Penn Neurosurgery Home >
- Faculty
Douglas H. Smith, MDProfessor of Neurosurgery
Member
Member
Member
Director
Department: Neurosurgery
Contact information
Department of Neurosurgery
3320 Smith Walk Hayden Hall 105 Philadelphia, PA 19104-6316
Office: 215-898-0881
Fax: 215-573-3808 Email: smithdou@mail.med.upenn.edu
Education:
B.S. (Biology) University of Connecticut, 1981. M.D. (Medicine) University of Noreste, 1986.
Post-Graduate Training
Permanent linkPostdoctoral Fellow in Molecular Biology and Protein Chemistry, University of Connecticut Health Center, 1986-1988. Postdoctoral Fellow in Neuropharmacology and Trauma, University of Connecticut Health Center, 1989-1990. Description of Research ExpertiseDouglas H. Smith, M.D. is the Director of the Center for Brain Injury and Repair and Professor of Neurosurgery at the University of Pennsylvania. Penn's multidisciplined CBIR includes over twenty-five principal investigators and their laboratory staff collectively studying mechanisms, diagnosis and potential treatments of traumatic brain injury. Over the last 18 years, Dr. Smith has devoted his full-time efforts to neurotrauma research following completion of fellowships in both molecular biology and neurotrauma at the University of Connecticut. He has been an active member of the National Neurotrauma Society and currently serves as an officer. In addition, Dr. Smith is director of a multi-center NIH program grant on mild traumatic brain injury and he oversees an NIH training grant for brain injury research. His laboratory’s research interests include investigating the biomechanical effects of traumatic brain injury, imaging techniques to diagnose diffuse axonal injury, and the link between diffuse axonal injury and Alzheimer's disease. Dr Smith's laboratory has also engineered nervous tissue constructs that have been shown to repair spinal cord and nerve damage. These collective efforts have resulted in over 130 published reports.To view the website for Dr. Smith’s lab, please click here Click here to view the website for the Center for Brain Injury & Repair (CBIR). Selected PublicationsUryu K, Chen XH, Martinez D, Browne KD, Johnson VE, Graham DI, Lee VM, Trojanowski JQ, Smith DH: Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Exp Neurol 208(2): 185-92, December 2007.Pfister BJ, Huang JH, Kameswaran N, Smith DH: Neural engineering to produce in vitro nerve constructs and neurointerface. Neurosurgery 60(1): 137-142, January 2007. Armstead WM, Nassar T, Akkawi S, Smith DH, Chen X-H, Cines DB, Higazi AA: Neutralizing the neurotoxic effects of exogenous and endogenous tPA. Nat Neurosci 9(9): 1150-1155, September 2006. Pfister BJ, Bonislawski DP, Smith DH, Cohen AS: Stretch-grown axons retain the ability to transmit active electrical signals. FEBS Lett 580(14): 3525-31, May 2006. Stein SC, Browne KD, Chen XH, Smith DH, Graham DI: Thromboembolism and delayed cerebral ischemia after subarachnoid hemorrhage: an autopsy study. Neurosurgery 59(4): 781-7, October 2006. Browne KD, Iwata A, Putt ME, Smith DH: Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats. Exp Neurol 201(2): 301-7, October 2006. Iwata A, Browne KD, Pfister BJ, Gruner JA, Smith DH: Long-term survival and outgrowth of mechanically engineered nervous tissue constructs implanted into spinal cord lesions. Tissue Eng 12(1): 101-110, January 2006. Pfister BJ, Iwata A, Taylor AG, Wolf JA, Meaney DF, Smith DH: Development of transplantable nervous tissue constructs comprised of stretch-grown axons. J Neurosci Meth 153(1): 95-103, May 2006. Jette N, Coderre E, Nikolaeva MA, Enright PD, Iwata A, Smith DH, Jiang Q, Stys PK: Spatiotemporal distribution of spectrin breakdown products induced by anoxia in adult rat optic nerve in vitro. J Cereb Blood F Metab 26(6): 777-86, June 2006. Maxwell WL, MacKinnon MA, Smith DH, McIntosh TK, Graham DI: Thalamic nuclei after human blunt head injury. J Neuropath Exp Neur 65(5): 478-88, May 2006.
|
