Douglas H. Smith, MD

faculty photo
Robert A. Groff Professor of Teaching and Research in Neurosurgery
Department: Neurosurgery

Contact information
105 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104-6316
Office: 215-573-3156
Fax: 215-573-3808
B.S. (Biology)
University of Connecticut, 1981.
M.D. (Medicine)
University of Noreste, 1986.
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Description of Research Expertise

Douglas H. Smith, MD is Director of the Center for Brain Injury and Repair (CBIR) and Professor of Neurosurgery at the Perelman School of Medicine. CBIR is renowned as a multi-disciplined collaborative bringing together over twenty-five principal investigators and their laboratory staffs whose work studies the mechanisms, diagnosis and potential treatments of traumatic brain injury. Dr. Smith's group has established that diffuse axonal injury (DAI) is a key pathological feature of concussion and that the extent of acute axonal pathology is predictive of cognitive outcome. In addition, his team has discovered mechanisms of concussion and more severe TBI that lead to progressive neurodegeneration such as chronic traumatic encephalopathy. These collective efforts are represented in over 250 published scientific reports with an h-index of over 80.

Dr. Smith directs an NIH training grant for brain injury. He currently serves as the Scientific Director of the Big 10-Ivy League Consortium on Concussion. Dr. Smith also serves on the Scientific Advisory Boards for the US National Football League (NFL), the National Collegiate Athletic Association (NCAA)-DoD Grand Alliance, “Concussion Assessment, Research and Education” (CARE) Consortium and the International Concussion Society.

Selected Publications

Lee Edward B, Kinch Kevin, Johnson Victoria E, Trojanowski John Q, Smith Douglas H, Stewart William: Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players. Acta neuropathologica Jun 2019.

Chen H Isaac, Jgamadze Dennis, Lim James, Mensah-Brown Kobina, Wolf John A, Mills Jason A, Smith Douglas H: Functional Cortical Axon Tracts Generated from Human Stem Cell-Derived Neurons. Tissue engineering. Part A 25(9-10): 736-745, May 2019.

Gan Zoe S, Stein Sherman C, Swanson Randel, Guan Shaobo, Garcia Lizette, Mehta Devanshi, Smith Douglas H: Blood Biomarkers for Traumatic Brain Injury: A Quantitative Assessment of Diagnostic and Prognostic Accuracy. Frontiers in neurology 10: 446, Apr 2019.

Carteri Randhall B, Kopczynski Afonso, Rodolphi Marcelo Salimen, Strogulski Nathan Ryzewski, Sartor Mônia, Feldmann Marceli, De Bastiani Marco Antonio, Duval Wannmacher Clovis Milton, de Franceschi Itiane Diehl, Hansel Gisele, Smith Douglas H, Portela Luis Valmor: Testosterone Administration after Traumatic Brain Injury Reduces Mitochondrial Dysfunction and Neurodegeneration. Journal of neurotrauma Apr 2019.

Stewart William, Allinson Kieren, Al-Sarraj Safa, Bachmeier Corbin, Barlow Karen, Belli Antonio, Burns Mark P, Carson Alan, Crawford Fiona, Dams-O'Connor Kristen, Diaz-Arrastia Ramon, Dixon C Edward, Edlow Brian L, Ferguson Scott, Fischl Bruce, Folkerth Rebecca D, Gentleman Steve, Giza Christopher C, Grady M Sean, Helmy Adel, Herceg Mark, Holton Janice L, Howell David, Hutchinson Peter J, Iacono Diego, Iglesias Juan E, Ikonomovic Milos D, Johnson Victoria E, Keene C Dirk, Kofler Julia K, Koliatsos Vassilis E, Lee Edward B, Levin Harvey, Lifshitz Jonathan, Ling Helen, Loane David J, Love Seth, Maas Andrew Ir, Marklund Niklas, Master Christina L, McElvenny Damien M, Meaney David F, Menon David K, Montine Thomas J, Mouzon Benoit, Mufson Elliott J, Ojo Joseph O, Prins Mayumi, Revesz Tamas, Ritchie Craig W, Smith Colin, Sylvester Richard, Tang Cheuk Y, Trojanowski John Q, Urankar Kathryn, Vink Robert, Wellington Cheryl, Wilde Elisabeth A, Wilson Lindsay, Yeates Keith, Smith Douglas H: Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology 18(3): 231-233, Mar 2019.

Su YouRong Sophie, Schuster James M, Smith Douglas H, Stein Sherman C: Cost-Effectiveness of Biomarker Screening for Traumatic Brain Injury. Journal of neurotrauma Mar 2019.

Smith Douglas H, Johnson Victoria E, Trojanowski John Q, Stewart William: Chronic traumatic encephalopathy - confusion and controversies. Nature reviews. Neurology 15(3): 179-183, Mar 2019.

Ulyanova Alexandra V, Koch Paul F, Cottone Carlo, Grovola Michael R, Adam Christopher D, Browne Kevin D, Weber Maura T, Russo Robin J, Gagnon Kimberly G, Smith Douglas H, Isaac Chen H, Johnson Victoria E, Kacy Cullen D, Wolf John A: Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus. eNeuro 5(5), Sep-Oct 2018.

Zanier Elisa R, Bertani Ilaria, Sammali Eliana, Pischiutta Francesca, Chiaravalloti Maria Antonietta, Vegliante Gloria, Masone Antonio, Corbelli Alessandro, Smith Douglas H, Menon David K, Stocchetti Nino, Fiordaliso Fabio, De Simoni Maria-Grazia, Stewart William, Chiesa Roberto: Induction of a transmissible tau pathology by traumatic brain injury. Brain : a journal of neurology 141(9): 2685-2699, Sep 2018.

Dollé Jean-Pierre, Rodgers Jeffrey M, Browne Kevin D, Troxler Thomas, Gai Feng, Smith Douglas H: Newfound effect of N-acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro. Neurobiology of disease 117: 161-169, Sep 2018.

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Last updated: 06/13/2019
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