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Douglas H. Smith, M.D.

Robert A. Groff Professor of Teaching and Research in Neurosurgery
Member , Mental Retardation Research Center, University of Pennsylvania
Member , Institute of Medicine and Engineering, University of Pennsylvania
Member , Functional Imaging Center, University of Pennsylvania
Director , Center for Brain Injury and Repair, University of Pennsylvania
Vice Chairman, Teaching and Research, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania
Department: Neurosurgery

Contact information
Department of Neurosurgery
3320 Smith Walk
Hayden Hall 105
Philadelphia, PA 19104-6316
Office: 215-573-3156
Fax: 215-573-3808
B.S. (Biology)
University of Connecticut, 1981.
M.D. (Medicine)
University of Noreste, 1986.
Post-Graduate Training
Postdoctoral Fellow in Molecular Biology and Protein Chemistry, University of Connecticut Health Center, 1986-1988.
Postdoctoral Fellow in Neuropharmacology and Trauma, University of Connecticut Health Center, 1989-1990.
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Description of Research Expertise

Douglas H. Smith, M.D. is the Director of the Center for Brain Injury and Repair and Professor of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania. Penn's multidisciplined CBIR includes over twenty-five principal investigators and their laboratory staff collectively studying mechanisms, diagnosis and potential treatments of traumatic brain injury. Over the last 18 years, Dr. Smith has devoted his full-time efforts to neurotrauma research following completion of fellowships in both molecular biology and neurotrauma at the University of Connecticut. He has been an active member of the National Neurotrauma Society and currently serves as an officer. In addition, Dr. Smith is director of a multi-center NIH program grant on mild traumatic brain injury and he oversees an NIH training grant for brain injury research. His laboratory’s research interests include investigating the biomechanical effects of traumatic brain injury, imaging techniques to diagnose diffuse axonal injury, and the link between diffuse axonal injury and Alzheimer's disease. Dr Smith's laboratory has also engineered nervous tissue constructs that have been shown to repair spinal cord and nerve damage. These collective efforts have resulted in over 170 published reports.

To view the website for Dr. Smith’s lab, please click here

Click here to view the website for the Center for Brain Injury & Repair (CBIR).

Selected Publications

Chen HI, Wolf JA, Smith DH: Multichannel activity propagation across an engineered axon network. J Neural Eng 14(2), April 2017.

Purohit Prashant K, Smith Douglas H: A model for stretch growth of neurons. Journal of biomechanics 49(16): 3934-3942, Dec 2016.

Nagata Katsuhiro, Kumasaka Kenichiro, Browne Kevin D, Li Shengjie, St-Pierre Jesse, Cognetti John, Marks Joshua, Johnson Victoria E, Smith Douglas H, Pascual Jose L: Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery. The journal of trauma and acute care surgery 81(6): 1088-1094, Aug 2016.

Stewart William, Smith Douglas H: Time to be blunt about blast traumatic brain injury. The Lancet. Neurology 15(9): 896-8, Aug 2016.

Smith Douglas H, Stewart William: Tackling concussion, beyond Hollywood. The Lancet. Neurology 15(7): 662-3, Jun 2016.

174. Owen-Smith AA, Smith DH, Rand CS, Tom JO, Laws R, Waterbury A, Williams A, Vollmer WM: Difference in Effectiveness of Medication Adherence Intervention by Health Literacy Level. Perm J. 20(3): 38-44, June 2016.

Hay Jennifer, Johnson Victoria E, Smith Douglas H, Stewart William: Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury. Annual review of pathology 11: 21-45, May 2016.

Li Shengjie, Eisenstadt Rachel, Kumasaka Kenichiro, Johnson Victoria E, Marks Joshua, Nagata Katsuhiro, Browne Kevin D, Smith Douglas H, Pascual Jose L: Does enoxaparin interfere with HMGB1 signaling after TBI? A potential mechanism for reduced cerebral edema and neurologic recovery. The journal of trauma and acute care surgery 80(3): 381-7; discussion 387-9, Mar 2016.

Jensen NF, Agama K, Roy A, Smith DH, Pfister TD, Rømer MU, Zhang HL, Doroshow JH, Knudsen BR, Stenvang J, Brünner N, Pommier Y. : Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations. J Exp Clin Cancer Res. 31: 35:56, March 2016.

Ali Zarina S, Johnson Victoria E, Stewart William, Zager Eric L, Xiao Rui, Heuer Gregory G, Weber Maura T, Mallela Arka N, Smith Douglas H: Neuropathological Characteristics of Brachial Plexus Avulsion Injury With and Without Concomitant Spinal Cord Injury. Journal of neuropathology and experimental neurology 75(1): 69-85, Jan 2016.

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Last updated: 10/23/2017
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