Division of Hematology/Oncology

Faculty

faculty photo

Susan M Domchek, MD

Basser Professor in Oncology
Director, Cancer Risk Evaluation Program, Abramson Cancer Center, University of Pennsylvania
Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania
Executive Director, Basser Research Center
Department: Medicine

Contact information
3 West Perelman Center
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-3360
Fax: 215-615-3349
Education:
BA (Engineering Sciences)
Dartmouth College, 1990.
MD (Internal Medicine)
Harvard Medical School, 1995.
Post-Graduate Training
Intern, Internal Medicine , Massachusetts General Hospital, Boston, MA, 1995-1996.
Resident, Internal Medicine, Massachusetts General Hospital, Boston, MA, 1996-1998.
Clinical Fellow in Hematology and Oncology, Dana-Farber Cancer Institute, Boston, MA, 1998-2001.
Chief Medical Resident, Massachusetts General Hospital, Boston, MA, 2000-2000.
Certifications
American Board of Internal Medicine (Internal Medicine), 1998.
American Board of Internal Medicine (Medical Oncology), 2001.
American Board of Internal Medicine (Medical Oncology), 2011.
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Description of Research Expertise

Breast cancer genetics
Breast cancer prevention and screening
Breast cancer immunotherapy clinical trials

Description of Clinical Expertise

Breast cancer prevention, screening and treatment
Breast cancer genetics

Selected Publications

Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, Lee A, Subramanian D, De Leeneer K, Fostira F, Tomiak E, Neuhausen SL, Teo ZL, Khan S, Aittomäki K, Moilanen JS, Turnbull C, Seal S, Mannermaa A, Kallioniemi A, Lindeman GJ, Buys SS, Andrulis IL, Radice P, Tondini C, Manoukian S, Toland AE, Miron P, Weitzel JN, Domchek SM, Poppe B, Claes KB, Yannoukakos D, Concannon P, Bernstein JL, James PA, Easton DF, Goldgar DE, Hopper JL, Rahman N, Peterlongo P, Nevanlinna H, King MC, Couch FJ, Southey MC, Winqvist R, Foulkes WD, Tischkowitz M.: Breast-cancer risk in families with mutations in PALB2. New England Journal of Medicine August 2014.

Bradbury AR1, Patrick-Miller L2, Domchek S3.: Multiplex genetic testing: reconsidering utility and informed consent in the era of next-generation sequencing. Genetics in Medicine July 2014.

Domchek SM1, Nathanson KL2.: Panel testing for inherited susceptibility to breast, ovarian, and colorectal cancer. Genetics in Medicine July 2014.

Pagani O1, Regan MM, Walley BA, Fleming GF, Colleoni M, Láng I, Gomez HL, Tondini C, Burstein HJ, Perez EA, Ciruelos E, Stearns V, Bonnefoi HR, Martino S, Geyer CE Jr, Pinotti G, Puglisi F, Crivellari D, Ruhstaller T, Winer EP, Rabaglio-Poretti M, Maibach R, Ruepp B, Giobbie-Hurder A, Price KN, Bernhard J, Luo W, Ribi K, Viale G, Coates AS, Gelber RD, Goldhirsch A, Francis PA; TEXT and SOFT Investigators; International Breast Cancer Study Group.: Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. New England Journal of Medicine July 2014.

Friebel TM, Domchek SM, Rebbeck TR.: Modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: systematic review and meta-analysis. Journal of the National Cancer Institute June 2014.

Hill DA1, Horick NK, Isaacs C, Domchek SM, Tomlinson GE, Lowery JT, Kinney AY, Berg JS, Edwards KL, Moorman PG, Plon SE, Strong LC, Ziogas A, Griffin CA, Kasten CH, Finkelstein DM.: Long-term risk of medical conditions associated with breast cancer treatment. Breast Cancer Research and Treatment. May 2014.

Hill DA, Horick NK, Isaacs C, Domchek SM, Tomlinson GE, Lowery JT, Kinney AY, Berg JS, Edwards KL, Moorman PG, Plon SE, Strong LC, Ziogas A, Griffin CA, Kasten CH, Finkelstein DM.: "Long-term risk of medical conditions associated with breast cancer treatment." Breast Cancer Res Treat May 2014.

