Jose L. Pascual Lopez, MD, PhD

faculty photo
Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Penn e-lert eICU, Philadelphia, PA
Attending Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Attending Surgical Intensivist, Pennsylvania Hospital, Philadelphia, PA
Clinical Associate , University of Pennsylvania School of Nursing
Patient Safety Officer, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending NeuroIntensivist, Hospital of the University of Pennsylvania, Philadelphia, PA
Attending Intensivist, Cpl. Michael J. Cresencz Veteran's Affairs Medical Center, Philadelphia, PA
Attending NeuroIntensivist, Penn Presbyterian Hospital, Philadelphia, PA
Co-Medical Director , Surgical ICU, Hospital of the University of Pennsylvania, Philadelphia, PA
Reviewer , Penn Acute Research Collaborative (PARC)
Department: Surgery

Contact information
Division of Trauma & Surgical Critical Care
Penn Presbyterian Medical Center
51 North 39th St., MOB 1st Fl., Ste. 120, Rm. 108
Philadelphia, PA 19104
Office: 215-662-7323
Fax: 215-243-4679
Education:
N/A (Physiology)
McGill University, Montreal, Quebec , 1990.
N/A (Biochemistry)
University of Ottawa, Ottawa, Ontario , 1992.
M.D.
University of Ottawa, Ottawa, Ontario, 1996.
Ph.D.
McGill University, Montreal, Quebec, 2005.
FRCS (C)
McGill University, Montreal, Quebec, 2005.
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Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Description of Clinical Expertise

Jose Pascual is an intensivist/surgeon at the University Of Pennsylvania, board certified in the US/Canada. He finished his fellowship in 2007 and his basic science PhD in resuscitation immunobiology, at McGill, in 2005. His thesis investigated the salutary effects of immunemodulating fluids in shock.

As faculty of Medical and Nursing Schools, Jose teaches students, residents, fellows and advance practice providers in several didactic and skills courses. However, most notable is his role as research mentor for medical, nursing and undergraduate students raising questions at the bedside and attempting to answer them through clinical or basic science research projects. In the last 5 years, Jose has mentored 23 research trainees, several of whom have won awards at national/international scientific meetings.

Jose Pascual’s research interests include Traumatic Brain Injury, shock and ICU education through simulation and patient safety initiatives. His TBI laboratory studies immune responses to injury through intravital microscopy of the cerebral microcirculation investigating the role of the neutrophil in injury and shock.

Jose has launched several ICU educational initiatives using simulation integrated within the ICU to teach day-to-day emergent event management by the multidisciplinary team (NPs, MDs, nurses, pharmacists) through learning from errors or near misses. Initiatives relating to videorecorded simulator-generated or real emergent events have been integrated in ICU Quality Improvement efforts and also published.

Selected Publications

Lourdes Araujo 1 2, Juan Martinez-Romo 3 4, Otilia Bisbal 5, Ricardo Sanchez-de-Madariaga 6 4; Cohort of the National AIDS Network (CoRIS): Discovering HIV related information by means of association rules and machine learning. Sci Rep 12(1): 18208, October 2023 Notes: doi: 10.1038/s41598-022-22695-y.

Toledo, S, Bondaruk, VF, Yahdjian, L, Oñatibia, GR, Loydi, A, Alberti, J, Bruschetti, M, Pascual, J, Peter, G, Agüero, WD, Namur, Blanco, L, Peri, PL : Environmental factors regulate soil microbial attributes and their response to drought in rangeland ecosystems. Sci Total Environ September 2023 Notes: DOI: 10.1016/j.scitotenv.2023.164406.

Gárate, G, González-Quintanilla, V, González, A 1, Marta Pascual 2 3 4, Sara Pérez-Pereda 1 2 3, Madera, J, Pascual, P: Serum Alpha and Beta-CGRP Levels in Chronic Migraine Patients Before and After Monoclonal Antibodies Against CGRP or its Receptor. Ann Neurol 94(2): 285-294, August 2023 Notes: DOI: 10.1002/ana.26658.

Perfezou, P, Hall, N, Duthe, JC, Abdi, B, Seang, S, Arvieux, C, Lamaury, I, Menard, A, Marcelin, AG, Katlama, C, Palich, R 3; Dat’AIDS study group: Doravirine plus lamivudine two-drug regimen as maintenance antiretroviral therapy in people living with HIV: a French observational study. J Antimicrob Chemother 78(8): 1929-1933, August 2023 Notes: doi: 10.1093/jac/dkad185.

Chang, CWJ, Provencio, JJ, Pascual, J, Heavner, MS, Olson, D, Livesay, Kaplan, LJ: State-of-the-Art Evaluation of Acute Adult Disorders of Consciousness for the General Intensivist. Crit Care Med 51(7): 945-963, July 2023 Notes: doi: 10.1097/CCM.0000000000005893. Epub 2023 Apr 17.

Pascual, J, Gil-Gil, M, Proszek, P, Zielinski, C, Reay, A, Ruiz-Borrego, M Cutts, R, Gil, EMC, Feber, A, Muñoz-Mateu, M, Swift, C, Bermejo, B, Herranz, J, Vila, MM, Antón, A, Kahan, Z, Csöszi, T, Liu, Y, Garcia, DF, Garcia-Murillas, I, Hubank, M, Turner, NC, Martín, M: Baseline mutations and ctDNA dynamics as prognostic and predictive factors in ER-positive/HER2-negative metastatic breast cancer patients. Clin Cancer Res . 10: 1078-0432, July 2023 Notes: 1158/1078-0432.CCR-23-0956.

Pascual, J, DeBlois, JP, Ray, C, Hametner, B, Heffernan, KS, Voss, MA: Central hemodynamic response to activation of the vestibular sympathetic reflex with head-down rotation in healthy young adults. J Appl Physiol (1985) 135(1): 68-76, July 2023 Notes: doi: 10.1152/japplphysiol.00107.2023.

Aguilera-Huertas, J, Cuartero, J, Ros, M, Pascual, J, Parras-Alcántara, L, González-Rosado, M, Özbolat, Zornoza, R, Egea-Cortines, M, María Hurtado-Navarro, M, Lozano-García, B: How binomial (traditional rainfed olive grove-Crocus sativus) crops impact the soil bacterial community and enhance microbial capacities. J Environ Manage July 2023 Notes: DOI: 10.1016/j.jenvman.2023.118572.

Loes, AVJ, Pascual, J, Willemsen, MA: Additional data on head circumference in patients with glucose transporter 1 deficiency syndrome: The Glut1 deficiency foundation conference cohort. Eur J Paediatr Neurol July 2023 Notes: DOI: 10.1016/j.ejpn.2023.05.011.

Culkin, MC, Bele, P, Georges, AP, Lopez, AJ, Niziolek, G, Jacovides, CL Song, H, Johnson, VE, Kaplan, LJ Smith, DH, Pascual, JL: Early posttraumatic brain injury tranexamic acid prevents blood-brain barrier hyperpermeability and improves surrogates of neuroclinical recovery. J Trauma Acute Care Surg 95(1): 47-54, July 2023 Notes: doi: 10.1097/TA.0000000000003971. Epub 2023 Apr 11.

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Last updated: 08/04/2023
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