Douglas B. Cines, M.D.
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
Dept. Pathology and Laboratory Medicine
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
513 A Stellar Chance
422 Curie Blvd.
University of Pennsylvania
Philadelphia, PA 19104
Office: 215-662-3966
Fax: 215-573-2012
Fax: 215-573-2012
Email:
DCINES@MAIL.MED.UPENN.EDU
DCINES@MAIL.MED.UPENN.EDU
Education:
A.B.
New York University, 1968.
M.D.
New York University School of Medicine, 1972.
A.B.
New York University, 1968.
M.D.
New York University School of Medicine, 1972.
Post-Graduate Training
Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973.
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975.
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978.
Intern in Medicine, N.C., Memorial Hospital, Chapel Hill, NC, 1972-1973.
Resident in Medicine, N.C, Memorial Hospital, Chapel Hill, NC, 1973-1975.
Fellow, Hematology-Oncology, Hospital of the University of Pennsylvania, 1975-1978.
Certifications
American Board of Internal Medicine , 1975.
American Board of Internal Medicine (Hematology), 1980.
Permanent linkAmerican Board of Internal Medicine , 1975.
American Board of Internal Medicine (Hematology), 1980.
Description of Research Expertise
Thormbosis, fibrinolysis, vascular biology, immunohematologyDescription of Clinical Expertise
Coagulation. Immune hematological disordersSelected Publications
Cuker, A, and Cines, D.B.: How I treat heparin-induced thrombocytopenia (HIT). Blood 2012.Pixley RA, Espinola RG, Ghebrehiwet B, Joseph K, Kao A, Bdeir K, Cines DB, Colman RW.: Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by Surface Plasmon Resonance (BiaCore). Thromb Haemost. 105(6): 1053-9, May 2011.
Nassar, T., Yarovoi, S., Fanne, R.A., Allen, T.C., Idell, S., Cines, D.B., and Higazi, A.A.-R. : Urokinase Plasminogen Activator Regulates Pulmonary Arterial Contractility and Vascular Permeability in Mice. Am J Respir Cell Mol Biol May 2011.
Gersh, K.C., Zaitsev, S., Cines, D.B., Muzykantov, V. and Weisel, J.W: Flow-dependent channel formation in clots by RBC bound fibrinolytic. Blood 117(18): 1964-7, May 2011.
Armstead, W.M., Kiessling, J.W., Cines, D.B. and Higazi, A.A.-R. : Glucagon Protects Against Impaired NMDA-Mediated Cerebrovasodilation and cerebral autoregulation during hypotension after brain injury by activating cAMP protein kinase A and inhibiting upregulation of tPA. J. Neurotrauma 28(3): 451-7, March 2011.
Armstead WM, Riley J, Cines DB, Higazi AA.: tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK. Brain Res. 1376: 88-93, Feb 2011.
Kowalska, M.A., Krishnaswamy, S., Rauova, L., Zhai, L., Hayes, V., Amirikian, K., Esko, J.D., Bougie, D.W., Aster, R.H., Cines, D.B., and Poncz, M. : Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: New insights into the prothrombotic nature of HIT. Blood 118(10): 2882-8, 2011.
Makarova, A.M., Lebedeva, T.V., Nassar, T., Higazi, A.A-R,, Xue, J., Carinato, M.E., Bdeir, Kh, Cines, D.B., and Stepanova, V. : Urokinase-type plasminogen activator (uPA) induced pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial NOS. J Biol Chem. 286: 23044-53, 2011.
Armstead, W.M., Ganguly, K., Riley, J., Kiessling, J.W., Cines, D.B., Higazi, A.A.-R., Zaitsev, S., and Muzykantov, V.R: RBC-coupled tPA prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig. Pediatr. Crit. Care Med. 12(6): e369-75, 2011.
Nassar, T., Bdeir, Kh., Yarovoi, S., Fanne, R.A., Murciano, J.-C., Idell, S., Allen, T.C., Cines, D.B. and Higazi, A.A.-R. : tPA regulates pulmonary vascular reactivity through NMDA receptors. Am. J. Physiol. Lung and Molec. Physiol. 301(L307), 2011.