Osorio A1, Milne RL2, Kuchenbaecker K3, Vaclová T4, Pita G5, Alonso R5, Peterlongo P6, Blanco I7, de la Hoya M8, Duran M9, Díez O10, Ramón Y Cajal T11, Konstantopoulou I12, Martínez-Bouzas C13, Andrés Conejero R14, Soucy P15, McGuffog L3, Barrowdale D3, Lee A3, Swe-Brca16, Arver B17, Rantala J18, Loman N19, Ehrencrona H20, Olopade OI21, Beattie MS22, Domchek SM23, Nathanson K23, Rebbeck TR24, Arun BK25, Karlan BY26, Walsh C26, Lester J26, John EM27, Whittemore AS28, Daly MB29, Southey M30, Hopper J31, Terry MB32, Buys SS33, Janavicius R34, Dorfling CM35, van Rensburg EJ35, Steele L36, Neuhausen SL36, Ding YC36, Hansen TV37, Jønson L37, Ejlertsen B38, Gerdes AM39, Infante M9, Herráez B5, Moreno LT5, Weitzel JN40, Herzog J40, Weeman K40, Manoukian S41, Peissel B41, Zaffaroni D41, Scuvera G41, Bonanni B42, Mariette F43, Volorio S43, Viel A44, Varesco L45, Papi L46, Ottini L47, Tibiletti MG48, Radice P49, Yannoukakos D12, Garber J50, Ellis S3, Frost D3, Platte R3, Fineberg E3, Evans G51, Lalloo F51, Izatt L52, Eeles R53, Adlard J54, Davidson R55, Cole T56, Eccles D57, Cook J58, Hodgson S59, Brewer C60, Tischkowitz M61, Douglas F62, Porteous M63, Side L64, Walker L65, Morrison P66, Donaldson A67, Kennedy J68, Foo C69, Godwin AK70, Schmutzler RK71, Wappenschmidt B71, Rhiem K71, Engel C72, Meindl A73, Ditsch N73, Arnold N74, Plendl HJ75, Niederacher D76, Sutter C77, Wang-Gohrke S78, Steinemann D79, Preisler-Adams S80, Kast K81, Varon-Mateeva R82, Gehrig A83, Stoppa-Lyonnet D84, Sinilnikova OM85, Mazoyer S86, Damiola F86, Poppe B87, Claes K87, Piedmonte M88, Tucker K89, Backes F90, Rodríguez G91, Brewster W92, Wakeley K93, Rutherford T94, Caldés T8, Nevanlinna H95, Aittomäki K95, Rookus MA96, van Os TA97, van der Kolk L98, de Lange JL96, Meijers-Heijboer HE99, van der Hout AH100, van Asperen CJ101, Gómez Garcia EB102, Hoogerbrugge N103, Collée JM104, van Deurzen CH105, van der Luijt RB106, Devilee P107, Hebon108, Olah E109, Lázaro C110, Teulé A7, Menéndez M110, Jakubowska A111, Cybulski C111, Gronwald J111, Lubinski J111, Durda K111, Jaworska-Bieniek K112, Johannsson OT113, Maugard C114, Montagna M115, Tognazzo S115, Teixeira MR116, Healey S117, Investigators K118, Olswold C119, Guidugli L120, Lindor N121, Slager S119, Szabo CI122, Vijai J123, Robson M124, Kauff N124, Zhang L125, Rau-Murthy R124, Fink-Retter A126, Singer CF126, Rappaport C126, Geschwantler Kaulich D126, Pfeiler G126, Tea MK126, Berger A126, Phelan CM127, Greene MH128, Mai PL128, Lejbkowicz F129, Andrulis I130, Mulligan AM131, Glendon G132, Toland AE133, Bojesen A134, Pedersen IS135, Sunde L136, Thomassen M137, Kruse TA137, Jensen UB136, Friedman E138, Laitman Y138, Shimon SP138, Simard J139, Easton DF3, Offit K123, Couch FJ140, Chenevix-Trench G117, Antoniou AC3, Benitez J141.: DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers. PLoS Genetics April 2014.

Goldsack JC1, Reilly C, Bush C, McElligott S, Bristol MN, Motanya UN, Field R, Vozniak JM, Wong YN, Schwartz JS, Domchek S.: Impact of shortages of injectable oncology drugs on patient care. American Journal of Health-System Pharmacy. April 2014.

Maslow BS, Morse CB, Schanne A, Loren A, Domchek SM, Gracia CR: Contraceptive use and the role of contraceptive counseling in reproductive-aged women with cancer. Contraception March 2014.

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Last updated: 10/03/2014
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