gutsche JT: Characteristics, outcomes, and trends of patients with COVID-19-related critical illness at a learning health system in the United States. Annals of Internal Medicine Jan. 19 2021 (Epub).

ElSaadani M, Ahmed SM, Jacovides C, Lopez A, Johnson VE, Kaplan LJ, Schwab CW, Smith DH, Pascual JL: Antithrombin III ameliorates post-traumatic brain injury cerebral leukocyte mobilization enhancing recovery of blood brain barrier integrity. Journal of Trauma & Acute Care Surgery 90(2): 274-280, Feb. 1 2021 Notes: Epub Oct. 22, 2020.

Leichtle SW, Wild J, Chang G, Pascual JL, Resnick S, Matsumisha K: Anticoagulation therapy in patients with traumatic brain injury (ACT-TBI): An Eastern Association for the Surgery of Trauma multicenter prospective study. Surgery 169(2): 470-476, Feb. 2021 Notes: Epub Sept. 12, 2020.

Abdallah HO, Zhao C, Kaufman E, Hatchimonji J, Swendiman RA, Kaplan LJ, Seamon M, Schwab CW, Pascual JL: Increased firearm injury during the COVID-19 pandemic: A hidden urban burden. Journal of the American College of Surgeons 232(2): 159-168.e3, Feb. 2021 Notes: Epub Nov. 6, 2020.

Rivas L, Estroff J, Sparks A, Nahmias J, Allen R, Smith SS, Kutcher M, Carter K, Grigorian A, Albertson S, Turay D, Quispe JC, Luo-Owen X, Vella M, Pascual J, Tororello G, Quattrone M, Bernard A, Ratnasekera A, Lee A, Tamburrini D, Rodriguez C, Harrell K, Jeyamurugan K, Bugaev N, Warner A, Weinberger J, Hazelton JP, Selevany M, Wright F, Kovar A, Urban S, Hamrick A, Mount M, Carrick M, Cullinane DC, Chang G, Jain G, Spalding C, Sarani B: The incidence of venous thromboembolic events in trauma patients after tranexamic acid administration: An EAST multicenter study. Blood Coagulation & Fibrinolysis 32(1): 37-43, Jan. 2021 Notes: Epub Nov. 12, 2020.

Joormann J, McLean SA, Beaudoin FL, An X, Stevens JS, Zeng D, Neylan TC, Clifford G, Linnstaedt SD, Germine LT, Rauch SL, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Fermann G, Hudak LA, Mohiuddin K, Murty V, McGrath ME, Haran JP, Pascual J, Seamon M, Peak DA, Pearson C, Domeier RM, Sergot P, Merchant R, Sanchez LD, Rathlev NK, Peacock WF, Bruce SE, Barch D, Pizzagalli DA, Luna B, Harte SE, Hwang I, Lee S, Sampson N, Koenen KC, Ressler KJ, Kessler RC: Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study. Psychological Medicine Oct. 29 2020 (Epub).

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Last updated: 11/02/2021
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