Jose L. Pascual Lopez, MD, PhD

faculty photo
Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Penn e-lert eICU, Philadelphia, PA
Attending Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Attending Surgical Intensivist, Pennsylvania Hospital, Philadelphia, PA
Clinical Associate , University of Pennsylvania School of Nursing
Patient Safety Officer, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending NeuroIntensivist, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Cpl. Michael J. Cresencz Veteran's Affairs Medical Center, Philadelphia, PA
Attending NeuroIntensivist, Penn Presbyterian Hospital, Philadelphia, PA
Co-Medical Director , Surgical ICU, Hospital of the University of Pennsylvania, Philadelphia, PA
Reviewer , Penn Acute Research Collaborative (PARC)
Department: Surgery

Contact information
Division of Trauma & Surgical Critical Care
Penn Presbyterian Medical Center
51 North 39th St., MOB 1st Fl., Ste. 120, Rm. 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
Education:
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
M.D.
University of Ottawa, Ottawa, Ontario, 1996.
Ph.D.
McGill University, Montreal, Quebec, 2005.
FRCS (C)
McGill University, Montreal, Quebec, 2005.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Description of Clinical Expertise

Jose Pascual is an intensivist/surgeon at the University Of Pennsylvania, board certified in the US/Canada. He finished his fellowship in 2007 and his basic science PhD in resuscitation immunobiology, at McGill, in 2005. His thesis investigated the salutary effects of immunemodulating fluids in shock.

As faculty of Medical and Nursing Schools, Jose teaches students, residents, fellows and advance practice providers in several didactic and skills courses. However, most notable is his role as research mentor for medical, nursing and undergraduate students raising questions at the bedside and attempting to answer them through clinical or basic science research projects. In the last 5 years, Jose has mentored 23 research trainees, several of whom have won awards at national/international scientific meetings.

Jose Pascual’s research interests include Traumatic Brain Injury, shock and ICU education through simulation and patient safety initiatives. His TBI laboratory studies immune responses to injury through intravital microscopy of the cerebral microcirculation investigating the role of the neutrophil in injury and shock.

Jose has launched several ICU educational initiatives using simulation integrated within the ICU to teach day-to-day emergent event management by the multidisciplinary team (NPs, MDs, nurses, pharmacists) through learning from errors or near misses. Initiatives relating to videorecorded simulator-generated or real emergent events have been integrated in ICU Quality Improvement efforts and also published.

Selected Publications

Roeckner AR, Lin ER, Hinrichs R, Harnett NG, Lebois LAM, van Rooij SJH, Ely TD, Jovanovic T, Murty VP, Bruce SE, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Joormann J, Sheridan JF, Harte SE, Koenen KC, Kessler RC, McLean SA, Ressler KJ, Stevens JS.: Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD. Neuropsychopharmacology May 2025.

Santos JLC, Harnett NG, van Rooij SJH, Ely TD, Jovanovic T, Lebois LAM, Beaudoin FL, An X, Neylan TC, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Pizzagalli DA, Harte SE, Ressler KJ, Koenen KC, McLean SA, Stevens JS.: Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators. Biol Psychiatry Cogn Neurosci Neuroimaging May 2025.

Vizer L, Pierce J, Ji Y, Bucher MA, Liu M, Ungar L, Giorgi S, Xing Z, House SL, Beaudoin FL, Stevens JS, Neylan TC, Clifford GD, Jovanovic T, Linnstaedt SD, Zeng D, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Merchant RC, Domeier RM, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Harte SE, Kessler RC, Koenen KC, McLean SA, An X.: Smartphone language features may help identify adverse post-traumatic neuropsychiatric sequelae and their trajectories. NPP Digit Psychiatry Neurosci May 2025.

Ellis RA, Webber TK, Noble NC, Linnstaedt SD, Hinrichs R, Wiltshire C, Reda MH, Davie W, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Punches BE, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Joormann J, Kessler RC, Ressler KJ, Koenen KC, McLean SA, Stevens JS, Jovanovic T, Seligowski AV.: Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men. Stress Health April 2025.

Jones FJS, Pai EL, Magee R, Boylan K, Chioma V, Little J, Yoshor D, Pascual JL, Banihashemi A, Prasad S, Lee EB, Orthmann-Murphy J.: Consecutive brain biopsies illustrate the histological evolution of acute hemorrhagic leukoencephalitis. J Neuropathol Exp Neurol Apr 2025.

Tianyi L, Huibregtse ME, Ely TD, van Rooij SJH, Lebois LAM, Webb EK, Jovanovic T, House SL, Bruce SE, Murty VP, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Hudak LA, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Sheridan JF, Kessler RC, Koenen KC, Ressler KJ, McLean SA, Stevens JS, Harnett NG.: Childhood adversity is associated with longitudinal white matter changes after adulthood trauma. medRxiv Mar 2025.

Itkin M, Horak J, Pascual JL, Chang CWJ, Lile D, Tomita B, Bass GA, Kovach SJ 3rd, Kaplan LJ.: Disorders of Lymphatic Architecture and Flow in Critical Illness. Crit Care Med 53: e665-e682, Mar 2025.

Garrison-Desany HM, Meyers JL, Linnstaedt SD, Koenen KC, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Jovanovic T, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Bruce SE, McLean SA, Denckla CA.: Multi-level socioeconomic modifiers of the comorbidity of post-traumatic stress and tobacco, alcohol, and cannabis use: the importance of income. Soc Psychiatry Psychiatr Epidemiol February 2025.

Liang SS, Roeckner AR, Ely TD, Lebois LAM, van Rooij SJH, Bruce SE, Jovanovic T, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Sheridan JF, Harte SE, Kessler RC, Koenen KC, McLean SA, Ressler KJ, Stevens JS, Webb EK, Harnett NG.: Associations between residential segregation, ambient air pollution, and hippocampal features in recent trauma survivors. medRxiv Feb 2025.

McKibben LA, Layne MN, Albertorio-Sáez LM, Zhao Y, Branham EM, House SL, Beaudoin FL, An X, Stevens JS, Neylan TC, Clifford GD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Datner EM, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sanchez LD, Bruce SE, Sheridan JF, Harte SE, Kessler RC, Koenen KC, Ressler KJ, McLean SA, Linnstaedt SD.: Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner. medRxiv Dec 2024.

back to top
Last updated: 06/03/2025
The Trustees of the University of Pennsylvania