faculty photo

Donald M. O'Rourke, M.D.

Associate Professor of Neurosurgery
Faculty, Department of Neurosurgery, Penn Neurological Institute, Hospital of the University of Pennsylvania
Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Translational Studies Program, University of Pennsylvania
Faculty, Department of Neurosurgery, Pennsylvania Hospital, UPHS
Founding Member, Center for Cancer Pharmacology, University of Pennsylvania
Director, Human Brain Tissue Bank, University of Pennsylvania
Associate Professor, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
Post-Graduate Training
Intern in General Surgery, Hospital of the University of Pennsylvania, Philadelphia, 1987-1988.
Resident in Neurosurgery, University of Pennsylvania, Philadelphia, 1988-1994.
Postdoctoral Research Fellow, M.D., Ph.D., University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, 1994-1996.
Diplomate, National Board of Medical Examiners, 1988.
Diplomate, American Board of Neurological Surgeons, 1998.
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Selected Publications

Walsh Alice M, Kapoor Gurpreet S, Buonato Janine M, Mathew Lijoy K, Bi Yingtao, Davuluri Ramana V, Martinez-Lage Maria, Simon M Celeste, O'Rourke Donald M, Lazzara Matthew J: Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma. Molecular cancer research : MCR May 2015.

Çoban G, Mohan S, Kural F, Wang S, O'Rourke D M, Poptani H: Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas. AJNR. American journal of neuroradiology Apr 2015.

Jabehdar Maralani Pejman, Melhem Elias R, Wang Sumei, Herskovits Edward H, Voluck Matthew R, Kim Sang Joon, Learned Kim O, O'Rourke Donald M, Mohan Suyash: Association of dynamic susceptibility contrast enhanced MR Perfusion parameters with prognosis in elderly patients with glioblastomas. European radiology Feb 2015.

Abdullah Kalil G, Ramayya Ashwin, Thawani Jayesh P, Macyszyn Lukasz, Martinez-Lage Maria, O'Rourke Donald M, Brem Steven: Factors associated with increased survival after surgical resection of glioblastoma in octogenarians. PloS one 10(5): e0127202, 2015.

Ojerholm Eric, Lee John Y K, Thawani Jayesh P, Miller Denise, O'Rourke Donald M, Dorsey Jay F, Geiger Geoffrey A, Nagda Suneel, Kolker James D, Lustig Robert A, Alonso-Basanta Michelle: Stereotactic radiosurgery to the resection bed for intracranial metastases and risk of leptomeningeal carcinomatosis. Journal of neurosurgery 121 Suppl: 75-83, Dec 2014.

Akbari Hamed, Macyszyn Luke, Da Xiao, Wolf Ronald L, Bilello Michel, Verma Ragini, O'Rourke Donald M, Davatzikos Christos: Pattern analysis of dynamic susceptibility contrast-enhanced MR imaging demonstrates peritumoral tissue heterogeneity. Radiology 273(2): 502-10, Nov 2014.

Wang S, Kim S J, Poptani H, Woo J H, Mohan S, Jin R, Voluck M R, O'Rourke D M, Wolf R L, Melhem E R, Kim S: Diagnostic utility of diffusion tensor imaging in differentiating glioblastomas from brain metastases. AJNR. American journal of neuroradiology 35(5): 928-34, May 2014.

Pal Sharmistha, Bi Yingtao, Macyszyn Luke, Showe Louise C, O'Rourke Donald M, Davuluri Ramana V: Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes. Nucleic acids research 42(8): e64, Apr 2014.

Delfin Gail, Leary Marion, Perman Sarah M, O'Rourke Donald M, Levine Joshua M, Abella Benjamin S: Postarrest targeted temperature management immediately following craniotomy-a case report. Therapeutic hypothermia and temperature management 3(3): 143-6, Sep 2013.

Chawla S, Krejza J, Vossough A, Zhang Y, Kapoor G S, Wang S, O'Rourke D M, Melhem E R, Poptani H: Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy. AJNR. American journal of neuroradiology 34(8): 1542-9, Aug 2013.

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Last updated: 09/19/2012
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